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For: Deng G, Peng E, Gum J, Terdiman J, Sleisenger M, Kim YS. Methylation of hMLH1 promoter correlates with the gene silencing with a region-specific manner in colorectal cancer. Br J Cancer 2002;86:574-9. [PMID: 11870540 DOI: 10.1038/sj.bjc.6600148] [Cited by in Crossref: 71] [Cited by in F6Publishing: 80] [Article Influence: 3.4] [Reference Citation Analysis]
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1 Schöniger S, Rüschoff J. Mismatch Repair Deficiency and Microsatellite Instability. Encyclopedia 2022;2:1559-1576. [DOI: 10.3390/encyclopedia2030106] [Cited by in F6Publishing: 1] [Reference Citation Analysis]
2 Hao J, Hassen D, Gudgeon JM, Snyder SR, Hampel H, Williams MS, Sharaf RN, Lu CY, Williams JL, Schlieder V, Rahm AK. Economic Evaluation of Universal Lynch Syndrome Screening Protocols among Newly Diagnosed Patients with Colorectal Cancer. J Pers Med 2021;11:1284. [PMID: 34945755 DOI: 10.3390/jpm11121284] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 0.5] [Reference Citation Analysis]
3 Karkampouna S, La Manna F, Benjak A, Kiener M, De Menna M, Zoni E, Grosjean J, Klima I, Garofoli A, Bolis M, Vallerga A, Theurillat JP, De Filippo MR, Genitsch V, Keller D, Booij TH, Stirnimann CU, Eng K, Sboner A, Ng CKY, Piscuoglio S, Gray PC, Spahn M, Rubin MA, Thalmann GN, Kruithof-de Julio M. Patient-derived xenografts and organoids model therapy response in prostate cancer. Nat Commun 2021;12:1117. [PMID: 33602919 DOI: 10.1038/s41467-021-21300-6] [Cited by in Crossref: 29] [Cited by in F6Publishing: 29] [Article Influence: 14.5] [Reference Citation Analysis]
4 Mäki-Nevala S, Ukwattage S, Olkinuora A, Almusa H, Ahtiainen M, Ristimäki A, Seppälä T, Lepistö A, Mecklin JP, Peltomäki P. Somatic mutation profiles as molecular classifiers of ulcerative colitis-associated colorectal cancer. Int J Cancer 2021;148:2997-3007. [PMID: 33521965 DOI: 10.1002/ijc.33492] [Cited by in Crossref: 3] [Cited by in F6Publishing: 3] [Article Influence: 1.5] [Reference Citation Analysis]
5 Pal S, Garg M, Pandey AK. Biomarkers as Putative Therapeutic Targets in Colorectal Cancer. Colon Cancer Diagnosis and Therapy 2021. [DOI: 10.1007/978-3-030-63369-1_8] [Reference Citation Analysis]
6 Vyas M, Firat C, Hechtman JF, Weiser MR, Yaeger R, Vanderbilt C, Benhamida JK, Keshinro A, Zhang L, Ntiamoah P, Gonzalez M, Andrade R, El Dika I, Markowitz AJ, Smith JJ, Garcia-Aguilar J, Vakiani E, Klimstra DS, Stadler ZK, Shia J. Discordant DNA mismatch repair protein status between synchronous or metachronous gastrointestinal carcinomas: frequency, patterns, and molecular etiologies. Fam Cancer 2021;20:201-13. [PMID: 33033905 DOI: 10.1007/s10689-020-00210-4] [Cited by in Crossref: 4] [Cited by in F6Publishing: 4] [Article Influence: 1.3] [Reference Citation Analysis]
7 de Vries NL, Mahfouz A, Koning F, de Miranda NFCC. Unraveling the Complexity of the Cancer Microenvironment With Multidimensional Genomic and Cytometric Technologies. Front Oncol 2020;10:1254. [PMID: 32793500 DOI: 10.3389/fonc.2020.01254] [Cited by in Crossref: 31] [Cited by in F6Publishing: 31] [Article Influence: 10.3] [Reference Citation Analysis]
