BPG is committed to discovery and dissemination of knowledge
Cited by in F6Publishing
For: Chaussade C, Rewcastle GW, Kendall JD, Denny WA, Cho K, Grønning LM, Chong ML, Anagnostou SH, Jackson SP, Daniele N. Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling. Biochem J. 2007;404:449-458. [PMID: 17362206 DOI: 10.1042/bj20070003] [Cited by in Crossref: 149] [Cited by in F6Publishing: 72] [Article Influence: 9.9] [Reference Citation Analysis]
Number Citing Articles
1 Jia S, Roberts TM, Zhao JJ. Should individual PI3 kinase isoforms be targeted in cancer? Curr Opin Cell Biol 2009;21:199-208. [PMID: 19200708 DOI: 10.1016/j.ceb.2008.12.007] [Cited by in Crossref: 77] [Cited by in F6Publishing: 71] [Article Influence: 5.9] [Reference Citation Analysis]
2 Guillermet-Guibert J, Bjorklof K, Salpekar A, Gonella C, Ramadani F, Bilancio A, Meek S, Smith AJ, Okkenhaug K, Vanhaesebroeck B. The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma. Proc Natl Acad Sci USA. 2008;105:8292-8297. [PMID: 18544649 DOI: 10.1073/pnas.0707761105] [Cited by in Crossref: 262] [Cited by in F6Publishing: 257] [Article Influence: 18.7] [Reference Citation Analysis]
3 Kingham E, Welham M. Distinct roles for isoforms of the catalytic subunit of class-IA PI3K in the regulation of behaviour of murine embryonic stem cells. J Cell Sci 2009;122:2311-21. [PMID: 19509054 DOI: 10.1242/jcs.046557] [Cited by in Crossref: 24] [Cited by in F6Publishing: 22] [Article Influence: 1.8] [Reference Citation Analysis]
4 Sparks JD, O'Dell C, Chamberlain JM, Sparks CE. Insulin-dependent apolipoprotein B degradation is mediated by autophagy and involves class I and class III phosphatidylinositide 3-kinases. Biochem Biophys Res Commun 2013;435:616-20. [PMID: 23685141 DOI: 10.1016/j.bbrc.2013.05.029] [Cited by in Crossref: 16] [Cited by in F6Publishing: 14] [Article Influence: 1.8] [Reference Citation Analysis]
5 Gilio K, Munnix IC, Mangin P, Cosemans JM, Feijge MA, van der Meijden PE, Olieslagers S, Chrzanowska-Wodnicka MB, Lillian R, Schoenwaelder S, Koyasu S, Sage SO, Jackson SP, Heemskerk JW. Non-redundant roles of phosphoinositide 3-kinase isoforms alpha and beta in glycoprotein VI-induced platelet signaling and thrombus formation. J Biol Chem 2009;284:33750-62. [PMID: 19815551 DOI: 10.1074/jbc.M109.048439] [Cited by in Crossref: 84] [Cited by in F6Publishing: 25] [Article Influence: 6.5] [Reference Citation Analysis]
6 Ukhanov K, Corey EA, Brunert D, Klasen K, Ache BW. Inhibitory odorant signaling in Mammalian olfactory receptor neurons. J Neurophysiol 2010;103:1114-22. [PMID: 20032232 DOI: 10.1152/jn.00980.2009] [Cited by in Crossref: 34] [Cited by in F6Publishing: 27] [Article Influence: 2.6] [Reference Citation Analysis]
7 Tang T, Zhu Q, Li X, Zhu G, Deng S, Wang Y, Ni L, Chen X, Zhang Y, Xia T, Zen K, Pan Y, Jin L. Protease Nexin I is a feedback regulator of EGF/PKC/MAPK/EGR1 signaling in breast cancer cells metastasis and stemness. Cell Death Dis 2019;10:649. [PMID: 31501409 DOI: 10.1038/s41419-019-1882-9] [Cited by in Crossref: 8] [Cited by in F6Publishing: 10] [Article Influence: 2.7] [Reference Citation Analysis]
8 Hsu WJ, Wildburger NC, Haidacher SJ, Nenov MN, Folorunso O, Singh AK, Chesson BC, Franklin WF, Cortez I, Sadygov RG, Dineley KT, Rudra JS, Taglialatela G, Lichti CF, Denner L, Laezza F. PPARgamma agonists rescue increased phosphorylation of FGF14 at S226 in the Tg2576 mouse model of Alzheimer's disease. Exp Neurol 2017;295:1-17. [PMID: 28522250 DOI: 10.1016/j.expneurol.2017.05.005] [Cited by in Crossref: 25] [Cited by in F6Publishing: 26] [Article Influence: 5.0] [Reference Citation Analysis]
