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For: Roncarati R, Sestan N, Scheinfeld MH, Berechid BE, Lopez PA, Meucci O, McGlade JC, Rakic P, D'Adamio L. The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling. Proc Natl Acad Sci U S A 2002;99:7102-7. [PMID: 12011466 DOI: 10.1073/pnas.102192599] [Cited by in Crossref: 151] [Cited by in F6Publishing: 143] [Article Influence: 7.6] [Reference Citation Analysis]
Number Citing Articles
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2 Wang N, Wang D, Shen Y. Numb deficiency causes impaired trafficking of mGlu5 in neurons and autistic-like behaviors. Neuroscience Letters 2019;707:134291. [DOI: 10.1016/j.neulet.2019.134291] [Cited by in Crossref: 2] [Cited by in F6Publishing: 2] [Article Influence: 0.7] [Reference Citation Analysis]
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5 Jhamandas JH, MacTavish D. Antagonist of the amylin receptor blocks beta-amyloid toxicity in rat cholinergic basal forebrain neurons. J Neurosci 2004;24:5579-84. [PMID: 15201330 DOI: 10.1523/JNEUROSCI.1051-04.2004] [Cited by in Crossref: 45] [Cited by in F6Publishing: 30] [Article Influence: 2.5] [Reference Citation Analysis]
6 Li H, Wang D, Shen Q, Schonemann MD, Gorski JA, Jones KR, Temple S, Jan LY, Jan YN. Inactivation of Numb and Numblike in Embryonic Dorsal Forebrain Impairs Neurogenesis and Disrupts Cortical Morphogenesis. Neuron 2003;40:1105-18. [DOI: 10.1016/s0896-6273(03)00755-4] [Cited by in Crossref: 141] [Cited by in F6Publishing: 77] [Article Influence: 7.4] [Reference Citation Analysis]
7 Abudoukelimu M, Fu ZY, Xiang Y, Ma YT, Zhu Q, Abudu M, Adi D, Yang YN, Li XM, Xie X, Liu F, Chen BD. Genetic variants of numb gene were associated with elevated total cholesterol level and low density lipoprotein cholesterol level in Chinese subjects, in Xinjiang, China. Diagn Pathol 2015;10:141. [PMID: 26264115 DOI: 10.1186/s13000-015-0373-2] [Cited by in Crossref: 3] [Article Influence: 0.4] [Reference Citation Analysis]
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9 Müller T, Schrötter A, Loosse C, Pfeiffer K, Theiss C, Kauth M, Meyer HE, Marcus K. A ternary complex consisting of AICD, FE65, and TIP60 down-regulates Stathmin1. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 2013;1834:387-94. [DOI: 10.1016/j.bbapap.2012.07.017] [Cited by in Crossref: 25] [Cited by in F6Publishing: 27] [Article Influence: 2.8] [Reference Citation Analysis]
10 Pece S, Confalonieri S, R Romano P, Di Fiore PP. NUMB-ing down cancer by more than just a NOTCH. Biochim Biophys Acta. 2011;1815:26-43. [PMID: 20940030 DOI: 10.1016/j.bbcan.2010.10.001] [Cited by in Crossref: 31] [Cited by in F6Publishing: 77] [Article Influence: 2.6] [Reference Citation Analysis]
11 Matsuda S, Giliberto L, Matsuda Y, McGowan EM, D'Adamio L. BRI2 inhibits amyloid beta-peptide precursor protein processing by interfering with the docking of secretases to the substrate. J Neurosci 2008;28:8668-76. [PMID: 18753367 DOI: 10.1523/JNEUROSCI.2094-08.2008] [Cited by in Crossref: 67] [Cited by in F6Publishing: 52] [Article Influence: 4.8] [Reference Citation Analysis]