8 Pećina-Šlaus N, Kafka A, Salamon I, Bukovac A. Mismatch Repair Pathway, Genome Stability and Cancer. Front Mol Biosci 2020;7:122. [PMID: 32671096 DOI: 10.3389/fmolb.2020.00122] [Cited by in Crossref: 71] [Cited by in F6Publishing: 73] [Article Influence: 23.7] [Reference Citation Analysis]
9 Pasanen A, Loukovaara M, Bützow R. Clinicopathological significance of deficient DNA mismatch repair and MLH1 promoter methylation in endometrioid endometrial carcinoma. Mod Pathol 2020;33:1443-52. [PMID: 32060377 DOI: 10.1038/s41379-020-0501-8] [Cited by in Crossref: 32] [Cited by in F6Publishing: 34] [Article Influence: 10.7] [Reference Citation Analysis]
10 Benhamida JK, Hechtman JF, Nafa K, Villafania L, Sadowska J, Wang J, Wong D, Zehir A, Zhang L, Bale T, Arcila ME, Ladanyi M. Reliable Clinical MLH1 Promoter Hypermethylation Assessment Using a High-Throughput Genome-Wide Methylation Array Platform. J Mol Diagn 2020;22:368-75. [PMID: 31881335 DOI: 10.1016/j.jmoldx.2019.11.005] [Cited by in Crossref: 11] [Cited by in F6Publishing: 12] [Article Influence: 2.8] [Reference Citation Analysis]
11 Larsen LK, Lind GE, Guldberg P, Dahl C. DNA-Methylation-Based Detection of Urological Cancer in Urine: Overview of Biomarkers and Considerations on Biomarker Design, Source of DNA, and Detection Technologies. Int J Mol Sci 2019;20:E2657. [PMID: 31151158 DOI: 10.3390/ijms20112657] [Cited by in Crossref: 34] [Cited by in F6Publishing: 36] [Article Influence: 8.5] [Reference Citation Analysis]
12 Mäki-Nevala S, Valo S, Ristimäki A, Sarhadi V, Knuutila S, Nyström M, Renkonen-Sinisalo L, Lepistö A, Mecklin JP, Peltomäki P. DNA methylation changes and somatic mutations as tumorigenic events in Lynch syndrome-associated adenomas retaining mismatch repair protein expression. EBioMedicine 2019;39:280-91. [PMID: 30578081 DOI: 10.1016/j.ebiom.2018.12.018] [Cited by in Crossref: 14] [Cited by in F6Publishing: 14] [Article Influence: 2.8] [Reference Citation Analysis]
13 Pinto D, Pinto C, Guerra J, Pinheiro M, Santos R, Vedeld HM, Yohannes Z, Peixoto A, Santos C, Pinto P, Lopes P, Lothe R, Lind GE, Henrique R, Teixeira MR. Contribution of MLH1 constitutional methylation for Lynch syndrome diagnosis in patients with tumor MLH1 downregulation. Cancer Med. 2018;7:433-444. [PMID: 29341452 DOI: 10.1002/cam4.1285] [Cited by in Crossref: 18] [Cited by in F6Publishing: 20] [Article Influence: 3.6] [Reference Citation Analysis]
14 Mayorga L, Gamboni B, Mampel A, Roqué M. A frame-shift deletion in the PURA gene associates with a new clinical finding: Hypoglycorrhachia. Is GLUT1 a new PURA target? Mol Genet Metab 2018;123:331-6. [PMID: 29307761 DOI: 10.1016/j.ymgme.2017.12.436] [Cited by in Crossref: 13] [Cited by in F6Publishing: 13] [Article Influence: 2.6] [Reference Citation Analysis]
15 Chen C, Peng H, Huang X, Zhao M, Li Z, Yin N, Wang X, Yu F, Yin B, Yuan Y, Lu Q. Genome-wide profiling of DNA methylation and gene expression in esophageal squamous cell carcinoma. Oncotarget 2016;7:4507-21. [PMID: 26683359 DOI: 10.18632/oncotarget.6607] [Cited by in Crossref: 16] [Cited by in F6Publishing: 16] [Article Influence: 2.3] [Reference Citation Analysis]
