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For: Alemi F, Kwon E, Poole DP, Lieu T, Lyo V, Cattaruzza F, Cevikbas F, Steinhoff M, Nassini R, Materazzi S, Guerrero-Alba R, Valdez-Morales E, Cottrell GS, Schoonjans K, Geppetti P, Vanner SJ, Bunnett NW, Corvera CU. The TGR5 receptor mediates bile acid-induced itch and analgesia. J Clin Invest. 2013;123:1513-1530. [PMID: 23524965 DOI: 10.1172/jci64551] [Cited by in Crossref: 210] [Cited by in F6Publishing: 94] [Article Influence: 23.3] [Reference Citation Analysis]
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7 Chen ZF. A neuropeptide code for itch. Nat Rev Neurosci 2021;22:758-76. [PMID: 34663954 DOI: 10.1038/s41583-021-00526-9] [Reference Citation Analysis]
8 Meixiong J, Vasavda C, Snyder SH, Dong X. MRGPRX4 is a G protein-coupled receptor activated by bile acids that may contribute to cholestatic pruritus. Proc Natl Acad Sci U S A. 2019;116:10525-10530. [PMID: 31068464 DOI: 10.1073/pnas.1903316116] [Cited by in Crossref: 34] [Cited by in F6Publishing: 33] [Article Influence: 11.3] [Reference Citation Analysis]
9 Badman MK, Chen J, Desai S, Vaidya S, Neelakantham S, Zhang J, Gan L, Danis K, Laffitte B, Klickstein LB. Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Novel Non-Bile Acid FXR Agonist Tropifexor (LJN452) in Healthy Volunteers. Clin Pharmacol Drug Dev 2020;9:395-410. [PMID: 31823525 DOI: 10.1002/cpdd.762] [Cited by in Crossref: 17] [Cited by in F6Publishing: 15] [Article Influence: 5.7] [Reference Citation Analysis]
10 Festa C, De Marino S, Carino A, Sepe V, Marchianò S, Cipriani S, Di Leva FS, Limongelli V, Monti MC, Capolupo A, Distrutti E, Fiorucci S, Zampella A. Targeting Bile Acid Receptors: Discovery of a Potent and Selective Farnesoid X Receptor Agonist as a New Lead in the Pharmacological Approach to Liver Diseases. Front Pharmacol 2017;8:162. [PMID: 28424617 DOI: 10.3389/fphar.2017.00162] [Cited by in Crossref: 19] [Cited by in F6Publishing: 18] [Article Influence: 3.8] [Reference Citation Analysis]
11 Meixiong J, Vasavda C, Green D, Zheng Q, Qi L, Kwatra SG, Hamilton JP, Snyder SH, Dong X. Identification of a bilirubin receptor that may mediate a component of cholestatic itch. Elife 2019;8:e44116. [PMID: 30657454 DOI: 10.7554/eLife.44116] [Cited by in Crossref: 38] [Cited by in F6Publishing: 17] [Article Influence: 12.7] [Reference Citation Analysis]
12 Tajiri K, Shimizu Y. Recent advances in the management of pruritus in chronic liver diseases. World J Gastroenterol 2017; 23(19): 3418-3426 [PMID: 28596678 DOI: 10.3748/wjg.v23.i19.3418] [Cited by in CrossRef: 17] [Cited by in F6Publishing: 15] [Article Influence: 3.4] [Reference Citation Analysis]
13 Loke MF, Wei H, Yeo J, Sng BL, Sia AT, Tan EC. Deep sequencing analysis to identify novel and rare variants in pain-related genes in patients with acute postoperative pain and high morphine use. J Pain Res 2019;12:2755-70. [PMID: 31571979 DOI: 10.2147/JPR.S213869] [Cited by in Crossref: 1] [Article Influence: 0.3] [Reference Citation Analysis]
