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For: Pollinger J, Gellrich L, Schierle S, Kilu W, Schmidt J, Kalinowsky L, Ohrndorf J, Kaiser A, Heering J, Proschak E, Merk D. Tuning Nuclear Receptor Selectivity of Wy14,643 towards Selective Retinoid X Receptor Modulation. J Med Chem 2019;62:2112-26. [PMID: 30702885 DOI: 10.1021/acs.jmedchem.8b01848] [Cited by in Crossref: 21] [Cited by in F6Publishing: 21] [Article Influence: 7.0] [Reference Citation Analysis]
Number Citing Articles
1 Schierle S, Chaikuad A, Lillich FF, Ni X, Woltersdorf S, Schallmayer E, Renelt B, Ronchetti R, Knapp S, Proschak E, Merk D. Oxaprozin Analogues as Selective RXR Agonists with Superior Properties and Pharmacokinetics. J Med Chem 2021;64:5123-36. [PMID: 33793232 DOI: 10.1021/acs.jmedchem.1c00235] [Reference Citation Analysis]
2 Chaikuad A, Pollinger J, Rühl M, Ni X, Kilu W, Heering J, Merk D. Comprehensive Set of Tertiary Complex Structures and Palmitic Acid Binding Provide Molecular Insights into Ligand Design for RXR Isoforms. Int J Mol Sci 2020;21:E8457. [PMID: 33187070 DOI: 10.3390/ijms21228457] [Cited by in Crossref: 2] [Cited by in F6Publishing: 2] [Article Influence: 1.0] [Reference Citation Analysis]
3 Willems S, Gellrich L, Chaikuad A, Kluge S, Werz O, Heering J, Knapp S, Lorkowski S, Schubert-Zsilavecz M, Merk D. Endogenous vitamin E metabolites mediate allosteric PPARγ activation with unprecedented co-regulatory interactions. Cell Chem Biol 2021:S2451-9456(21)00212-9. [PMID: 33989565 DOI: 10.1016/j.chembiol.2021.04.019] [Cited by in Crossref: 1] [Cited by in F6Publishing: 2] [Article Influence: 1.0] [Reference Citation Analysis]
4 Willems S, Zaienne D, Merk D. Targeting Nuclear Receptors in Neurodegeneration and Neuroinflammation. J Med Chem 2021;64:9592-638. [PMID: 34251209 DOI: 10.1021/acs.jmedchem.1c00186] [Reference Citation Analysis]
5 Dou X, Duerfeldt AS. Small-Molecule Modulation of PPARs for the Treatment of Prevalent Vascular Retinal Diseases. Int J Mol Sci 2020;21:E9251. [PMID: 33291567 DOI: 10.3390/ijms21239251] [Cited by in Crossref: 2] [Cited by in F6Publishing: 1] [Article Influence: 1.0] [Reference Citation Analysis]
6 Yu OB, Webb DA, Di Milo ES, Mutchie TR, Teske KA, Chen T, Lin W, Peluso-Iltis C, Rochel N, Helmstädter M, Merk D, Arnold LA. Biological evaluation and synthesis of calcitroic acid. Bioorg Chem 2021;116:105310. [PMID: 34482171 DOI: 10.1016/j.bioorg.2021.105310] [Reference Citation Analysis]
7 Pollinger J, Schierle S, Gellrich L, Ohrndorf J, Kaiser A, Heitel P, Chaikuad A, Knapp S, Merk D. A Novel Biphenyl-based Chemotype of Retinoid X Receptor Ligands Enables Subtype and Heterodimer Preferences. ACS Med Chem Lett 2019;10:1346-52. [PMID: 31531208 DOI: 10.1021/acsmedchemlett.9b00306] [Cited by in Crossref: 6] [Cited by in F6Publishing: 6] [Article Influence: 2.0] [Reference Citation Analysis]
8 Schierle S, Merk D. Therapeutic modulation of retinoid X receptors – SAR and therapeutic potential of RXR ligands and recent patents. Expert Opinion on Therapeutic Patents 2019;29:605-21. [DOI: 10.1080/13543776.2019.1643322] [Cited by in Crossref: 11] [Cited by in F6Publishing: 9] [Article Influence: 3.7] [Reference Citation Analysis]