16 Jansen AM, Geilenkirchen MA, van Wezel T, Jagmohan-Changur SC, Ruano D, van der Klift HM, van den Akker BE, Laros JF, van Galen M, Wagner A, Letteboer TG, Gómez-García EB, Tops CM, Vasen HF, Devilee P, Hes FJ, Morreau H, Wijnen JT. Whole Gene Capture Analysis of 15 CRC Susceptibility Genes in Suspected Lynch Syndrome Patients. PLoS One 2016;11:e0157381. [PMID: 27300758 DOI: 10.1371/journal.pone.0157381] [Cited by in Crossref: 12] [Cited by in F6Publishing: 12] [Article Influence: 1.7] [Reference Citation Analysis]
17 Lin C, Ng HL, Pan W, Chen H, Zhang G, Bian Z, Lu A, Yang Z. Exploring Different Strategies for Efficient Delivery of Colorectal Cancer Therapy. Int J Mol Sci 2015;16:26936-52. [PMID: 26569228 DOI: 10.3390/ijms161125995] [Cited by in Crossref: 24] [Cited by in F6Publishing: 24] [Article Influence: 3.0] [Reference Citation Analysis]
18 Alnaes GI, Ronneberg JA, Kristensen VN, Tost J. Heterogeneous DNA Methylation Patterns in the GSTP1 Promoter Lead to Discordant Results between Assay Technologies and Impede Its Implementation as Epigenetic Biomarkers in Breast Cancer. Genes (Basel) 2015;6:878-900. [PMID: 26393654 DOI: 10.3390/genes6030878] [Cited by in Crossref: 14] [Cited by in F6Publishing: 16] [Article Influence: 1.8] [Reference Citation Analysis]
19 Flis S, Gnyszka A, Flis K. DNA methyltransferase inhibitors improve the effect of chemotherapeutic agents in SW48 and HT-29 colorectal cancer cells. PLoS One 2014;9:e92305. [PMID: 24676085 DOI: 10.1371/journal.pone.0092305] [Cited by in Crossref: 33] [Cited by in F6Publishing: 36] [Article Influence: 3.7] [Reference Citation Analysis]
20 Hitchins MP. The role of epigenetics in Lynch syndrome. Fam Cancer 2013;12:189-205. [PMID: 23462881 DOI: 10.1007/s10689-013-9613-3] [Cited by in Crossref: 44] [Cited by in F6Publishing: 47] [Article Influence: 4.9] [Reference Citation Analysis]
21 Hegde M, Ferber M, Mao R, Samowitz W, Ganguly A; Working Group of the American College of Medical Genetics and Genomics (ACMG) Laboratory Quality Assurance Committee. ACMG technical standards and guidelines for genetic testing for inherited colorectal cancer (Lynch syndrome, familial adenomatous polyposis, and MYH-associated polyposis). Genet Med. 2014;16:101-116. [PMID: 24310308 DOI: 10.1038/gim.2013.166] [Cited by in Crossref: 110] [Cited by in F6Publishing: 124] [Article Influence: 11.0] [Reference Citation Analysis]
22 Hanks J, Ayed I, Kukreja N, Rogers C, Harris J, Gheorghiu A, Liu CL, Emery P, Pufulete M. The association between MTHFR 677C>T genotype and folate status and genomic and gene-specific DNA methylation in the colon of individuals without colorectal neoplasia. Am J Clin Nutr 2013;98:1564-74. [PMID: 24108782 DOI: 10.3945/ajcn.113.061432] [Cited by in Crossref: 19] [Cited by in F6Publishing: 20] [Article Influence: 1.9] [Reference Citation Analysis]
23 Jensen LH, Rasmussen AA, Byriel L, Kuramochi H, Crüger DG, Lindebjerg J, Danenberg PV, Jakobsen A, Danenberg K. Regulation of MLH1 mRNA and protein expression by promoter methylation in primary colorectal cancer: a descriptive and prognostic cancer marker study. Cell Oncol (Dordr). 2013;36:411-419. [PMID: 24027018 DOI: 10.1007/s13402-013-0148-2] [Cited by in Crossref: 17] [Cited by in F6Publishing: 13] [Article Influence: 1.7] [Reference Citation Analysis]
24 Eng C, Lynch P, Skibber J. Colon Cancer. 60 Years of Survival Outcomes at The University of Texas MD Anderson Cancer Center 2013. [DOI: 10.1007/978-1-4614-5197-6_8] [Cited by in Crossref: 2] [Cited by in F6Publishing: 2] [Article Influence: 0.2] [Reference Citation Analysis]
