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For: Harikumar KB, Sung B, Pandey MK, Guha S, Krishnan S, Aggarwal BB. Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-kappaB signaling pathway. Mol Pharmacol. 2010;77:818-827. [PMID: 20103608 DOI: 10.1124/mol.109.062760] [Cited by in Crossref: 46] [Cited by in F6Publishing: 44] [Article Influence: 4.2] [Reference Citation Analysis]
Number Citing Articles
1 Wang H, Zhang L, Jiang N, Wang Z, Chong Y, Fu F. Anti-inflammatory effects of escin are correlated with the glucocorticoid receptor/NF-κB signaling pathway, but not the COX/PGF2α signaling pathway. Exp Ther Med 2013;6:419-22. [PMID: 24137201 DOI: 10.3892/etm.2013.1128] [Cited by in Crossref: 23] [Cited by in F6Publishing: 18] [Article Influence: 2.9] [Reference Citation Analysis]
2 Li B, Wu GL, Dai W, Wang G, Su HY, Shen XP, Zhan R, Xie JM, Wang Z, Qin ZH, Gao QG, Shen GH. Aescin-induced reactive oxygen species play a pro-survival role in human cancer cells via ATM/AMPK/ULK1-mediated autophagy. Acta Pharmacol Sin 2018;39:1874-84. [PMID: 29921885 DOI: 10.1038/s41401-018-0047-1] [Cited by in Crossref: 5] [Cited by in F6Publishing: 6] [Article Influence: 1.7] [Reference Citation Analysis]
3 Gurovic MS, Lanza AM, Adánez Mdel C, Omaña MC, Gómez IG, Murray AP, López PS. Cytotoxic effects induced by combination of heliantriol B2 and dequalinium against human leukemic cell lines. Phytother Res 2011;25:603-10. [PMID: 20981868 DOI: 10.1002/ptr.3310] [Cited by in Crossref: 4] [Cited by in F6Publishing: 4] [Article Influence: 0.4] [Reference Citation Analysis]
4 Du J, Long F, Chen C. Research Progress on Natural Triterpenoid Saponins in the Chemoprevention and Chemotherapy of Cancer. Natural Products and Cancer Signaling: Isoprenoids, Polyphenols and Flavonoids. Elsevier; 2014. pp. 95-130. [DOI: 10.1016/b978-0-12-802215-3.00006-9] [Cited by in Crossref: 18] [Cited by in F6Publishing: 5] [Article Influence: 2.6] [Reference Citation Analysis]
5 Jiang N, Xin W, Wang T, Zhang L, Fan H, Du Y, Li C, Fu F. Protective effect of aescin from the seeds of Aesculus hippocastanum on liver injury induced by endotoxin in mice. Phytomedicine 2011;18:1276-84. [DOI: 10.1016/j.phymed.2011.06.011] [Cited by in Crossref: 25] [Cited by in F6Publishing: 19] [Article Influence: 2.5] [Reference Citation Analysis]
6 Wang Z, Chen Q, Li B, Xie JM, Yang XD, Zhao K, Wu Y, Ye ZY, Chen ZR, Qin ZH, Xing CG. Escin-induced DNA damage promotes escin-induced apoptosis in human colorectal cancer cells via p62 regulation of the ATM/γH2AX pathway. Acta Pharmacol Sin 2018;39:1645-60. [PMID: 29849127 DOI: 10.1038/aps.2017.192] [Cited by in Crossref: 7] [Cited by in F6Publishing: 6] [Article Influence: 2.3] [Reference Citation Analysis]
7 Li B, Wang Z, Xie JM, Wang G, Qian LQ, Guan XM, Shen XP, Qin ZH, Shen GH, Li XQ, Gao QG. TIGAR knockdown enhanced the anticancer effect of aescin via regulating autophagy and apoptosis in colorectal cancer cells. Acta Pharmacol Sin 2019;40:111-21. [PMID: 29769743 DOI: 10.1038/s41401-018-0001-2] [Cited by in Crossref: 8] [Cited by in F6Publishing: 9] [Article Influence: 2.7] [Reference Citation Analysis]