12 Alberi L, Hoey SE, Brai E, Scotti AL, Marathe S. Notch signaling in the brain: in good and bad times. Ageing Res Rev 2013;12:801-14. [PMID: 23570941 DOI: 10.1016/j.arr.2013.03.004] [Cited by in Crossref: 54] [Cited by in F6Publishing: 50] [Article Influence: 6.0] [Reference Citation Analysis]
13 Matrone C. A new molecular explanation for age-related neurodegeneration: the Tyr682 residue of amyloid precursor protein. Bioessays 2013;35:847-52. [PMID: 23943322 DOI: 10.1002/bies.201300041] [Cited by in Crossref: 10] [Cited by in F6Publishing: 13] [Article Influence: 1.1] [Reference Citation Analysis]
14 Ma R, Kutchy NA, Chen L, Meigs DD, Hu G. Primary cilia and ciliary signaling pathways in aging and age-related brain disorders. Neurobiol Dis 2022;163:105607. [PMID: 34979259 DOI: 10.1016/j.nbd.2021.105607] [Reference Citation Analysis]
15 Kerr ML, Small DH. Cytoplasmic domain of the ?-amyloid protein precursor of Alzheimer's disease: Function, regulation of proteolysis, and implications for drug development. J Neurosci Res 2005;80:151-9. [DOI: 10.1002/jnr.20408] [Cited by in Crossref: 31] [Cited by in F6Publishing: 28] [Article Influence: 1.8] [Reference Citation Analysis]
16 Xie Z, Tanzi RE. Alzheimer's disease and post-operative cognitive dysfunction. Exp Gerontol 2006;41:346-59. [PMID: 16564662 DOI: 10.1016/j.exger.2006.01.014] [Cited by in Crossref: 91] [Cited by in F6Publishing: 84] [Article Influence: 5.7] [Reference Citation Analysis]
17 Ma QH, Bagnard D, Xiao ZC, Dawe GS. A TAG on to the neurogenic functions of APP. Cell Adh Migr 2008;2:2-8. [PMID: 19262125 DOI: 10.4161/cam.2.1.5790] [Cited by in Crossref: 11] [Cited by in F6Publishing: 11] [Article Influence: 0.8] [Reference Citation Analysis]
18 Xie Z, Dong Y, Maeda U, Xia W, Tanzi RE. RNAi-mediated knock-down of Dab and Numb attenuate Aβ levels via γ-secretase mediated APP processing. Transl Neurodegener 2012;1:8. [PMID: 23211096 DOI: 10.1186/2047-9158-1-8] [Cited by in Crossref: 12] [Cited by in F6Publishing: 8] [Article Influence: 1.2] [Reference Citation Analysis]
19 Lombino F, Biundo F, Tamayev R, Arancio O, D'Adamio L. An intracellular threonine of amyloid-β precursor protein mediates synaptic plasticity deficits and memory loss. PLoS One 2013;8:e57120. [PMID: 23451158 DOI: 10.1371/journal.pone.0057120] [Cited by in Crossref: 17] [Cited by in F6Publishing: 16] [Article Influence: 1.9] [Reference Citation Analysis]
20 Mazzola JL, Sirover MA. Subcellular analysis of aberrant protein structure in age-related neurodegenerative disorders. Journal of Neuroscience Methods 2004;137:241-6. [DOI: 10.1016/j.jneumeth.2004.02.029] [Cited by in Crossref: 6] [Cited by in F6Publishing: 3] [Article Influence: 0.3] [Reference Citation Analysis]
21 Wu F, Yao PJ. Clathrin-mediated endocytosis and Alzheimer's disease: an update. Ageing Res Rev 2009;8:147-9. [PMID: 19491039 DOI: 10.1016/j.arr.2009.03.002] [Cited by in Crossref: 47] [Cited by in F6Publishing: 44] [Article Influence: 3.6] [Reference Citation Analysis]
22 Jiang X, Xing H, Kim TM, Jung Y, Huang W, Yang HW, Song S, Park PJ, Carroll RS, Johnson MD. Numb regulates glioma stem cell fate and growth by altering epidermal growth factor receptor and Skp1-Cullin-F-box ubiquitin ligase activity. Stem Cells. 2012;30:1313-1326. [PMID: 22553175 DOI: 10.1002/stem.1120] [Cited by in Crossref: 41] [Cited by in F6Publishing: 36] [Article Influence: 4.1] [Reference Citation Analysis]