25 Hitchins MP. The Role of Epimutations of the Mismatch Repair Genes in the Development of Lynch Syndrome Related Cancers. DNA Alterations in Lynch Syndrome 2013. [DOI: 10.1007/978-94-007-6597-9_6] [Reference Citation Analysis]
26 Yu J, Zhao F, Liang LP, Shi XY. Clinical significance of expression of hMLH-1 and hMSH-2 in sporadic colorectal carcinoma in Chinese Han patients in Xinjiang. Shijie Huaren Xiaohua Zazhi 2012; 20(33): 3218-3224 [DOI: 10.11569/wcjd.v20.i33.3218] [Reference Citation Analysis]
27 Derks S, van Engeland M. Promoter CpG island methylation in colorectal cancer:. Epigenomics 2012. [DOI: 10.1017/cbo9780511777271.028] [Reference Citation Analysis]
28 Pineda M, Mur P, Iniesta MD, Borràs E, Campos O, Vargas G, Iglesias S, Fernández A, Gruber SB, Lázaro C, Brunet J, Navarro M, Blanco I, Capellá G. MLH1 methylation screening is effective in identifying epimutation carriers. Eur J Hum Genet 2012;20:1256-64. [PMID: 22763379 DOI: 10.1038/ejhg.2012.136] [Cited by in Crossref: 27] [Cited by in F6Publishing: 28] [Article Influence: 2.5] [Reference Citation Analysis]
29 Huang Q, Huang JF, Zhang B, Baum L, Fu WL. Methylation variable position profiles of hMLH1 promoter CpG islands in human sporadic colorectal carcinoma. Diagn Mol Pathol 2012;21:24-33. [PMID: 22306672 DOI: 10.1097/PDM.0b013e318230effd] [Cited by in Crossref: 5] [Cited by in F6Publishing: 6] [Article Influence: 0.5] [Reference Citation Analysis]
30 Mikeska T, Candiloro IL, Dobrovic A. The implications of heterogeneous DNA methylation for the accurate quantification of methylation. Epigenomics 2010;2:561-73. [PMID: 22121974 DOI: 10.2217/epi.10.32] [Cited by in Crossref: 106] [Cited by in F6Publishing: 115] [Article Influence: 9.6] [Reference Citation Analysis]
31 Wu PY, Zhang Z, Wang JM, Guo WW, Xiao N, He Q, Wang YP, Fan YM. Germline promoter hypermethylation of tumor suppressor genes in gastric cancer. World J Gastroenterol 2012; 18(1): 70-78 [PMID: 22228973 DOI: 10.3748/wjg.v18.i1.70] [Cited by in CrossRef: 11] [Cited by in F6Publishing: 11] [Article Influence: 1.0] [Reference Citation Analysis]
32 Al-ghnaniem Abbadi R, Emery P, Pufulete M. Short-Term Folate Supplementation in Physiological Doses Has No Effect on ESR1 and MLH1 Methylation in Colonic Mucosa of Individuals with Adenoma. J Nutrigenet Nutrigenomics 2012;5:327-38. [DOI: 10.1159/000345819] [Cited by in Crossref: 10] [Cited by in F6Publishing: 11] [Article Influence: 0.9] [Reference Citation Analysis]
33 Onrat S, Ceken I, Ellidokuz E, Kupelioğlu A. Alterations of copy number of methylation pattern in mismatch repair genes by methylation specific-multiplex ligation-dependent probe amplification in cases of colon cancer. Balkan J Med Genet 2011;14:25-34. [PMID: 24052709 DOI: 10.2478/v10034-011-0044-x] [Reference Citation Analysis]
34 Miladi-abdennadher I, Abdelmaksoud-damak R, Ayadi L, Khabir A, Frikha F, Kallel L, Frikha M, Sellami-boudawara T, Gargouri A, Mokdad-gargouri R. Aberrant methylation of hMLH1 and p16INK4a in Tunisian patients with sporadic colorectal adenocarcinoma. Bioscience Reports 2011;31:257-64. [DOI: 10.1042/bsr20100023] [Cited by in Crossref: 15] [Cited by in F6Publishing: 16] [Article Influence: 1.3] [Reference Citation Analysis]