9 Li Y, Chen X, Tang X, Zhang C, Wang L, Chen P, Pan M, Lu C. DNA synthesis during endomitosis is stimulated by insulin via the PI3K/Akt and TOR signaling pathways in the silk gland cells of Bombyx mori. Int J Mol Sci 2015;16:6266-80. [PMID: 25794286 DOI: 10.3390/ijms16036266] [Cited by in Crossref: 6] [Cited by in F6Publishing: 6] [Article Influence: 0.9] [Reference Citation Analysis]
10 Lam JB, Chow KH, Xu A, Lam KS, Liu J, Wong NS, Moon RT, Shepherd PR, Cooper GJ, Wang Y. Adiponectin haploinsufficiency promotes mammary tumor development in MMTV-PyVT mice by modulation of phosphatase and tensin homolog activities. PLoS One 2009;4:e4968. [PMID: 19319191 DOI: 10.1371/journal.pone.0004968] [Cited by in Crossref: 56] [Cited by in F6Publishing: 58] [Article Influence: 4.3] [Reference Citation Analysis]
11 Madishetti S, Schneble N, König C, Hirsch E, Schulz S, Müller JP, Wetzker R. PI3Kγ integrates cAMP and Akt signalling of the μ-opioid receptor. Br J Pharmacol 2014;171:3328-37. [PMID: 24654606 DOI: 10.1111/bph.12698] [Cited by in Crossref: 13] [Cited by in F6Publishing: 12] [Article Influence: 1.9] [Reference Citation Analysis]
12 Bilanges B, Alliouachene S, Pearce W, Morelli D, Szabadkai G, Chung YL, Chicanne G, Valet C, Hill JM, Voshol PJ, Collinson L, Peddie C, Ali K, Ghazaly E, Rajeeve V, Trichas G, Srinivas S, Chaussade C, Salamon RS, Backer JM, Scudamore CL, Whitehead MA, Keaney EP, Murphy LO, Semple RK, Payrastre B, Tooze SA, Vanhaesebroeck B. Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism. Nat Commun. 2017;8:1804. [PMID: 29180704 DOI: 10.1038/s41467-017-01969-4] [Cited by in Crossref: 34] [Cited by in F6Publishing: 32] [Article Influence: 6.8] [Reference Citation Analysis]
13 Juvin V, Malek M, Anderson KE, Dion C, Chessa T, Lecureuil C, Ferguson GJ, Cosulich S, Hawkins PT, Stephens LR. Signaling via class IA Phosphoinositide 3-kinases (PI3K) in human, breast-derived cell lines. PLoS One 2013;8:e75045. [PMID: 24124465 DOI: 10.1371/journal.pone.0075045] [Cited by in Crossref: 11] [Cited by in F6Publishing: 8] [Article Influence: 1.2] [Reference Citation Analysis]
14 Hansen M, Peltier J, Killy B, Amin B, Bodendorfer B, Härtlova A, Uebel S, Bosmann M, Hofmann J, Büttner C, Ekici AB, Kuttke M, Franzyk H, Foged C, Beer-Hammer S, Schabbauer G, Trost M, Lang R. Macrophage Phosphoproteome Analysis Reveals MINCLE-dependent and -independent Mycobacterial Cord Factor Signaling. Mol Cell Proteomics 2019;18:669-85. [PMID: 30635358 DOI: 10.1074/mcp.RA118.000929] [Cited by in Crossref: 11] [Cited by in F6Publishing: 6] [Article Influence: 3.7] [Reference Citation Analysis]
15 Höland K, Boller D, Hagel C, Dolski S, Treszl A, Pardo OE, Cwiek P, Salm F, Leni Z, Shepherd PR, Styp-Rekowska B, Djonov V, von Bueren AO, Frei K, Arcaro A. Targeting class IA PI3K isoforms selectively impairs cell growth, survival, and migration in glioblastoma. PLoS One 2014;9:e94132. [PMID: 24718026 DOI: 10.1371/journal.pone.0094132] [Cited by in Crossref: 28] [Cited by in F6Publishing: 26] [Article Influence: 3.5] [Reference Citation Analysis]
16 Abramson HN. Kinase inhibitors as potential agents in the treatment of multiple myeloma. Oncotarget 2016;7:81926-68. [PMID: 27655636 DOI: 10.18632/oncotarget.10745] [Cited by in Crossref: 9] [Cited by in F6Publishing: 12] [Article Influence: 2.3] [Reference Citation Analysis]