23 Marcotullio LD, Ferretti E, Greco A, De Smaele E, Po A, Sico MA, Alimandi M, Giannini G, Maroder M, Screpanti I, Gulino A. Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination. Nat Cell Biol 2006;8:1415-23. [DOI: 10.1038/ncb1510] [Cited by in Crossref: 197] [Cited by in F6Publishing: 197] [Article Influence: 12.3] [Reference Citation Analysis]
24 Russo C, Venezia V, Repetto E, Nizzari M, Violani E, Carlo P, Schettini G. The amyloid precursor protein and its network of interacting proteins: physiological and pathological implications. Brain Research Reviews 2005;48:257-64. [DOI: 10.1016/j.brainresrev.2004.12.016] [Cited by in Crossref: 51] [Cited by in F6Publishing: 48] [Article Influence: 3.0] [Reference Citation Analysis]
25 Müller T, Meyer HE, Egensperger R, Marcus K. The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease. Prog Neurobiol 2008;85:393-406. [PMID: 18603345 DOI: 10.1016/j.pneurobio.2008.05.002] [Cited by in Crossref: 135] [Cited by in F6Publishing: 147] [Article Influence: 9.6] [Reference Citation Analysis]
26 Di Stadio CS, Altieri F, Minopoli G, Miselli G, Rippa E, Arcari P. Role of human GKN1 on APP processing in gastric cancer. Biochimie. 2017;135:149-153. [PMID: 28214529 DOI: 10.1016/j.biochi.2017.02.007] [Cited by in Crossref: 5] [Cited by in F6Publishing: 4] [Article Influence: 1.0] [Reference Citation Analysis]
27 Kim MY, Mo JS, Ann EJ, Yoon JH, Jung J, Choi YH, Kim SM, Kim HY, Ahn JS, Kim H, Kim K, Hoe HS, Park HS. Regulation of Notch1 signaling by the APP intracellular domain facilitates degradation of the Notch1 intracellular domain and RBP-Jk. J Cell Sci 2011;124:1831-43. [PMID: 21558417 DOI: 10.1242/jcs.076117] [Cited by in Crossref: 17] [Cited by in F6Publishing: 18] [Article Influence: 1.5] [Reference Citation Analysis]
28 Kyriazis GA, Wei Z, Vandermey M, Jo DG, Xin O, Mattson MP, Chan SL. Numb endocytic adapter proteins regulate the transport and processing of the amyloid precursor protein in an isoform-dependent manner: implications for Alzheimer disease pathogenesis. J Biol Chem 2008;283:25492-502. [PMID: 18599481 DOI: 10.1074/jbc.M802072200] [Cited by in Crossref: 59] [Cited by in F6Publishing: 34] [Article Influence: 4.2] [Reference Citation Analysis]
29 Matsuda S, Matsuda Y, D'Adamio L. BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2. J Biol Chem 2009;284:15815-25. [PMID: 19366692 DOI: 10.1074/jbc.M109.006403] [Cited by in Crossref: 31] [Cited by in F6Publishing: 19] [Article Influence: 2.4] [Reference Citation Analysis]
30 Schmidt B. Aspartic proteases involved in Alzheimer's disease. Chembiochem 2003;4:366-78. [PMID: 12740808 DOI: 10.1002/cbic.200200532] [Cited by in Crossref: 26] [Cited by in F6Publishing: 24] [Article Influence: 1.4] [Reference Citation Analysis]
31 Schettini G, Govoni S, Racchi M, Rodriguez G. Phosphorylation of APP-CTF-AICD domains and interaction with adaptor proteins: signal transduction and/or transcriptional role--relevance for Alzheimer pathology. J Neurochem 2010;115:1299-308. [PMID: 21039524 DOI: 10.1111/j.1471-4159.2010.07044.x] [Cited by in Crossref: 48] [Cited by in F6Publishing: 50] [Article Influence: 4.0] [Reference Citation Analysis]
