Grapefruit-seed extract attenuates ethanol-and stress-induced gastric lesions via activation of prostaglandin, nitric oxide and sensory nerve pathways

Figure 2 Effect of intragastric (ig) pretreatment with GSE applied in graded doses ranging from 8 mg/kg up to 64 mg/kg or 16,16 dimethyl PGE₂ (5 μg/kg ig) on the mean number of gastric lesions induced by 3. 5 h of WRS and accompanying changes in the GBF. Results are mean ± SE from 6 to 8 animals per group. ^aP < 0.05 vs vehicle (Veh).