17 Zhu L, Wu G, Yang X, Jia X, Li J, Bai X, Li W, Zhao Y, Li Y, Cheng W, Liu S, Jin S. Low density lipoprotein mimics insulin action on autophagy and glucose uptake in endothelial cells. Sci Rep 2019;9:3020. [PMID: 30816192 DOI: 10.1038/s41598-019-39559-7] [Cited by in Crossref: 5] [Cited by in F6Publishing: 5] [Article Influence: 1.7] [Reference Citation Analysis]
18 Zhang Y, Hoppe AD, Swanson JA. Coordination of Fc receptor signaling regulates cellular commitment to phagocytosis. Proc Natl Acad Sci U S A 2010;107:19332-7. [PMID: 20974965 DOI: 10.1073/pnas.1008248107] [Cited by in Crossref: 60] [Cited by in F6Publishing: 54] [Article Influence: 5.0] [Reference Citation Analysis]
19 Netland IA, Førde HE, Sleire L, Leiss L, Rahman MA, Skeie BS, Gjerde CH, Enger PØ, Goplen D. Dactolisib (NVP-BEZ235) toxicity in murine brain tumour models. BMC Cancer 2016;16:657. [PMID: 27542970 DOI: 10.1186/s12885-016-2712-4] [Cited by in Crossref: 12] [Cited by in F6Publishing: 10] [Article Influence: 2.0] [Reference Citation Analysis]
20 Beltran L, Chaussade C, Vanhaesebroeck B, Cutillas PR. Calpain interacts with class IA phosphoinositide 3-kinases regulating their stability and signaling activity. Proc Natl Acad Sci U S A 2011;108:16217-22. [PMID: 21930956 DOI: 10.1073/pnas.1107692108] [Cited by in Crossref: 27] [Cited by in F6Publishing: 17] [Article Influence: 2.5] [Reference Citation Analysis]
21 Zhao Y, Biswas SK, McNulty PH, Kozak M, Jun JY, Segar L. PDGF-induced vascular smooth muscle cell proliferation is associated with dysregulation of insulin receptor substrates. Am J Physiol Cell Physiol 2011;300:C1375-85. [PMID: 21325637 DOI: 10.1152/ajpcell.00670.2008] [Cited by in Crossref: 27] [Cited by in F6Publishing: 28] [Article Influence: 2.5] [Reference Citation Analysis]
22 Smith GC, Ong WK, Rewcastle GW, Kendall JD, Han W, Shepherd PR. Effects of acutely inhibiting PI3K isoforms and mTOR on regulation of glucose metabolism in vivo. Biochem J 2012;442:161-9. [PMID: 22142257 DOI: 10.1042/BJ20111913] [Cited by in Crossref: 41] [Cited by in F6Publishing: 16] [Article Influence: 4.1] [Reference Citation Analysis]
23 Wang J, Gong GQ, Zhou Y, Lee WJ, Buchanan CM, Denny WA, Rewcastle GW, Kendall JD, Dickson JMJ, Flanagan JU, Shepherd PR, Yang DH, Wang MW. High-throughput screening campaigns against a PI3Kα isoform bearing the H1047R mutation identified potential inhibitors with novel scaffolds. Acta Pharmacol Sin 2018;39:1816-22. [PMID: 29991713 DOI: 10.1038/s41401-018-0057-z] [Cited by in Crossref: 6] [Cited by in F6Publishing: 6] [Article Influence: 1.5] [Reference Citation Analysis]
24 Ivison SM, Khan MA, Graham NR, Shobab LA, Yao Y, Kifayet A, Sly LM, Steiner TS. The p110α and p110β isoforms of class I phosphatidylinositol 3-kinase are involved in toll-like receptor 5 signaling in epithelial cells. Mediators Inflamm 2010;2010:652098. [PMID: 20953381 DOI: 10.1155/2010/652098] [Cited by in Crossref: 4] [Cited by in F6Publishing: 4] [Article Influence: 0.3] [Reference Citation Analysis]
25 Bonet IJM, Khomula EV, Araldi D, Green PG, Levine JD. PI3Kγ/AKT Signaling in High Molecular Weight Hyaluronan (HMWH)-Induced Anti-Hyperalgesia and Reversal of Nociceptor Sensitization. J Neurosci 2021;41:8414-26. [PMID: 34417329 DOI: 10.1523/JNEUROSCI.1189-21.2021] [Reference Citation Analysis]
