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For: Gazák R, Walterová D, Kren V. Silybin and silymarin--new and emerging applications in medicine. Curr Med Chem. 2007;14:315-338. [PMID: 17305535 DOI: 10.2174/092986707779941159] [Cited by in Crossref: 340] [Cited by in F6Publishing: 319] [Article Influence: 22.7] [Reference Citation Analysis]
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2 Shrotriya SN, Vidhate BV, Shukla MS. Formulation and development of Silybin loaded solid lipid nanoparticle enriched gel for irritant contact dermatitis. Journal of Drug Delivery Science and Technology 2017;41:164-73. [DOI: 10.1016/j.jddst.2017.07.006] [Cited by in Crossref: 9] [Cited by in F6Publishing: 6] [Article Influence: 1.8] [Reference Citation Analysis]
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4 Hrčková G, Kubašková TM, Reiterová K, Biedermann D. Co-administration of silymarin elevates the therapeutic effect of praziquantel through modulation of specific antibody profiles, Th1/Th2/Tregs cytokines and down-regulation of fibrogenesis in mice with Mesocestoides vogae (Cestoda) infection. Exp Parasitol 2020;213:107888. [PMID: 32259552 DOI: 10.1016/j.exppara.2020.107888] [Cited by in Crossref: 3] [Cited by in F6Publishing: 2] [Article Influence: 1.5] [Reference Citation Analysis]
5 Hu Q, Liu M, You Y, Zhou G, Chen Y, Yuan H, Xie L, Han S, Zhu K. Dual inhibition of reactive oxygen species and spleen tyrosine kinase as a therapeutic strategy in liver fibrosis. Free Radic Biol Med 2021;175:193-205. [PMID: 34492311 DOI: 10.1016/j.freeradbiomed.2021.08.241] [Reference Citation Analysis]
6 Gharagozloo M, Jafari S, Esmaeil N, Javid EN, Bagherpour B, Rezaei A. Immunosuppressive effect of silymarin on mitogen-activated protein kinase signalling pathway: the impact on T cell proliferation and cytokine production. Basic Clin Pharmacol Toxicol 2013;113:209-14. [PMID: 23701595 DOI: 10.1111/bcpt.12088] [Cited by in Crossref: 21] [Cited by in F6Publishing: 21] [Article Influence: 2.3] [Reference Citation Analysis]
7 Zhao H, Michaelis ML, Blagg BS. Hsp90 Modulation for the Treatment of Alzheimer’s Disease. Current State of Alzheimer's Disease Research and Therapeutics. Elsevier; 2012. pp. 1-25. [DOI: 10.1016/b978-0-12-394816-8.00001-5] [Cited by in Crossref: 40] [Cited by in F6Publishing: 25] [Article Influence: 4.0] [Reference Citation Analysis]
8 Tariq A, Sana M, Shaheen A, Ismat F, Mahboob S, Rauf W, Mirza O, Iqbal M, Rahman M. Restraining the multidrug efflux transporter STY4874 of Salmonella Typhi by reserpine and plant extracts. Lett Appl Microbiol 2019;69:161-7. [PMID: 31267555 DOI: 10.1111/lam.13196] [Cited by in Crossref: 5] [Cited by in F6Publishing: 5] [Article Influence: 1.7] [Reference Citation Analysis]
9 Han HS, Koo SY, Choi KY. Emerging nanoformulation strategies for phytocompounds and applications from drug delivery to phototherapy to imaging. Bioactive Materials 2021. [DOI: 10.1016/j.bioactmat.2021.11.027] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 1.0] [Reference Citation Analysis]
10 Tumova L, Tuma J, Dolezal M. Pyrazinecarboxamides as potential elicitors of flavonolignan and flavonoid production in Silybum marianum and Ononis arvensis cultures in vitro. Molecules 2011;16:9142-52. [PMID: 22045042 DOI: 10.3390/molecules16119142] [Cited by in Crossref: 11] [Cited by in F6Publishing: 8] [Article Influence: 1.0] [Reference Citation Analysis]
