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For: Lee M, Chan JY, Kong S, Yu B, Eng-choon VO, Nai-ching HW, Mak Chung-wai T, Fung K. Effects of polyphyllin D, a steroidal saponin in Paris Polyphylla , in growth inhibition of human breast cancer cells and in xenograft. Cancer Biology & Therapy 2014;4:1248-54. [DOI: 10.4161/cbt.4.11.2136] [Cited by in Crossref: 103] [Cited by in F6Publishing: 95] [Article Influence: 14.7] [Reference Citation Analysis]
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11 Zheng W, Yan C, Zhang Y, Li Z, Li Z, Li X, Wang Z, Wang X, Chen W, Yu X. Antiparasitic efficacy of Gracillin and Zingibernsis newsaponin from Costus speciosus (Koen ex. Retz) Sm. against Ichthyophthirius multifiliis. Parasitology 2015;142:473-9. [DOI: 10.1017/s0031182014001358] [Cited by in Crossref: 13] [Cited by in F6Publishing: 2] [Article Influence: 1.9] [Reference Citation Analysis]
12 Zhu X, Jiang H, Li J, Xu J, Fei Z. Anticancer Effects of Paris Saponins by Apoptosis and PI3K/AKT Pathway in Gefitinib-Resistant Non-Small Cell Lung Cancer. Med Sci Monit 2016;22:1435-41. [PMID: 27125283 DOI: 10.12659/msm.898558] [Cited by in Crossref: 44] [Cited by in F6Publishing: 22] [Article Influence: 8.8] [Reference Citation Analysis]
13 Sachan R, Kundu A, Jeon Y, Choi WS, Yoon K, Kim IS, Kwak JH, Kim HS. Afrocyclamin A, a triterpene saponin, induces apoptosis and autophagic cell death via the PI3K/Akt/mTOR pathway in human prostate cancer cells. Phytomedicine 2018;51:139-50. [DOI: 10.1016/j.phymed.2018.10.012] [Cited by in Crossref: 16] [Cited by in F6Publishing: 17] [Article Influence: 5.3] [Reference Citation Analysis]
14 Shi YM, Yang L, Geng YD, Zhang C, Kong LY. Polyphyllin I induced-apoptosis is enhanced by inhibition of autophagy in human hepatocellular carcinoma cells. Phytomedicine 2015;22:1139-49. [PMID: 26598912 DOI: 10.1016/j.phymed.2015.08.014] [Cited by in Crossref: 35] [Cited by in F6Publishing: 36] [Article Influence: 5.8] [Reference Citation Analysis]
15 Guan Y, Zheng D, Zhou L, Wang H, Yan Z, Wang N, Chang H, She P, Lei P. Synthesis of 5(6)-dihydro-OSW-1 analogs bearing three kinds of disaccharides linking at 15-hydroxy and their antitumor activities. Bioorg Med Chem Lett 2011;21:2921-4. [PMID: 21482468 DOI: 10.1016/j.bmcl.2011.03.065] [Cited by in Crossref: 12] [Cited by in F6Publishing: 6] [Article Influence: 1.2] [Reference Citation Analysis]
16 Xiao M, Dai X, He X, Zhou R, Zhang B, Hu G, Huang Z, Fan X. Paris saponin I induces G₂/M cell cycle arrest and apoptosis in human gastric carcinoma SGC7901 cells. J Huazhong Univ Sci Technolog Med Sci 2011;31:768-72. [PMID: 22173496 DOI: 10.1007/s11596-011-0674-y] [Cited by in Crossref: 12] [Cited by in F6Publishing: 9] [Article Influence: 1.2] [Reference Citation Analysis]
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18 Yang C, Cai H, Meng X. Polyphyllin D induces apoptosis and differentiation in K562 human leukemia cells. Int Immunopharmacol 2016;36:17-22. [PMID: 27104314 DOI: 10.1016/j.intimp.2016.04.011] [Cited by in Crossref: 14] [Cited by in F6Publishing: 12] [Article Influence: 2.8] [Reference Citation Analysis]