26 Conte E, Fruciano M, Fagone E, Gili E, Caraci F, Iemmolo M, Crimi N, Vancheri C. Inhibition of PI3K prevents the proliferation and differentiation of human lung fibroblasts into myofibroblasts: the role of class I P110 isoforms. PLoS One. 2011;6:e24663. [PMID: 21984893 DOI: 10.1371/journal.pone.0024663] [Cited by in Crossref: 79] [Cited by in F6Publishing: 72] [Article Influence: 7.2] [Reference Citation Analysis]
27 Smirnova T, Zhou ZN, Flinn RJ, Wyckoff J, Boimel PJ, Pozzuto M, Coniglio SJ, Backer JM, Bresnick AR, Condeelis JS, Hynes NE, Segall JE. Phosphoinositide 3-kinase signaling is critical for ErbB3-driven breast cancer cell motility and metastasis. Oncogene 2012;31:706-15. [PMID: 21725367 DOI: 10.1038/onc.2011.275] [Cited by in Crossref: 39] [Cited by in F6Publishing: 42] [Article Influence: 3.5] [Reference Citation Analysis]
28 Senapedis WT, Kennedy CJ, Boyle PM, Silver PA. Whole genome siRNA cell-based screen links mitochondria to Akt signaling network through uncoupling of electron transport chain. Mol Biol Cell 2011;22:1791-805. [PMID: 21460183 DOI: 10.1091/mbc.E10-10-0854] [Cited by in Crossref: 26] [Cited by in F6Publishing: 19] [Article Influence: 2.4] [Reference Citation Analysis]
29 Clement E, Inuzuka H, Nihira NT, Wei W, Toker A. Skp2-dependent reactivation of AKT drives resistance to PI3K inhibitors. Sci Signal 2018;11:eaao3810. [PMID: 29535262 DOI: 10.1126/scisignal.aao3810] [Cited by in Crossref: 20] [Cited by in F6Publishing: 22] [Article Influence: 5.0] [Reference Citation Analysis]
30 Ihle NT, Lemos R, Schwartz D, Oh J, Halter RJ, Wipf P, Kirkpatrick L, Powis G. Peroxisome proliferator-activated receptor gamma agonist pioglitazone prevents the hyperglycemia caused by phosphatidylinositol 3-kinase pathway inhibition by PX-866 without affecting antitumor activity. Mol Cancer Ther 2009;8:94-100. [PMID: 19139117 DOI: 10.1158/1535-7163.MCT-08-0714] [Cited by in Crossref: 20] [Cited by in F6Publishing: 8] [Article Influence: 1.5] [Reference Citation Analysis]
31 Gunn RM, Hailes HC. Insights into the PI3-K-PKB-mTOR signalling pathway from small molecules. J Chem Biol 2008;1:49-62. [PMID: 19568798 DOI: 10.1007/s12154-008-0008-0] [Cited by in Crossref: 17] [Cited by in F6Publishing: 14] [Article Influence: 1.2] [Reference Citation Analysis]
32 Ciraolo E, Iezzi M, Marone R, Marengo S, Curcio C, Costa C, Azzolino O, Gonella C, Rubinetto C, Wu H. Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development. Sci Signal. 2008;1:ra3. [PMID: 18780892 DOI: 10.1126/scisignal.1161577] [Cited by in Crossref: 178] [Cited by in F6Publishing: 186] [Article Influence: 12.7] [Reference Citation Analysis]
33 Teng Y, Fan Y, Ma J, Lu W, Liu N, Chen Y, Pan W, Tao X. The PI3K/Akt Pathway: Emerging Roles in Skin Homeostasis and a Group of Non-Malignant Skin Disorders. Cells 2021;10:1219. [PMID: 34067630 DOI: 10.3390/cells10051219] [Reference Citation Analysis]
34 John DA, Williams LK, Kanamarlapudi V, Humphrey TJ, Wilkinson TS. The Bacterial Species Campylobacter jejuni Induce Diverse Innate Immune Responses in Human and Avian Intestinal Epithelial Cells. Front Microbiol 2017;8:1840. [PMID: 29033908 DOI: 10.3389/fmicb.2017.01840] [Cited by in Crossref: 10] [Cited by in F6Publishing: 10] [Article Influence: 2.0] [Reference Citation Analysis]
35 Huang WS, Wang TB, He Y, Chen YJ, Zhong SL, Tan M. Phosphoinositide-3-kinase, catalytic, alpha polypeptide RNA interference inhibits growth of colon cancer cell SW948. World J Gastroenterol 2012; 18(26): 3458-3464 [PMID: 22807617 DOI: 10.3748/wjg.v18.i26.3458] [Cited by in CrossRef: 2] [Cited by in F6Publishing: 3] [Article Influence: 0.2] [Reference Citation Analysis]