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15 Cai Z, Yuan S, Zhong Y, Deng L, Li J, Tan X, Feng J. Amelioration of Endothelial Dysfunction in Diabetes: Role of Takeda G Protein-Coupled Receptor 5. Front Pharmacol 2021;12:637051. [PMID: 33995040 DOI: 10.3389/fphar.2021.637051] [Reference Citation Analysis]
16 Liu JY, Chen HY, Zhang GX. Role and significance of bile acid membrane receptor GPBAR1 in pathogenesis of obstructive jaundice. Shijie Huaren Xiaohua Zazhi 2020; 28(21): 1053-1058 [DOI: 10.11569/wcjd.v28.i21.1053] [Reference Citation Analysis]
17 Bertolini A, Fiorotto R, Strazzabosco M. Bile acids and their receptors: modulators and therapeutic targets in liver inflammation. Semin Immunopathol 2022. [PMID: 35415765 DOI: 10.1007/s00281-022-00935-7] [Reference Citation Analysis]
18 Sun S, Dong X. Trp channels and itch. Semin Immunopathol 2016;38:293-307. [PMID: 26385480 DOI: 10.1007/s00281-015-0530-4] [Cited by in Crossref: 33] [Cited by in F6Publishing: 30] [Article Influence: 4.7] [Reference Citation Analysis]
19 Solorzano C, Villafuerte D, Meda K, Cevikbas F, Bráz J, Sharif-Naeini R, Juarez-Salinas D, Llewellyn-Smith IJ, Guan Z, Basbaum AI. Primary afferent and spinal cord expression of gastrin-releasing peptide: message, protein, and antibody concerns. J Neurosci. 2015;35:648-657. [PMID: 25589759 DOI: 10.1523/jneurosci.2955-14.2015] [Cited by in Crossref: 72] [Cited by in F6Publishing: 44] [Article Influence: 10.3] [Reference Citation Analysis]
20 Zhang X. Targeting TRP ion channels for itch relief. Naunyn Schmiedebergs Arch Pharmacol 2015;388:389-99. [PMID: 25418889 DOI: 10.1007/s00210-014-1068-z] [Cited by in Crossref: 18] [Cited by in F6Publishing: 17] [Article Influence: 2.3] [Reference Citation Analysis]
21 Lin B, Wang Y, Zhang P, Yuan Y, Zhang Y, Chen G. Gut microbiota regulates neuropathic pain: potential mechanisms and therapeutic strategy. J Headache Pain 2020;21:103. [PMID: 32807072 DOI: 10.1186/s10194-020-01170-x] [Cited by in Crossref: 7] [Cited by in F6Publishing: 8] [Article Influence: 3.5] [Reference Citation Analysis]
22 Cipriani S, Renga B, D'Amore C, Simonetti M, De Tursi AA, Carino A, Monti MC, Sepe V, Zampella A, Fiorucci S. Impaired Itching Perception in Murine Models of Cholestasis Is Supported by Dysregulation of GPBAR1 Signaling. PLoS One 2015;10:e0129866. [PMID: 26177448 DOI: 10.1371/journal.pone.0129866] [Cited by in Crossref: 28] [Cited by in F6Publishing: 26] [Article Influence: 4.0] [Reference Citation Analysis]
23 Pecova T, Kocan I, Vysehradsky R, Pecova R. Itch and Cough - Similar Role of Sensory Nerves in Their Pathogenesis. Physiol Res 2020;69:S43-54. [PMID: 32228011 DOI: 10.33549/physiolres.934403] [Cited by in Crossref: 3] [Cited by in F6Publishing: 1] [Article Influence: 1.5] [Reference Citation Analysis]
24 Li J, Liu M, Li Y, Sun DD, Shu Z, Tan Q, Guo S, Xie R, Gao L, Ru H, Zang Y, Liu H, Li J, Zhou Y. Discovery and Optimization of Non-bile Acid FXR Agonists as Preclinical Candidates for the Treatment of Nonalcoholic Steatohepatitis. J Med Chem 2020;63:12748-72. [PMID: 32991173 DOI: 10.1021/acs.jmedchem.0c01065] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 0.5] [Reference Citation Analysis]
