Published online Apr 7, 2015. doi: 10.3748/wjg.v21.i13.3888
Peer-review started: August 24, 2014
First decision: September 27, 2014
Revised: October 13, 2014
Accepted: December 5, 2014
Article in press: December 8, 2014
Published online: April 7, 2015
AIM: To explore the effect of in vitro porcine esophageal variceal pressure on complete ligation degree for polycyclic ligators.
METHODS: An in vitro model of experimental porcine venous vessels was used to test various venous pressures. Three treatment groups were designated according to the preset pressure range: P1 = 25-30 cmH2O; P2 = 35-40 cmH2O; P3 = 45-50 cmH2O. The effect of pressure on ligation was assessed and compared among the groups.
RESULTS: Complete ligation was achieved at a rate of 56.25% (18/32) in group P1, 37.5% (12/32) in group P2, and 33.33% (11/33) in group P3 (χ2 = 3.6126; P = 0.0573).
CONCLUSION: Higher variceal pressures impair the ligation completion rate. Therefore, measuring variceal pressure may help predict the effect of endoscopic ligation and guide treatment choice.
Core tip: This study aims to explore the factors influencing rebleeding after endoscopic variceal ligation, and provide the theoretic basis for prevention and reduction of rebleeding after the procedure.