8 Varinská L, Fáber L, Kello M, Petrovová E, Balážová Ľ, Solár P, Čoma M, Urdzík P, Mojžiš J, Švajdlenka E, Mučaji P, Gál P. β-Escin Effectively Modulates HUVECS Proliferation and Tube Formation. Molecules 2018;23:E197. [PMID: 29342121 DOI: 10.3390/molecules23010197] [Cited by in Crossref: 6] [Cited by in F6Publishing: 4] [Article Influence: 2.0] [Reference Citation Analysis]
9 Hou H, Li WX, Cui X, Zhou DC, Zhang B, Geng XP. CARMA3/NF-κB signaling contributes to tumorigenesis of hepatocellular carcinoma and is inhibited by sodium aescinate. World J Gastroenterol 2019; 25(36): 5483-5493 [PMID: 31576094 DOI: 10.3748/wjg.v25.i36.5483] [Cited by in CrossRef: 2] [Cited by in F6Publishing: 3] [Article Influence: 1.0] [Reference Citation Analysis]
10 Zeniou M, Fève M, Mameri S, Dong J, Salomé C, Chen W, El-Habr EA, Bousson F, Sy M, Obszynski J, Boh A, Villa P, Assad Kahn S, Didier B, Bagnard D, Junier MP, Chneiweiss H, Haiech J, Hibert M, Kilhoffer MC. Chemical Library Screening and Structure-Function Relationship Studies Identify Bisacodyl as a Potent and Selective Cytotoxic Agent Towards Quiescent Human Glioblastoma Tumor Stem-Like Cells. PLoS One 2015;10:e0134793. [PMID: 26270679 DOI: 10.1371/journal.pone.0134793] [Cited by in Crossref: 16] [Cited by in F6Publishing: 16] [Article Influence: 2.7] [Reference Citation Analysis]
11 Yadav VR, Prasad S, Sung B, Kannappan R, Aggarwal BB. Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer. Toxins (Basel) 2010;2:2428-66. [PMID: 22069560 DOI: 10.3390/toxins2102428] [Cited by in Crossref: 164] [Cited by in F6Publishing: 159] [Article Influence: 14.9] [Reference Citation Analysis]
12 Kenny HA, Lal-Nag M, White EA, Shen M, Chiang CY, Mitra AK, Zhang Y, Curtis M, Schryver EM, Bettis S, Jadhav A, Boxer MB, Li Z, Ferrer M, Lengyel E. Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy. Nat Commun 2015;6:6220. [PMID: 25653139 DOI: 10.1038/ncomms7220] [Cited by in Crossref: 108] [Cited by in F6Publishing: 97] [Article Influence: 18.0] [Reference Citation Analysis]
13 Domanski D, Zegrocka-Stendel O, Perzanowska A, Dutkiewicz M, Kowalewska M, Grabowska I, Maciejko D, Fogtman A, Dadlez M, Koziak K. Molecular Mechanism for Cellular Response to β-Escin and Its Therapeutic Implications. PLoS One 2016;11:e0164365. [PMID: 27727329 DOI: 10.1371/journal.pone.0164365] [Cited by in Crossref: 23] [Cited by in F6Publishing: 20] [Article Influence: 4.6] [Reference Citation Analysis]
14 Katsori AM, Palagani A, Bougarne N, Hadjipavlou-Litina D, Haegeman G, Vanden Berghe W. Inhibition of the NF-κB signaling pathway by a novel heterocyclic curcumin analogue. Molecules. 2015;20:863-878. [PMID: 25580684 DOI: 10.3390/molecules20010863] [Cited by in Crossref: 15] [Cited by in F6Publishing: 16] [Article Influence: 2.5] [Reference Citation Analysis]
15 Cheng CL, Chao WT, Li YH, Ou YC, Wang SS, Chiu KY, Yuan SY. Escin induces apoptosis in human bladder cancer cells: An in vitro and in vivo study. Eur J Pharmacol 2018;840:79-88. [PMID: 30287153 DOI: 10.1016/j.ejphar.2018.09.033] [Cited by in Crossref: 4] [Cited by in F6Publishing: 4] [Article Influence: 1.3] [Reference Citation Analysis]
16 Tan SM, Li F, Rajendran P, Kumar AP, Hui KM, Sethi G. Identification of beta-escin as a novel inhibitor of signal transducer and activator of transcription 3/Janus-activated kinase 2 signaling pathway that suppresses proliferation and induces apoptosis in human hepatocellular carcinoma cells. J Pharmacol Exp Ther. 2010;334:285-293. [PMID: 20378717 DOI: 10.1124/jpet.110.165498] [Cited by in Crossref: 105] [Cited by in F6Publishing: 95] [Article Influence: 9.5] [Reference Citation Analysis]