19 Wu L, Li Q, Liu Y. Polyphyllin D induces apoptosis in K562/A02 cells through G2/M phase arrest. Journal of Pharmacy and Pharmacology 2014;66:713-21. [DOI: 10.1111/jphp.12188] [Cited by in Crossref: 22] [Cited by in F6Publishing: 21] [Article Influence: 2.8] [Reference Citation Analysis]
20 Cheung KL, Chen H, Chen Q, Wang J, Ho HP, Wong CK, Kong SK. CTAB-coated gold nanorods elicit allergic response through degranulation and cell death in human basophils. Nanoscale 2012;4:4447-9. [PMID: 22699707 DOI: 10.1039/c2nr30435j] [Cited by in Crossref: 18] [Cited by in F6Publishing: 18] [Article Influence: 2.0] [Reference Citation Analysis]
21 Xia L, Ouyang P, Gao W, Yi T, Zhang X, Zhao Z, Yang H. Rapid and Sensitive Determination of the Major Steroidal Saponins of Ypsilandra thibetica Franch by Ultra High-Performance Liquid Chromatography Coupled with Triple Quadrupole Mass Spectrometry. J Chromatogr Sci 2016;54:1010-5. [DOI: 10.1093/chromsci/bmw037] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 0.2] [Reference Citation Analysis]
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23 Wang B, Ji S, Zhang H, Zhao L, Lv L, Li Y, Zhou G, Zhang G. Liquid chromatography tandem mass spectrometry in study of the pharmacokinetics of six steroidal saponins in rats. Steroids 2013;78:1164-70. [PMID: 24012730 DOI: 10.1016/j.steroids.2013.08.009] [Cited by in Crossref: 23] [Cited by in F6Publishing: 20] [Article Influence: 2.9] [Reference Citation Analysis]
24 Stefanowicz-Hajduk J, Bartoszewski R, Bartoszewska S, Kochan K, Adamska A, Kosiński I, Ochocka JR. Pennogenyl Saponins from Paris quadrifolia L. Induce Extrinsic and Intrinsic Pathway of Apoptosis in Human Cervical Cancer HeLa Cells. PLoS One 2015;10:e0135993. [PMID: 26295969 DOI: 10.1371/journal.pone.0135993] [Cited by in Crossref: 16] [Cited by in F6Publishing: 12] [Article Influence: 2.7] [Reference Citation Analysis]
25 Zhu D, Yu B. Synthesis of the Diverse Glycosides in Traditional Chinese Medicine: Synthesis of the Diverse Glycosides in Traditional Chinese Medicine. Chin J Chem 2018;36:681-91. [DOI: 10.1002/cjoc.201800156] [Cited by in Crossref: 32] [Cited by in F6Publishing: 14] [Article Influence: 10.7] [Reference Citation Analysis]
26 Ayyasamy V, Owens KM, Desouki MM, Liang P, Bakin A, Thangaraj K, Buchsbaum DJ, LoBuglio AF, Singh KK. Cellular model of Warburg effect identifies tumor promoting function of UCP2 in breast cancer and its suppression by genipin. PLoS One 2011;6:e24792. [PMID: 21935467 DOI: 10.1371/journal.pone.0024792] [Cited by in Crossref: 86] [Cited by in F6Publishing: 92] [Article Influence: 8.6] [Reference Citation Analysis]
27 Gao LL, Li FR, Jiao P, Yang MF, Zhou XJ, Si YH, Jiang WJ, Zheng TT. Paris chinensis dioscin induces G2/M cell cycle arrest and apoptosis in human gastric cancer SGC-7901 cells. World J Gastroenterol 2011; 17(39): 4389-4395 [PMID: 22110264 DOI: 10.3748/wjg.v17.i39.4389] [Cited by in CrossRef: 33] [Cited by in F6Publishing: 31] [Article Influence: 3.3] [Reference Citation Analysis]
