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After having a PhD in 2001 from the Cadi Ayyad University (Marrakech, Morocco) working on cellular and molecular differences and their relationship with evolutionary aspects within some vertebrates, I went on a postdoc in Canada in 2002 to work on the pathophysiology of hepatic encephalopathy. We were able to shade light on the possible involvement of neurosteroids in diseases severity and symptoms such as fatigue particularly in chronic form of liver diseases. We demonstrated that brain accumulation of these neuroactive compounds may increases GABAergic tone, and may explain several aspects related to the use of GABA ligands in treatment of hepatic encephalopathy. We also were able to address a possible relationship of neurosteroids with fatigue symptoms, and propose their use as therapeutic agents such as DHEAS. Thanks to IBRO, I was able to return back home in 2009 to work as research associate within the Cadi Ayyad University on neurotoxicity particularly related to heavy metals such as lead before having a permanent position as Assistant Professor at Hassan First University (Settat, Morocco) since 2012.