17 Shanmugam MK, Nguyen AH, Kumar AP, Tan BK, Sethi G. Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: potential role in prevention and therapy of cancer. Cancer Lett 2012;320:158-70. [PMID: 22406826 DOI: 10.1016/j.canlet.2012.02.037] [Cited by in Crossref: 141] [Cited by in F6Publishing: 129] [Article Influence: 15.7] [Reference Citation Analysis]
18 Rimmon A, Vexler A, Berkovich L, Earon G, Ron I, Lev-Ari S. Escin Chemosensitizes Human Pancreatic Cancer Cells and Inhibits the Nuclear Factor-kappaB Signaling Pathway. Biochem Res Int 2013;2013:251752. [PMID: 24282639 DOI: 10.1155/2013/251752] [Cited by in Crossref: 21] [Cited by in F6Publishing: 20] [Article Influence: 2.6] [Reference Citation Analysis]
19 Suryavanshi SV, Kulkarni YA. Escin alleviates peripheral neuropathy in streptozotocin induced diabetes in rats. Life Sciences 2020;254:117777. [DOI: 10.1016/j.lfs.2020.117777] [Cited by in Crossref: 4] [Cited by in F6Publishing: 4] [Article Influence: 4.0] [Reference Citation Analysis]
20 Mojžišová G, Mojžiš J, Pilátová M, Varinská L, Ivanová L, Strojný L, Richnavský J. Antiproliferative and antiangiogenic properties of horse chestnut extract. Phytother Res 2013;27:159-65. [PMID: 22451355 DOI: 10.1002/ptr.4688] [Cited by in Crossref: 6] [Cited by in F6Publishing: 4] [Article Influence: 0.7] [Reference Citation Analysis]
21 Lindner I, Meier C, Url A, Unger H, Grassauer A, Prieschl-Grassauer E, Doerfler P. Beta-escin has potent anti-allergic efficacy and reduces allergic airway inflammation. BMC Immunol 2010;11:24. [PMID: 20487574 DOI: 10.1186/1471-2172-11-24] [Cited by in Crossref: 18] [Cited by in F6Publishing: 13] [Article Influence: 1.6] [Reference Citation Analysis]
22 Gupta SC, Kim JH, Prasad S, Aggarwal BB. Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals. Cancer Metastasis Rev. 2010;29:405-434. [PMID: 20737283 DOI: 10.1007/s10555-010-9235-2] [Cited by in Crossref: 518] [Cited by in F6Publishing: 455] [Article Influence: 47.1] [Reference Citation Analysis]
23 Omi K, Matsuo Y, Ueda G, Aoyama Y, Kato T, Hayashi Y, Imafuji H, Saito K, Tsuboi K, Morimoto M, Ogawa R, Takahashi H, Takiguchi S. Escin inhibits angiogenesis by suppressing interleukin‑8 and vascular endothelial growth factor production by blocking nuclear factor‑κB activation in pancreatic cancer cell lines. Oncol Rep 2021;45:55. [PMID: 33760162 DOI: 10.3892/or.2021.8006] [Reference Citation Analysis]
24 Lee HS, Hong JE, Kim EJ, Kim SH. Escin Suppresses Migration and Invasion Involving the Alteration of CXCL16/CXCR6 Axis in Human Gastric Adenocarcinoma AGS Cells. Nutrition and Cancer 2014;66:938-45. [DOI: 10.1080/01635581.2014.922202] [Cited by in Crossref: 13] [Cited by in F6Publishing: 10] [Article Influence: 1.9] [Reference Citation Analysis]
25 Zhang X, Zhang S, Yang Y, Wang D, Gao H. Natural barrigenol-like triterpenoids: A comprehensive review of their contributions to medicinal chemistry. Phytochemistry 2019;161:41-74. [PMID: 30818173 DOI: 10.1016/j.phytochem.2019.01.017] [Cited by in Crossref: 17] [Cited by in F6Publishing: 12] [Article Influence: 8.5] [Reference Citation Analysis]