28 Ehianeta TS, Shen D, Xu P, Yu B. Synthesis of spirostanol saponins via gold(I)‐catalyzed glycosylation in the presence of Ga(OTf) 3 , In(OTf) 3 , or HOTf. Chin J Chem 2019;37:827-33. [DOI: 10.1002/cjoc.201900126] [Cited by in Crossref: 3] [Cited by in F6Publishing: 1] [Article Influence: 1.5] [Reference Citation Analysis]
29 Pang D, Li C, Yang C, Zou Y, Feng B, Li L, Liu W, Geng Y, Luo Q, Chen Z, Huang C. Polyphyllin VII Promotes Apoptosis and Autophagic Cell Death via ROS-Inhibited AKT Activity, and Sensitizes Glioma Cells to Temozolomide. Oxid Med Cell Longev 2019;2019:1805635. [PMID: 31814867 DOI: 10.1155/2019/1805635] [Cited by in Crossref: 5] [Cited by in F6Publishing: 4] [Article Influence: 2.5] [Reference Citation Analysis]
30 Man S, Gao W, Zhang Y, Huang L, Liu C. Chemical study and medical application of saponins as anti-cancer agents. Fitoterapia 2010;81:703-14. [PMID: 20550961 DOI: 10.1016/j.fitote.2010.06.004] [Cited by in Crossref: 223] [Cited by in F6Publishing: 170] [Article Influence: 20.3] [Reference Citation Analysis]
31 Wei JC, Gao WY, Yan XD, Wang Y, Jing SS, Xiao PG. Chemical constituents of plants from the genus Paris. Chem Biodivers 2014;11:1277-97. [PMID: 25238072 DOI: 10.1002/cbdv.201300083] [Cited by in Crossref: 20] [Cited by in F6Publishing: 14] [Article Influence: 3.3] [Reference Citation Analysis]
32 He DX, Li GH, Gu XT, Zhang L, Mao AQ, Wei J, Liu DQ, Shi GY, Ma X. A new agent developed by biotransformation of polyphyllin VII inhibits chemoresistance in breast cancer. Oncotarget 2016;7:31814-24. [PMID: 26701723 DOI: 10.18632/oncotarget.6674] [Cited by in Crossref: 14] [Cited by in F6Publishing: 14] [Article Influence: 3.5] [Reference Citation Analysis]
33 Chan JY, Koon JC, Liu X, Detmar M, Yu B, Kong S, Fung K. Polyphyllin D, a steroidal saponin from Paris polyphylla, inhibits endothelial cell functions in vitro and angiogenesis in zebrafish embryos in vivo. Journal of Ethnopharmacology 2011;137:64-9. [DOI: 10.1016/j.jep.2011.04.021] [Cited by in Crossref: 41] [Cited by in F6Publishing: 39] [Article Influence: 4.1] [Reference Citation Analysis]
34 Ma D, Lu H, Xu L, Xiao W. Polyphyllin D Exerts Potent Anti-tumour Effects on Lewis Cancer Cells under Hypoxic Conditions. J Int Med Res 2009;37:631-40. [DOI: 10.1177/147323000903700305] [Cited by in Crossref: 22] [Cited by in F6Publishing: 17] [Article Influence: 1.8] [Reference Citation Analysis]
35 Watanabe S, Suzuki T, Hara F, Yasui T, Uga N, Naoe A. Polyphyllin D, a steroidal saponin in Paris polyphylla, induces apoptosis and necroptosis cell death of neuroblastoma cells. Pediatr Surg Int 2017;33:713-9. [PMID: 28260192 DOI: 10.1007/s00383-017-4069-4] [Cited by in Crossref: 16] [Cited by in F6Publishing: 15] [Article Influence: 4.0] [Reference Citation Analysis]