25 Bunnett NW. Neuro-humoral signalling by bile acids and the TGR5 receptor in the gastrointestinal tract. J Physiol 2014;592:2943-50. [PMID: 24614746 DOI: 10.1113/jphysiol.2014.271155] [Cited by in Crossref: 48] [Cited by in F6Publishing: 45] [Article Influence: 6.0] [Reference Citation Analysis]
26 Ferrell JM, Chiang JY. Bile acid receptors and signaling crosstalk in the liver, gut and brain. Liver Research 2021;5:105-18. [DOI: 10.1016/j.livres.2021.07.002] [Cited by in Crossref: 2] [Cited by in F6Publishing: 1] [Article Influence: 2.0] [Reference Citation Analysis]
27 Takanami K, Sakamoto H. The Gastrin-Releasing Peptide Receptor (GRPR) in the Spinal Cord as a Novel Pharmacological Target. Curr Neuropharmacol 2014;12:434-43. [PMID: 25426011 DOI: 10.2174/1570159X12666140923201432] [Cited by in Crossref: 13] [Cited by in F6Publishing: 5] [Article Influence: 1.6] [Reference Citation Analysis]
28 Abu-Hayyeh S, Ovadia C, Lieu T, Jensen DD, Chambers J, Dixon PH, Lövgren-Sandblom A, Bolier R, Tolenaars D, Kremer AE. Prognostic and mechanistic potential of progesterone sulfates in intrahepatic cholestasis of pregnancy and pruritus gravidarum. Hepatology. 2016;63:1287-1298. [PMID: 26426865 DOI: 10.1002/hep.28265] [Cited by in Crossref: 56] [Cited by in F6Publishing: 50] [Article Influence: 8.0] [Reference Citation Analysis]
29 Shiratori-Hayashi M, Tsuda M. Spinal glial cells in itch modulation. Pharmacol Res Perspect 2021;9:e00754. [PMID: 34677000 DOI: 10.1002/prp2.754] [Cited by in Crossref: 1] [Article Influence: 1.0] [Reference Citation Analysis]
30 Langedijk JAGM, Beuers UH, Oude Elferink RPJ. Cholestasis-Associated Pruritus and Its Pruritogens. Front Med (Lausanne) 2021;8:639674. [PMID: 33791327 DOI: 10.3389/fmed.2021.639674] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 1.0] [Reference Citation Analysis]
31 Grace MS, Lieu T, Darby B, Abogadie FC, Veldhuis N, Bunnett NW, McIntyre P. The tyrosine kinase inhibitor bafetinib inhibits PAR2-induced activation of TRPV4 channels in vitro and pain in vivo. Br J Pharmacol 2014;171:3881-94. [PMID: 24779362 DOI: 10.1111/bph.12750] [Cited by in Crossref: 33] [Cited by in F6Publishing: 33] [Article Influence: 4.7] [Reference Citation Analysis]
32 Moore C, Gupta R, Jordt SE, Chen Y, Liedtke WB. Regulation of Pain and Itch by TRP Channels. Neurosci Bull 2018;34:120-42. [PMID: 29282613 DOI: 10.1007/s12264-017-0200-8] [Cited by in Crossref: 95] [Cited by in F6Publishing: 89] [Article Influence: 19.0] [Reference Citation Analysis]
33 Duboc H, Taché Y, Hofmann AF. The bile acid TGR5 membrane receptor: from basic research to clinical application. Dig Liver Dis 2014;46:302-12. [PMID: 24411485 DOI: 10.1016/j.dld.2013.10.021] [Cited by in Crossref: 229] [Cited by in F6Publishing: 216] [Article Influence: 28.6] [Reference Citation Analysis]
34 Liu XY, Wan L, Huo FQ, Barry DM, Li H, Zhao ZQ, Chen ZF. B-type natriuretic peptide is neither itch-specific nor functions upstream of the GRP-GRPR signaling pathway. Mol Pain 2014;10:4. [PMID: 24438367 DOI: 10.1186/1744-8069-10-4] [Cited by in Crossref: 45] [Cited by in F6Publishing: 46] [Article Influence: 5.6] [Reference Citation Analysis]
