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Liu M, Luo Z, Li Z, Lai X, Loh XJ, Wu C, Li Z, Wu Y. Engineered celastrol and plasmid co-delivery for in situ expression and targeted mitochondrial relocation of Nur77 protein towards effective drug resistance reversion. Chemical Engineering Journal 2023;453:139879. [DOI: 10.1016/j.cej.2022.139879] [Reference Citation Analysis]
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Niu T, Wei Z, Fu J, Chen S, Wang R, Wang Y, Zheng R. Venlafaxine, an anti-depressant drug, induces apoptosis in MV3 human melanoma cells through JNK1/2-Nur77 signaling pathway. Front Pharmacol 2022;13:1080412. [PMID: 36686679 DOI: 10.3389/fphar.2022.1080412] [Reference Citation Analysis]
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Qin J, Chen X, Liu W, Chen J, Liu W, Xia Y, Li Z, Li M, Wang S, Yuan Q, Qiu Y, Wu Z, Fang M. Discovery of 5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-indole-2-carboxamide derivatives as novel anti-cancer agents targeting Nur77. European Journal of Medicinal Chemistry 2022;244:114849. [DOI: 10.1016/j.ejmech.2022.114849] [Reference Citation Analysis]
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Li X, Chen Q, Liu J, Lai S, Zhang M, Zhen T, Hu H, Gao X, Wong AST, Zeng JZ. Orphan Nuclear Receptor Nur77 Mediates the Lethal Endoplasmic Reticulum Stress and Therapeutic Efficacy of Cryptomeridiol in Hepatocellular Carcinoma. Cells 2022;11. [PMID: 36497127 DOI: 10.3390/cells11233870] [Reference Citation Analysis]
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Chen X, Tu X, Zhang X, Cao B, Liu W, Zhang J, Xia Y, Bao G, Xu D, Zhang X, Zeng Z, Su Y. SAR study of oxidative DIMs analogs targeting the Nur77-mediated apoptotic pathway of cancer cells. Bioorg Chem 2022;129:106156. [PMID: 36179441 DOI: 10.1016/j.bioorg.2022.106156] [Reference Citation Analysis]
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Abdel-latif RT, Wadie W, Abdel-mottaleb Y, Abdallah DM, El-maraghy NN, El-abhar HS. Reposition of the anti-inflammatory drug diacerein in an in-vivo colorectal cancer model. Saudi Pharmaceutical Journal 2021. [DOI: 10.1016/j.jsps.2021.12.009] [Reference Citation Analysis]
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Peng SZ, Chen XH, Chen SJ, Zhang J, Wang CY, Liu WR, Zhang D, Su Y, Zhang XK. Phase separation of Nur77 mediates celastrol-induced mitophagy by promoting the liquidity of p62/SQSTM1 condensates. Nat Commun 2021;12:5989. [PMID: 34645818 DOI: 10.1038/s41467-021-26295-8] [Cited by in Crossref: 9] [Cited by in F6Publishing: 10] [Article Influence: 4.5] [Reference Citation Analysis]
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Safe S, Shrestha R, Mohankumar K. Orphan nuclear receptor 4A1 (NR4A1) and novel ligands. Essays Biochem 2021:EBC20200164. [PMID: 34096590 DOI: 10.1042/EBC20200164] [Cited by in Crossref: 10] [Cited by in F6Publishing: 10] [Article Influence: 5.0] [Reference Citation Analysis]
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Li B, Yao J, He F, Liu J, Lin Z, Liu S, Wang W, Wu T, Huang J, Chen K, Fang M, Chen J, Zeng JZ. Synthesis, SAR study, and bioactivity evaluation of a series of Quinoline-Indole-Schiff base derivatives: Compound 10E as a new Nur77 exporter and autophagic death inducer. Bioorg Chem 2021;113:105008. [PMID: 34089944 DOI: 10.1016/j.bioorg.2021.105008] [Cited by in Crossref: 2] [Cited by in F6Publishing: 3] [Article Influence: 1.0] [Reference Citation Analysis]
