BPG is committed to discovery and dissemination of knowledge
Cited by in F6Publishing
For: Caglayan C, Kandemir FM, Darendelioğlu E, Yıldırım S, Kucukler S, Dortbudak MB. Rutin ameliorates mercuric chloride-induced hepatotoxicity in rats via interfering with oxidative stress, inflammation and apoptosis. J Trace Elem Med Biol 2019;56:60-8. [PMID: 31442956 DOI: 10.1016/j.jtemb.2019.07.011] [Cited by in Crossref: 38] [Cited by in F6Publishing: 34] [Article Influence: 12.7] [Reference Citation Analysis]
Number Citing Articles
1 Li Z, Yang Y, Liu M, Zhang C, Shao J, Hou X, Tian J, Cui Q. A comprehensive review on phytochemistry, bioactivities, toxicity studies, and clinical studies on Ficus carica Linn. leaves. Biomed Pharmacother 2021;137:111393. [PMID: 33761610 DOI: 10.1016/j.biopha.2021.111393] [Cited by in Crossref: 2] [Article Influence: 2.0] [Reference Citation Analysis]
2 Khan A, Iqubal A, Haque SE. Combinatorial Delivery of Cinnamaldehyde and Quercetin Ameliorates Isoproterenol-Induced Cardiac Inflammation, Apoptosis and Myocardial Infarction via Modulation of NF-kB P65 and Cleaved Caspase-3 Signaling Molecules in Wistar Rats. Pharm Chem J. [DOI: 10.1007/s11094-022-02621-2] [Reference Citation Analysis]
3 Alhusaini A, Alghilani S, Alhuqbani W, Hasan IH. Vitamin E and Lactobacillus Provide Protective Effects Against Liver Injury Induced by HgCl2: Role of CHOP, GPR87, and mTOR Proteins. Dose Response 2021;19:15593258211011360. [PMID: 33994889 DOI: 10.1177/15593258211011360] [Reference Citation Analysis]
4 Yardim A, Kandemir FM, Ozdemir S, Kucukler S, Comakli S, Gur C, Celik H. Quercetin provides protection against the peripheral nerve damage caused by vincristine in rats by suppressing caspase 3, NF-κB, ATF-6 pathways and activating Nrf2, Akt pathways. Neurotoxicology 2020;81:137-46. [PMID: 33038355 DOI: 10.1016/j.neuro.2020.10.001] [Cited by in Crossref: 8] [Cited by in F6Publishing: 6] [Article Influence: 4.0] [Reference Citation Analysis]
5 Lv S, Yu H, Liu X, Gao X. The Study on the Mechanism of Hugan Tablets in Treating Drug-Induced Liver Injury Induced by Atorvastatin. Front Pharmacol 2021;12:683707. [PMID: 34262454 DOI: 10.3389/fphar.2021.683707] [Reference Citation Analysis]
6 Kandemir FM, Ileriturk M, Gur C. Rutin protects rat liver and kidney from sodium valproate-induce damage by attenuating oxidative stress, ER stress, inflammation, apoptosis and autophagy. Mol Biol Rep. [DOI: 10.1007/s11033-022-07395-0] [Reference Citation Analysis]
7 Stratakis N, Golden-Mason L, Margetaki K, Zhao Y, Valvi D, Garcia E, Maitre L, Andrusaityte S, Basagana X, Borràs E, Bustamante M, Casas M, Fossati S, Grazuleviciene R, Haug LS, Heude B, McEachan RRC, Meltzer HM, Papadopoulou E, Roumeliotaki T, Robinson O, Sabidó E, Urquiza J, Vafeiadi M, Varo N, Wright J, Vos MB, Hu H, Vrijheid M, Berhane KT, Conti DV, McConnell R, Rosen HR, Chatzi L. In Utero Exposure to Mercury Is Associated With Increased Susceptibility to Liver Injury and Inflammation in Childhood. Hepatology 2021;74:1546-59. [PMID: 33730435 DOI: 10.1002/hep.31809] [Cited by in Crossref: 2] [Cited by in F6Publishing: 1] [Article Influence: 2.0] [Reference Citation Analysis]
