Effects of dietary intake and genetic factors on hypermethylation of the hMLH1 gene promoter in gastric cancer

Table 6 Distribution of controls and cases with or without promoter hypermethylation of the hMLH1 gene according to the genetic poly-morphisms of GSTM1, GSTT1, CYP1A1, CYP2E1, NAT2, ALDH2, and L-myc

	Controls	Cases without	Cases with
	(n)	hMLH1 promoter	hMLH1 promoter
		hypermethylation	hypermethylation
		(n)	(n)
GSTM1
Undeleted	90	21	13
Deleted	130	48	25
Odds ratio	Referent (1.00)	1.67 (0.93 – 3.00)	1.18 (0.56 – 2.47)
GSTT1
Undeleted	117	32	17
Deleted	103	37	21
Odds ratio	Referent (1.00)	1.32 (0.76 – 2.29)	1.47 (0.72 – 2.98)
CYP1A1
Ile/Ile	115	36	22
Ile/Val+Val/Val	104	33	15
Odds ratio	Referent (1.00)	1.02 (0.59 – 1.77)	0.74 (0.36 – 1.52)
CYP2E1
c1/c1	129	44	25
c1/c2+c2/c2	88	26	13
Odds ratio	Referent (1.00)	0.89 (0.51 – 1.56)	0.76 (0.37 – 1.59)
ALDH2
NN	139	38	26
ND+DD	79	31	11
Odds ratio	Referent (1.00)	1.45 (0.83 – 2.52)	0.73 (0.34 – 1.56)
L-myc
Low	52	20	9
High	164	48	29
Odds ratio	Referent (1.00)	1.59 (0.86 – 2.92)	1.56 (0.61 – 3.99)

Odds ratio was adjusted for age and sex.