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Niu B, Liu J, Lv B, Lin J, Li X, Wu C, Jiang X, Zeng Z, Zhang XK, Zhou H. Interplay between transforming growth factor-β and Nur77 in dual regulations of inhibitor of differentiation 1 for colonic tumorigenesis. Nat Commun 2021;12:2809. [PMID: 33990575 DOI: 10.1038/s41467-021-23048-5] [Cited by in Crossref: 6] [Cited by in F6Publishing: 9] [Article Influence: 3.0] [Reference Citation Analysis]
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Upreti C, Woodruff CM, Zhang XL, Yim MJ, Zhou ZY, Pagano AM, Rehanian DS, Yin D, Kandel ER, Stanton PK, Nicholls RE. Loss of retinoid X receptor gamma subunit impairs group 1 mGluR mediated electrophysiological responses and group 1 mGluR dependent behaviors. Sci Rep 2021;11:5552. [PMID: 33692389 DOI: 10.1038/s41598-021-84943-x] [Cited by in Crossref: 3] [Cited by in F6Publishing: 3] [Article Influence: 1.5] [Reference Citation Analysis]
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Shao M, Lu L, Wang Q, Ma L, Tian X, Li C, Li C, Guo D, Wang Q, Wang W, Wang Y. The multi-faceted role of retinoid X receptor in cardiovascular diseases. Biomed Pharmacother 2021;137:111264. [PMID: 33761589 DOI: 10.1016/j.biopha.2021.111264] [Cited by in Crossref: 3] [Cited by in F6Publishing: 3] [Article Influence: 1.5] [Reference Citation Analysis]
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Tu X, Chen X, Zhang D, Gao M, Liang J, Bao G, Zhang J, Peng S, Zhang X, Zeng Z, Su Y. Optimization of novel oxidative DIMs as Nur77 modulators of the Nur77-Bcl-2 apoptotic pathway. Eur J Med Chem 2021;211:113020. [PMID: 33279290 DOI: 10.1016/j.ejmech.2020.113020] [Cited by in Crossref: 4] [Cited by in F6Publishing: 4] [Article Influence: 1.3] [Reference Citation Analysis]
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Deng Z, Liu Q, Wang M, Wei HK, Peng J. GPA Peptide-Induced Nur77 Localization at Mitochondria Inhibits Inflammation and Oxidative Stress through Activating Autophagy in the Intestine. Oxid Med Cell Longev 2020;2020:4964202. [PMID: 32904539 DOI: 10.1155/2020/4964202] [Cited by in Crossref: 9] [Cited by in F6Publishing: 10] [Article Influence: 3.0] [Reference Citation Analysis]
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Li S, Li Y, Deng B, Yan J, Wang Y. Identification of the Differentially Expressed Genes Involved in the Synergistic Neurotoxicity of an HIV Protease Inhibitor and Methamphetamine. Curr HIV Res 2019;17:290-303. [PMID: 31550215 DOI: 10.2174/1570162X17666190924200354] [Cited by in Crossref: 1] [Cited by in F6Publishing: 2] [Article Influence: 0.3] [Reference Citation Analysis]
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Reddy AT, Lakshmi SP, Banno A, Jadhav SK, Pulikkal Kadamberi I, Kim SC, Reddy RC. Cigarette smoke downregulates Nur77 to exacerbate inflammation in chronic obstructive pulmonary disease (COPD). PLoS One 2020;15:e0229256. [PMID: 32084204 DOI: 10.1371/journal.pone.0229256] [Cited by in Crossref: 7] [Cited by in F6Publishing: 7] [Article Influence: 2.3] [Reference Citation Analysis]
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Close AF, Dadheech N, Lemieux H, Wang Q, Buteau J. Disruption of Beta-Cell Mitochondrial Networks by the Orphan Nuclear Receptor Nor1/Nr4a3. Cells 2020;9:E168. [PMID: 31936632 DOI: 10.3390/cells9010168] [Cited by in Crossref: 7] [Cited by in F6Publishing: 8] [Article Influence: 2.3] [Reference Citation Analysis]
