Pituitary adenylate cyclase activating-peptide and its receptor antagonists in development of acute pancreatitis in rats

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Jan 28, 2005 (publication date) through Apr 18, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 28, 2005; 11(4): 538-544
Published online Jan 28, 2005. doi: 10.3748/wjg.v11.i4.538

Table 5 Ascites and its gross appearance (effect of PACAP receptor antagonists) (mean±SE).

Group	Volume of ascites (mL)	Ascites amylase(IU/L)	Nucleated cell countof ascites (×10⁸/L)	Saponi-fication (n)	Hemorr-hage (n)
Normal control		213±44/7	1.71±1.02/9
Caerulein-induced pancreatitis		39075±50341/3	7.54±2.85/4^a
Sodium taurocholate-induced pancreatitis	3.55±1.86/12	11463±5486/10^a	2.9±3.06/8	2/12	3/12
10 μg PACAP6-27		2000±1273/2	3.43±1.22/6^a
100 μg PACAP6-27		600±283/2	1.39±0.98/2
Caerulein+10 μg PACAP6-27		5725±3104/4^a	7.04±4.93/5^a
Caerulein +100 μg PACAP6-27	3/1	90250±94964/2^a	1.53±0.82/2
Sodium taurocholate+10 μg PACAP6-27	2.58±0.86/6	49467±45529/6^a	2.35±1.81/6	1/6	3/6
Sodium taurocholate+100 μg PACAP6-27	3.42±1.99/6	64083±40650/6^a	3.44±1.7/6^a	4/6	2/6
10 μg (4-Cl-D-Phe6, Leu17) VIP		750±495/2^a	5.52±2.38/4^a
100 μg (4-Cl-D-Phe6, Leu17) VIP		201	3.4/1
Caerulein+10 μg (4-Cl-D-Phe6, Leu17) VIP		6100±1697/2^a	5.38±2.17/5^a
Caerulein+100 μg (4-Cl-D-Phe6, Leu17) VIP		217	1.06±0.51/3
Sodium taurocholate+10 μg (4-Cl-D-Phe6, Leu17) VIP	2.25±0.88/6	32700±13611/6^a	2.25±0.86/6		3/6
Sodium taurocholate+100 μg (4-Cl-D-Phe6, Leu17) VIP	4.17±1.13/6	68817±46943/6^a	2.51±1.5/4		2/6

^aP<0.05 vs normal control.

Citation: Chen YD, Zhou ZG, Wang Z, Gao HK, Yan WW, Wang C, Zhao GP, Peng XH. Pituitary adenylate cyclase activating-peptide and its receptor antagonists in development of acute pancreatitis in rats. World J Gastroenterol 2005; 11(4): 538-544
URL: https://www.wjgnet.com/1007-9327/full/v11/i4/538.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i4.538