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For: Li L, Gao Y, Zhang L, Zeng J, He D, Sun Y. Silibinin inhibits cell growth and induces apoptosis by caspase activation, down-regulating survivin and blocking EGFR–ERK activation in renal cell carcinoma. Cancer Letters 2008;272:61-9. [DOI: 10.1016/j.canlet.2008.06.033] [Cited by in Crossref: 62] [Cited by in F6Publishing: 45] [Article Influence: 4.4] [Reference Citation Analysis]
Number Citing Articles
1 Shete MB, Deshpande AS, Shende P. Silybin-based herbal nanocarriers: an advancement in anticancer therapy. Materials Technology. [DOI: 10.1080/10667857.2022.2081286] [Reference Citation Analysis]
2 Koltai T, Fliegel L. Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions. J Evid Based Integr Med 2022;27:2515690X211068826. [PMID: 35018864 DOI: 10.1177/2515690X211068826] [Cited by in Crossref: 2] [Cited by in F6Publishing: 1] [Article Influence: 2.0] [Reference Citation Analysis]
3 Li F, Aljahdali IAM, Zhang R, Nastiuk KL, Krolewski JJ, Ling X. Kidney cancer biomarkers and targets for therapeutics: survivin (BIRC5), XIAP, MCL-1, HIF1α, HIF2α, NRF2, MDM2, MDM4, p53, KRAS and AKT in renal cell carcinoma. J Exp Clin Cancer Res 2021;40:254. [PMID: 34384473 DOI: 10.1186/s13046-021-02026-1] [Cited by in F6Publishing: 9] [Reference Citation Analysis]
4 Yang C, Li F, Ma J, Zhang HB, Jia J, Zeng J, Wang X, He D, Guo P. Evaluation of anti-cancer potency of silibinin on murine renal carcinoma RenCa cells in an animal model with an intact immune system. Anticancer Drugs 2020;31:785-91. [PMID: 32209841 DOI: 10.1097/CAD.0000000000000931] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 1.0] [Reference Citation Analysis]
5 Koltai T. Targeting the pH Paradigm at the Bedside: A Practical Approach. Int J Mol Sci 2020;21:E9221. [PMID: 33287221 DOI: 10.3390/ijms21239221] [Cited by in Crossref: 2] [Cited by in F6Publishing: 2] [Article Influence: 1.0] [Reference Citation Analysis]
6 Mishra S, Verma SS, Rai V, Awasthee N, Chava S, Hui KM, Kumar AP, Challagundla KB, Sethi G, Gupta SC. Long non-coding RNAs are emerging targets of phytochemicals for cancer and other chronic diseases. Cell Mol Life Sci 2019;76:1947-66. [PMID: 30879091 DOI: 10.1007/s00018-019-03053-0] [Cited by in Crossref: 77] [Cited by in F6Publishing: 78] [Article Influence: 25.7] [Reference Citation Analysis]
7 Nafees S, Mehdi SH, Zafaryab M, Zeya B, Sarwar T, Rizvi MA. Synergistic Interaction of Rutin and Silibinin on Human Colon Cancer Cell Line. Arch Med Res 2018;49:226-34. [PMID: 30314650 DOI: 10.1016/j.arcmed.2018.09.008] [Cited by in Crossref: 24] [Cited by in F6Publishing: 22] [Article Influence: 6.0] [Reference Citation Analysis]
8 Bai ZL, Tay V, Guo SZ, Ren J, Shu MG. Silibinin Induced Human Glioblastoma Cell Apoptosis Concomitant with Autophagy through Simultaneous Inhibition of mTOR and YAP. Biomed Res Int 2018;2018:6165192. [PMID: 29780826 DOI: 10.1155/2018/6165192] [Cited by in Crossref: 15] [Cited by in F6Publishing: 21] [Article Influence: 3.8] [Reference Citation Analysis]