35 Goel A, Nguyen TP, Leung HC, Nagasaka T, Rhees J, Hotchkiss E, Arnold M, Banerji P, Koi M, Kwok CT, Packham D, Lipton L, Boland CR, Ward RL, Hitchins MP. De novo constitutional MLH1 epimutations confer early-onset colorectal cancer in two new sporadic Lynch syndrome cases, with derivation of the epimutation on the paternal allele in one. Int J Cancer. 2011;128:869-878. [PMID: 20473912 DOI: 10.1002/ijc.25422] [Cited by in Crossref: 64] [Cited by in F6Publishing: 70] [Article Influence: 5.3] [Reference Citation Analysis]
36 Bouzourene H, Hutter P, Losi L, Martin P, Benhattar J. Selection of patients with germline MLH1 mutated Lynch syndrome by determination of MLH1 methylation and BRAF mutation. Fam Cancer. 2010;9:167-172. [PMID: 19949877 DOI: 10.1007/s10689-009-9302-4] [Cited by in Crossref: 36] [Cited by in F6Publishing: 34] [Article Influence: 2.8] [Reference Citation Analysis]
37 Berginc G, Bracko M, Glavac D. MS-MLPA reveals progressive age-dependent promoter methylation of tumor suppressor genes and possible role of IGSF4 gene in colorectal carcinogenesis of microsatellite instable tumors. Cancer Invest 2010;28:94-102. [PMID: 19995226 DOI: 10.3109/07357900902849673] [Cited by in Crossref: 7] [Cited by in F6Publishing: 7] [Article Influence: 0.5] [Reference Citation Analysis]
38 Deng D, Liu Z, Du Y. Epigenetic alterations as cancer diagnostic, prognostic, and predictive biomarkers. Adv Genet 2010;71:125-76. [PMID: 20933128 DOI: 10.1016/B978-0-12-380864-6.00005-5] [Cited by in Crossref: 63] [Cited by in F6Publishing: 72] [Article Influence: 4.8] [Reference Citation Analysis]
39 van Vlodrop IJ, Baldewijns MM, Smits KM, Schouten LJ, van Neste L, van Criekinge W, van Poppel H, Lerut E, Schuebel KE, Ahuja N, Herman JG, de Bruïne AP, van Engeland M. Prognostic significance of Gremlin1 (GREM1) promoter CpG island hypermethylation in clear cell renal cell carcinoma. Am J Pathol 2010;176:575-84. [PMID: 20042676 DOI: 10.2353/ajpath.2010.090442] [Cited by in Crossref: 50] [Cited by in F6Publishing: 56] [Article Influence: 3.6] [Reference Citation Analysis]
40 Palomaki GE, McClain MR, Melillo S, Hampel HL, Thibodeau SN. EGAPP supplementary evidence review: DNA testing strategies aimed at reducing morbidity and mortality from Lynch syndrome. Genet Med 2009;11:42-65. [PMID: 19125127 DOI: 10.1097/GIM.0b013e31818fa2db] [Cited by in Crossref: 342] [Cited by in F6Publishing: 383] [Article Influence: 24.4] [Reference Citation Analysis]
41 Sheng JQ, Zhang H, Ji M, Fu L, Mu H, Zhang MZ, Huang JS, Han M, Li AQ, Wei Z, Sun ZQ, Wu ZT, Xia CH, Li SR. Genetic diagnosis strategy of hereditary non-polyposis colorectal cancer. World J Gastroenterol 2009; 15(8): 983-989 [PMID: 19248199 DOI: 10.3748/wjg.15.983] [Cited by in CrossRef: 8] [Cited by in F6Publishing: 9] [Article Influence: 0.6] [Reference Citation Analysis]
42 Kumar K, Brim H, Giardiello F, Smoot DT, Nouraie M, Lee EL, Ashktorab H. Distinct BRAF (V600E) and KRAS mutations in high microsatellite instability sporadic colorectal cancer in African Americans. Clin Cancer Res. 2009;15:1155-1161. [PMID: 19190129 DOI: 10.1158/1078-0432.ccr-08-1029] [Cited by in Crossref: 47] [Cited by in F6Publishing: 55] [Article Influence: 3.4] [Reference Citation Analysis]