26 Du Y, Wang T, Jiang N, Ren R, Zhao D, Li C, Fu F. Protective effect of sodium aescinate on lung injury induced by methyl parathion. Hum Exp Toxicol 2011;30:1584-91. [DOI: 10.1177/0960327110393764] [Cited by in Crossref: 9] [Cited by in F6Publishing: 8] [Article Influence: 0.8] [Reference Citation Analysis]
27 Liu M, Chen YL, Kuo YH, Lu MK, Liao CC. Aqueous extract of Sapindus mukorossi induced cell death of A549 cells and exhibited antitumor property in vivo. Sci Rep 2018;8:4831. [PMID: 29555954 DOI: 10.1038/s41598-018-23096-w] [Cited by in Crossref: 8] [Cited by in F6Publishing: 5] [Article Influence: 2.7] [Reference Citation Analysis]
28 Mabhida SE, Dludla PV, Johnson R, Ndlovu M, Louw J, Opoku AR, Mosa RA. Protective effect of triterpenes against diabetes-induced β-cell damage: An overview of in vitro and in vivo studies. Pharmacol Res 2018;137:179-92. [PMID: 30315968 DOI: 10.1016/j.phrs.2018.10.004] [Cited by in Crossref: 13] [Cited by in F6Publishing: 10] [Article Influence: 4.3] [Reference Citation Analysis]
29 Wang YW, Wang SJ, Zhou YN, Pan SH, Sun B. Escin augments the efficacy of gemcitabine through down-regulation of nuclear factor-κB and nuclear factor-κB-regulated gene products in pancreatic cancer both in vitro and in vivo. J Cancer Res Clin Oncol. 2012;138:785-797. [PMID: 22270965 DOI: 10.1007/s00432-012-1152-z] [Cited by in Crossref: 58] [Cited by in F6Publishing: 52] [Article Influence: 6.4] [Reference Citation Analysis]
30 Golan-goldhirsh A, Gopas J. Plant derived inhibitors of NF-κB. Phytochem Rev 2014;13:107-21. [DOI: 10.1007/s11101-013-9293-5] [Cited by in Crossref: 22] [Cited by in F6Publishing: 12] [Article Influence: 2.8] [Reference Citation Analysis]
31 Zhu L, Yang XP, Janic B, Rhaleb NE, Harding P, Nakagawa P, Peterson EL, Carretero OA. Ac-SDKP suppresses TNF-α-induced ICAM-1 expression in endothelial cells via inhibition of IκB kinase and NF-κB activation. Am J Physiol Heart Circ Physiol 2016;310:H1176-83. [PMID: 26945075 DOI: 10.1152/ajpheart.00252.2015] [Cited by in Crossref: 11] [Cited by in F6Publishing: 12] [Article Influence: 2.2] [Reference Citation Analysis]
32 Jang CH, Cho YB, Choi CH, Jang YS, Jang SJ, Jung WK, Park BY, Kim MY. ALH-L1005 attenuates endotoxin induced inner ear damage. Int J Pediatr Otorhinolaryngol 2014;78:465-70. [PMID: 24418183 DOI: 10.1016/j.ijporl.2013.12.022] [Cited by in Crossref: 6] [Cited by in F6Publishing: 6] [Article Influence: 0.8] [Reference Citation Analysis]
33 Sipos W, Reutterer B, Frank M, Unger H, Grassauer A, Prieschl-grassauer E, Doerfler P. Escin Inhibits Type I Allergic Dermatitis in a Novel Porcine Model. Int Arch Allergy Immunol 2013;161:44-52. [DOI: 10.1159/000343289] [Cited by in Crossref: 14] [Cited by in F6Publishing: 13] [Article Influence: 1.8] [Reference Citation Analysis]
34 Choi HS, Seo HS, Kim JH, Um JY, Shin YC, Ko SG. Ethanol extract of paeonia suffruticosa Andrews (PSE) induced AGS human gastric cancer cell apoptosis via fas-dependent apoptosis and MDM2-p53 pathways. J Biomed Sci. 2012;19:82. [PMID: 22963678 DOI: 10.1186/1423-0127-19-82] [Cited by in Crossref: 28] [Cited by in F6Publishing: 20] [Article Influence: 3.1] [Reference Citation Analysis]