36 Zhang T, Liu H, Liu X, Xu D, Chen X, Wang Q. Qualitative and quantitative analysis of steroidal saponins in crude extracts from Paris polyphylla var. yunnanensis and P. polyphylla var. chinensis by high performance liquid chromatography coupled with mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 2010;51:114-24. [DOI: 10.1016/j.jpba.2009.08.020] [Cited by in Crossref: 46] [Cited by in F6Publishing: 35] [Article Influence: 4.2] [Reference Citation Analysis]
37 Raomai S, Kumaria S, Kehie M, Tandon P. Plantlet regeneration of Paris polyphylla Sm. via thin cell layer culture and enhancement of steroidal saponins in mini-rhizome cultures using elicitors. Plant Growth Regul 2015;75:341-53. [DOI: 10.1007/s10725-014-9957-1] [Cited by in Crossref: 14] [Cited by in F6Publishing: 5] [Article Influence: 2.0] [Reference Citation Analysis]
38 Chen YS, He Y, Chen C, Zeng Y, Xue D, Wen FY, Wang L, Zhang H, Du JR. Growth inhibition by pennogenyl saponins from Rhizoma paridis on hepatoma xenografts in nude mice. Steroids 2014;83:39-44. [PMID: 24530287 DOI: 10.1016/j.steroids.2014.01.014] [Cited by in Crossref: 20] [Cited by in F6Publishing: 17] [Article Influence: 2.9] [Reference Citation Analysis]
39 Liu Z, Wang J, Gao W, Man S, Guo H, Zhang J, Liu C. Formulation and in vitro absorption analysis of Rhizoma paridis steroidal saponins. Int J Pharm 2013;441:680-6. [PMID: 23107795 DOI: 10.1016/j.ijpharm.2012.10.028] [Cited by in Crossref: 18] [Cited by in F6Publishing: 16] [Article Influence: 2.0] [Reference Citation Analysis]
40 Kong M, Fan J, Dong A, Cheng H, Xu R. Effects of polyphyllin I on growth inhibition of human non-small lung cancer cells and in xenograft. Acta Biochim Biophys Sin (Shanghai) 2010;42:827-33. [PMID: 20978038 DOI: 10.1093/abbs/gmq091] [Cited by in Crossref: 32] [Cited by in F6Publishing: 32] [Article Influence: 3.2] [Reference Citation Analysis]
41 Zhou X, Seto SW, Chang D, Kiat H, Razmovski-Naumovski V, Chan K, Bensoussan A. Synergistic Effects of Chinese Herbal Medicine: A Comprehensive Review of Methodology and Current Research. Front Pharmacol 2016;7:201. [PMID: 27462269 DOI: 10.3389/fphar.2016.00201] [Cited by in Crossref: 110] [Cited by in F6Publishing: 100] [Article Influence: 22.0] [Reference Citation Analysis]
42 Tian Y, Gong G, Ma L, Wang Z, Song D, Fang M. Anti-cancer effects of Polyphyllin I: An update in 5 years. Chemico-Biological Interactions 2020;316:108936. [DOI: 10.1016/j.cbi.2019.108936] [Cited by in Crossref: 8] [Cited by in F6Publishing: 8] [Article Influence: 8.0] [Reference Citation Analysis]
43 Liu J, Zhang Y, Chen L, Yu F, Li X, Dan Tao, Zhao J, Zhou S. Polyphyllin I induces G2/M phase arrest and apoptosis in U251 human glioma cells via mitochondrial dysfunction and the JNK signaling pathway. Acta Biochimica et Biophysica Sinica 2017;49:479-86. [DOI: 10.1093/abbs/gmx033] [Cited by in Crossref: 19] [Cited by in F6Publishing: 19] [Article Influence: 4.8] [Reference Citation Analysis]