9 Zhang F, Ma X, Li H, Zhang Y, Li X, Chen L, Guo G, Gao Y, Gu L, Xie Y, Duan J, Zhang X. FOXK2 suppresses the malignant phenotype and induces apoptosis through inhibition of EGFR in clear-cell renal cell carcinoma. Int J Cancer 2018;142:2543-57. [PMID: 29368368 DOI: 10.1002/ijc.31278] [Cited by in Crossref: 18] [Cited by in F6Publishing: 22] [Article Influence: 4.5] [Reference Citation Analysis]
10 Imai-Sumida M, Chiyomaru T, Majid S, Saini S, Nip H, Dahiya R, Tanaka Y, Yamamura S. Silibinin suppresses bladder cancer through down-regulation of actin cytoskeleton and PI3K/Akt signaling pathways. Oncotarget 2017;8:92032-42. [PMID: 29190895 DOI: 10.18632/oncotarget.20734] [Cited by in Crossref: 19] [Cited by in F6Publishing: 18] [Article Influence: 3.8] [Reference Citation Analysis]
11 Kim JS, Han NK, Kim SH, Lee HJ. Silibinin attenuates radiation-induced intestinal fibrosis and reverses epithelial-to-mesenchymal transition. Oncotarget 2017;8:69386-97. [PMID: 29050211 DOI: 10.18632/oncotarget.20624] [Cited by in Crossref: 9] [Cited by in F6Publishing: 11] [Article Influence: 1.8] [Reference Citation Analysis]
12 Braný D, Dvorská D, Slávik P, Školka R, Adamkov M. Survivin and gynaecological tumours. Pathology - Research and Practice 2017;213:295-300. [DOI: 10.1016/j.prp.2017.02.009] [Cited by in Crossref: 7] [Cited by in F6Publishing: 8] [Article Influence: 1.4] [Reference Citation Analysis]
13 Jahanafrooz Z, Motamed N, Bakhshandeh B. Effects of miR-21 downregulation and silibinin treatment in breast cancer cell lines. Cytotechnology 2017;69:667-80. [PMID: 28321778 DOI: 10.1007/s10616-017-0076-5] [Cited by in Crossref: 11] [Cited by in F6Publishing: 9] [Article Influence: 2.2] [Reference Citation Analysis]
14 DE Oliveira DT, Savio AL, Marcondes JP, Barros TM, Barbosa LC, Salvadori DM, DA Silva GN. Cytotoxic and toxicogenomic effects of silibinin in bladder cancer cells with different TP53 status. J Biosci 2017;42:91-101. [PMID: 28229968 DOI: 10.1007/s12038-016-9654-5] [Cited by in Crossref: 12] [Cited by in F6Publishing: 9] [Article Influence: 2.4] [Reference Citation Analysis]
15 Ezhilarasan D, Evraerts J, Sid B, Calderon PB, Karthikeyan S, Sokal E, Najimi M. Silibinin induces hepatic stellate cell cycle arrest via enhancing p53/p27 and inhibiting Akt downstream signaling protein expression. Hepatobiliary & Pancreatic Diseases International 2017;16:80-7. [DOI: 10.1016/s1499-3872(16)60166-2] [Cited by in Crossref: 20] [Cited by in F6Publishing: 9] [Article Influence: 4.0] [Reference Citation Analysis]
16 Youn CK, Cho SI, Lee MY, Jeon YJ, Lee SK. Inhibition of ERK1/2 by silymarin in mouse mesangial cells. Korean J Physiol Pharmacol 2017;21:117-24. [PMID: 28066148 DOI: 10.4196/kjpp.2017.21.1.117] [Cited by in Crossref: 3] [Cited by in F6Publishing: 1] [Article Influence: 0.5] [Reference Citation Analysis]