11 Faixová D, Hrčková G, Mačák Kubašková T, Mudroňová D. Antiparasitic Effects of Selected Isoflavones on Flatworms. Helminthologia 2021;58:1-16. [PMID: 33664614 DOI: 10.2478/helm-2021-0004] [Cited by in Crossref: 3] [Cited by in F6Publishing: 2] [Article Influence: 3.0] [Reference Citation Analysis]
12 Diaz C, Guzmán J, Jiménez VA, Alderete JB. Partially PEGylated PAMAM dendrimers as solubility enhancers of Silybin. Pharmaceutical Development and Technology 2017;23:689-96. [DOI: 10.1080/10837450.2017.1315134] [Cited by in Crossref: 16] [Cited by in F6Publishing: 11] [Article Influence: 3.2] [Reference Citation Analysis]
13 Abd Eldaim MA, Barakat ER, Alkafafy M, Elaziz SAA. Antioxidant and anti-apoptotic prophylactic effect of silymarin against lead-induced hepatorenal toxicity in rats. Environ Sci Pollut Res Int 2021. [PMID: 34100211 DOI: 10.1007/s11356-021-14722-8] [Reference Citation Analysis]
14 Malekpour-dehkordi Z, Nourbakhsh M, Shahidi M, Sarraf N, Sharifi R. "Silymarin diminishes oleic acid-induced lipid accumulation in HepG2 cells by modulating the expression of endoplasmic reticulum stress markers". Journal of Herbal Medicine 2022. [DOI: 10.1016/j.hermed.2022.100565] [Reference Citation Analysis]
15 Fehér P, Ujhelyi Z, Váradi J, Fenyvesi F, Róka E, Juhász B, Varga B, Bombicz M, Priksz D, Bácskay I, Vecsernyés M. Efficacy of Pre- and Post-Treatment by Topical Formulations Containing Dissolved and Suspended Silybum marianum against UVB-Induced Oxidative Stress in Guinea Pig and on HaCaT Keratinocytes. Molecules 2016;21:E1269. [PMID: 27669200 DOI: 10.3390/molecules21101269] [Cited by in Crossref: 19] [Cited by in F6Publishing: 12] [Article Influence: 3.2] [Reference Citation Analysis]
16 Chavda VP, Patel AB, Mistry KJ, Suthar SF, Wu ZX, Chen ZS, Hou K. Nano-Drug Delivery Systems Entrapping Natural Bioactive Compounds for Cancer: Recent Progress and Future Challenges. Front Oncol 2022;12:867655. [PMID: 35425710 DOI: 10.3389/fonc.2022.867655] [Cited by in Crossref: 4] [Cited by in F6Publishing: 3] [Article Influence: 4.0] [Reference Citation Analysis]
17 Tarirai C, Viljoen AM, Hamman JH. Herb-drug pharmacokinetic interactions reviewed. Expert Opin Drug Metab Toxicol 2010;6:1515-38. [PMID: 21067427 DOI: 10.1517/17425255.2010.529129] [Cited by in Crossref: 50] [Cited by in F6Publishing: 40] [Article Influence: 4.2] [Reference Citation Analysis]
18 Zhang Q, Ahn JM, Kim IH. Micelle silymarin supplementation to sows' diet from day 109 of gestation to entire lactation period enhances reproductive performance and affects serum hormones and metabolites. J Anim Sci 2021;99:skab354. [PMID: 34850001 DOI: 10.1093/jas/skab354] [Reference Citation Analysis]
19 Catanzaro D, Gabbia D, Cocetta V, Biagi M, Ragazzi E, Montopoli M, Carrara M. Silybin counteracts doxorubicin resistance by inhibiting GLUT1 expression. Fitoterapia 2018;124:42-8. [PMID: 29031537 DOI: 10.1016/j.fitote.2017.10.007] [Cited by in Crossref: 16] [Cited by in F6Publishing: 13] [Article Influence: 3.2] [Reference Citation Analysis]
20 Gazák R, Purchartová K, Marhol P, Zivná L, Sedmera P, Valentová K, Kato N, Matsumura H, Kaihatsu K, Kren V. Antioxidant and antiviral activities of silybin fatty acid conjugates. Eur J Med Chem 2010;45:1059-67. [PMID: 20036447 DOI: 10.1016/j.ejmech.2009.11.056] [Cited by in Crossref: 46] [Cited by in F6Publishing: 44] [Article Influence: 3.5] [Reference Citation Analysis]
