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For: Kaur M, Agarwal R. Silymarin and epithelial cancer chemoprevention: how close we are to bedside? Toxicol Appl Pharmacol 2007;224:350-9. [PMID: 17184801 DOI: 10.1016/j.taap.2006.11.011] [Cited by in Crossref: 54] [Cited by in F6Publishing: 52] [Article Influence: 3.4] [Reference Citation Analysis]
Number Citing Articles
1 Wadhwa K, Pahwa R, Kumar M, Kumar S, Sharma PC, Singh G, Verma R, Mittal V, Singh I, Kaushik D, Jeandet P. Mechanistic Insights into the Pharmacological Significance of Silymarin. Molecules 2022;27:5327. [PMID: 36014565 DOI: 10.3390/molecules27165327] [Reference Citation Analysis]
2 Melim C, Magalhães M, Santos AC, Campos EJ, Cabral C. Nanoparticles as phytochemical carriers for cancer treatment: News of the last decade. Expert Opin Drug Deliv 2022. [PMID: 35166619 DOI: 10.1080/17425247.2022.2041599] [Cited by in Crossref: 2] [Cited by in F6Publishing: 2] [Article Influence: 2.0] [Reference Citation Analysis]
3 Binienda A, Ziolkowska S, Pluciennik E. The Anticancer Properties of Silibinin: Its Molecular Mechanism and Therapeutic Effect in Breast Cancer. Anticancer Agents Med Chem 2020;20:1787-96. [PMID: 31858905 DOI: 10.2174/1871520620666191220142741] [Cited by in Crossref: 3] [Cited by in F6Publishing: 6] [Article Influence: 3.0] [Reference Citation Analysis]
4 Ashtiani HRA, Dadgar A, Akaberi M. Improvement of Cell Proliferation and Antioxidant Activity of Silymarin in Hair Follicles Dermal Papillae Isolated from the Human Scalp: Comparison with Vitamin C Effects. Int J Trichology 2020;12:168-75. [PMID: 33376286 DOI: 10.4103/ijt.ijt_124_19] [Cited by in F6Publishing: 1] [Reference Citation Analysis]
5 Aboelwafa HR, El-Kott AF, Abd-Ella EM, Yousef HN. The Possible Neuroprotective Effect of Silymarin against Aluminum Chloride-Prompted Alzheimer's-Like Disease in Rats. Brain Sci 2020;10:E628. [PMID: 32932753 DOI: 10.3390/brainsci10090628] [Cited by in Crossref: 10] [Cited by in F6Publishing: 15] [Article Influence: 5.0] [Reference Citation Analysis]
6 Lazzeroni M, Petrangolini G, Legarreta Iriberri JA, Pascual Avellana J, Tost Robusté D, Cagnacci S, Macis D, Aristarco V, Bonanni B, Morazzoni P, Johansson H, Riva A. Development of an HPLC-MS/MS Method for the Determination of Silybin in Human Plasma, Urine and Breast Tissue. Molecules 2020;25:E2918. [PMID: 32599946 DOI: 10.3390/molecules25122918] [Reference Citation Analysis]
7 Dobiasová S, Řehořová K, Kučerová D, Biedermann D, Káňová K, Petrásková L, Koucká K, Václavíková R, Valentová K, Ruml T, Macek T, Křen V, Viktorová J. Multidrug Resistance Modulation Activity of Silybin Derivatives and Their Anti-inflammatory Potential. Antioxidants (Basel) 2020;9:E455. [PMID: 32466263 DOI: 10.3390/antiox9050455] [Cited by in Crossref: 15] [Cited by in F6Publishing: 13] [Article Influence: 7.5] [Reference Citation Analysis]
8 Takke A, Shende P. Nanotherapeutic silibinin: An insight of phytomedicine in healthcare reformation. Nanomedicine: Nanotechnology, Biology and Medicine 2019;21:102057. [DOI: 10.1016/j.nano.2019.102057] [Cited by in Crossref: 17] [Cited by in F6Publishing: 17] [Article Influence: 5.7] [Reference Citation Analysis]