43 Pappas JJ, Toulouse A, Hébert J, Fetni R, Bradley WEC. Allelic methylation bias of the RARB2 tumor suppressor gene promoter in cancer. Genes Chromosom Cancer 2008;47:978-93. [DOI: 10.1002/gcc.20603] [Cited by in Crossref: 8] [Cited by in F6Publishing: 8] [Article Influence: 0.5] [Reference Citation Analysis]
44 Deng G, Kakar S, Tanaka H, Matsuzaki K, Miura S, Sleisenger MH, Kim YS. Proximal and distal colorectal cancers show distinct gene-specific methylation profiles and clinical and molecular characteristics. Eur J Cancer 2008;44:1290-301. [PMID: 18486467 DOI: 10.1016/j.ejca.2008.03.014] [Cited by in Crossref: 53] [Cited by in F6Publishing: 54] [Article Influence: 3.5] [Reference Citation Analysis]
45 Lind GE, Ahlquist T, Kolberg M, Berg M, Eknaes M, Alonso MA, Kallioniemi A, Meling GI, Skotheim RI, Rognum TO. Hypermethylated MAL gene - a silent marker of early colon tumorigenesis. J Transl Med. 2008;6:13. [PMID: 18346269 DOI: 10.1186/1479-5876-6-13] [Cited by in Crossref: 38] [Cited by in F6Publishing: 43] [Article Influence: 2.5] [Reference Citation Analysis]
46 Rahner N, Friedrichs N, Steinke V, Aretz S, Friedl W, Buettner R, Mangold E, Propping P, Walldorf C. Coexisting somatic promoter hypermethylation and pathogenic MLH1 germline mutation in Lynch syndrome. J Pathol 2008;214:10-6. [PMID: 17973250 DOI: 10.1002/path.2263] [Cited by in Crossref: 48] [Cited by in F6Publishing: 51] [Article Influence: 3.2] [Reference Citation Analysis]
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48 Al-Ghnaniem R, Peters J, Foresti R, Heaton N, Pufulete M. Methylation of estrogen receptor alpha and mutL homolog 1 in normal colonic mucosa: association with folate and vitamin B-12 status in subjects with and without colorectal neoplasia. Am J Clin Nutr 2007;86:1064-72. [PMID: 17921385 DOI: 10.1093/ajcn/86.4.1064] [Cited by in Crossref: 33] [Cited by in F6Publishing: 33] [Article Influence: 2.1] [Reference Citation Analysis]
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51 Overbeek LI, Kets CM, Hebeda KM, Bodmer D, van der Looij E, Willems R, Goossens M, Arts N, Brunner HG, van Krieken JH, Hoogerbrugge N, Ligtenberg MJ. Patients with an unexplained microsatellite instable tumour have a low risk of familial cancer. Br J Cancer 2007;96:1605-12. [PMID: 17453009 DOI: 10.1038/sj.bjc.6603754] [Cited by in Crossref: 33] [Cited by in F6Publishing: 37] [Article Influence: 2.1] [Reference Citation Analysis]
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53 Skarda J, Fridman E, Plevova P, Hajduch M, Radova L, Ofek E, Kopolovic J, Kolek V, Kolar Z. PROGNOSTIC VALUE OF hMLH1 AND hMSH2 IMMUNOHISTOCHEMICAL EXPRESSION IN NON-SMALL CELL LUNG CANCER. A TISSUE MICROARRAY STUDY. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2006;150:255-9. [DOI: 10.5507/bp.2006.037] [Cited by in Crossref: 8] [Cited by in F6Publishing: 9] [Article Influence: 0.5] [Reference Citation Analysis]
54 Xiao GZ, Liu XS. Expression of DNA mismatch repair gene hMLH1 and its significance in gastric cancer and premalignant lesions. Shijie Huaren Xiaohua Zazhi 2006; 14(21): 2093-2097 [DOI: 10.11569/wcjd.v14.i21.2093] [Cited by in F6Publishing: 2] [Reference Citation Analysis]
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