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Chen X, Cao X, Tu X, Alitongbieke G, Xia Z, Li X, Chen Z, Yin M, Xu D, Guo S, Li Z, Chen L, Zhang X, Xu D, Gao M, Liu J, Zeng Z, Zhou H, Su Y, Zhang XK. BI1071, a Novel Nur77 Modulator, Induces Apoptosis of Cancer Cells by Activating the Nur77-Bcl-2 Apoptotic Pathway. Mol Cancer Ther 2019;18:886-99. [PMID: 30926635 DOI: 10.1158/1535-7163.MCT-18-0918] [Cited by in Crossref: 11] [Cited by in F6Publishing: 12] [Article Influence: 2.8] [Reference Citation Analysis]
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Banno A, Lakshmi SP, Reddy AT, Kim SC, Reddy RC. Key Functions and Therapeutic Prospects of Nur77 in Inflammation Related Lung Diseases. Am J Pathol 2019;189:482-91. [PMID: 30414411 DOI: 10.1016/j.ajpath.2018.10.002] [Cited by in Crossref: 19] [Cited by in F6Publishing: 21] [Article Influence: 3.8] [Reference Citation Analysis]
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Hiwatashi N, Mukudai S, Bing R, Branski RC. The effects of cytosporone-B, a novel antifibrotic agent, on vocal fold fibroblasts. Laryngoscope 2018;128:E425-8. [PMID: 30325029 DOI: 10.1002/lary.27361] [Cited by in Crossref: 12] [Cited by in F6Publishing: 13] [Article Influence: 2.4] [Reference Citation Analysis]
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Wu L, Chen L. Characteristics of Nur77 and its ligands as potential anticancer compounds (Review). Mol Med Rep 2018;18:4793-801. [PMID: 30272297 DOI: 10.3892/mmr.2018.9515] [Cited by in Crossref: 11] [Cited by in F6Publishing: 15] [Article Influence: 2.2] [Reference Citation Analysis]
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Yu S, Yin Y, Wang Q, Wang L. Dual gene deficient models of ApcMin/+ mouse in assessing molecular mechanisms of intestinal carcinogenesis. Biomed Pharmacother 2018;108:600-9. [PMID: 30243094 DOI: 10.1016/j.biopha.2018.09.056] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 0.2] [Reference Citation Analysis]
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Bonansco C, Martínez-pinto J, Silva RA, Velásquez VB, Martorell A, Selva MV, Espinosa P, Moya PR, Cruz G, Andrés ME, Sotomayor-zárate R. Neonatal exposure to oestradiol increases dopaminergic transmission in nucleus accumbens and morphine-induced conditioned place preference in adult female rats. J Neuroendocrinol 2018;30:e12574. [DOI: 10.1111/jne.12574] [Cited by in Crossref: 15] [Cited by in F6Publishing: 16] [Article Influence: 3.0] [Reference Citation Analysis]
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Pearce MC, Gamble JT, Kopparapu PR, O'Donnell EF, Mueller MJ, Jang HS, Greenwood JA, Satterthwait AC, Tanguay RL, Zhang XK, Kolluri SK. Induction of apoptosis and suppression of tumor growth by Nur77-derived Bcl-2 converting peptide in chemoresistant lung cancer cells. Oncotarget 2018;9:26072-85. [PMID: 29899843 DOI: 10.18632/oncotarget.25437] [Cited by in Crossref: 19] [Cited by in F6Publishing: 21] [Article Influence: 3.8] [Reference Citation Analysis]
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Sanchez M, Xia Z, Rico-Bautista E, Cao X, Cuddy M, Castro DJ, Correa RG, Chen L, Yu J, Bobkov A, Ruvolo V, Andreeff M, Oshima RG, Matsuzawa SI, Reed JC, Zhang XK, Hansel D, Wolf DA, Dawson MI. Oxidized analogs of Di(1H-indol-3-yl)methyl-4-substituted benzenes are NR4A1-dependent UPR inducers with potent and safe anti-cancer activity. Oncotarget 2018;9:25057-74. [PMID: 29861853 DOI: 10.18632/oncotarget.25285] [Cited by in Crossref: 4] [Cited by in F6Publishing: 4] [Article Influence: 0.8] [Reference Citation Analysis]