36 Whitehead MA, Bombardieri M, Pitzalis C, Vanhaesebroeck B. Isoform-selective induction of human p110δ PI3K expression by TNFα: identification of a new and inducible PIK3CD promoter. Biochem J 2012;443:857-67. [PMID: 22375552 DOI: 10.1042/BJ20112214] [Cited by in Crossref: 31] [Cited by in F6Publishing: 21] [Article Influence: 3.1] [Reference Citation Analysis]
37 Kolic J, Manning Fox JE, Chepurny OG, Spigelman AF, Ferdaoussi M, Schwede F, Holz GG, MacDonald PE. PI3 kinases p110α and PI3K-C2β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets. Mol Metab 2016;5:459-71. [PMID: 27408772 DOI: 10.1016/j.molmet.2016.05.003] [Cited by in Crossref: 7] [Cited by in F6Publishing: 5] [Article Influence: 1.2] [Reference Citation Analysis]
38 So L, Yea SS, Oak JS, Lu M, Manmadhan A, Ke QH, Janes MR, Kessler LV, Kucharski JM, Li LS, Martin MB, Ren P, Jessen KA, Liu Y, Rommel C, Fruman DA. Selective inhibition of phosphoinositide 3-kinase p110α preserves lymphocyte function. J Biol Chem 2013;288:5718-31. [PMID: 23275335 DOI: 10.1074/jbc.M112.379446] [Cited by in Crossref: 50] [Cited by in F6Publishing: 26] [Article Influence: 5.0] [Reference Citation Analysis]
39 Zhao HY, Zhang YY, Xing T, Tang SQ, Wen Q, Lyu ZS, Lv M, Wang Y, Xu LP, Zhang XH, Kong Y, Huang XJ. M2 macrophages, but not M1 macrophages, support megakaryopoiesis by upregulating PI3K-AKT pathway activity. Signal Transduct Target Ther 2021;6:234. [PMID: 34140465 DOI: 10.1038/s41392-021-00627-y] [Reference Citation Analysis]
40 Yamaguchi H, Yoshida S, Muroi E, Yoshida N, Kawamura M, Kouchi Z, Nakamura Y, Sakai R, Fukami K. Phosphoinositide 3-kinase signaling pathway mediated by p110α regulates invadopodia formation. J Cell Biol 2011;193:1275-88. [PMID: 21708979 DOI: 10.1083/jcb.201009126] [Cited by in F6Publishing: 84] [Reference Citation Analysis]
41 Beemiller P, Zhang Y, Mohan S, Levinsohn E, Gaeta I, Hoppe AD, Swanson JA. A Cdc42 activation cycle coordinated by PI 3-kinase during Fc receptor-mediated phagocytosis. Mol Biol Cell 2010;21:470-80. [PMID: 19955216 DOI: 10.1091/mbc.e08-05-0494] [Cited by in Crossref: 69] [Cited by in F6Publishing: 49] [Article Influence: 5.3] [Reference Citation Analysis]
42 Wojtalla A, Salm F, Christiansen DG, Cremona T, Cwiek P, Shalaby T, Gross N, Grotzer MA, Arcaro A. Novel agents targeting the IGF-1R/PI3K pathway impair cell proliferation and survival in subsets of medulloblastoma and neuroblastoma. PLoS One 2012;7:e47109. [PMID: 23056595 DOI: 10.1371/journal.pone.0047109] [Cited by in Crossref: 13] [Cited by in F6Publishing: 17] [Article Influence: 1.3] [Reference Citation Analysis]
43 Tato I, Bartrons R, Ventura F, Rosa JL. Amino acids activate mammalian target of rapamycin complex 2 (mTORC2) via PI3K/Akt signaling. J Biol Chem 2011;286:6128-42. [PMID: 21131356 DOI: 10.1074/jbc.M110.166991] [Cited by in Crossref: 118] [Cited by in F6Publishing: 75] [Article Influence: 9.8] [Reference Citation Analysis]
44 Thorpe LM, Yuzugullu H, Zhao JJ. PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting. Nat Rev Cancer. 2015;15:7-24. [PMID: 25533673 DOI: 10.1038/nrc3860] [Cited by in Crossref: 709] [Cited by in F6Publishing: 657] [Article Influence: 101.3] [Reference Citation Analysis]
45 Sweetlove M, Wrightson E, Kolekar S, Rewcastle GW, Baguley BC, Shepherd PR, Jamieson SM. Inhibitors of pan-PI3K Signaling Synergize with BRAF or MEK Inhibitors to Prevent BRAF-Mutant Melanoma Cell Growth. Front Oncol 2015;5:135. [PMID: 26137449 DOI: 10.3389/fonc.2015.00135] [Cited by in Crossref: 35] [Cited by in F6Publishing: 39] [Article Influence: 5.0] [Reference Citation Analysis]