8 Chu JH, Yan YX, Gao PC, Chen XW, Fan RF. Response of selenoproteins gene expression profile to mercuric chloride exposure in chicken kidney. Res Vet Sci 2020;133:4-11. [PMID: 32916514 DOI: 10.1016/j.rvsc.2020.08.020] [Cited by in Crossref: 2] [Cited by in F6Publishing: 1] [Article Influence: 1.0] [Reference Citation Analysis]
9 Pinto DCGA, Simões MAM, Silva AMS. Genista tridentata L.: A Rich Source of Flavonoids with Anti-inflammatory Activity. Medicines (Basel) 2020;7:E31. [PMID: 32486147 DOI: 10.3390/medicines7060031] [Cited by in Crossref: 2] [Cited by in F6Publishing: 1] [Article Influence: 1.0] [Reference Citation Analysis]
10 Yıldız MO, Çelik H, Caglayan C, Genç A, Doğan T, Satıcı E. Neuroprotective effects of carvacrol against cadmium-induced neurotoxicity in rats: role of oxidative stress, inflammation and apoptosis. Metab Brain Dis 2022. [PMID: 35316447 DOI: 10.1007/s11011-022-00945-2] [Cited by in Crossref: 1] [Article Influence: 1.0] [Reference Citation Analysis]
11 Albasher G, Alkahtani S, Alarifi S. Berberine mitigates oxidative damage associated with testicular impairment following mercury chloride intoxication. J Food Biochem 2020;44:e13385. [PMID: 33460233 DOI: 10.1111/jfbc.13385] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 0.5] [Reference Citation Analysis]
12 Tian C, Shao Y, Jin Z, Liang Y, Li C, Qu C, Sun S, Cui C, Liu M. The protective effect of rutin against lipopolysaccharide induced acute lung injury in mice based on the pharmacokinetic and pharmacodynamic combination model. J Pharm Biomed Anal 2021;209:114480. [PMID: 34839052 DOI: 10.1016/j.jpba.2021.114480] [Reference Citation Analysis]
13 Gao PC, Chu JH, Chen XW, Li LX, Fan RF. Selenium alleviates mercury chloride-induced liver injury by regulating mitochondrial dynamics to inhibit the crosstalk between energy metabolism disorder and NF-κB/NLRP3 inflammasome-mediated inflammation. Ecotoxicol Environ Saf 2021;228:113018. [PMID: 34837874 DOI: 10.1016/j.ecoenv.2021.113018] [Reference Citation Analysis]
14 Küçükler S, Çomaklı S, Özdemir S, Çağlayan C, Kandemir FM. Hesperidin protects against the chlorpyrifos-induced chronic hepato-renal toxicity in rats associated with oxidative stress, inflammation, apoptosis, autophagy, and up-regulation of PARP-1/VEGF. Environ Toxicol 2021;36:1600-17. [PMID: 33908150 DOI: 10.1002/tox.23156] [Cited by in Crossref: 1] [Cited by in F6Publishing: 4] [Article Influence: 1.0] [Reference Citation Analysis]
15 Küçükler S, Kandemir FM, Özdemir S, Çomaklı S, Caglayan C. Protective effects of rutin against deltamethrin-induced hepatotoxicity and nephrotoxicity in rats via regulation of oxidative stress, inflammation, and apoptosis. Environ Sci Pollut Res Int 2021. [PMID: 34218375 DOI: 10.1007/s11356-021-15190-w] [Reference Citation Analysis]
16 Renu K, Chakraborty R, Myakala H, Koti R, Famurewa AC, Madhyastha H, Vellingiri B, George A, Valsala Gopalakrishnan A. Molecular mechanism of heavy metals (Lead, Chromium, Arsenic, Mercury, Nickel and Cadmium) - induced hepatotoxicity - A review. Chemosphere 2021;271:129735. [PMID: 33736223 DOI: 10.1016/j.chemosphere.2021.129735] [Cited by in Crossref: 15] [Cited by in F6Publishing: 11] [Article Influence: 15.0] [Reference Citation Analysis]
17 Kucukler S, Caglayan C, Darendelioğlu E, Kandemir FM. Morin attenuates acrylamide-induced testicular toxicity in rats by regulating the NF-κB, Bax/Bcl-2 and PI3K/Akt/mTOR signaling pathways. Life Sci 2020;261:118301. [PMID: 32827546 DOI: 10.1016/j.lfs.2020.118301] [Cited by in Crossref: 8] [Cited by in F6Publishing: 7] [Article Influence: 4.0] [Reference Citation Analysis]