9 Vitória JJM, Trigo D, da Cruz E Silva OAB. Revisiting APP secretases: an overview on the holistic effects of retinoic acid receptor stimulation in APP processing. Cell Mol Life Sci 2022;79:101. [PMID: 35089425 DOI: 10.1007/s00018-021-04090-4] [Cited by in Crossref: 1] [Article Influence: 1.0] [Reference Citation Analysis]
10 Ren S, Jiao L, Yang S, Zhang L, Song J, Yu H, Wang J, Lv T, Sun L, Lu Y, Du G. A Novel Co-Crystal of Bexarotene and Ligustrazine Improves Pharmacokinetics and Tissue Distribution of Bexarotene in SD Rats. Pharmaceutics 2020;12:E906. [PMID: 32977470 DOI: 10.3390/pharmaceutics12100906] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 0.5] [Reference Citation Analysis]
11 Schierle S, Neumann S, Heitel P, Willems S, Kaiser A, Pollinger J, Merk D. Design and Structural Optimization of Dual FXR/PPARδ Activators. J Med Chem 2020;63:8369-79. [PMID: 32687365 DOI: 10.1021/acs.jmedchem.0c00618] [Cited by in Crossref: 3] [Cited by in F6Publishing: 3] [Article Influence: 1.5] [Reference Citation Analysis]
12 Merk D, Sreeramulu S, Kudlinzki D, Saxena K, Linhard V, Gande SL, Hiller F, Lamers C, Nilsson E, Aagaard A, Wissler L, Dekker N, Bamberg K, Schubert-Zsilavecz M, Schwalbe H. Molecular tuning of farnesoid X receptor partial agonism. Nat Commun 2019;10:2915. [PMID: 31266946 DOI: 10.1038/s41467-019-10853-2] [Cited by in Crossref: 28] [Cited by in F6Publishing: 31] [Article Influence: 9.3] [Reference Citation Analysis]
13 Hinnah K, Willems S, Morstein J, Heering J, Hartrampf FWW, Broichhagen J, Leippe P, Merk D, Trauner D. Photohormones Enable Optical Control of the Peroxisome Proliferator-Activated Receptor γ (PPARγ). J Med Chem 2020;63:10908-20. [PMID: 32886507 DOI: 10.1021/acs.jmedchem.0c00654] [Cited by in Crossref: 9] [Cited by in F6Publishing: 6] [Article Influence: 4.5] [Reference Citation Analysis]
14 Lewandowski CT, Maldonado Weng J, LaDu MJ. Alzheimer's disease pathology in APOE transgenic mouse models: The Who, What, When, Where, Why, and How. Neurobiol Dis 2020;139:104811. [PMID: 32087290 DOI: 10.1016/j.nbd.2020.104811] [Cited by in Crossref: 13] [Cited by in F6Publishing: 12] [Article Influence: 6.5] [Reference Citation Analysis]
15 Chen Y, Li J, Wu Z, Liu G, Li H, Tang Y, Li W. Computational Insight into the Allosteric Activation Mechanism of Farnesoid X Receptor. J Chem Inf Model 2020;60:1540-50. [PMID: 32097559 DOI: 10.1021/acs.jcim.9b00914] [Reference Citation Analysis]
16 Li F, Wang H, Wang Y, Feng S, Hu B, Zhang X, Wang J, Li W, Cheng M. Computational investigation reveals Picrasidine C as selective PPARα lead: binding pattern, selectivity mechanism and ADME/tox profile. J Biomol Struct Dyn 2020;38:5401-18. [PMID: 31787028 DOI: 10.1080/07391102.2019.1699861] [Cited by in Crossref: 4] [Cited by in F6Publishing: 3] [Article Influence: 1.3] [Reference Citation Analysis]
