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For: Mahoney CE, Pirman D, Chubukov V, Sleger T, Hayes S, Fan ZP, Allen EL, Chen Y, Huang L, Liu M, Zhang Y, McDonald G, Narayanaswamy R, Choe S, Chen Y, Gross S, Cianchetta G, Padyana AK, Murray S, Liu W, Marks KM, Murtie J, Dorsch M, Jin S, Nagaraja N, Biller SA, Roddy T, Popovici-Muller J, Smolen GA. A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition. Nat Commun 2019;10:96. [PMID: 30626880 DOI: 10.1038/s41467-018-07959-4] [Cited by in Crossref: 32] [Cited by in F6Publishing: 29] [Article Influence: 10.7] [Reference Citation Analysis]
Number Citing Articles
1 Brown AJ, Chua NK, Yan N. The shape of human squalene epoxidase expands the arsenal against cancer. Nat Commun 2019;10:888. [PMID: 30792392 DOI: 10.1038/s41467-019-08866-y] [Cited by in Crossref: 19] [Cited by in F6Publishing: 20] [Article Influence: 6.3] [Reference Citation Analysis]
2 Coates HW, Capell-Hattam IM, Brown AJ. The mammalian cholesterol synthesis enzyme squalene monooxygenase is proteasomally truncated to a constitutively active form. J Biol Chem 2021;296:100731. [PMID: 33933449 DOI: 10.1016/j.jbc.2021.100731] [Cited by in Crossref: 2] [Cited by in F6Publishing: 1] [Article Influence: 2.0] [Reference Citation Analysis]
3 Madan B, Virshup DM, Nes WD, Leaver DJ. Unearthing the Janus-face cholesterogenesis pathways in cancer. Biochem Pharmacol 2021;:114611. [PMID: 34010597 DOI: 10.1016/j.bcp.2021.114611] [Reference Citation Analysis]
4 Sagatova AA. Strategies to Better Target Fungal Squalene Monooxygenase. J Fungi (Basel) 2021;7:49. [PMID: 33450973 DOI: 10.3390/jof7010049] [Cited by in Crossref: 1] [Article Influence: 1.0] [Reference Citation Analysis]
5 Sun H, Li L, Li W, Yang F, Zhang Z, Liu Z, Du W. p53 transcriptionally regulates SQLE to repress cholesterol synthesis and tumor growth. EMBO Rep 2021;22:e52537. [PMID: 34459531 DOI: 10.15252/embr.202152537] [Cited by in F6Publishing: 1] [Reference Citation Analysis]
6 Csáky Z, Garaiová M, Kodedová M, Valachovič M, Sychrová H, Hapala I. Squalene lipotoxicity in a lipid droplet‐less yeast mutant is linked to plasma membrane dysfunction. Yeast 2020;37:45-62. [DOI: 10.1002/yea.3454] [Cited by in Crossref: 13] [Cited by in F6Publishing: 9] [Article Influence: 6.5] [Reference Citation Analysis]
7 Gouirand V, Gicquel T, Lien EC, Jaune-Pons E, Da Costa Q, Finetti P, Metay E, Duluc C, Mayers JR, Audebert S, Camoin L, Borge L, Rubis M, Leca J, Nigri J, Bertucci F, Dusetti N, Lucio Iovanna J, Tomasini R, Bidaut G, Guillaumond F, Vander Heiden MG, Vasseur S. Ketogenic HMG-CoA lyase and its product β-hydroxybutyrate promote pancreatic cancer progression. EMBO J 2022;:e110466. [PMID: 35307861 DOI: 10.15252/embj.2021110466] [Cited by in Crossref: 2] [Cited by in F6Publishing: 2] [Article Influence: 2.0] [Reference Citation Analysis]
8 Nagaraja R, Olaharski A, Narayanaswamy R, Mahoney C, Pirman D, Gross S, Roddy TP, Popovici-Muller J, Smolen GA, Silverman L. Preclinical toxicology profile of squalene epoxidase inhibitors. Toxicol Appl Pharmacol 2020;401:115103. [PMID: 32522582 DOI: 10.1016/j.taap.2020.115103] [Cited by in Crossref: 4] [Cited by in F6Publishing: 2] [Article Influence: 2.0] [Reference Citation Analysis]
9 Chua NK, Hart-Smith G, Brown AJ. Non-canonical ubiquitination of the cholesterol-regulated degron of squalene monooxygenase. J Biol Chem 2019;294:8134-47. [PMID: 30940729 DOI: 10.1074/jbc.RA119.007798] [Cited by in Crossref: 21] [Cited by in F6Publishing: 11] [Article Influence: 7.0] [Reference Citation Analysis]
10 Reis RAG, Li H, Johnson M, Sobrado P. New frontiers in flavin-dependent monooxygenases. Arch Biochem Biophys 2021;699:108765. [PMID: 33460580 DOI: 10.1016/j.abb.2021.108765] [Cited by in Crossref: 3] [Cited by in F6Publishing: 3] [Article Influence: 3.0] [Reference Citation Analysis]
