Published online Mar 21, 2023. doi: 10.3748/wjg.v29.i11.1735
Peer-review started: December 3, 2022
First decision: December 19, 2022
Revised: January 2, 2023
Accepted: March 3, 2023
Article in press: March 3, 2023
Published online: March 21, 2023
In the American Joint Committee on Cancer (AJCC) TNM staging system, tumor deposit (TD) was classified as pN1c in stage III colon cancer patients without lymph node metastasis, but extranodal deposits are a distinct form of metastatic disease in patients with colon cancer in some studies.
To conduct a retrospective study to investigate risk factors for extranodal TDs in stage III colon cancer.
We used SPSS Statistics software. Student’s t-test and the chi-square test were utilized to investigate quantitative variables and qualitative variables. Multivariate Cox regression analysis was performed to investigate the association between the covariates and extranodal TDs. The Kaplan-Meier method was utilized to analyze the overall survival and disease-free survival rates.
We selected 155 patients diagnosed with stage III colon cancer from the database of the Cancer Registry of the Tri-Service General Hospital retrospectively. The patients were categorized into the groups with/without N1c. Multivariate Cox regression analysis and Kaplan-Meier method were done. The primary outcomes investigate the association between the covariates and extranodal TDs, and prognostic significance of the covariates regarding the survival.
Patients with lymphovascular invasion (LVI) had a higher risk of TDs. Overall survival rates of patients with and without LVI were 6.64 years and 8.61 years, respectively. The N1c patients without LVI had higher overall survival than those who with LVI.
Stage III colon cancer patients with TDs and LVI could have poor prognosis and outcome.
Greater attention must be paid to the issue of TD. Amendment in the delivery of proper care to these patients may increase survival and should be a target of future quality ambition.