21 Loguercio C, Andreone P, Brisc C, Brisc MC, Bugianesi E, Chiaramonte M, Cursaro C, Danila M, de Sio I, Floreani A, Freni MA, Grieco A, Groppo M, Lazzari R, Lobello S, Lorefice E, Margotti M, Miele L, Milani S, Okolicsanyi L, Palasciano G, Portincasa P, Saltarelli P, Smedile A, Somalvico F, Spadaro A, Sporea I, Sorrentino P, Vecchione R, Tuccillo C, Blanco CDV, Federico A. Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: A randomized controlled trial. Free Radical Biology and Medicine 2012;52:1658-65. [DOI: 10.1016/j.freeradbiomed.2012.02.008] [Cited by in Crossref: 135] [Cited by in F6Publishing: 122] [Article Influence: 13.5] [Reference Citation Analysis]
22 Nazemian F, Karimi G, Moatamedi M, Charkazi S, Shamsara J, Mohammadpour AH. Effect of silymarin administration on TNF-α serum concentration in peritoneal dialysis patients. Phytother Res 2010;24:1654-7. [DOI: 10.1002/ptr.3175] [Cited by in Crossref: 18] [Cited by in F6Publishing: 16] [Article Influence: 1.5] [Reference Citation Analysis]
23 Kauntz H, Bousserouel S, Gossé F, Raul F. The flavonolignan silibinin potentiates TRAIL-induced apoptosis in human colon adenocarcinoma and in derived TRAIL-resistant metastatic cells. Apoptosis 2012;17:797-809. [PMID: 22555452 DOI: 10.1007/s10495-012-0731-4] [Cited by in Crossref: 33] [Cited by in F6Publishing: 28] [Article Influence: 3.3] [Reference Citation Analysis]
24 Roubalová L, Dinkova-Kostova AT, Biedermann D, Křen V, Ulrichová J, Vrba J. Flavonolignan 2,3-dehydrosilydianin activates Nrf2 and upregulates NAD(P)H:quinone oxidoreductase 1 in Hepa1c1c7 cells. Fitoterapia 2017;119:115-20. [PMID: 28450126 DOI: 10.1016/j.fitote.2017.04.012] [Cited by in Crossref: 22] [Cited by in F6Publishing: 18] [Article Influence: 4.4] [Reference Citation Analysis]
25 Mady FM, Essa H, El-Ammawi T, Abdelkader H, Hussein AK. Formulation and clinical evaluation of silymarin pluronic-lecithin organogels for treatment of atopic dermatitis. Drug Des Devel Ther 2016;10:1101-10. [PMID: 27022248 DOI: 10.2147/DDDT.S103423] [Cited by in Crossref: 5] [Cited by in F6Publishing: 6] [Article Influence: 0.8] [Reference Citation Analysis]
26 Sozen H, Celik OI, Cetin ES, Yilmaz N, Aksozek A, Topal Y, Cigerci IH, Beydilli H. Evaluation of the Protective Effect of Silibinin in Rats with Liver Damage Caused by Itraconazole. Cell Biochem Biophys 2015;71:1215-23. [DOI: 10.1007/s12013-014-0331-8] [Cited by in Crossref: 18] [Cited by in F6Publishing: 21] [Article Influence: 2.3] [Reference Citation Analysis]
27 Ezhilarasan D, Karthikeyan S, Vivekanandan P. Ameliorative effect of silibinin against N-nitrosodimethylamine-induced hepatic fibrosis in rats. Environmental Toxicology and Pharmacology 2012;34:1004-13. [DOI: 10.1016/j.etap.2012.07.004] [Cited by in Crossref: 31] [Cited by in F6Publishing: 34] [Article Influence: 3.1] [Reference Citation Analysis]
28 Stastnik O, Pavlata L, Mrkvicova E. The Milk Thistle Seed Cakes and Hempseed Cakes are Potential Feed for Poultry. Animals (Basel) 2020;10:E1384. [PMID: 32785057 DOI: 10.3390/ani10081384] [Cited by in Crossref: 3] [Cited by in F6Publishing: 3] [Article Influence: 1.5] [Reference Citation Analysis]