9 Peritore AF, Siracusa R, Crupi R, Cuzzocrea S. Therapeutic Efficacy of Palmitoylethanolamide and Its New Formulations in Synergy with Different Antioxidant Molecules Present in Diets. Nutrients 2019;11:E2175. [PMID: 31514292 DOI: 10.3390/nu11092175] [Cited by in Crossref: 20] [Cited by in F6Publishing: 25] [Article Influence: 6.7] [Reference Citation Analysis]
10 Stoev S, Njobeh P, Zarkov I, Mircheva T, Zapryanova D, Denev S, Dimitrova B. Selected herbal feed additives showing protective effects against ochratoxin A toxicosis in broiler chicks. World Mycotoxin Journal 2019;12:257-68. [DOI: 10.3920/wmj2019.2432] [Cited by in Crossref: 8] [Cited by in F6Publishing: 8] [Article Influence: 2.7] [Reference Citation Analysis]
11 Zhang T, Kawaguchi N, Yoshihara K, Hayama E, Furutani Y, Kawaguchi K, Tanaka T, Nakanishi T. Silibinin efficacy in a rat model of pulmonary arterial hypertension using monocrotaline and chronic hypoxia. Respir Res 2019;20:79. [PMID: 31023308 DOI: 10.1186/s12931-019-1041-y] [Cited by in Crossref: 5] [Cited by in F6Publishing: 10] [Article Influence: 1.7] [Reference Citation Analysis]
12 Kawaguchi N, Zhang TT, Nakanishi T. Involvement of CXCR4 in Normal and Abnormal Development. Cells 2019;8:E185. [PMID: 30791675 DOI: 10.3390/cells8020185] [Cited by in Crossref: 41] [Cited by in F6Publishing: 57] [Article Influence: 13.7] [Reference Citation Analysis]
13 Fernandes Veloso Borges F, Ribeiro E Silva C, Moreira Goes W, Ribeiro Godoy F, Craveiro Franco F, Hollanda Véras J, Luiz Cardoso Bailão EF, de Melo E Silva D, Gomes Cardoso C, Divino da Cruz A, Chen-Chen L. Protective Effects of Silymarin and Silibinin against DNA Damage in Human Blood Cells. Biomed Res Int 2018;2018:6056948. [PMID: 30370304 DOI: 10.1155/2018/6056948] [Cited by in Crossref: 8] [Cited by in F6Publishing: 8] [Article Influence: 2.0] [Reference Citation Analysis]
14 Ijaz S, Akhtar N, Khan MS, Hameed A, Irfan M, Arshad MA, Ali S, Asrar M. Plant derived anticancer agents: A green approach towards skin cancers. Biomedicine & Pharmacotherapy 2018;103:1643-51. [DOI: 10.1016/j.biopha.2018.04.113] [Cited by in Crossref: 32] [Cited by in F6Publishing: 54] [Article Influence: 8.0] [Reference Citation Analysis]
15 Cheng YY, Hsieh CH, Tsai TH. Concurrent administration of anticancer chemotherapy drug and herbal medicine on the perspective of pharmacokinetics. J Food Drug Anal 2018;26:S88-95. [PMID: 29703390 DOI: 10.1016/j.jfda.2018.01.003] [Cited by in Crossref: 28] [Cited by in F6Publishing: 34] [Article Influence: 7.0] [Reference Citation Analysis]
16 Bijak M, Synowiec E, Sitarek P, Sliwiński T, Saluk-Bijak J. Evaluation of the Cytotoxicity and Genotoxicity of Flavonolignans in Different Cellular Models. Nutrients 2017;9:E1356. [PMID: 29240674 DOI: 10.3390/nu9121356] [Cited by in Crossref: 15] [Cited by in F6Publishing: 18] [Article Influence: 3.0] [Reference Citation Analysis]
17 Bayram D, Çetin E, Kara M, Özgöçmen M, Candan I. The apoptotic effects of silibinin on MDA-MB-231 and MCF-7 human breast carcinoma cells. Hum Exp Toxicol 2017;36:573-86. [DOI: 10.1177/0960327116658105] [Cited by in Crossref: 7] [Cited by in F6Publishing: 9] [Article Influence: 1.2] [Reference Citation Analysis]