35 An P, Wei G, Huang P, Li W, Qi X, Lin Y, Vaid KA, Wang J, Zhang S, Li Y, Or YS, Jiang LJ, Popov YV. A novel non-bile acid FXR agonist EDP-305 potently suppresses liver injury and fibrosis without worsening of ductular reaction. Liver Int 2020;40:1655-69. [PMID: 32329946 DOI: 10.1111/liv.14490] [Cited by in Crossref: 12] [Cited by in F6Publishing: 14] [Article Influence: 6.0] [Reference Citation Analysis]
36 Canals M, Poole DP, Veldhuis NA, Schmidt BL, Bunnett NW. G-Protein-Coupled Receptors Are Dynamic Regulators of Digestion and Targets for Digestive Diseases. Gastroenterology 2019;156:1600-16. [PMID: 30771352 DOI: 10.1053/j.gastro.2019.01.266] [Cited by in Crossref: 6] [Cited by in F6Publishing: 5] [Article Influence: 2.0] [Reference Citation Analysis]
37 Di Leva FS, Festa C, Carino A, De Marino S, Marchianò S, Di Marino D, Finamore C, Monti MC, Zampella A, Fiorucci S, Limongelli V. Discovery of ((1,2,4-oxadiazol-5-yl)pyrrolidin-3-yl)ureidyl derivatives as selective non-steroidal agonists of the G-protein coupled bile acid receptor-1. Sci Rep 2019;9:2504. [PMID: 30792450 DOI: 10.1038/s41598-019-38840-z] [Cited by in Crossref: 6] [Cited by in F6Publishing: 7] [Article Influence: 2.0] [Reference Citation Analysis]
38 Donepudi AC, Boehme S, Li F, Chiang JY. G-protein-coupled bile acid receptor plays a key role in bile acid metabolism and fasting-induced hepatic steatosis in mice. Hepatology. 2017;65:813-827. [PMID: 27351453 DOI: 10.1002/hep.28707] [Cited by in Crossref: 64] [Cited by in F6Publishing: 61] [Article Influence: 10.7] [Reference Citation Analysis]
39 Zaufel A, van de Wiel SMW, Yin L, Fauler G, Chien D, Dong X, Gilmer JF, Truong JK, Dawson PA, van de Graaf SFJ, Fickert P, Moustafa T. Secondary (iso)BAs cooperate with endogenous ligands to activate FXR under physiological and pathological conditions. Biochim Biophys Acta Mol Basis Dis 2021;1867:166153. [PMID: 33895309 DOI: 10.1016/j.bbadis.2021.166153] [Reference Citation Analysis]
40 Zaborska KE, Cummings BP. Rethinking Bile Acid Metabolism and Signaling for Type 2 Diabetes Treatment. Curr Diab Rep 2018;18:109. [PMID: 30232649 DOI: 10.1007/s11892-018-1092-3] [Cited by in Crossref: 11] [Cited by in F6Publishing: 12] [Article Influence: 2.8] [Reference Citation Analysis]
41 Keitel V, Reich M, Häussinger D. TGR5: pathogenetic role and/or therapeutic target in fibrosing cholangitis? Clin Rev Allergy Immunol 2015;48:218-25. [PMID: 25138774 DOI: 10.1007/s12016-014-8443-x] [Cited by in F6Publishing: 28] [Reference Citation Analysis]
42 Kriegermeier A, Green R. Pediatric Cholestatic Liver Disease: Review of Bile Acid Metabolism and Discussion of Current and Emerging Therapies. Front Med (Lausanne) 2020;7:149. [PMID: 32432119 DOI: 10.3389/fmed.2020.00149] [Cited by in Crossref: 9] [Cited by in F6Publishing: 7] [Article Influence: 4.5] [Reference Citation Analysis]
43 Li Y, Lu LG. Therapeutic Roles of Bile Acid Signaling in Chronic Liver Diseases. J Clin Transl Hepatol 2018;6:425-30. [PMID: 30637221 DOI: 10.14218/JCTH.2018.00025] [Cited by in Crossref: 3] [Cited by in F6Publishing: 2] [Article Influence: 0.8] [Reference Citation Analysis]