29 Ferreira A, Pousinho S, Fortuna A, Falcão A, Alves G. Flavonoid compounds as reversal agents of the P-glycoprotein-mediated multidrug resistance: biology, chemistry and pharmacology. Phytochem Rev 2015;14:233-72. [DOI: 10.1007/s11101-014-9358-0] [Cited by in Crossref: 28] [Cited by in F6Publishing: 18] [Article Influence: 3.5] [Reference Citation Analysis]
30 Pérez-Sánchez A, Cuyàs E, Ruiz-Torres V, Agulló-Chazarra L, Verdura S, González-Álvarez I, Bermejo M, Joven J, Micol V, Bosch-Barrera J, Menendez JA. Intestinal Permeability Study of Clinically Relevant Formulations of Silibinin in Caco-2 Cell Monolayers. Int J Mol Sci 2019;20:E1606. [PMID: 30935093 DOI: 10.3390/ijms20071606] [Cited by in Crossref: 13] [Cited by in F6Publishing: 10] [Article Influence: 4.3] [Reference Citation Analysis]
31 Křenek K, Marhol P, Peikerová Ž, Křen V, Biedermann D. Preparatory separation of the silymarin flavonolignans by Sephadex LH-20 gel. Food Research International 2014;65:115-20. [DOI: 10.1016/j.foodres.2014.02.001] [Cited by in Crossref: 37] [Cited by in F6Publishing: 16] [Article Influence: 4.6] [Reference Citation Analysis]
32 Romanucci V, Pagano R, Lembo A, Capasso D, Di Gaetano S, Zarrelli A, Di Fabio G. Phosphodiester Silybin Dimers Powerful Radical Scavengers: A Antiproliferative Activity on Different Cancer Cell Lines. Molecules 2022;27:1702. [DOI: 10.3390/molecules27051702] [Reference Citation Analysis]
33 Han Y, Guo D, Chen Y, Tan Z, Zhou H. Effect of continuous silymarin administration on oral talinolol pharmacokinetics in healthy volunteers. Xenobiotica 2009;39:694-9. [DOI: 10.1080/00498250903060077] [Cited by in Crossref: 28] [Cited by in F6Publishing: 18] [Article Influence: 2.2] [Reference Citation Analysis]
34 Saewan N, Jimtaisong A. Natural products as photoprotection. J Cosmet Dermatol 2015;14:47-63. [PMID: 25582033 DOI: 10.1111/jocd.12123] [Cited by in Crossref: 106] [Cited by in F6Publishing: 76] [Article Influence: 15.1] [Reference Citation Analysis]
35 Tong WW, Zhang C, Hong T, Liu DH, Wang C, Li J, He XK, Xu WD. Silibinin alleviates inflammation and induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes and has a therapeutic effect on arthritis in rats. Sci Rep 2018;8:3241. [PMID: 29459717 DOI: 10.1038/s41598-018-21674-6] [Cited by in Crossref: 24] [Cited by in F6Publishing: 24] [Article Influence: 6.0] [Reference Citation Analysis]
36 El-Lakkany NM, Hammam OA, El-Maadawy WH, Badawy AA, Ain-Shoka AA, Ebeid FA. Anti-inflammatory/anti-fibrotic effects of the hepatoprotective silymarin and the schistosomicide praziquantel against Schistosoma mansoni-induced liver fibrosis. Parasit Vectors 2012;5:9. [PMID: 22236605 DOI: 10.1186/1756-3305-5-9] [Cited by in Crossref: 55] [Cited by in F6Publishing: 49] [Article Influence: 5.5] [Reference Citation Analysis]
37 Romanucci V, Gravante R, Cimafonte M, Marino CD, Mailhot G, Brigante M, Zarrelli A, Fabio GD. Phosphate-Linked Silibinin Dimers (PLSd): New Promising Modified Metabolites. Molecules 2017;22:E1323. [PMID: 28800072 DOI: 10.3390/molecules22081323] [Cited by in Crossref: 11] [Cited by in F6Publishing: 10] [Article Influence: 2.2] [Reference Citation Analysis]
38 Mashhadi Akbar Boojar M, Mashhadi Akbar Boojar M, Golmohammad S. Overview of Silibinin anti-tumor effects. Journal of Herbal Medicine 2020;23:100375. [DOI: 10.1016/j.hermed.2020.100375] [Cited by in Crossref: 3] [Cited by in F6Publishing: 1] [Article Influence: 1.5] [Reference Citation Analysis]
