Cytotoxic T lymphocyte associated antigen-4 gene polymorphisms confer susceptibility to primary biliary cirrhosis and autoimmune hepatitis in Chinese population

Table 1 CTLA-4 exon 1 + 49 polymorphism in patients with AIH, PBC and controls

	Control (% )	AIH (%)	P	PBC (%)	P
Genotype frequencies			0.4		0.006
A/A	23 (14.4)	6 (9.7 )		6 (7.8)
A/G	93 (58.1)	34 (54.8)		34 (44.2)
G/G	44 (27.5)	22 (35.5)		37 (48.0)
Allele frequencies(1)			0.22		0.0046
A	139 (43.4)	46 (37.1)		46 (29.9)
G	181 (56.6)	78 (62.9)		108 (70.1)
Phenotype frequencies(2)			0.32		0.035
A positive	116 (72.5)	40 (64.5)		40 (51.9)
G positive	137 (85.6)	56 (90.3)		71 (92.2)

¹Odds ratio for G allele (AIH) = 1.3, 95%CI = 0.85-1.99; Odds ratio for G allele (PBC) = 1, 95%CI = 1.20-2.72, ²Odds ratio for G phenotype (AIH) = 1.27, 95%CI = 0.79-2.05; Odds ratio for G phenotype (PBC) = 1.65, 95%CI = 1.03-2.63.