18 Almeer RS, Alkahtani S, Alarifi S, Moneim AEA, Abdi S, Albasher G. Ziziphus spina-christi Leaf Extract Mitigates Mercuric Chloride-induced Cortical Damage in Rats. Comb Chem High Throughput Screen 2022;25:103-13. [PMID: 33280592 DOI: 10.2174/1386207323666201204124412] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 1.0] [Reference Citation Analysis]
19 Kucukler S, Darendelioğlu E, Caglayan C, Ayna A, Yıldırım S, Kandemir FM. Zingerone attenuates vancomycin-induced hepatotoxicity in rats through regulation of oxidative stress, inflammation and apoptosis. Life Sci 2020;259:118382. [PMID: 32898532 DOI: 10.1016/j.lfs.2020.118382] [Cited by in Crossref: 7] [Cited by in F6Publishing: 3] [Article Influence: 3.5] [Reference Citation Analysis]
20 Oluranti OI, Adeyemo VA, Achile EO, Fatokun BP, Ojo AO. Rutin Improves Cardiac and Erythrocyte Membrane-Bound ATPase Activities in Male Rats Exposed to Cadmium Chloride and Lead Acetate. Biol Trace Elem Res 2021. [PMID: 33844168 DOI: 10.1007/s12011-021-02711-4] [Cited by in Crossref: 2] [Cited by in F6Publishing: 2] [Article Influence: 2.0] [Reference Citation Analysis]
21 Liu L, Zhao L, Liu Y, Yu X, Qiao X. Rutin Ameliorates Cadmium-Induced Necroptosis in the Chicken Liver via Inhibiting Oxidative Stress and MAPK/NF-κB Pathway. Biol Trace Elem Res 2021. [PMID: 34091842 DOI: 10.1007/s12011-021-02764-5] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 1.0] [Reference Citation Analysis]
22 Sheta NM, Boshra SA, Mamdouh MA, Abdel-Haleem KM. Design and optimization of silymarin loaded in lyophilized fast melt tablets to attenuate lung toxicity induced via HgCl2 in rats. Drug Deliv 2022;29:1299-311. [PMID: 35470762 DOI: 10.1080/10717544.2022.2068696] [Reference Citation Analysis]
23 Arab-Nozari M, Ahangar N, Mohammadi E, Lorigooini Z, Shokrzadeh M, Amiri FT, Shaki F. Ginkgo biloba attenuated hepatotoxicity induced by combined exposure to cadmium and fluoride via modulating the redox imbalance, Bax/Bcl-2 and NF-kB signaling pathways in male rats. Mol Biol Rep 2020;47:6961-72. [PMID: 32920758 DOI: 10.1007/s11033-020-05755-2] [Cited by in Crossref: 1] [Article Influence: 0.5] [Reference Citation Analysis]
24 Boudreau A, Richard AJ, Harvey I, Stephens JM. Artemisia scoparia and Metabolic Health: Untapped Potential of an Ancient Remedy for Modern Use. Front Endocrinol 2022;12:727061. [DOI: 10.3389/fendo.2021.727061] [Reference Citation Analysis]
25 Han B, Lv Z, Han X, Li S, Han B, Yang Q, Wang X, Wu P, Li J, Deng N, Zhang Z. Harmful Effects of Inorganic Mercury Exposure on Kidney Cells: Mitochondrial Dynamics Disorder and Excessive Oxidative Stress. Biol Trace Elem Res 2021. [PMID: 34060062 DOI: 10.1007/s12011-021-02766-3] [Cited by in Crossref: 14] [Cited by in F6Publishing: 12] [Article Influence: 14.0] [Reference Citation Analysis]
26 Guo W, Xiang Q, Mao B, Tang X, Cui S, Li X, Zhao J, Zhang H, Chen W. Protective Effects of Microbiome-Derived Inosine on Lipopolysaccharide-Induced Acute Liver Damage and Inflammation in Mice via Mediating the TLR4/NF-κB Pathway. J Agric Food Chem 2021;69:7619-28. [PMID: 34156842 DOI: 10.1021/acs.jafc.1c01781] [Reference Citation Analysis]