18 Borges FF, Silva CR, Véras JH, Cardoso CG, da Cruz AD, Chen LC. Antimutagenic, Antigenotoxic, and Anticytotoxic Activities of Silybum Marianum [L.] Gaertn Assessed by the Salmonella Mutagenicity Assay (Ames Test) and the Micronucleus Test in Mice Bone Marrow. Nutr Cancer 2016;68:848-55. [PMID: 27352027 DOI: 10.1080/01635581.2016.1180414] [Cited by in Crossref: 3] [Cited by in F6Publishing: 2] [Article Influence: 0.5] [Reference Citation Analysis]
19 Johannes J, Jayarama-Naidu R, Meyer F, Wirth EK, Schweizer U, Schomburg L, Köhrle J, Renko K. Silychristin, a Flavonolignan Derived From the Milk Thistle, Is a Potent Inhibitor of the Thyroid Hormone Transporter MCT8. Endocrinology 2016;157:1694-701. [PMID: 26910310 DOI: 10.1210/en.2015-1933] [Cited by in Crossref: 28] [Cited by in F6Publishing: 36] [Article Influence: 4.7] [Reference Citation Analysis]
20 Fan L, Ma Y, Liu Y, Zheng D, Huang G. Silymarin induces cell cycle arrest and apoptosis in ovarian cancer cells. European Journal of Pharmacology 2014;743:79-88. [DOI: 10.1016/j.ejphar.2014.09.019] [Cited by in Crossref: 35] [Cited by in F6Publishing: 44] [Article Influence: 4.4] [Reference Citation Analysis]
21 Murata N, Murakami K, Ozawa Y, Kinoshita N, Irie K, Shirasawa T, Shimizu T. Silymarin Attenuated the Amyloid β Plaque Burden and Improved Behavioral Abnormalities in an Alzheimer’s Disease Mouse Model. Bioscience, Biotechnology, and Biochemistry 2014;74:2299-306. [DOI: 10.1271/bbb.100524] [Cited by in Crossref: 43] [Cited by in F6Publishing: 45] [Article Influence: 5.4] [Reference Citation Analysis]
22 Ho BY, Lin CH, Apaya MK, Chao WW, Shyur LF. Silibinin and Paclitaxel Cotreatment Significantly Suppress the Activity and Lung Metastasis of Triple Negative 4T1 Mammary Tumor Cell in Mice. J Tradit Complement Med 2012;2:301-11. [PMID: 24716145 DOI: 10.1016/s2225-4110(16)30116-x] [Cited by in Crossref: 19] [Cited by in F6Publishing: 18] [Article Influence: 2.4] [Reference Citation Analysis]
23 Woo SM, Min K, Kim S, Park J, Kim DE, Chun K, Kim YH, Lee T, Kim SH, Choi YH, Chang J, Kwon TK. Silibinin induces apoptosis of HT29 colon carcinoma cells through early growth response-1 (EGR-1)-mediated non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) up-regulation. Chemico-Biological Interactions 2014;211:36-43. [DOI: 10.1016/j.cbi.2014.01.004] [Cited by in Crossref: 17] [Cited by in F6Publishing: 20] [Article Influence: 2.1] [Reference Citation Analysis]
24 Milić N, Milošević N, Suvajdžić L, Žarkov M, Abenavoli L. New Therapeutic Potentials of Milk Thistle ( Silybum marianum ). Natural Product Communications 2013;8:1934578X1300801. [DOI: 10.1177/1934578x1300801236] [Cited by in Crossref: 9] [Cited by in F6Publishing: 6] [Article Influence: 1.0] [Reference Citation Analysis]
25 Woo SM, Min K, Chae IG, Chun K, Kwon TK. Silymarin suppresses the PGE 2 -induced cell migration through inhibition of EP2 activation; G protein-dependent PKA-CREB and G protein-independent Src-STAT3 signal pathways: SILYMARIN INHIBITS THE PGE 2 -INDUCED MIGRATION. Mol Carcinog 2015;54:216-28. [DOI: 10.1002/mc.22092] [Cited by in Crossref: 9] [Cited by in F6Publishing: 9] [Article Influence: 1.0] [Reference Citation Analysis]
