Published online Sep 14, 2015. doi: 10.3748/wjg.v21.i34.9838
Peer-review started: April 7, 2015
First decision: June 2, 2015
Revised: June 15, 2015
Accepted: August 25, 2015
Article in press: August 25, 2015
Published online: September 14, 2015
Core tip: Gastric cancer (GC), although declining in incidence in recent decades, is still the fourth most common malignancy and the third leading cause of cancer-related death worldwide. Although reliable biomarkers are necessary to improve the management of GC, conventional tumor markers have insufficient diagnostic performance. Detection of molecular markers in gastric tissue and blood samples may enhance the sensitivity and specificity of diagnostic and prognostic tests for early stage GC and provide a means to monitor recurrence and predict response to treatment. In this review, we introduce recently reported candidates for GC-related biomarkers and overview important findings.