27 Celik H, Kucukler S, Ozdemir S, Comakli S, Gur C, Kandemir FM, Yardim A. Lycopene protects against central and peripheral neuropathy by inhibiting oxaliplatin-induced ATF-6 pathway, apoptosis, inflammation and oxidative stress in brains and sciatic tissues of rats. Neurotoxicology 2020;80:29-40. [PMID: 32544411 DOI: 10.1016/j.neuro.2020.06.005] [Cited by in Crossref: 11] [Cited by in F6Publishing: 9] [Article Influence: 5.5] [Reference Citation Analysis]
28 Li S, Zhang Q, Ding Y, Wang X, Liu P. Flavonoids ameliorate aluminum chloride-induced learning and memory impairments via suppression of apoptosis and oxidative stress in rats. J Inorg Biochem 2020;212:111252. [PMID: 32950828 DOI: 10.1016/j.jinorgbio.2020.111252] [Cited by in Crossref: 1] [Article Influence: 0.5] [Reference Citation Analysis]
29 Yardım A, Kucukler S, Özdemir S, Çomaklı S, Caglayan C, Kandemir FM, Çelik H. Silymarin alleviates docetaxel-induced central and peripheral neurotoxicity by reducing oxidative stress, inflammation and apoptosis in rats. Gene 2021;769:145239. [PMID: 33069805 DOI: 10.1016/j.gene.2020.145239] [Cited by in Crossref: 4] [Cited by in F6Publishing: 2] [Article Influence: 2.0] [Reference Citation Analysis]
30 Li N, Liu J, Yang L, Kang Y, Cao Y, Chen K, Sun H, Chen W, Dai Q, Sakai Y. Synergistic effect of antioxidant systems enhance cadmium phytoextraction and translocation in Amaranthus hypochondriacus under rutin application. South African Journal of Botany 2022;149:582-90. [DOI: 10.1016/j.sajb.2022.06.053] [Reference Citation Analysis]
31 Yesildag K, Gur C, Ileriturk M, Kandemir FM. Evaluation of oxidative stress, inflammation, apoptosis, oxidative DNA damage and metalloproteinases in the lungs of rats treated with cadmium and carvacrol. Mol Biol Rep 2021. [PMID: 34792728 DOI: 10.1007/s11033-021-06948-z] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 1.0] [Reference Citation Analysis]
32 Ileriturk M, Kandemir O, Kandemir FM. Evaluation of protective effects of quercetin against cypermethrin-induced lung toxicity in rats via oxidative stress, inflammation, apoptosis, autophagy, and endoplasmic reticulum stress pathway. Environ Toxicol 2022. [PMID: 35876585 DOI: 10.1002/tox.23624] [Reference Citation Analysis]
33 Muvhulawa N, Dludla PV, Ziqubu K, Mthembu SX, Mthiyane F, Nkambule BB, Mazibuko-mbeje SE. Rutin ameliorates inflammation and improves metabolic function: A comprehensive analysis of scientific literature. Pharmacological Research 2022. [DOI: 10.1016/j.phrs.2022.106163] [Cited by in Crossref: 2] [Cited by in F6Publishing: 1] [Article Influence: 2.0] [Reference Citation Analysis]
34 Luiz TC, Da Cunha APS, Aguiar DH, Sugui MM, Bicudo RDC, Sinhorin AP, Sinhorin VDG. Antioxidant potential of Carica papaya Linn (Caricaceae) leaf extract in mice with cyclophosphamide induced oxidative stress. Sci Med 2020;30:e34702. [DOI: 10.15448/1980-6108.2020.1.34702] [Cited by in Crossref: 1] [Article Influence: 0.5] [Reference Citation Analysis]
35 Çelik H, Kandemir FM, Caglayan C, Özdemir S, Çomaklı S, Kucukler S, Yardım A. Neuroprotective effect of rutin against colistin-induced oxidative stress, inflammation and apoptosis in rat brain associated with the CREB/BDNF expressions. Mol Biol Rep 2020;47:2023-34. [PMID: 32030599 DOI: 10.1007/s11033-020-05302-z] [Cited by in Crossref: 22] [Cited by in F6Publishing: 22] [Article Influence: 11.0] [Reference Citation Analysis]