26 Lin CH, Li CH, Liao PL, Tse LS, Huang WK, Cheng HW, Cheng YW. Silibinin inhibits VEGF secretion and age-related macular degeneration in a hypoxia-dependent manner through the PI-3 kinase/Akt/mTOR pathway. Br J Pharmacol 2013;168:920-31. [PMID: 23004355 DOI: 10.1111/j.1476-5381.2012.02227.x] [Cited by in Crossref: 40] [Cited by in F6Publishing: 37] [Article Influence: 4.4] [Reference Citation Analysis]
27 Tanaka T. Role of Apoptosis in the Chemoprevention of Cancer. Journal of Experimental & Clinical Medicine 2013;5:89-91. [DOI: 10.1016/j.jecm.2013.04.001] [Cited by in Crossref: 9] [Cited by in F6Publishing: 6] [Article Influence: 1.0] [Reference Citation Analysis]
28 Nagy L, Kuki Á, Nagy T, Mándi A, Deák G, Nagy M, Batta G, Zsuga M, Kéki S. Collision-induced dissociation study of isosilychristin, a constituent of Silymarin: Letter to the Editor. Rapid Commun Mass Spectrom 2013;27:1413-6. [DOI: 10.1002/rcm.6581] [Cited by in Crossref: 2] [Cited by in F6Publishing: 1] [Article Influence: 0.2] [Reference Citation Analysis]
29 Cho HJ, Suh DS, Moon SH, Song YJ, Yoon MS, Park DY, Choi KU, Kim YK, Kim KH. Silibinin inhibits tumor growth through downregulation of extracellular signal-regulated kinase and Akt in vitro and in vivo in human ovarian cancer cells. J Agric Food Chem 2013;61:4089-96. [PMID: 23570653 DOI: 10.1021/jf400192v] [Cited by in Crossref: 20] [Cited by in F6Publishing: 22] [Article Influence: 2.2] [Reference Citation Analysis]
30 Blaylock RL. Immunoexcitatory mechanisms in glioma proliferation, invasion and occasional metastasis. Surg Neurol Int 2013;4:15. [PMID: 23493580 DOI: 10.4103/2152-7806.106577] [Cited by in Crossref: 8] [Cited by in F6Publishing: 11] [Article Influence: 0.9] [Reference Citation Analysis]
31 Stagos D, Amoutzias GD, Matakos A, Spyrou A, Tsatsakis AM, Kouretas D. Chemoprevention of liver cancer by plant polyphenols. Food and Chemical Toxicology 2012;50:2155-70. [DOI: 10.1016/j.fct.2012.04.002] [Cited by in Crossref: 100] [Cited by in F6Publishing: 102] [Article Influence: 10.0] [Reference Citation Analysis]
32 Nejati-Koshki K, Zarghami N, Pourhassan-Moghaddam M, Rahmati-Yamchi M, Mollazade M, Nasiri M, Esfahlan RJ, Barkhordari A, Tayefi-Nasrabadi H. Inhibition of leptin gene expression and secretion by silibinin: possible role of estrogen receptors. Cytotechnology 2012;64:719-26. [PMID: 22526491 DOI: 10.1007/s10616-012-9452-3] [Cited by in Crossref: 24] [Cited by in F6Publishing: 25] [Article Influence: 2.4] [Reference Citation Analysis]
33 Sangeetha N, Viswanathan P, Balasubramanian T, Nalini N. Colon cancer chemopreventive efficacy of silibinin through perturbation of xenobiotic metabolizing enzymes in experimental rats. European Journal of Pharmacology 2012;674:430-8. [DOI: 10.1016/j.ejphar.2011.11.008] [Cited by in Crossref: 24] [Cited by in F6Publishing: 24] [Article Influence: 2.4] [Reference Citation Analysis]
34 Toyoda-hokaiwado N, Yasui Y, Muramatsu M, Masumura K, Takamune M, Yamada M, Ohta T, Tanaka T, Nohmi T. Chemopreventive effects of silymarin against 1,2-dimethylhydrazine plus dextran sodium sulfate-induced inflammation-associated carcinogenicity and genotoxicity in the colon of gpt delta rats. Carcinogenesis 2011;32:1512-7. [DOI: 10.1093/carcin/bgr130] [Cited by in Crossref: 14] [Cited by in F6Publishing: 13] [Article Influence: 1.3] [Reference Citation Analysis]
