Basic Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 7, 2015; 21(13): 3888-3892
Published online Apr 7, 2015. doi: 10.3748/wjg.v21.i13.3888
Esophageal variceal pressure influence on the effect of ligation
Zhi-Qun Li, En-Qiang LingHu, Min Hu, Wei-Min Li, Qi-Yang Huang, Yong-Wei Zhao
Zhi-Qun Li, En-Qiang LingHu, Qi-Yang Huang, Yong-Wei Zhao, Department of Hepatology and Gastroenterology, Chinese PLA General Hospital, Beijing 100853, China
Zhi-Qun Li, Min Hu, Department of Gastroenterology and Hepatology, Chinese PLA 261 Hospital, Beijing 100094, China
Wei-Min Li, Gynaecology and Obstetrics, Pinggu District Hospital, Beijing 101200, China
Author contributions: LingHu EQ designed this research; Li ZQ performed this research, participated in the design, and drafted the manuscript; Hu M and Li WM carried out this research; Huang QY and Zhao YW participated in its design and coordination; all authors read and approved the final manuscript.
Supported by Special Financial Grant from the China Postdoctoral Science Foundation, No. 2012T50868; and Beijing Municipal Committee and Municipal Government Priority Access to the District Project of Emergency Startup Funds, No. Z111107056811048.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: En-Qiang LingHu, MD, Professor, Chief Physician, Department of Hepatology and Gastroenterology, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China.
Telephone: +86-10-68182255 Fax: +86-10-68154653
Received: August 24, 2014
Peer-review started: August 24, 2014
First decision: September 27, 2014
Revised: October 13, 2014
Accepted: December 5, 2014
Article in press: December 8, 2014
Published online: April 7, 2015

AIM: To explore the effect of in vitro porcine esophageal variceal pressure on complete ligation degree for polycyclic ligators.

METHODS: An in vitro model of experimental porcine venous vessels was used to test various venous pressures. Three treatment groups were designated according to the preset pressure range: P1 = 25-30 cmH2O; P2 = 35-40 cmH2O; P3 = 45-50 cmH2O. The effect of pressure on ligation was assessed and compared among the groups.

RESULTS: Complete ligation was achieved at a rate of 56.25% (18/32) in group P1, 37.5% (12/32) in group P2, and 33.33% (11/33) in group P3 (χ2 = 3.6126; P = 0.0573).

CONCLUSION: Higher variceal pressures impair the ligation completion rate. Therefore, measuring variceal pressure may help predict the effect of endoscopic ligation and guide treatment choice.

Keywords: Endoscopic variceal ligation, Mold of animal, Variceal pressure

Core tip: This study aims to explore the factors influencing rebleeding after endoscopic variceal ligation, and provide the theoretic basis for prevention and reduction of rebleeding after the procedure.