17 Hartmann M, Bibli SI, Tews D, Ni X, Kircher T, Kramer JS, Kilu W, Heering J, Hernandez-Olmos V, Weizel L, Scriba GKE, Krait S, Knapp S, Chaikuad A, Merk D, Fleming I, Fischer-Posovszky P, Proschak E. Combined Cardioprotective and Adipocyte Browning Effects Promoted by the Eutomer of Dual sEH/PPARγ Modulator. J Med Chem 2021;64:2815-28. [PMID: 33620196 DOI: 10.1021/acs.jmedchem.0c02063] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 1.0] [Reference Citation Analysis]
18 Hanke T, Cheung S, Kilu W, Heering J, Ni X, Planz V, Schierle S, Faudone G, Friedrich M, Wanior M, Werz O, Windbergs M, Proschak E, Schubert-zsilavecz M, Chaikuad A, Knapp S, Merk D. A Selective Modulator of Peroxisome Proliferator-Activated Receptor γ with an Unprecedented Binding Mode. J Med Chem 2020;63:4555-61. [DOI: 10.1021/acs.jmedchem.9b01786] [Cited by in Crossref: 3] [Cited by in F6Publishing: 3] [Article Influence: 1.5] [Reference Citation Analysis]
19 H M Ehrler J, Brunst S, Tjaden A, Kilu W, Heering J, Hernandez-Olmos V, Krommes A, Kramer JS, Steinhilber D, Schubert-Zsilavecz M, Müller-Knapp S, Merk D, Proschak E. Compilation and Evaluation of Fatty Acid Mimetics Screening Library. Biochem Pharmacol 2022;:115191. [PMID: 35907497 DOI: 10.1016/j.bcp.2022.115191] [Reference Citation Analysis]
20 Hernandez-Olmos V, Knape T, Heering J, von Knethen A, Kilu W, Kaiser A, Wurglics M, Helmstädter M, Merk D, Schubert-Zsilavecz M, Parnham MJ, Steinhilber D, Proschak E. Structure optimization of a new class of PPARγ antagonists. Bioorg Med Chem 2019;27:115082. [PMID: 31548084 DOI: 10.1016/j.bmc.2019.115082] [Reference Citation Analysis]
21 Helmstädter M, Schmidt J, Kaiser A, Weizel L, Proschak E, Merk D. Differential Therapeutic Effects of FXR Activation, sEH Inhibition, and Dual FXR/sEH Modulation in NASH in Diet-Induced Obese Mice. ACS Pharmacol Transl Sci 2021;4:966-79. [PMID: 33860214 DOI: 10.1021/acsptsci.1c00041] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 1.0] [Reference Citation Analysis]
22 Takamura Y, Kato I, Fujita-takahashi M, Azuma-nishii M, Watanabe M, Nozaki R, Akehi M, Sasaki T, Hirano H, Kakuta H. Teratogenicity and Fetal-Transfer Assessment of the Retinoid X Receptor Agonist Bexarotene. ACS Pharmacol Transl Sci . [DOI: 10.1021/acsptsci.2c00126] [Reference Citation Analysis]
23 Willems S, Kilu W, Ni X, Chaikuad A, Knapp S, Heering J, Merk D. The orphan nuclear receptor Nurr1 is responsive to non-steroidal anti-inflammatory drugs. Commun Chem 2020;3. [DOI: 10.1038/s42004-020-0331-0] [Cited by in Crossref: 10] [Cited by in F6Publishing: 5] [Article Influence: 5.0] [Reference Citation Analysis]
24 Heitel P, Faudone G, Helmstädter M, Schmidt J, Kaiser A, Tjaden A, Schröder M, Müller S, Schierle S, Pollinger J, Merk D. A triple farnesoid X receptor and peroxisome proliferator-activated receptor α/δ activator reverses hepatic fibrosis in diet-induced NASH in mice. Commun Chem 2020;3. [DOI: 10.1038/s42004-020-00411-z] [Cited by in Crossref: 3] [Cited by in F6Publishing: 2] [Article Influence: 1.5] [Reference Citation Analysis]