46 Whiteford JR, Xian X, Chaussade C, Vanhaesebroeck B, Nourshargh S, Couchman JR. Syndecan-2 is a novel ligand for the protein tyrosine phosphatase receptor CD148. Mol Biol Cell 2011;22:3609-24. [PMID: 21813734 DOI: 10.1091/mbc.E11-02-0099] [Cited by in Crossref: 61] [Cited by in F6Publishing: 43] [Article Influence: 5.5] [Reference Citation Analysis]
47 Blanco B, Herrero-Sánchez MC, Rodríguez-Serrano C, Sánchez-Barba M, Del Cañizo MC. Profound blockade of T cell activation requires concomitant inhibition of different class I PI3K isoforms. Immunol Res 2015;62:175-88. [PMID: 25869396 DOI: 10.1007/s12026-015-8648-y] [Cited by in Crossref: 11] [Cited by in F6Publishing: 9] [Article Influence: 1.8] [Reference Citation Analysis]
48 Shi J, Ju M, Large WA, Albert AP. Pharmacological profile of phosphatidylinositol 3-kinases and related phosphatidylinositols mediating endothelin(A) receptor-operated native TRPC channels in rabbit coronary artery myocytes. Br J Pharmacol 2012;166:2161-75. [PMID: 22404177 DOI: 10.1111/j.1476-5381.2012.01937.x] [Cited by in Crossref: 13] [Cited by in F6Publishing: 13] [Article Influence: 1.3] [Reference Citation Analysis]
49 Chen T, Ni N, Yuan L, Xu L, Bahri N, Sun B, Wu Y, Ou WB. Proteasome Inhibition Suppresses KIT-Independent Gastrointestinal Stromal Tumors Via Targeting Hippo/YAP/Cyclin D1 Signaling. Front Pharmacol 2021;12:686874. [PMID: 34025442 DOI: 10.3389/fphar.2021.686874] [Reference Citation Analysis]
50 Yea SS, So L, Mallya S, Lee J, Rajasekaran K, Malarkannan S, Fruman DA. Effects of novel isoform-selective phosphoinositide 3-kinase inhibitors on natural killer cell function. PLoS One 2014;9:e99486. [PMID: 24915189 DOI: 10.1371/journal.pone.0099486] [Cited by in Crossref: 10] [Cited by in F6Publishing: 9] [Article Influence: 1.3] [Reference Citation Analysis]
51 Matheny RW Jr, Riddle-Kottke MA, Leandry LA, Lynch CM, Abdalla MN, Geddis AV, Piper DR, Zhao JJ. Role of phosphoinositide 3-OH kinase p110β in skeletal myogenesis. Mol Cell Biol 2015;35:1182-96. [PMID: 25605332 DOI: 10.1128/MCB.00550-14] [Cited by in Crossref: 14] [Cited by in F6Publishing: 11] [Article Influence: 2.0] [Reference Citation Analysis]
52 Alliouachene S, Bilanges B, Chaussade C, Pearce W, Foukas LC, Scudamore CL, Moniz LS, Vanhaesebroeck B. Inactivation of class II PI3K-C2α induces leptin resistance, age-dependent insulin resistance and obesity in male mice. Diabetologia 2016;59:1503-12. [PMID: 27138914 DOI: 10.1007/s00125-016-3963-y] [Cited by in Crossref: 13] [Cited by in F6Publishing: 14] [Article Influence: 2.2] [Reference Citation Analysis]
53 Jamieson S, Flanagan JU, Kolekar S, Buchanan C, Kendall JD, Lee WJ, Rewcastle GW, Denny WA, Singh R, Dickson J. A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types. Biochem J. 2011;438:53-62. [PMID: 21668414 DOI: 10.1042/BJ20110502] [Cited by in Crossref: 120] [Cited by in F6Publishing: 70] [Article Influence: 10.9] [Reference Citation Analysis]
54 Du L, Roberts JD Jr. Transforming growth factor-β downregulates sGC subunit expression in pulmonary artery smooth muscle cells via MEK and ERK signaling. Am J Physiol Lung Cell Mol Physiol 2019;316:L20-34. [PMID: 30260287 DOI: 10.1152/ajplung.00319.2018] [Cited by in Crossref: 6] [Cited by in F6Publishing: 6] [Article Influence: 1.5] [Reference Citation Analysis]
