Letter to the Editor
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 14, 2024; 30(6): 607-609
Published online Feb 14, 2024. doi: 10.3748/wjg.v30.i6.607
Angiotensin-converting enzyme 2 alleviates liver fibrosis through the renin-angiotensin system
Bai-Wei Zhao, Ying-Jia Chen, Ruo-Peng Zhang, Yong-Ming Chen, Bo-Wen Huang
Bai-Wei Zhao, Ruo-Peng Zhang, Yong-Ming Chen, Bo-Wen Huang, Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, Guangdong Province, China
Ying-Jia Chen, Health Science Center, Peking University, Beijing 100191, China
Co-first authors: Bai-Wei Zhao and Ying-Jia Chen.
Author contributions: Zhao BW and Chen YJ share the first author; Huang BW and Chen YJ designed research; Zhao BW and Zhang RP performed research; Chen YJ and Chen YM wrote the letter; Huang BW and Zhao BW revised the letter.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bo-Wen Huang, MD, Professor, Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, No. 651 Dongfeng East Road, Yuexiu District, Guangzhou 510060, Guangdong Province, China. huangbw1@sysucc.org.cn
Received: October 31, 2023
Peer-review started: October 31, 2023
First decision: December 6, 2023
Revised: December 17, 2023
Accepted: January 15, 2024
Article in press: January 15, 2024
Published online: February 14, 2024
Core Tip

Core Tip: This letter to the editor adds to the ongoing conversation regarding the involvement of angiotensin-converting enzyme 2 (ACE2) in liver fibrosis from the perspective of its effect on the renin-angiotensin system (RAS). The major highlight of this letter is the discussion of the role of ACE2 in regulating liver fibrosis through RAS beyond the pathway studied in the article titled Angiotensin-converting enzyme 2 improves liver fibrosis in mice by regulating autophagy of hepatic stellate cells’.