36 Mesalam NM, Aldhumri SA, Gabr SA, Ibrahim MA, Al-Mokaddem AK, Abdel-Moneim AE. Putative abrogation impacts of Ajwa seeds on oxidative damage, liver dysfunction and associated complications in rats exposed to carbon tetrachloride. Mol Biol Rep 2021;48:5305-18. [PMID: 34244886 DOI: 10.1007/s11033-021-06544-1] [Reference Citation Analysis]
37 Çelik H, Kucukler S, Çomaklı S, Caglayan C, Özdemir S, Yardım A, Karaman M, Kandemir FM. Neuroprotective effect of chrysin on isoniazid-induced neurotoxicity via suppression of oxidative stress, inflammation and apoptosis in rats. Neurotoxicology 2020;81:197-208. [PMID: 33121995 DOI: 10.1016/j.neuro.2020.10.009] [Cited by in Crossref: 7] [Cited by in F6Publishing: 5] [Article Influence: 3.5] [Reference Citation Analysis]
38 Fu K, Wang C, Ma C, Zhou H, Li Y. The Potential Application of Chinese Medicine in Liver Diseases: A New Opportunity. Front Pharmacol 2021;12:771459. [PMID: 34803712 DOI: 10.3389/fphar.2021.771459] [Reference Citation Analysis]
39 Kucukler S, Benzer F, Yildirim S, Gur C, Kandemir FM, Bengu AS, Ayna A, Caglayan C, Dortbudak MB. Protective Effects of Chrysin Against Oxidative Stress and Inflammation Induced by Lead Acetate in Rat Kidneys: a Biochemical and Histopathological Approach. Biol Trace Elem Res 2021;199:1501-14. [PMID: 32613487 DOI: 10.1007/s12011-020-02268-8] [Cited by in Crossref: 21] [Cited by in F6Publishing: 18] [Article Influence: 10.5] [Reference Citation Analysis]
40 Caglayan C, Kandemir FM, Darendelioğlu E, Küçükler S, Ayna A. Hesperidin protects liver and kidney against sodium fluoride-induced toxicity through anti-apoptotic and anti-autophagic mechanisms. Life Sci 2021;281:119730. [PMID: 34147482 DOI: 10.1016/j.lfs.2021.119730] [Cited by in F6Publishing: 1] [Reference Citation Analysis]
41 Wang F, Long S, Zhang J. Moringa oleifera Lam. leaf extract safely inhibits periodontitis by regulating the expression of p38α/MAPK14-OPG/RANKL. Arch Oral Biol 2021;132:105280. [PMID: 34678605 DOI: 10.1016/j.archoralbio.2021.105280] [Reference Citation Analysis]
42 Zhao B, Zhang W, Xiong Y, Zhang Y, Zhang D, Xu X. Effects of rutin on the oxidative stress, proliferation and osteogenic differentiation of periodontal ligament stem cells in LPS-induced inflammatory environment and the underlying mechanism. J Mol Hist 2020;51:161-71. [DOI: 10.1007/s10735-020-09866-9] [Cited by in Crossref: 7] [Cited by in F6Publishing: 7] [Article Influence: 3.5] [Reference Citation Analysis]
43 Ijinu TP, Manikantan K, Aneeshkumar AL, Soorya V, Latha PG, George V, Pushpangadan P. Ameliorative effect of the ethnomedicinal plant Blepharis maderaspatensis (L.) B.Heyne ex Roth on lipopolysaccharide-induced acute liver inflammation and oxidative stress in Wistar rat model. Phytomedicine Plus 2022;2:100247. [DOI: 10.1016/j.phyplu.2022.100247] [Reference Citation Analysis]
44 Över SB, Güven C, Taskin E, Sevgiler Y. Oxidative and apoptotic effects of fluoxetine and its metabolite norfluoxetine in Daphnia magna. Arh Hig Rada Toksikol 2020;71:211-22. [PMID: 33074175 DOI: 10.2478/aiht-2020-71-3473] [Cited by in Crossref: 1] [Cited by in F6Publishing: 2] [Article Influence: 0.5] [Reference Citation Analysis]