35 Sung B, Prasad S, Yadav VR, Lavasanifar A, Aggarwal BB. Cancer and diet: How are they related? Free Radic Res 2011;45:864-79. [PMID: 21651450 DOI: 10.3109/10715762.2011.582869] [Cited by in Crossref: 39] [Cited by in F6Publishing: 34] [Article Influence: 3.9] [Reference Citation Analysis]
36 Patlolla JMR, Rao CV. Anti-inflammatory and Anti-cancer Properties of β-Escin, a Triterpene Saponin. Curr Pharmacol Rep 2015;1:170-8. [DOI: 10.1007/s40495-015-0019-9] [Cited by in Crossref: 17] [Cited by in F6Publishing: 8] [Article Influence: 2.8] [Reference Citation Analysis]
37 Cheong DHJ, Arfuso F, Sethi G, Wang L, Hui KM, Kumar AP, Tran T. Molecular targets and anti-cancer potential of escin. Cancer Lett. 2018;422:1-8. [PMID: 29474858 DOI: 10.1016/j.canlet.2018.02.027] [Cited by in Crossref: 26] [Cited by in F6Publishing: 23] [Article Influence: 8.7] [Reference Citation Analysis]
38 Zou J, Lin J, Li C, Zhao R, Fan L, Yu J, Shao J. Ursolic Acid in Cancer Treatment and Metastatic Chemoprevention: From Synthesized Derivatives to Nanoformulations in Preclinical Studies. CCDT 2019;19:245-56. [DOI: 10.2174/1568009618666181016145940] [Cited by in Crossref: 8] [Cited by in F6Publishing: 8] [Article Influence: 4.0] [Reference Citation Analysis]
39 Pal S, Bhattacharjee A, Ali A, Mandal NC, Mandal SC, Pal M. Chronic inflammation and cancer: potential chemoprevention through nuclear factor kappa B and p53 mutual antagonism. J Inflamm (Lond) 2014;11:23. [PMID: 25152696 DOI: 10.1186/1476-9255-11-23] [Cited by in Crossref: 70] [Cited by in F6Publishing: 70] [Article Influence: 10.0] [Reference Citation Analysis]
40 Sikorska M, Dutkiewicz M, Zegrocka-Stendel O, Kowalewska M, Grabowska I, Koziak K. Beneficial effects of β-escin on muscle regeneration in rat model of skeletal muscle injury. Phytomedicine 2021;93:153791. [PMID: 34666284 DOI: 10.1016/j.phymed.2021.153791] [Reference Citation Analysis]
41 Wang K, Jiang Y, Wang W, Ma J, Chen M. Escin activates AKT-Nrf2 signaling to protect retinal pigment epithelium cells from oxidative stress. Biochem Biophys Res Commun 2015;468:541-7. [PMID: 26505797 DOI: 10.1016/j.bbrc.2015.10.117] [Cited by in Crossref: 20] [Cited by in F6Publishing: 21] [Article Influence: 3.3] [Reference Citation Analysis]
42 Sung B, Prasad S, Gupta SC, Patchva S, Aggarwal BB. Regulation of Inflammation-Mediated Chronic Diseases by Botanicals. Recent Trends in Medicinal Plants Research. Elsevier; 2012. pp. 57-132. [DOI: 10.1016/b978-0-12-394591-4.00003-9] [Cited by in Crossref: 10] [Article Influence: 1.1] [Reference Citation Analysis]
43 Niero EL, Rocha-Sales B, Lauand C, Cortez BA, de Souza MM, Rezende-Teixeira P, Urabayashi MS, Martens AA, Neves JH, Machado-Santelli GM. The multiple facets of drug resistance: one history, different approaches. J Exp Clin Cancer Res 2014;33:37. [PMID: 24775603 DOI: 10.1186/1756-9966-33-37] [Cited by in Crossref: 77] [Cited by in F6Publishing: 71] [Article Influence: 11.0] [Reference Citation Analysis]
44 Gupta SC, Tyagi AK, Deshmukh-taskar P, Hinojosa M, Prasad S, Aggarwal BB. Downregulation of tumor necrosis factor and other proinflammatory biomarkers by polyphenols. Archives of Biochemistry and Biophysics 2014;559:91-9. [DOI: 10.1016/j.abb.2014.06.006] [Cited by in Crossref: 153] [Cited by in F6Publishing: 139] [Article Influence: 21.9] [Reference Citation Analysis]