39 Huang G, Schramm S, Heilmann J, Biedermann D, Křen V, Decker M. Unconventional application of the Mitsunobu reaction: Selective flavonolignan dehydration yielding hydnocarpins. Beilstein J Org Chem 2016;12:662-9. [PMID: 27340458 DOI: 10.3762/bjoc.12.66] [Cited by in Crossref: 6] [Cited by in F6Publishing: 5] [Article Influence: 1.0] [Reference Citation Analysis]
40 Qi Y, Li G, Zhou Y, Wang M, Bi K, Dai R. DETERMINATION OF FK506 IN RAT BLOOD BY LC-MS/MS AND EFFECT OF SILYMARIN ON ITS PHARMACOKINETICS. Journal of Liquid Chromatography & Related Technologies 2012;35:2217-27. [DOI: 10.1080/10826076.2011.629392] [Reference Citation Analysis]
41 Bijak M. Silybin, a Major Bioactive Component of Milk Thistle (Silybum marianum L. Gaernt.)-Chemistry, Bioavailability, and Metabolism. Molecules 2017;22:E1942. [PMID: 29125572 DOI: 10.3390/molecules22111942] [Cited by in F6Publishing: 70] [Reference Citation Analysis]
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43 Brantley SJ, Oberlies NH, Kroll DJ, Paine MF. Two flavonolignans from milk thistle (Silybum marianum) inhibit CYP2C9-mediated warfarin metabolism at clinically achievable concentrations. J Pharmacol Exp Ther 2010;332:1081-7. [PMID: 19934397 DOI: 10.1124/jpet.109.161927] [Cited by in Crossref: 52] [Cited by in F6Publishing: 53] [Article Influence: 4.0] [Reference Citation Analysis]
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46 Verdura S, Cuyàs E, Llorach-Parés L, Pérez-Sánchez A, Micol V, Nonell-Canals A, Joven J, Valiente M, Sánchez-Martínez M, Bosch-Barrera J, Menendez JA. Silibinin is a direct inhibitor of STAT3. Food Chem Toxicol 2018;116:161-72. [PMID: 29660364 DOI: 10.1016/j.fct.2018.04.028] [Cited by in Crossref: 32] [Cited by in F6Publishing: 31] [Article Influence: 8.0] [Reference Citation Analysis]
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50 Vazquez-Martin A, Cufí S, Oliveras-Ferraros C, Torres-Garcia VZ, Corominas-Faja B, Cuyàs E, Bonavia R, Visa J, Martin-Castillo B, Barrajón-Catalán E. IGF-1R/epithelial-to-mesenchymal transition (EMT) crosstalk suppresses the erlotinib-sensitizing effect of EGFR exon 19 deletion mutations. Sci Rep. 2013;3:2560. [PMID: 23994953 DOI: 10.1038/srep02560] [Cited by in Crossref: 52] [Cited by in F6Publishing: 55] [Article Influence: 6.5] [Reference Citation Analysis]
51 Aziz M, Saeed F, Ahmad N, Ahmad A, Afzaal M, Hussain S, Mohamed AA, Alamri MS, Anjum FM. Biochemical profile of milk thistle (Silybum Marianum L.) with special reference to silymarin content. Food Sci Nutr 2021;9:244-50. [PMID: 33473288 DOI: 10.1002/fsn3.1990] [Cited by in Crossref: 3] [Cited by in F6Publishing: 1] [Article Influence: 1.5] [Reference Citation Analysis]
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53 Jiang YY, Huang H, Wang HJ, Wu D, Yang R, Tashiro S, Onodera S, Ikejima T. Interruption of mitochondrial complex IV activity and cytochrome c expression activated O₂·⁻-mediated cell survival in silibinin-treated human melanoma A375-S2 cells via IGF-1R-PI3K-Akt and IGF-1R-PLC γ-PKC pathways. Eur J Pharmacol 2011;668:78-87. [PMID: 21703257 DOI: 10.1016/j.ejphar.2011.06.007] [Cited by in Crossref: 13] [Cited by in F6Publishing: 12] [Article Influence: 1.2] [Reference Citation Analysis]
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