32 Noviello C, Vito P, Lopez P, Abdallah M, D'Adamio L. Autosomal recessive hypercholesterolemia protein interacts with and regulates the cell surface level of Alzheimer's amyloid beta precursor protein. J Biol Chem 2003;278:31843-7. [PMID: 12805363 DOI: 10.1074/jbc.M304133200] [Cited by in Crossref: 22] [Cited by in F6Publishing: 9] [Article Influence: 1.2] [Reference Citation Analysis]
33 Salmina AB, Malinovskaya NA, Morgun AV, Khilazheva ED, Uspenskaya YA, Illarioshkin SN. Reproducibility of developmental neuroplasticity in in vitro brain tissue models. Rev Neurosci 2022. [PMID: 34983132 DOI: 10.1515/revneuro-2021-0137] [Reference Citation Analysis]
34 Matsuda S, Matsuda Y, D'Adamio L. CD74 interacts with APP and suppresses the production of Abeta. Mol Neurodegener 2009;4:41. [PMID: 19849849 DOI: 10.1186/1750-1326-4-41] [Cited by in Crossref: 23] [Cited by in F6Publishing: 21] [Article Influence: 1.8] [Reference Citation Analysis]
35 Abudoukelimu M, Fu ZY, Maimaiti A, Ma YT, Abudu M, Zhu Q, Adi D, Yang YN, Li XM, Xie X, Liu F, Chen BD. The association of cholesterol absorption gene Numb polymorphism with Coronary Artery Disease among Han Chinese and Uighur Chinese in Xinjiang, China. Lipids Health Dis 2015;14:120. [PMID: 26415596 DOI: 10.1186/s12944-015-0102-6] [Cited by in Crossref: 6] [Cited by in F6Publishing: 6] [Article Influence: 0.9] [Reference Citation Analysis]
36 Hunter S, Martin S, Brayne C. The APP Proteolytic System and Its Interactions with Dynamic Networks in Alzheimer's Disease. Methods Mol Biol 2016;1303:71-99. [PMID: 26235060 DOI: 10.1007/978-1-4939-2627-5_3] [Cited by in Crossref: 5] [Cited by in F6Publishing: 5] [Article Influence: 0.8] [Reference Citation Analysis]
37 Rašin M, Gazula V, Breunig JJ, Kwan KY, Johnson MB, Liu-chen S, Li H, Jan LY, Jan Y, Rakic P, Šestan N. Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors. Nat Neurosci 2007;10:819-27. [DOI: 10.1038/nn1924] [Cited by in Crossref: 235] [Cited by in F6Publishing: 227] [Article Influence: 15.7] [Reference Citation Analysis]
38 Kohli BM, Pflieger D, Mueller LN, Carbonetti G, Aebersold R, Nitsch RM, Konietzko U. Interactome of the amyloid precursor protein APP in brain reveals a protein network involved in synaptic vesicle turnover and a close association with Synaptotagmin-1. J Proteome Res 2012;11:4075-90. [PMID: 22731840 DOI: 10.1021/pr300123g] [Cited by in Crossref: 52] [Cited by in F6Publishing: 50] [Article Influence: 5.2] [Reference Citation Analysis]
39 Li PS, Fu ZY, Zhang YY, Zhang JH, Xu CQ, Ma YT, Li BL, Song BL. The clathrin adaptor Numb regulates intestinal cholesterol absorption through dynamic interaction with NPC1L1. Nat Med 2014;20:80-6. [PMID: 24336247 DOI: 10.1038/nm.3417] [Cited by in Crossref: 54] [Cited by in F6Publishing: 46] [Article Influence: 6.0] [Reference Citation Analysis]
40 Del Prete D, Lombino F, Liu X, D'Adamio L. APP is cleaved by Bace1 in pre-synaptic vesicles and establishes a pre-synaptic interactome, via its intracellular domain, with molecular complexes that regulate pre-synaptic vesicles functions. PLoS One 2014;9:e108576. [PMID: 25247712 DOI: 10.1371/journal.pone.0108576] [Cited by in Crossref: 40] [Cited by in F6Publishing: 39] [Article Influence: 5.0] [Reference Citation Analysis]