44 Kwon SJ, Ahn D, Yang HM, Kang HJ, Chung SJ. Polyphyllin D Shows Anticancer Effect through a Selective Inhibition of Src Homology Region 2-Containing Protein Tyrosine Phosphatase-2 (SHP2). Molecules 2021;26:848. [PMID: 33562835 DOI: 10.3390/molecules26040848] [Cited by in Crossref: 1] [Article Influence: 1.0] [Reference Citation Analysis]
45 Hoi SW, Wong HM, Chan JY, Yue GG, Tse GM, Law BK, Fong WP, Fung KP. Photodynamic therapy of Pheophorbide a inhibits the proliferation of human breast tumour via both caspase-dependent and -independent apoptotic pathways in in vitro and in vivo models. Phytother Res 2012;26:734-42. [PMID: 22072524 DOI: 10.1002/ptr.3607] [Cited by in Crossref: 22] [Cited by in F6Publishing: 21] [Article Influence: 2.2] [Reference Citation Analysis]
46 Long F, Chen Y, Zhang L, Kuang X, Yu Y, Wang L, Liu X, Wang L, Zhou Y, Sang N, Du J. Pennogenyl saponins induce cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. Journal of Ethnopharmacology 2015;162:112-20. [DOI: 10.1016/j.jep.2014.12.065] [Cited by in Crossref: 17] [Cited by in F6Publishing: 14] [Article Influence: 2.8] [Reference Citation Analysis]
47 Guo Y, Liu Z, Li K, Cao G, Sun C, Cheng G, Zhang D, Peng W, Liu J, Qi Y, Zhang L, Wang P, Chen Y, Lin Z, Guan Y, Zhang J, Wen J, Wang F, Kong F, Xu D, Zhao S. Paris Polyphylla-Derived Saponins Inhibit Growth of Bladder Cancer Cells by Inducing Mutant P53 Degradation While Up-Regulating CDKN1A Expression. Curr Urol 2018;11:131-8. [PMID: 29692692 DOI: 10.1159/000447207] [Cited by in Crossref: 2] [Cited by in F6Publishing: 2] [Article Influence: 0.7] [Reference Citation Analysis]
48 Wang W, Liu Y, Sun M, Sai N, You L, Dong X, Yin X, Ni J. Hepatocellular Toxicity of Paris Saponins I, II, VI and VII on Two Kinds of Hepatocytes-HL-7702 and HepaRG Cells, and the Underlying Mechanisms. Cells 2019;8:E690. [PMID: 31324003 DOI: 10.3390/cells8070690] [Cited by in Crossref: 5] [Cited by in F6Publishing: 3] [Article Influence: 2.5] [Reference Citation Analysis]
49 Zhou Y, Yang J, Chen C, Li Z, Chen Y, Zhang X, Wang L, Zhou J. Polyphyllin Ⅲ-Induced Ferroptosis in MDA-MB-231 Triple-Negative Breast Cancer Cells can Be Protected Against by KLF4-Mediated Upregulation of xCT. Front Pharmacol 2021;12:670224. [PMID: 34040532 DOI: 10.3389/fphar.2021.670224] [Cited by in Crossref: 1] [Cited by in F6Publishing: 2] [Article Influence: 1.0] [Reference Citation Analysis]
50 Liu Z, Zheng Q, Chen W, Man S, Teng Y, Meng X, Zhang Y, Yu P, Gao W. Paris saponin I inhibits proliferation and promotes apoptosis through down-regulating AKT activity in human non-small-cell lung cancer cells and inhibiting ERK expression in human small-cell lung cancer cells. RSC Adv 2016;6:70816-24. [DOI: 10.1039/c6ra13352e] [Cited by in Crossref: 6] [Article Influence: 1.2] [Reference Citation Analysis]
51 Fan C, Jin HZ, Wu L, Zhang Y, Ye RD, Zhang W, Zhang Y. An Exploration of Traditional Chinese Medicinal Plants with Anti-Inflammatory Activities. Evid Based Complement Alternat Med 2017;2017:1231820. [PMID: 28473862 DOI: 10.1155/2017/1231820] [Cited by in Crossref: 5] [Cited by in F6Publishing: 3] [Article Influence: 1.3] [Reference Citation Analysis]