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Hu M, Luo Q, Alitongbieke G, Chong S, Xu C, Xie L, Chen X, Zhang D, Zhou Y, Wang Z, Ye X, Cai L, Zhang F, Chen H, Jiang F, Fang H, Yang S, Liu J, Diaz-Meco MT, Su Y, Zhou H, Moscat J, Lin X, Zhang XK. Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy. Mol Cell 2017;66:141-153.e6. [PMID: 28388439 DOI: 10.1016/j.molcel.2017.03.008] [Cited by in Crossref: 149] [Cited by in F6Publishing: 156] [Article Influence: 24.8] [Reference Citation Analysis]
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Kim JH, Lee H, Shin EA, Kim DH, Choi JB, Kim SH. Implications of Bcl-2 and its interplay with other molecules and signaling pathways in prostate cancer progression. Expert Opin Ther Targets 2017;21:911-20. [PMID: 28816549 DOI: 10.1080/14728222.2017.1369044] [Cited by in Crossref: 13] [Cited by in F6Publishing: 13] [Article Influence: 2.2] [Reference Citation Analysis]
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Wang D, Li X, Bao Y, Liu J, Zhang X, Yao X, Sun X, Tang J. Synthesis of MeON-neoglycosides of digoxigenin with 6-deoxy- and 2,6-dideoxy- d -glucose derivatives and their anticancer activity. Bioorganic & Medicinal Chemistry Letters 2017;27:3359-64. [DOI: 10.1016/j.bmcl.2017.06.008] [Cited by in Crossref: 15] [Cited by in F6Publishing: 15] [Article Influence: 2.5] [Reference Citation Analysis]
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Lee HS, Safe S, Lee SO. Inactivation of the orphan nuclear receptor NR4A1 contributes to apoptosis induction by fangchinoline in pancreatic cancer cells. Toxicol Appl Pharmacol 2017;332:32-9. [PMID: 28754437 DOI: 10.1016/j.taap.2017.07.017] [Cited by in Crossref: 17] [Cited by in F6Publishing: 18] [Article Influence: 2.8] [Reference Citation Analysis]
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Liu J, Wang GH, Duan YH, Dai Y, Bao Y, Hu M, Zhou YQ, Li M, Jiang F, Zhou H, Yao XS, Zhang XK. Modulation of the Nur77-Bcl-2 apoptotic pathway by p38α MAPK. Oncotarget 2017;8:69731-45. [PMID: 29050237 DOI: 10.18632/oncotarget.19227] [Cited by in Crossref: 10] [Cited by in F6Publishing: 11] [Article Influence: 1.7] [Reference Citation Analysis]
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Li XM, Yang TY, He XS, Wang JR, Gan WJ, Zhang S, Li JM, Wu H. Orphan nuclear receptor Nur77 inhibits poly (I:C)-triggered acute liver inflammation by inducing the ubiquitin-editing enzyme A20. Oncotarget 2017;8:61025-35. [PMID: 28977843 DOI: 10.18632/oncotarget.17731] [Cited by in Crossref: 4] [Cited by in F6Publishing: 5] [Article Influence: 0.7] [Reference Citation Analysis]
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Hedrick E, Lee SO, Safe S. The nuclear orphan receptor NR4A1 regulates β1-integrin expression in pancreatic and colon cancer cells and can be targeted by NR4A1 antagonists. Mol Carcinog 2017;56:2066-75. [PMID: 28418095 DOI: 10.1002/mc.22662] [Cited by in Crossref: 15] [Cited by in F6Publishing: 16] [Article Influence: 2.5] [Reference Citation Analysis]
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Lu WJ, Chua MS, Wei W, So SK. NDRG1 promotes growth of hepatocellular carcinoma cells by directly interacting with GSK-3β and Nur77 to prevent β-catenin degradation. Oncotarget 2015;6:29847-59. [PMID: 26359353 DOI: 10.18632/oncotarget.4913] [Cited by in Crossref: 24] [Cited by in F6Publishing: 26] [Article Influence: 3.4] [Reference Citation Analysis]