11 Lee S, Nam M, Lee AR, Lee J, Woo J, Kang NS, Balupuri A, Lee M, Kim SY, Ro H, Choi YW, Kim DU, Hoe KL. Systematic Target Screening Revealed That Tif302 Could Be an Off-Target of the Antifungal Terbinafine in Fission Yeast. Biomol Ther (Seoul) 2021;29:234-47. [PMID: 33223513 DOI: 10.4062/biomolther.2020.166] [Reference Citation Analysis]
12 Paolicelli RC, Widmann C. Squalene: friend or foe for cancers. Current Opinion in Lipidology 2019;30:353-4. [DOI: 10.1097/mol.0000000000000619] [Cited by in Crossref: 4] [Cited by in F6Publishing: 2] [Article Influence: 1.3] [Reference Citation Analysis]
13 Ge PY, Qi YY, Qu SY, Zhao X, Ni SJ, Yao ZY, Guo R, Yang NY, Zhang QC, Zhu HX. Potential Mechanism of S. baicalensis on Lipid Metabolism Explored via Network Pharmacology and Untargeted Lipidomics. Drug Des Devel Ther 2021;15:1915-30. [PMID: 33976541 DOI: 10.2147/DDDT.S301679] [Reference Citation Analysis]
14 Xu X, Chen J, Li Y, Yang X, Wang Q, Wen Y, Yan M, Zhang J, Xu Q, Wei Y, Chen W, Wang X. Targeting epigenetic modulation of cholesterol synthesis as a therapeutic strategy for head and neck squamous cell carcinoma. Cell Death Dis 2021;12:482. [PMID: 33986254 DOI: 10.1038/s41419-021-03760-2] [Reference Citation Analysis]
15 Yoshioka H, Coates HW, Chua NK, Hashimoto Y, Brown AJ, Ohgane K. A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate. Proc Natl Acad Sci U S A 2020;117:7150-8. [PMID: 32170014 DOI: 10.1073/pnas.1915923117] [Cited by in Crossref: 21] [Cited by in F6Publishing: 19] [Article Influence: 10.5] [Reference Citation Analysis]
16 Bian X, Liu R, Meng Y, Xing D, Xu D, Lu Z. Lipid metabolism and cancer. J Exp Med 2021;218:e20201606. [PMID: 33601415 DOI: 10.1084/jem.20201606] [Cited by in Crossref: 4] [Cited by in F6Publishing: 4] [Article Influence: 4.0] [Reference Citation Analysis]
17 Xu H, Zhou S, Tang Q, Xia H, Bi F. Cholesterol metabolism: New functions and therapeutic approaches in cancer. Biochim Biophys Acta Rev Cancer 2020;1874:188394. [PMID: 32698040 DOI: 10.1016/j.bbcan.2020.188394] [Cited by in Crossref: 60] [Cited by in F6Publishing: 52] [Article Influence: 30.0] [Reference Citation Analysis]
18 Tan JME, van der Stoel MM, van den Berg M, van Loon NM, Moeton M, Scholl E, van der Wel NN, Kovačević I, Hordijk PL, Loregger A, Huveneers S, Zelcer N. The MARCH6-SQLE Axis Controls Endothelial Cholesterol Homeostasis and Angiogenic Sprouting. Cell Reports 2020;32:107944. [DOI: 10.1016/j.celrep.2020.107944] [Cited by in Crossref: 2] [Cited by in F6Publishing: 2] [Article Influence: 1.0] [Reference Citation Analysis]
19 Chua NK, Coates HW, Brown AJ. Squalene monooxygenase: a journey to the heart of cholesterol synthesis. Progress in Lipid Research 2020;79:101033. [DOI: 10.1016/j.plipres.2020.101033] [Cited by in Crossref: 13] [Cited by in F6Publishing: 10] [Article Influence: 6.5] [Reference Citation Analysis]
20 He J, Siu MKY, Ngan HYS, Chan KKL. Aberrant Cholesterol Metabolism in Ovarian Cancer: Identification of Novel Therapeutic Targets. Front Oncol 2021;11:738177. [PMID: 34820325 DOI: 10.3389/fonc.2021.738177] [Reference Citation Analysis]
21 Riscal R, Skuli N, Simon MC. Even Cancer Cells Watch Their Cholesterol! Mol Cell 2019;76:220-31. [PMID: 31586545 DOI: 10.1016/j.molcel.2019.09.008] [Cited by in Crossref: 41] [Cited by in F6Publishing: 40] [Article Influence: 13.7] [Reference Citation Analysis]
22 Cristea S, Coles GL, Hornburg D, Gershkovitz M, Arand J, Cao S, Sen T, Williamson SC, Kim JW, Drainas AP, He A, Cam LL, Byers LA, Snyder MP, Contrepois K, Sage J. The MEK5-ERK5 Kinase Axis Controls Lipid Metabolism in Small-Cell Lung Cancer. Cancer Res 2020;80:1293-303. [PMID: 31969375 DOI: 10.1158/0008-5472.CAN-19-1027] [Cited by in Crossref: 7] [Cited by in F6Publishing: 9] [Article Influence: 3.5] [Reference Citation Analysis]