55 Gritsman K, Yuzugullu H, Von T, Yan H, Clayton L, Fritsch C, Maira SM, Hollingworth G, Choi C, Khandan T, Paktinat M, Okabe RO, Roberts TM, Zhao JJ. Hematopoiesis and RAS-driven myeloid leukemia differentially require PI3K isoform p110α. J Clin Invest 2014;124:1794-809. [PMID: 24569456 DOI: 10.1172/JCI69927] [Cited by in Crossref: 40] [Cited by in F6Publishing: 28] [Article Influence: 5.0] [Reference Citation Analysis]
56 Gonzalez M, Sealls W, Jesch ED, Brosnan MJ, Ladunga I, Ding X, Black PN, DiRusso CC. Defining a relationship between dietary fatty acids and the cytochrome P450 system in a mouse model of fatty liver disease. Physiol Genomics 2011;43:121-35. [PMID: 21098682 DOI: 10.1152/physiolgenomics.00209.2010] [Cited by in Crossref: 13] [Cited by in F6Publishing: 13] [Article Influence: 1.1] [Reference Citation Analysis]
57 Chen EW, Brzostek J, Gascoigne NRJ, Rybakin V. Development of a screening strategy for new modulators of T cell receptor signaling and T cell activation. Sci Rep 2018;8:10046. [PMID: 29968737 DOI: 10.1038/s41598-018-28106-5] [Cited by in Crossref: 6] [Cited by in F6Publishing: 4] [Article Influence: 1.5] [Reference Citation Analysis]
58 Al-Qassab H, Smith MA, Irvine EE, Guillermet-Guibert J, Claret M, Choudhury AI, Selman C, Piipari K, Clements M, Lingard S, Chandarana K, Bell JD, Barsh GS, Smith AJ, Batterham RL, Ashford ML, Vanhaesebroeck B, Withers DJ. Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons. Cell Metab 2009;10:343-54. [PMID: 19883613 DOI: 10.1016/j.cmet.2009.09.008] [Cited by in Crossref: 125] [Cited by in F6Publishing: 125] [Article Influence: 10.4] [Reference Citation Analysis]
59 Campa CC, Silva RL, Margaria JP, Pirali T, Mattos MS, Kraemer LR, Reis DC, Grosa G, Copperi F, Dalmarco EM, Lima-Júnior RCP, Aprile S, Sala V, Dal Bello F, Prado DS, Alves-Filho JC, Medana C, Cassali GD, Tron GC, Teixeira MM, Ciraolo E, Russo RC, Hirsch E. Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis. Nat Commun 2018;9:5232. [PMID: 30542075 DOI: 10.1038/s41467-018-07698-6] [Cited by in Crossref: 32] [Cited by in F6Publishing: 32] [Article Influence: 8.0] [Reference Citation Analysis]
60 Huang Y, He Z, Gao Y, Lieu L, Yao T, Sun J, Liu T, Javadi C, Box M, Afrin S, Guo H, Williams KW. Phosphoinositide 3-Kinase Is Integral for the Acute Activity of Leptin and Insulin in Male Arcuate NPY/AgRP Neurons. J Endocr Soc 2018;2:518-32. [PMID: 29850651 DOI: 10.1210/js.2018-00061] [Cited by in Crossref: 17] [Cited by in F6Publishing: 15] [Article Influence: 4.3] [Reference Citation Analysis]
61 Chu KM, Minogue S, Hsuan JJ, Waugh MG. Differential effects of the phosphatidylinositol 4-kinases, PI4KIIα and PI4KIIIβ, on Akt activation and apoptosis. Cell Death Dis 2010;1:e106. [PMID: 21218173 DOI: 10.1038/cddis.2010.84] [Cited by in Crossref: 49] [Cited by in F6Publishing: 48] [Article Influence: 4.5] [Reference Citation Analysis]
62 Matheny RW Jr, Adamo ML. PI3K p110 alpha and p110 beta have differential effects on Akt activation and protection against oxidative stress-induced apoptosis in myoblasts. Cell Death Differ 2010;17:677-88. [PMID: 19834495 DOI: 10.1038/cdd.2009.150] [Cited by in Crossref: 41] [Cited by in F6Publishing: 34] [Article Influence: 3.2] [Reference Citation Analysis]
63 Tran KB, Kolekar S, Jabed A, Jaynes P, Shih JH, Wang Q, Flanagan JU, Rewcastle GW, Baguley BC, Shepherd PR. Diverse mechanisms activate the PI 3-kinase/mTOR pathway in melanomas: implications for the use of PI 3-kinase inhibitors to overcome resistance to inhibitors of BRAF and MEK. BMC Cancer 2021;21:136. [PMID: 33549048 DOI: 10.1186/s12885-021-07826-4] [Cited by in F6Publishing: 2] [Reference Citation Analysis]