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Hedrick E, Lee SO, Doddapaneni R, Singh M, Safe S. NR4A1 Antagonists Inhibit β1-Integrin-Dependent Breast Cancer Cell Migration. Mol Cell Biol 2016;36:1383-94. [PMID: 26929200 DOI: 10.1128/MCB.00912-15] [Cited by in Crossref: 39] [Cited by in F6Publishing: 39] [Article Influence: 5.6] [Reference Citation Analysis]
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Li XM, Zhang S, He XS, Guo PD, Lu XX, Wang JR, Li JM, Wu H. Nur77-mediated TRAF6 signalling protects against LPS-induced sepsis in mice. J Inflamm (Lond) 2016;13:4. [PMID: 26839514 DOI: 10.1186/s12950-016-0112-9] [Cited by in Crossref: 18] [Cited by in F6Publishing: 19] [Article Influence: 2.6] [Reference Citation Analysis]
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Wu H, Li XM, Wang JR, Gan WJ, Jiang FQ, Liu Y, Zhang XD, He XS, Zhao YY, Lu XX. NUR77 exerts a protective effect against inflammatory bowel disease by negatively regulating the TRAF6/TLR-IL-1R signalling axis. J Pathol. 2016;238:457-469. [PMID: 26564988 DOI: 10.1002/path.4670] [Cited by in Crossref: 45] [Cited by in F6Publishing: 51] [Article Influence: 5.6] [Reference Citation Analysis]
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Xie L, Jiang F, Zhang X, Alitongbieke G, Shi X, Meng M, Xu Y, Ren A, Wang J, Cai L, Zhou Y, Xu Y, Su Y, Liu J, Zeng Z, Wang G, Zhou H, Chen QC, Zhang XK. Honokiol sensitizes breast cancer cells to TNF-α induction of apoptosis by inhibiting Nur77 expression. Br J Pharmacol 2016;173:344-56. [PMID: 26505879 DOI: 10.1111/bph.13375] [Cited by in Crossref: 18] [Cited by in F6Publishing: 20] [Article Influence: 2.3] [Reference Citation Analysis]
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Agostini-Dreyer A, Jetzt AE, Stires H, Cohick WS. Endogenous IGFBP-3 Mediates Intrinsic Apoptosis Through Modulation of Nur77 Phosphorylation and Nuclear Export. Endocrinology 2015;156:4141-51. [PMID: 26340041 DOI: 10.1210/en.2015-1215] [Cited by in Crossref: 17] [Cited by in F6Publishing: 16] [Article Influence: 2.1] [Reference Citation Analysis]
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Hedrick E, Lee SO, Doddapaneni R, Singh M, Safe S. Nuclear receptor 4A1 as a drug target for breast cancer chemotherapy. Endocr Relat Cancer 2015;22:831-40. [PMID: 26229035 DOI: 10.1530/ERC-15-0063] [Cited by in Crossref: 43] [Cited by in F6Publishing: 43] [Article Influence: 5.4] [Reference Citation Analysis]
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Hedrick E, Lee SO, Kim G, Abdelrahim M, Jin UH, Safe S, Abudayyeh A. Nuclear Receptor 4A1 (NR4A1) as a Drug Target for Renal Cell Adenocarcinoma. PLoS One 2015;10:e0128308. [PMID: 26035713 DOI: 10.1371/journal.pone.0128308] [Cited by in Crossref: 41] [Cited by in F6Publishing: 45] [Article Influence: 5.1] [Reference Citation Analysis]
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Li X, Lee SO, Safe S. Structure-dependent activation of NR4A2 (Nurr1) by 1,1-bis(3’-indolyl)-1-(aromatic)methane analogs in pancreatic cancer cells. Biochem Pharmacol. 2012;83:1445-1455. [PMID: 22405837 DOI: 10.1016/j.bcp.2012.02.021] [Cited by in Crossref: 60] [Cited by in F6Publishing: 60] [Article Influence: 5.5] [Reference Citation Analysis]
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