23 Ortiz N, Delgado-Carazo JC, Díaz C. Importance of Mevalonate Pathway Lipids on the Growth and Survival of Primary and Metastatic Gastric Carcinoma Cells. Clin Exp Gastroenterol 2021;14:217-28. [PMID: 34103960 DOI: 10.2147/CEG.S310235] [Cited by in Crossref: 3] [Cited by in F6Publishing: 3] [Article Influence: 3.0] [Reference Citation Analysis]
24 Ortiz N, Díaz C. Mevalonate pathway as a novel target for the treatment of metastatic gastric cancer. Oncol Lett 2020;20:320. [PMID: 33093924 DOI: 10.3892/ol.2020.12183] [Cited by in Crossref: 2] [Cited by in F6Publishing: 2] [Article Influence: 1.0] [Reference Citation Analysis]
25 Lee N, Spears ME, Carlisle AE, Kim D. Endogenous toxic metabolites and implications in cancer therapy. Oncogene 2020;39:5709-20. [PMID: 32709924 DOI: 10.1038/s41388-020-01395-9] [Cited by in Crossref: 5] [Cited by in F6Publishing: 3] [Article Influence: 2.5] [Reference Citation Analysis]
26 Kopecka J, Godel M, Riganti C. Cholesterol metabolism: At the cross road between cancer cells and immune environment. Int J Biochem Cell Biol 2020;129:105876. [PMID: 33166677 DOI: 10.1016/j.biocel.2020.105876] [Cited by in Crossref: 4] [Cited by in F6Publishing: 4] [Article Influence: 2.0] [Reference Citation Analysis]
27 Feltrin S, Ravera F, Traversone N, Ferrando L, Bedognetti D, Ballestrero A, Zoppoli G. Sterol synthesis pathway inhibition as a target for cancer treatment. Cancer Letters 2020;493:19-30. [DOI: 10.1016/j.canlet.2020.07.010] [Cited by in Crossref: 4] [Cited by in F6Publishing: 4] [Article Influence: 2.0] [Reference Citation Analysis]
28 Kalogirou C, Linxweiler J, Schmucker P, Snaebjornsson MT, Schmitz W, Wach S, Krebs M, Hartmann E, Puhr M, Müller A, Spahn M, Seitz AK, Frank T, Marouf H, Büchel G, Eckstein M, Kübler H, Eilers M, Saar M, Junker K, Röhrig F, Kneitz B, Rosenfeldt MT, Schulze A. MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer. Nat Commun 2021;12:5066. [PMID: 34417456 DOI: 10.1038/s41467-021-25325-9] [Cited by in Crossref: 1] [Article Influence: 1.0] [Reference Citation Analysis]
29 Hu LP, Huang W, Wang X, Xu C, Qin WT, Li D, Tian G, Li Q, Zhou Y, Chen S, Nie HZ, Hao Y, Song J, Zhang XL, Sundquist J, Sundquist K, Li J, Jiang SH, Zhang ZG, Ji J. Terbinafine prevents colorectal cancer growth by inducing dNTP starvation and reducing immune suppression. Mol Ther 2022:S1525-0016(22)00375-6. [PMID: 35765243 DOI: 10.1016/j.ymthe.2022.06.015] [Reference Citation Analysis]
30 Liu Y, Fang L, Liu W. High SQLE Expression and Gene Amplification Correlates with Poor Prognosis in Head and Neck Squamous Cell Carcinoma. Cancer Manag Res 2021;13:4709-23. [PMID: 34163246 DOI: 10.2147/CMAR.S305719] [Reference Citation Analysis]
31 Ornell KJ, Coburn JM. Developing preclinical models of neuroblastoma: driving therapeutic testing. BMC Biomed Eng 2019;1:33. [PMID: 32903387 DOI: 10.1186/s42490-019-0034-8] [Cited by in Crossref: 7] [Cited by in F6Publishing: 5] [Article Influence: 2.3] [Reference Citation Analysis]
32 Qi X, Fu Y, Sheng J, Zhang M, Zhang M, Wang Y, Li G. A novel ferroptosis-related gene signature for predicting outcomes in cervical cancer. Bioengineered 2021;12:1813-25. [PMID: 33989111 DOI: 10.1080/21655979.2021.1925003] [Cited by in Crossref: 1] [Cited by in F6Publishing: 2] [Article Influence: 1.0] [Reference Citation Analysis]
33 Zang T, Wang S, Su S, Gao M, Chen Q, Liang C, Jing J, Zhang R, Zhang X. Off-On Squalene Epoxidase-Specific Fluorescent Probe for Fast Imaging in Living Cells. Anal Chem 2021;93:14716-21. [PMID: 34702029 DOI: 10.1021/acs.analchem.1c03168] [Reference Citation Analysis]
34 Nathan JA. Squalene and cholesterol in the balance at the ER membrane. Proc Natl Acad Sci U S A 2020;117:8228-30. [PMID: 32238557 DOI: 10.1073/pnas.2003388117] [Cited by in Crossref: 6] [Cited by in F6Publishing: 4] [Article Influence: 3.0] [Reference Citation Analysis]