64 Ziegler R, Häusermann F, Kirchner S, Polonchuk L. Cardiac Safety of Kinase Inhibitors - Improving Understanding and Prediction of Liabilities in Drug Discovery Using Human Stem Cell-Derived Models. Front Cardiovasc Med 2021;8:639824. [PMID: 34222360 DOI: 10.3389/fcvm.2021.639824] [Reference Citation Analysis]
65 McNulty S, Bornmann W, Schriewer J, Werner C, Smith SK, Olson VA, Damon IK, Buller RM, Heuser J, Kalman D. Multiple phosphatidylinositol 3-kinases regulate vaccinia virus morphogenesis. PLoS One 2010;5:e10884. [PMID: 20526370 DOI: 10.1371/journal.pone.0010884] [Cited by in Crossref: 11] [Cited by in F6Publishing: 10] [Article Influence: 0.9] [Reference Citation Analysis]
66 Waardenberg AJ, Bernardo BC, Ng DCH, Shepherd PR, Cemerlang N, Sbroggiò M, Wells CA, Dalrymple BP, Brancaccio M, Lin RCY, McMullen JR. Phosphoinositide 3-kinase (PI3K(p110alpha)) directly regulates key components of the Z-disc and cardiac structure. J Biol Chem 2011;286:30837-46. [PMID: 21757757 DOI: 10.1074/jbc.M111.271684] [Cited by in Crossref: 27] [Cited by in F6Publishing: 14] [Article Influence: 2.5] [Reference Citation Analysis]
67 Ihle NT, Powis G. Take your PIK: phosphatidylinositol 3-kinase inhibitors race through the clinic and toward cancer therapy. Mol Cancer Ther 2009;8:1-9. [PMID: 19139107 DOI: 10.1158/1535-7163.MCT-08-0801] [Cited by in Crossref: 130] [Cited by in F6Publishing: 43] [Article Influence: 10.0] [Reference Citation Analysis]
68 Ihle NT, Powis G. Inhibitors of phosphatidylinositol-3-kinase in cancer therapy. Mol Aspects Med 2010;31:135-44. [PMID: 20176047 DOI: 10.1016/j.mam.2010.02.003] [Cited by in Crossref: 30] [Cited by in F6Publishing: 30] [Article Influence: 2.5] [Reference Citation Analysis]
69 Renshaw J, Taylor KR, Bishop R, Valenti M, De Haven Brandon A, Gowan S, Eccles SA, Ruddle RR, Johnson LD, Raynaud FI, Selfe JL, Thway K, Pietsch T, Pearson AD, Shipley J. Dual blockade of the PI3K/AKT/mTOR (AZD8055) and RAS/MEK/ERK (AZD6244) pathways synergistically inhibits rhabdomyosarcoma cell growth in vitro and in vivo. Clin Cancer Res 2013;19:5940-51. [PMID: 23918606 DOI: 10.1158/1078-0432.CCR-13-0850] [Cited by in Crossref: 95] [Cited by in F6Publishing: 69] [Article Influence: 10.6] [Reference Citation Analysis]
70 Zhang B, Luk C, Valadares J, Aronis C, Foukas LC. Dominant Role of PI3K p110α over p110β in Insulin and β-Adrenergic Receptor Signalling. Int J Mol Sci 2021;22:12813. [PMID: 34884613 DOI: 10.3390/ijms222312813] [Reference Citation Analysis]
71 Liu Q, Li J, Liang Q, Wang D, Luo Y, Yu F, Janicki JS, Fan D. Sparstolonin B suppresses rat vascular smooth muscle cell proliferation, migration, inflammatory response and lipid accumulation. Vascul Pharmacol 2015;67-69:59-66. [PMID: 25869499 DOI: 10.1016/j.vph.2015.03.015] [Cited by in Crossref: 12] [Cited by in F6Publishing: 12] [Article Influence: 1.7] [Reference Citation Analysis]
72 Jiang X, Chen S, Asara JM, Balk SP. Phosphoinositide 3-kinase pathway activation in phosphate and tensin homolog (PTEN)-deficient prostate cancer cells is independent of receptor tyrosine kinases and mediated by the p110beta and p110delta catalytic subunits. J Biol Chem 2010;285:14980-9. [PMID: 20231295 DOI: 10.1074/jbc.M109.085696] [Cited by in Crossref: 58] [Cited by in F6Publishing: 42] [Article Influence: 4.8] [Reference Citation Analysis]