52 Wu S, Gao W, Qiu F, Man S, Fu S, Liu C. Simultaneous quantification of Polyphyllin D and Paris H, two potential antitumor active components in Paris polyphylla by liquid chromatography-tandem mass spectrometry and the application to pharmacokinetics in rats. J Chromatogr B Analyt Technol Biomed Life Sci 2012;905:54-60. [PMID: 22917593 DOI: 10.1016/j.jchromb.2012.08.002] [Cited by in Crossref: 11] [Cited by in F6Publishing: 10] [Article Influence: 1.2] [Reference Citation Analysis]
53 Gauthier C, Legault J, Girard-lalancette K, Mshvildadze V, Pichette A. Haemolytic activity, cytotoxicity and membrane cell permeabilization of semi-synthetic and natural lupane- and oleanane-type saponins. Bioorganic & Medicinal Chemistry 2009;17:2002-8. [DOI: 10.1016/j.bmc.2009.01.022] [Cited by in Crossref: 116] [Cited by in F6Publishing: 99] [Article Influence: 9.7] [Reference Citation Analysis]
54 Liu Z, Gao W, Jing S, Zhang Y, Man S, Wang Y, Zhang J, Liu C. Correlation among cytotoxicity, hemolytic activity and the composition of steroidal saponins from Paris L. J Ethnopharmacol 2013;149:422-30. [PMID: 23850834 DOI: 10.1016/j.jep.2013.06.033] [Cited by in Crossref: 20] [Cited by in F6Publishing: 19] [Article Influence: 2.5] [Reference Citation Analysis]
55 Li GB, Fu RQ, Shen HM, Zhou J, Hu XY, Liu YX, Li YN, Zhang HW, Liu X, Zhang YH, Huang C, Zhang R, Gao N. Polyphyllin I induces mitophagic and apoptotic cell death in human breast cancer cells by increasing mitochondrial PINK1 levels. Oncotarget 2017;8:10359-74. [PMID: 28060722 DOI: 10.18632/oncotarget.14413] [Cited by in Crossref: 31] [Cited by in F6Publishing: 33] [Article Influence: 10.3] [Reference Citation Analysis]
56 Raomai S, Kumaria S, Tandon P. Plant regeneration through direct somatic embryogenesis from immature zygotic embryos of the medicinal plant, Paris polyphylla Sm. Plant Cell Tiss Organ Cult 2014;118:445-55. [DOI: 10.1007/s11240-014-0496-2] [Cited by in Crossref: 13] [Cited by in F6Publishing: 5] [Article Influence: 1.9] [Reference Citation Analysis]
57 Gupta DD, Mishra S, Verma SS, Shekher A, Rai V, Awasthee N, Das TJ, Paul D, Das SK, Tag H, Chandra Gupta S, Hui PK. Evaluation of antioxidant, anti-inflammatory and anticancer activities of diosgenin enriched Paris polyphylla rhizome extract of Indian Himalayan landraces. J Ethnopharmacol 2021;270:113842. [PMID: 33460752 DOI: 10.1016/j.jep.2021.113842] [Cited by in F6Publishing: 1] [Reference Citation Analysis]
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59 Joshi B, Panda SK, Jouneghani RS, Liu M, Parajuli N, Leyssen P, Neyts J, Luyten W. Antibacterial, Antifungal, Antiviral, and Anthelmintic Activities of Medicinal Plants of Nepal Selected Based on Ethnobotanical Evidence. Evid Based Complement Alternat Med 2020;2020:1043471. [PMID: 32382275 DOI: 10.1155/2020/1043471] [Cited by in Crossref: 7] [Cited by in F6Publishing: 4] [Article Influence: 7.0] [Reference Citation Analysis]
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