Copyright ©2006 Baishideng Publishing Group Co.
World J Gastroenterol. May 21, 2006; 12(19): 2991-2999
Published online May 21, 2006. doi: 10.3748/wjg.v12.i19.2991
Table 3 Summary of all meta-analyses looking at the association between H pylori and gastric cancer
StudyFactorsHuang et al 1998[16]Danesh 1999[19]Eslick et al 1999[18]Xue et al 2001[93]HCCG 2001[94]Huang et al 2003[95]
JournalGastroenterologyAliment Pharm TherAm J GastroenterolWorld J GastroenterolGutGastroenterology
Number of studies194442111216
Cohort studies5108000
Case-control studies143434111216
Peer-reviewed papers1837421212
Non-English language studiesEnglish onlyNo restrictionsNo restrictionsChinese onlyNo restrictions
Searching method(s)MEDLINE,MEDLINE, Reference lists, hand searchingMEDLINE, Current contents, CINAHL, CANCER CD, Biological abstracts, manual searches, contact investigatorsChinese Biomedical database (CBM)MEDLINE, contact investigatorsMEDLINE, PubMed, contact investigators
Conference proceedings (1994-1996), manual searches
Search terms usedCampylobacter pylori, stomach neoplasms, Helicobacter pyloriCampylobacter pylori, gastric adenocarcinoma, gastric cancer,Campylobacter pyloridis, Campylobacter pylori, gastric carcinoma, gastric cancer, Helicobacter pyloriHelicobacter pylori, gastric carcinoma, gastric cancer, precancerous lesion of stomachHelicobacter pylori, meta-analysis, stomach neoplasms
Stomach cancer,
Helicobacter pylori
Time period1983-19961983-19981983-March 19991995-20011985-19991990-2003
H pylori statusSerology onlySerology onlySerology & histologySerologySerology
Statistical analysisRandom-effects M-H or D&LInverse-variance- weighted log risk oddsRandom-effects D&LFixed-effectsLogistic regressionRandom-effects D&L
Number of studies in analysis191042111216
Pooled oddas ratio (OR)1.922.52.042.562.362.28
95% confidence interval (CI)1.32-2.781.90-3.401.69-2.451.85-3.551.98-2.811.71-3.05
Overall (P-value) heterogeneity0.2> 0.050.001> 0.050.09< 0.001
Quality assessmentYesNoYesNoNoYes
Assessment of publication biasNoNoYesNoYes
Duplicate studiesRemovedRemovedRemoved
Number of reviewersTwoOneTwoThree