With a medical degree in Italy and his research specialization in 1989 at CNR and University of Naples, Italy, Gaetano Corso was nominated permanent assistant at Faculty of Medicine where he continued as clinical biochemist and initiated a laboratory of mass spectrometry for clinical applications. In 2002 he moved at University of Foggia, Italy, as associate professor of Clinical Biochemistry. Over the last 20 years, he has focused his scientific interests on the topics related to metabolic profiles, before the exploit of metabolomics, and establishing interdisciplinary approaches he has studied organic acids and lipid profiles in biological fluids, cells, tissues, and lipoproteins, in samples of patients affected by different disorders, which have contributed to knowledge of intermediate metabolism, cholesterol biosynthesis defects, and lipoprotein oxidation. With his expertise in clinical biochemistry, he has established a series of platforms for high-throughput methods by tandem mass spectrometry to analyze drugs and their metabolites for clinical pharmacology studies, and for diagnostic applications. The studies on cholesterol biosynthesis defects led in 2002 to the annual award from the SSIEM for the discovery of Lathosterolosis, a novel defect of cholesterol biosynthesis in human. Recently, his research field is mostly concentrated to develop and optimize for clinical biochemistry applications new ionization techniques based on desorption ionization of molecules at ambient environment to analyze metabolic profiles in dried samples (blood, urine) by mass spectrometry. His studies have been published in numerous SCI journal papers and book chapters, worked as a guest professor in foreign universities and institutes, coordinated/participated in several national projects, served as an evaluation expert for organizations such as Italian Ministry of University and Research and National Researches Council.