45 Kandemir FM, Yıldırım S, Kucukler S, Caglayan C, Darendelioğlu E, Dortbudak MB. Protective effects of morin against acrylamide-induced hepatotoxicity and nephrotoxicity: A multi-biomarker approach. Food Chem Toxicol 2020;138:111190. [PMID: 32068001 DOI: 10.1016/j.fct.2020.111190] [Cited by in Crossref: 27] [Cited by in F6Publishing: 22] [Article Influence: 13.5] [Reference Citation Analysis]
46 Liu M, Qiu Z, Zhao X, Sun L, Wang L, Ren X, Deng Y, Mafra I. Assessing the Quality of Calyx of Physalis alkekengi L. var. franchetii Based on Quantitative Analysis of Q-Marker Combined with Chemometrics and Machine Learning Algorithms. Journal of Chemistry 2021;2021:1-11. [DOI: 10.1155/2021/8502929] [Reference Citation Analysis]
47 Iova GM, Calniceanu H, Popa A, Szuhanek CA, Marcu O, Ciavoi G, Scrobota I. The Antioxidant Effect of Curcumin and Rutin on Oxidative Stress Biomarkers in Experimentally Induced Periodontitis in Hyperglycemic Wistar Rats. Molecules 2021;26:1332. [PMID: 33801378 DOI: 10.3390/molecules26051332] [Cited by in F6Publishing: 2] [Reference Citation Analysis]
48 Temel Y, Kucukler S, Yıldırım S, Caglayan C, Kandemir FM. Protective effect of chrysin on cyclophosphamide-induced hepatotoxicity and nephrotoxicity via the inhibition of oxidative stress, inflammation, and apoptosis. Naunyn Schmiedebergs Arch Pharmacol 2020;393:325-37. [PMID: 31620822 DOI: 10.1007/s00210-019-01741-z] [Cited by in Crossref: 24] [Cited by in F6Publishing: 20] [Article Influence: 8.0] [Reference Citation Analysis]
49 Iqubal A, Syed MA, Ali J, Najmi AK, Haque MM, Haque SE. Nerolidol protects the liver against cyclophosphamide-induced hepatic inflammation, apoptosis, and fibrosis via modulation of Nrf2, NF-κB p65, and caspase-3 signaling molecules in Swiss albino mice. Biofactors 2020;46:963-73. [PMID: 32941697 DOI: 10.1002/biof.1679] [Cited by in Crossref: 11] [Cited by in F6Publishing: 9] [Article Influence: 5.5] [Reference Citation Analysis]
50 Gao PC, Chen XW, Chu JH, Li LX, Wang ZY, Fan RF. Antagonistic effect of selenium on mercuric chloride in the central immune organs of chickens: The role of microRNA-183/135b-FOXO1/TXNIP/NLRP3 inflammasome axis. Environ Toxicol 2022. [PMID: 34995020 DOI: 10.1002/tox.23463] [Reference Citation Analysis]
51 Cai Y, Zheng Q, Sun R, Wu J, Li X, Liu R. Recent progress in the study of Artemisiae Scopariae Herba (Yin Chen), a promising medicinal herb for liver diseases. Biomedicine & Pharmacotherapy 2020;130:110513. [DOI: 10.1016/j.biopha.2020.110513] [Cited by in Crossref: 4] [Cited by in F6Publishing: 4] [Article Influence: 2.0] [Reference Citation Analysis]
52 Kandemir FM, Caglayan C, Aksu EH, Yildirim S, Kucukler S, Gur C, Eser G. Protective effect of rutin on mercuric chloride-induced reproductive damage in male rats. Andrologia 2020;52:e13524. [PMID: 32022330 DOI: 10.1111/and.13524] [Cited by in Crossref: 15] [Cited by in F6Publishing: 13] [Article Influence: 7.5] [Reference Citation Analysis]
53 Salinas-Nolasco C, Barragán-Zarate GS, Lagunez-Rivera L, Solano R, Favari L, Jiménez-Andrade JM, Chávez-Piña AE. Role of LTB4 and nitric oxide in the gastroprotective effect of Prosthechea karwinskii leaves extract in the indomethacin-induced gastric injury in the rat. Nat Prod Res 2022;:1-4. [PMID: 35722687 DOI: 10.1080/14786419.2022.2089880] [Reference Citation Analysis]