35 Das S, Roy P, Auddy RG, Mukherjee A. Silymarin nanoparticle prevents paracetamol-induced hepatotoxicity. Int J Nanomedicine 2011;6:1291-301. [PMID: 21753880 DOI: 10.2147/IJN.S15160] [Cited by in Crossref: 5] [Cited by in F6Publishing: 20] [Article Influence: 0.5] [Reference Citation Analysis]
36 Jiang YY, Huang H, Wang HJ, Wu D, Yang R, Tashiro S, Onodera S, Ikejima T. Interruption of mitochondrial complex IV activity and cytochrome c expression activated O₂·⁻-mediated cell survival in silibinin-treated human melanoma A375-S2 cells via IGF-1R-PI3K-Akt and IGF-1R-PLC γ-PKC pathways. Eur J Pharmacol 2011;668:78-87. [PMID: 21703257 DOI: 10.1016/j.ejphar.2011.06.007] [Cited by in Crossref: 13] [Cited by in F6Publishing: 12] [Article Influence: 1.2] [Reference Citation Analysis]
37 Banaee M, Sureda A, Mirvaghefi AR, Rafei GR. Effects of long-term silymarin oral supplementation on the blood biochemical profile of rainbow trout (Oncorhynchus mykiss). Fish Physiol Biochem 2011;37:885-96. [PMID: 21519846 DOI: 10.1007/s10695-011-9486-z] [Cited by in Crossref: 30] [Cited by in F6Publishing: 38] [Article Influence: 2.7] [Reference Citation Analysis]
38 Jeong JC, Shin WY, Kim TH, Kwon CH, Kim JH, Kim YK, Kim KH. Silibinin induces apoptosis via calpain-dependent AIF nuclear translocation in U87MG human glioma cell death. J Exp Clin Cancer Res 2011;30:44. [PMID: 21501525 DOI: 10.1186/1756-9966-30-44] [Cited by in Crossref: 24] [Cited by in F6Publishing: 23] [Article Influence: 2.2] [Reference Citation Analysis]
39 Noh EM, Yi MS, Youn HJ, Lee BK, Lee YR, Han JH, Yu HN, Kim JS, Jung SH. Silibinin enhances ultraviolet B-induced apoptosis in mcf-7 human breast cancer cells. J Breast Cancer 2011;14:8-13. [PMID: 21847388 DOI: 10.4048/jbc.2011.14.1.8] [Cited by in Crossref: 17] [Cited by in F6Publishing: 17] [Article Influence: 1.5] [Reference Citation Analysis]
40 Tiwari P, Kumar A, Balakrishnan S, Kushwaha HS, Mishra KP. Silibinin-induced apoptosis in MCF7 and T47D human breast carcinoma cells involves caspase-8 activation and mitochondrial pathway. Cancer Invest 2011;29:12-20. [PMID: 21166494 DOI: 10.3109/07357907.2010.535053] [Cited by in Crossref: 23] [Cited by in F6Publishing: 24] [Article Influence: 2.1] [Reference Citation Analysis]
41 Colombo V, Lupi M, Falcetta F, Forestieri D, D'Incalci M, Ubezio P. Chemotherapeutic activity of silymarin combined with doxorubicin or paclitaxel in sensitive and multidrug-resistant colon cancer cells. Cancer Chemother Pharmacol 2011;67:369-79. [PMID: 20431887 DOI: 10.1007/s00280-010-1335-8] [Cited by in Crossref: 26] [Cited by in F6Publishing: 19] [Article Influence: 2.2] [Reference Citation Analysis]
42 Rajamanickam S, Velmurugan B, Kaur M, Singh RP, Agarwal R. Chemoprevention of intestinal tumorigenesis in APCmin/+ mice by silibinin. Cancer Res. 2010;70:2368-2378. [PMID: 20215518 DOI: 10.1158/0008-5472.can-09-3249] [Cited by in Crossref: 62] [Cited by in F6Publishing: 57] [Article Influence: 5.2] [Reference Citation Analysis]