41 Marks N, Berg MJ. Neurosecretases provide strategies to treat sporadic and familial Alzheimer disorders. Neurochemistry International 2008;52:184-215. [DOI: 10.1016/j.neuint.2007.06.020] [Cited by in Crossref: 20] [Cited by in F6Publishing: 21] [Article Influence: 1.4] [Reference Citation Analysis]
42 Sun J, Zhao F, Zhang W, Lv J, Lv J, Yin A. BMSCs and miR-124a ameliorated diabetic nephropathy via inhibiting notch signalling pathway. J Cell Mol Med 2018;22:4840-55. [PMID: 30024097 DOI: 10.1111/jcmm.13747] [Cited by in Crossref: 13] [Cited by in F6Publishing: 14] [Article Influence: 3.3] [Reference Citation Analysis]
43 Sun M, Asghar SZ, Zhang H. The polarity protein Par3 regulates APP trafficking and processing through the endocytic adaptor protein Numb. Neurobiol Dis 2016;93:1-11. [PMID: 27072891 DOI: 10.1016/j.nbd.2016.03.022] [Cited by in Crossref: 15] [Cited by in F6Publishing: 14] [Article Influence: 2.5] [Reference Citation Analysis]
44 Ntelios D, Berninger B, Tzimagiorgis G. Numb and Alzheimer's disease: the current picture. Front Neurosci 2012;6:145. [PMID: 23060745 DOI: 10.3389/fnins.2012.00145] [Cited by in Crossref: 6] [Cited by in F6Publishing: 5] [Article Influence: 0.6] [Reference Citation Analysis]
45 Esposito L, Gan L, Yu G, Essrich C, Mucke L. Intracellularly generated amyloid-β peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells: Proapoptotic role of cellular Aβ. Journal of Neurochemistry 2004;91:1260-74. [DOI: 10.1111/j.1471-4159.2004.02816.x] [Cited by in Crossref: 23] [Cited by in F6Publishing: 23] [Article Influence: 1.3] [Reference Citation Analysis]
46 Zhang R, Engler A, Taylor V. Notch: an interactive player in neurogenesis and disease. Cell Tissue Res 2018;371:73-89. [PMID: 28620760 DOI: 10.1007/s00441-017-2641-9] [Cited by in Crossref: 43] [Cited by in F6Publishing: 39] [Article Influence: 8.6] [Reference Citation Analysis]
47 Shariati SA, Lau P, Hassan BA, Müller U, Dotti CG, De Strooper B, Gärtner A. APLP2 regulates neuronal stem cell differentiation during cortical development. J Cell Sci 2013;126:1268-77. [PMID: 23345401 DOI: 10.1242/jcs.122440] [Cited by in Crossref: 28] [Cited by in F6Publishing: 30] [Article Influence: 3.1] [Reference Citation Analysis]
48 Shao X, Liu Y, Yu Q, Ding Z, Qian W, Zhang L, Zhang J, Jiang N, Gui L, Xu Z, Hong Y, Ma Y, Wei Y, Liu X, Jiang C, Zhu M, Li H, Li H. Numb regulates vesicular docking for homotypic fusion of early endosomes via membrane recruitment of Mon1b. Cell Res 2016;26:593-612. [PMID: 26987402 DOI: 10.1038/cr.2016.34] [Cited by in Crossref: 15] [Cited by in F6Publishing: 15] [Article Influence: 2.5] [Reference Citation Analysis]
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51 LaFerla FM. Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease. Nat Rev Neurosci 2002;3:862-72. [PMID: 12415294 DOI: 10.1038/nrn960] [Cited by in Crossref: 666] [Cited by in F6Publishing: 659] [Article Influence: 33.3] [Reference Citation Analysis]
