Published online Jun 15, 1998. doi: 10.3748/wjg.v4.i3.256
Revised: March 20, 1998
Accepted: May 10, 1998
Published online: June 15, 1998
AIM: To observe the protective effect of combined i.v. administraction of Yuanhu injection (YHI) and Huoxuehuayu injection-I (HHI-I) against acute pancreatitis (AP) in rabbits.
METHODS: Sever acute pancreatitis (SAP) was induced by retrograde infusion of artificial bile juice into biliary-pancreatic duct, and treated with YHI and HHI-I intravenously. The protective effect was judged by the survival time and rate, serum amylase, serum interleukin-6, pancreatic microcirculation and pathological alteration.
RESULTS: Combined use of YHI and HHI-I could markedly increase the rabbits’ 5-d survival rate after AP (83.3% in the treatment group and 33.3% in control). The serum amylase value (x-±s) decreased to 1596.6 U/L ± 760.50 U/L in the 5th day from the high level (6320.83 U/L ± 2614.12 U/L) in the 1st day after AP in the treatment group, while in the control group the amylase activity in the 5th day was 2095.0 U/L ± 1081.87 U/L, being significantly different from that before AP (837.17 U/L ± 189.12 U/L). YHI and HHI-I also obviously improved the pancreatic microcirculation and lowered the serum interleukin-6 level, one of the indices of severe pancreatitis. Pathological examination indicated all the changes typical for AP in YHI and HHI-I treatment group were milder than those in the control.
CONCLUSION: YHI and HHI-I used in combination might have protective effect against acute pancreatitis in rabbits.