Basic Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 14, 2015; 21(2): 475-483
Published online Jan 14, 2015. doi: 10.3748/wjg.v21.i2.475
Chemokine ligand 20 enhances progression of hepatocellular carcinoma via epithelial-mesenchymal transition
Ke-Zhu Hou, Zhi-Qiang Fu, Hua Gong
Ke-Zhu Hou, Zhi-Qiang Fu, Hua Gong, Department of First General Surgery, Shidong Hospital, Shanghai 200438, China
Author contributions: Fu ZQ and Gong H designed the study; Hou KZ performed the majority of experiments; Fu ZQ analyzed the data; Gong H wrote the manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Hua Gong, MD, PhD, Department of First General Surgery, Shidong Hospital, No. 999 Shiguang Road, Yangpu district, Shanghai 200438, China. huagong_1978@163.com
Telephone: +86-21-65881977 Fax: +86-21-65881977
Received: April 20, 2014
Peer-review started: April 21, 2014
First decision: May 13, 2014
Revised: June 8, 2014
Accepted: July 11, 2014
Article in press: July 11, 2014
Published online: January 14, 2015
Core Tip

Core tip: This study examined the expression and prognostic value of chemokine ligand 20 in hepatocellular carcinoma. The results indicate that increased expression of this protein regulates the growth and migration of hepatocellular carcinoma cells and epithelial-mesenchymal transition via phosphoinositide kinase-3/AKT, and Wnt/β-catenin signaling pathways and is therefore a potential treatment target.