52 Xie L, Varathan P, Nho K, Saykin AJ, Salama P, Yan J. Identification of functionally connected multi-omic biomarkers for Alzheimer's disease using modularity-constrained Lasso. PLoS One 2020;15:e0234748. [PMID: 32555747 DOI: 10.1371/journal.pone.0234748] [Cited by in Crossref: 3] [Cited by in F6Publishing: 1] [Article Influence: 1.5] [Reference Citation Analysis]
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55 Kuo CT, Mirzadeh Z, Soriano-Navarro M, Rasin M, Wang D, Shen J, Sestan N, Garcia-Verdugo J, Alvarez-Buylla A, Jan LY. Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche. Cell. 2006;127:1253-1264. [PMID: 17174898 DOI: 10.1016/j.cell.2006.10.041] [Cited by in Crossref: 139] [Cited by in F6Publishing: 176] [Article Influence: 9.3] [Reference Citation Analysis]
56 Fortini ME. Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling. Nat Rev Mol Cell Biol 2002;3:673-84. [PMID: 12209127 DOI: 10.1038/nrm910] [Cited by in Crossref: 539] [Cited by in F6Publishing: 365] [Article Influence: 27.0] [Reference Citation Analysis]
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58 Banote RK, Edling M, Eliassen F, Kettunen P, Zetterberg H, Abramsson A. β-Amyloid precursor protein-b is essential for Mauthner cell development in the zebrafish in a Notch-dependent manner. Dev Biol 2016;413:26-38. [PMID: 26994945 DOI: 10.1016/j.ydbio.2016.03.012] [Cited by in Crossref: 12] [Cited by in F6Publishing: 12] [Article Influence: 2.0] [Reference Citation Analysis]
59 Matsuda S, Matsuda Y, D'adamio L. Amyloid β Protein Precursor (AβPP), but Not AβPP-like Protein 2, Is Bridged to the Kinesin Light Chain by the Scaffold Protein JNK-interacting Protein 1. Journal of Biological Chemistry 2003;278:38601-6. [DOI: 10.1074/jbc.m304379200] [Cited by in Crossref: 74] [Cited by in F6Publishing: 43] [Article Influence: 3.9] [Reference Citation Analysis]
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62 Zhou D, Noviello C, D'Ambrosio C, Scaloni A, D'Adamio L. Growth factor receptor-bound protein 2 interaction with the tyrosine-phosphorylated tail of amyloid beta precursor protein is mediated by its Src homology 2 domain. J Biol Chem 2004;279:25374-80. [PMID: 15054097 DOI: 10.1074/jbc.M400488200] [Cited by in Crossref: 36] [Cited by in F6Publishing: 25] [Article Influence: 2.0] [Reference Citation Analysis]
63 Matrone C, Luvisetto S, La Rosa LR, Tamayev R, Pignataro A, Canu N, Yang L, Barbagallo AP, Biundo F, Lombino F, Zheng H, Ammassari-Teule M, D'Adamio L. Tyr682 in the Aβ-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance. Aging Cell 2012;11:1084-93. [PMID: 23020178 DOI: 10.1111/acel.12009] [Cited by in Crossref: 25] [Cited by in F6Publishing: 26] [Article Influence: 2.5] [Reference Citation Analysis]
64 Schmid RS, McGrath B, Berechid BE, Boyles B, Marchionni M, Sestan N, Anton ES. Neuregulin 1-erbB2 signaling is required for the establishment of radial glia and their transformation into astrocytes in cerebral cortex. Proc Natl Acad Sci U S A 2003;100:4251-6. [PMID: 12649319 DOI: 10.1073/pnas.0630496100] [Cited by in Crossref: 148] [Cited by in F6Publishing: 147] [Article Influence: 7.8] [Reference Citation Analysis]
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