44 Vuppalanchi R, Noureddin M, Alkhouri N, Sanyal AJ. Therapeutic pipeline in nonalcoholic steatohepatitis. Nat Rev Gastroenterol Hepatol 2021;18:373-92. [PMID: 33568794 DOI: 10.1038/s41575-020-00408-y] [Cited by in Crossref: 14] [Cited by in F6Publishing: 12] [Article Influence: 14.0] [Reference Citation Analysis]
45 Luna RA, Savidge TC, Williams KC. The Brain-Gut-Microbiome Axis: What Role Does It Play in Autism Spectrum Disorder? Curr Dev Disord Rep 2016;3:75-81. [PMID: 27398286 DOI: 10.1007/s40474-016-0077-7] [Cited by in Crossref: 27] [Cited by in F6Publishing: 21] [Article Influence: 4.5] [Reference Citation Analysis]
46 Lefort C, Cani PD. The Liver under the Spotlight: Bile Acids and Oxysterols as Pivotal Actors Controlling Metabolism. Cells 2021;10:400. [PMID: 33669184 DOI: 10.3390/cells10020400] [Cited by in Crossref: 2] [Cited by in F6Publishing: 2] [Article Influence: 2.0] [Reference Citation Analysis]
47 Hegade VS, Bolier R, Oude Elferink RP, Beuers U, Kendrick S, Jones DE. A systematic approach to the management of cholestatic pruritus in primary biliary cirrhosis. Frontline Gastroenterol 2016;7:158-66. [PMID: 28839853 DOI: 10.1136/flgastro-2015-100618] [Cited by in Crossref: 14] [Cited by in F6Publishing: 11] [Article Influence: 2.0] [Reference Citation Analysis]
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49 Bajaj JS, Fagan A, Sikaroodi M, Kakiyama G, Takei H, Degefu Y, Pandak WM, Hylemon PB, Fuchs M, John B, Heuman DM, Gavis E, Nittono H, Patil R, Gillevet PM. Alterations in Skin Microbiomes of Patients With Cirrhosis. Clin Gastroenterol Hepatol 2019;17:2581-2591.e15. [PMID: 30905718 DOI: 10.1016/j.cgh.2019.03.028] [Cited by in Crossref: 4] [Cited by in F6Publishing: 4] [Article Influence: 1.3] [Reference Citation Analysis]
50 Ejelonu OC. Mechanisms of action of aqueous extract from the Hunteria umbellata seed and metformin in diabetes. World J Meta-Anal 2019; 7(9): 418-422 [DOI: 10.13105/wjma.v7.i9.418] [Cited by in Crossref: 1] [Article Influence: 0.3] [Reference Citation Analysis]
51 Di Leva FS, Festa C, Renga B, Sepe V, Novellino E, Fiorucci S, Zampella A, Limongelli V. Structure-based drug design targeting the cell membrane receptor GPBAR1: exploiting the bile acid scaffold towards selective agonism. Sci Rep 2015;5:16605. [PMID: 26567894 DOI: 10.1038/srep16605] [Cited by in Crossref: 18] [Cited by in F6Publishing: 16] [Article Influence: 2.6] [Reference Citation Analysis]
52 Jensen DD, Lieu T, Halls ML, Veldhuis NA, Imlach WL, Mai QN, Poole DP, Quach T, Aurelio L, Conner J, Herenbrink CK, Barlow N, Simpson JS, Scanlon MJ, Graham B, McCluskey A, Robinson PJ, Escriou V, Nassini R, Materazzi S, Geppetti P, Hicks GA, Christie MJ, Porter CJH, Canals M, Bunnett NW. Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief. Sci Transl Med 2017;9:eaal3447. [PMID: 28566424 DOI: 10.1126/scitranslmed.aal3447] [Cited by in Crossref: 79] [Cited by in F6Publishing: 71] [Article Influence: 19.8] [Reference Citation Analysis]
53 Pederson M, Mayo MJ. Therapeutics for Pruritus in Cholestatic Liver Disease: Many Treatments but Few Cures. Curr Hepatology Rep 2018;17:143-51. [DOI: 10.1007/s11901-018-0397-7] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 0.3] [Reference Citation Analysis]
