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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 28, 2020; 26(24): 3344-3364
Published online Jun 28, 2020. doi: 10.3748/wjg.v26.i24.3344
Published online Jun 28, 2020. doi: 10.3748/wjg.v26.i24.3344
Intestinal Ca2+ absorption revisited: A molecular and clinical approach
Vanessa A Areco, Romina Kohan, Germán Talamoni, Nori G Tolosa de Talamoni, María E Peralta López, Laboratorio “Dr. Fernando Cañas”, Cátedra de Bioquímica y Biología Molecular, Facultad de Ciencias Médicas, INICSA (CONICET-Universidad Nacional de Córdoba), Córdoba 5000, Argentina
Author contributions: Areco VA, Kohan R, Talamoni G, Tolosa de Talamoni NG and Peralta López ME participated in the collection of information, analysis, organization of the information, writing, preparation of figure and table and final editing.
Supported by Consejo Nacional de Investigaciones Cientí ficas y Tecnoló gicas , Argentina PIP 2017-2019, No. 11220170100012CO ; and Secretarí a de Ciencia y Té cnica de la Universidad Nacional de Có rdoba , Argentina (Programa 2018-2019), No. 30920180100056CB .
Conflict-of-interest statement: The authors declare that there are no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Nori G Tolosa de Talamoni, PhD, Professor, Laboratorio “Dr. Fernando Cañas”, Cátedra de Bioquímica y Biología Molecular, Facultad de Ciencias Médicas, INICSA (CONICET-Universidad Nacional de Córdoba), Pabellón Argentina, 2do. Piso, Ciudad Universitaria, Córdoba 5000, Argentina. ntolosa@biomed.fcm.unc.edu.ar
Received: February 26, 2020
Peer-review started: February 26, 2020
First decision: May 1, 2020
Revised: May 11, 2020
Accepted: June 10, 2020
Article in press: June 10, 2020
Published online: June 28, 2020
Peer-review started: February 26, 2020
First decision: May 1, 2020
Revised: May 11, 2020
Accepted: June 10, 2020
Article in press: June 10, 2020
Published online: June 28, 2020
Core Tip
Core tip: The intestinal Ca2+ absorption occurs mainly via the paracellular and the transcellular pathways. Both ways are regulated by calcitriol and other hormones as well as dietary factors. Fibroblast growth factor 23 (FGF-23) is a strong antagonist of vitamin D action. Part of the intestinal Ca2+ movement seems to be vitamin D independent. Intestinal Ca2+ absorption changes according to different physiological conditions. Oxidative stress inhibits the intestinal Ca2+ absorption whereas the antioxidants counteract the prooxidant effects. Most diseases that occur with altered intestinal Ca2+ absorption is related to changes in the vitamin D endocrine system. Further research could clarify many unknown points in this subject.