Effect of verapamil on nitric oxide synthase in a portal vein-ligated rat model: Role of prostaglandin

Table 3 Effect of verapamil in combination with NNA, INDO, and NNA plus INDO on systemic and splanchnic vascular resistance in PVL rats (mean ± SE)

	Verapamil		Verapamil+NNA		Verapamil+INDO		Verapamil+NNA+INDO
	(n = 8)		(n = 8)		(n = 7)		(n = 8)
	Before	After	Before	After	Before	After	Before	After
TPR (dyh.s.cm-5× 104)	8.96 ± 0.87	6.45 ± 0.78 a	8.84 ± 0.72	8.47 ± 0.98	8.76 ± 0.88	8.52 ± 0.91	8.78 ± 0.93	8.58 ± 0.89
SAR (dyh.s.cm-5× 105)	4.38 ± 0.72	3.16 ± 0.62 a	4.51 ± 0.89	4.18 ± 0.71	4.45 ± 0.92	4.20 ± 0.84	4.46 ± 0.84	4.22 ± 0.94
PVR (dyh.s.cm-5 × 104)	7.49 ± 0.68	6.12 ± 0.58 a	7.46 ± 0.72	7.23 ± 0.67	7.54 ± 0.97	7.41 ± 0.95	7.46 ± 0.65	6.95 ± 0.87

TPR: total peripheral resistance; SAR: splanchnic arterial resistance; PVR: portal venous resistance; NNA: N^w-nitro–L-arginine; INDO: indomethacin. ^aP < 0.05 vs control group.