Combined Traditional And Modera Medicine
Copyright ©The Author(s) 1998. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 15, 1998; 4(5): 439-442
Published online Oct 15, 1998. doi: 10.3748/wjg.v4.i5.439
Clinical and experimental study of effect of Raondix Salviae Militiorrhiza and other blood-activating and stasis-eliminating Chinese herbs on hemodynamics of portal hypertension
Xi-Xian Yao, Dong-Lai Cui, Yi-Feng Sun, Xiao-Tian Li
Xi-Xian Yao, Dong-Lai Cui, Yi-Feng Sun, Xiao-Tian Li, Department of Internal Medicine, Second Affiliated Hospital, Hebei Medical University, Shijiazhang 050000, Hebei Province, China
Xi-Xian Yao, male, born on 1931-06-01 in Hebei Province, graduated from Hebei Medical College, having 100 papers published, member of Standing Committee of Chinese Society of Digestion, CMA & Hebei Branch, professor, Department of Internal Medicine, Second Affiliated Hospital, Hebei Medical University, Shijiazhang 050000, Hebei Province, China
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Xi-Xian Yao, Department of Internal Medicine, Second Affiliated Hospital, Hebei Medical University, Shijiazhang 050000, Hebei Province, China
Telephone: +86-311-7046901 ext 5003
Received: May 6, 1998
Revised: July 19, 1998
Accepted: August 13, 1998
Published online: October 15, 1998
Abstract

AIM: To study the effects of Radix Salviae Militiorrhiza (RSM), other blood-activating and stasis-eliminating Chinese herbs on hemodynamics of portal hypertension.

METHODS: Portal pressure of cirrhotic dogs after chronic common bile duct ligation was measured directly; portal blood flow in patients with liver cirrhosis were detected by ultrasound Doppler.

RESULTS: After administration of RSM and Radix Angelicae Sinensis (RAS) by intravenous infusion in cirrhosis dogs, the portal venous pressure (Ppv), wedge hepatic venous pressure (WHVP), hepatic venous pressure gradient (HVPG), were significantly decreased (P < 0.05-0.01), but the mean arterial pressure (MAP), and the heart rate (HR) remained unchanged. When nifedipine was used, Ppv, WHVP, MAP and HR were significantly decreased (P < 0.05), and the MVPG unchanged (P < 0.05). After administration of RSM, RSM + nifedipine and RSM + Hirudin + Nifedpin for 10-12 weeks, the diameter of portal vein (Dpv), spleen vein (Dsv), the portal venous flow (Qpv) and splenic venous flow (Qsv) in patients with hepatic cirrhosis were significantly lowered (P < 0.05-0.01), and the effect of RAS was weaker.

CONCLUSION: The efficacy of decreasing Ppv by Chinese herbs-RSM, RAS, etc. as compared with nifedipine, demonstrated that the Chinese herbs were slower in action than that of nifedipine, but more long-lasting and without side effects. Hence, long-term administration of Chinese herbs, would be more beneficial.

Keywords: hypertension, portal; liver cirrhosis; hemodynamics; drugs, Chinese herbal; blood activating and stasis eliminating