43 Shaker E, Mahmoud H, Mnaa S. Silymarin, the antioxidant component and Silybum marianum extracts prevent liver damage. Food and Chemical Toxicology 2010;48:803-6. [DOI: 10.1016/j.fct.2009.12.011] [Cited by in Crossref: 142] [Cited by in F6Publishing: 142] [Article Influence: 11.8] [Reference Citation Analysis]
44 Schmit TL, Ledesma MC, Ahmad N. Modulating polo-like kinase 1 as a means for cancer chemoprevention. Pharm Res 2010;27:989-98. [PMID: 20107874 DOI: 10.1007/s11095-010-0051-8] [Cited by in Crossref: 22] [Cited by in F6Publishing: 20] [Article Influence: 1.8] [Reference Citation Analysis]
45 Li L, Zeng J, Gao Y, He D. Targeting silibinin in the antiproliferative pathway. Expert Opinion on Investigational Drugs 2010;19:243-55. [DOI: 10.1517/13543780903533631] [Cited by in Crossref: 43] [Cited by in F6Publishing: 36] [Article Influence: 3.6] [Reference Citation Analysis]
46 Galhardi F, Mesquita K, Monserrat J, Barros D. Effect of silymarin on biochemical parameters of oxidative stress in aged and young rat brain. Food and Chemical Toxicology 2009;47:2655-60. [DOI: 10.1016/j.fct.2009.07.030] [Cited by in Crossref: 36] [Cited by in F6Publishing: 36] [Article Influence: 2.8] [Reference Citation Analysis]
47 Ramakrishnan G, Lo Muzio L, Elinos-Báez CM, Jagan S, Augustine TA, Kamaraj S, Anandakumar P, Devaki T. Silymarin inhibited proliferation and induced apoptosis in hepatic cancer cells. Cell Prolif. 2009;42:229-240. [PMID: 19317806 DOI: 10.1111/j.1365-2184.2008.00581.x] [Cited by in Crossref: 47] [Cited by in F6Publishing: 50] [Article Influence: 3.6] [Reference Citation Analysis]
48 Kim KW, Choi CH, Kim TH, Kwon CH, Woo JS, Kim YK. Silibinin inhibits glioma cell proliferation via Ca2+/ROS/MAPK-dependent mechanism in vitro and glioma tumor growth in vivo. Neurochem Res 2009;34:1479-90. [PMID: 19263218 DOI: 10.1007/s11064-009-9935-6] [Cited by in Crossref: 37] [Cited by in F6Publishing: 37] [Article Influence: 2.8] [Reference Citation Analysis]
49 Deep G, Raina K, Singh RP, Oberlies NH, Kroll DJ, Agarwal R. Isosilibinin inhibits advanced human prostate cancer growth in athymic nude mice: comparison with silymarin and silibinin. Int J Cancer 2008;123:2750-8. [PMID: 18798272 DOI: 10.1002/ijc.23879] [Cited by in Crossref: 29] [Cited by in F6Publishing: 29] [Article Influence: 2.2] [Reference Citation Analysis]
50 Wu J, Lin L, Tsai T. Drug–drug interactions of silymarin on the perspective of pharmacokinetics. Journal of Ethnopharmacology 2009;121:185-93. [DOI: 10.1016/j.jep.2008.10.036] [Cited by in Crossref: 101] [Cited by in F6Publishing: 96] [Article Influence: 7.8] [Reference Citation Analysis]
51 Ramakrishnan G, Jagan S, Kamaraj S, Anandakumar P, Devaki T. Silymarin attenuated mast cell recruitment thereby decreased the expressions of matrix metalloproteinases-2 and 9 in rat liver carcinogenesis. Invest New Drugs 2009;27:233-40. [DOI: 10.1007/s10637-008-9163-y] [Cited by in Crossref: 22] [Cited by in F6Publishing: 20] [Article Influence: 1.6] [Reference Citation Analysis]
52 Tyagi A, Sharma Y, Agarwal C, Agarwal R. Silibinin impairs constitutively active TGFalpha-EGFR autocrine loop in advanced human prostate carcinoma cells. Pharm Res 2008;25:2143-50. [PMID: 18253818 DOI: 10.1007/s11095-008-9545-z] [Cited by in Crossref: 22] [Cited by in F6Publishing: 18] [Article Influence: 1.6] [Reference Citation Analysis]