54 Perino A, Pols TW, Nomura M, Stein S, Pellicciari R, Schoonjans K. TGR5 reduces macrophage migration through mTOR-induced C/EBPβ differential translation. J Clin Invest 2014;124:5424-36. [PMID: 25365223 DOI: 10.1172/JCI76289] [Cited by in Crossref: 97] [Cited by in F6Publishing: 50] [Article Influence: 12.1] [Reference Citation Analysis]
55 Wang Q, Li ZX, Liu BW, He ZG, Liu C, Chen M, Liu SG, Wu WZ, Xiang HB. Altered expression of differential gene and lncRNA in the lower thoracic spinal cord on different time courses of experimental obstructive jaundice model accompanied with altered peripheral nociception in rats. Oncotarget 2017;8:106098-112. [PMID: 29285317 DOI: 10.18632/oncotarget.22532] [Cited by in Crossref: 3] [Cited by in F6Publishing: 5] [Article Influence: 0.6] [Reference Citation Analysis]
56 Ahmadi S, Poureidi M, Rostamzadeh J. Hepatic encephalopathy induces site-specific changes in gene expression of GluN1 subunit of NMDA receptor in rat brain. Metab Brain Dis 2015;30:1035-41. [PMID: 25896221 DOI: 10.1007/s11011-015-9669-x] [Cited by in Crossref: 7] [Cited by in F6Publishing: 7] [Article Influence: 1.0] [Reference Citation Analysis]
57 Chen M, Li ZX, Wang Q, Xiang HB. Altered Expression of Differential Genes in Thoracic Spinal Cord Involved in Experimental Cholestatic Itch Mouse Model. Curr Med Sci 2018;38:679-83. [PMID: 30128878 DOI: 10.1007/s11596-018-1930-1] [Cited by in Crossref: 5] [Cited by in F6Publishing: 6] [Article Influence: 1.3] [Reference Citation Analysis]
58 Dawson PA, Karpen SJ. Bile acids reach out to the spinal cord: new insights to the pathogenesis of itch and analgesia in cholestatic liver disease. Hepatology 2014;59:1638-41. [PMID: 24532150 DOI: 10.1002/hep.26786] [Cited by in Crossref: 11] [Cited by in F6Publishing: 11] [Article Influence: 1.4] [Reference Citation Analysis]
59 Yu H, Zhao T, Liu S, Wu Q, Johnson O, Wu Z, Zhuang Z, Shi Y, Peng L, He R, Yang Y, Sun J, Wang X, Xu H, Zeng Z, Zou P, Lei X, Luo W, Li Y. MRGPRX4 is a bile acid receptor for human cholestatic itch. Elife 2019;8:e48431. [PMID: 31500698 DOI: 10.7554/eLife.48431] [Cited by in Crossref: 21] [Cited by in F6Publishing: 8] [Article Influence: 7.0] [Reference Citation Analysis]
60 Han L, Dong X. Itch mechanisms and circuits. Annu Rev Biophys 2014;43:331-55. [PMID: 24819620 DOI: 10.1146/annurev-biophys-051013-022826] [Cited by in Crossref: 90] [Cited by in F6Publishing: 80] [Article Influence: 11.3] [Reference Citation Analysis]
61 Rossi R, Ciofalo M. Current Advances in the Synthesis and Biological Evaluation of Pharmacologically Relevant 1,2,4,5-Tetrasubstituted-1H-Imidazole Derivatives. COC 2019;23:2016-101. [DOI: 10.2174/1385272823666191014154129] [Cited by in Crossref: 3] [Article Influence: 1.0] [Reference Citation Analysis]
62 Sasaki T, Kuboyama A, Mita M, Murata S, Shimizu M, Inoue J, Mori K, Sato R. The exercise-inducible bile acid receptor Tgr5 improves skeletal muscle function in mice. J Biol Chem 2018;293:10322-32. [PMID: 29773650 DOI: 10.1074/jbc.RA118.002733] [Cited by in Crossref: 19] [Cited by in F6Publishing: 10] [Article Influence: 4.8] [Reference Citation Analysis]
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