17 Lu X, Yang L, Lu C, Xu Z, Qiu H, Wu J, Wang J, Tong J, Zhu Y, Shen J. Molecular Role of EGFR-MAPK Pathway in Patchouli Alcohol-Induced Apoptosis and Cell Cycle Arrest on A549 Cells In Vitro and In Vivo. Biomed Res Int 2016;2016:4567580. [PMID: 27830146 DOI: 10.1155/2016/4567580] [Cited by in Crossref: 7] [Cited by in F6Publishing: 8] [Article Influence: 1.2] [Reference Citation Analysis]
18 Wang S, Xu Y, Chan HF, Kim H, Wang Y, Leong KW, Chen M. Nanoparticle-mediated inhibition of survivin to overcome drug resistance in cancer therapy. Journal of Controlled Release 2016;240:454-64. [DOI: 10.1016/j.jconrel.2016.04.018] [Cited by in Crossref: 35] [Cited by in F6Publishing: 33] [Article Influence: 5.8] [Reference Citation Analysis]
19 Lu X, Qiu H, Yang L, Zhang J, Ma S, Zhen L. Anti-proliferation effects, efficacy of cyasterone in vitro and in vivo and its mechanism. Biomed Pharmacother 2016;84:330-9. [PMID: 27668532 DOI: 10.1016/j.biopha.2016.09.041] [Cited by in Crossref: 5] [Cited by in F6Publishing: 4] [Article Influence: 0.8] [Reference Citation Analysis]
20 Chen J, Lu X, Lu C, Wang C, Xu H, Xu X, Gou H, Zhu B, Du W. 13-Methyl-palmatrubine induces apoptosis and cell cycle arrest in A549 cells in vitro and in vivo. Oncol Rep 2016;36:2526-34. [PMID: 27633656 DOI: 10.3892/or.2016.5093] [Cited by in Crossref: 9] [Cited by in F6Publishing: 12] [Article Influence: 1.5] [Reference Citation Analysis]
21 Lu X, Yang L, Chen J, Zhou J, Tang X, Zhu Y, Qiu H, Shen J. The action and mechanism of myrislignan on A549 cells in vitro and in vivo. J Nat Med 2017;71:76-85. [PMID: 27491743 DOI: 10.1007/s11418-016-1029-6] [Cited by in Crossref: 10] [Cited by in F6Publishing: 8] [Article Influence: 1.7] [Reference Citation Analysis]
22 Ezhilarasan D, Evraerts J, Brice S, Buc-Calderon P, Karthikeyan S, Sokal E, Najimi M. Silibinin Inhibits Proliferation and Migration of Human Hepatic Stellate LX-2 Cells. J Clin Exp Hepatol 2016;6:167-74. [PMID: 27746612 DOI: 10.1016/j.jceh.2016.01.002] [Cited by in Crossref: 21] [Cited by in F6Publishing: 18] [Article Influence: 3.5] [Reference Citation Analysis]
23 Abdollahi P, Ebrahimi M, Motamed N, Samani FS. Silibinin affects tumor cell growth because of reduction of stemness properties and induction of apoptosis in 2D and 3D models of MDA-MB-468. Anticancer Drugs 2015;26:487-97. [PMID: 25603020 DOI: 10.1097/CAD.0000000000000205] [Cited by in Crossref: 8] [Cited by in F6Publishing: 4] [Article Influence: 1.1] [Reference Citation Analysis]
24 Grill AE, Koniar B, Panyam J. Co-delivery of natural metabolic inhibitors in a self-microemulsifying drug delivery system for improved oral bioavailability of curcumin. Drug Deliv Transl Res 2014;4:344-52. [PMID: 25422796 DOI: 10.1007/s13346-014-0199-6] [Cited by in Crossref: 32] [Cited by in F6Publishing: 31] [Article Influence: 4.6] [Reference Citation Analysis]
25 Li F, Ma Z, Guan Z, Chen Y, Wu K, Guo P, Wang X, He D, Zeng J. Autophagy induction by silibinin positively contributes to its anti-metastatic capacity via AMPK/mTOR pathway in renal cell carcinoma. Int J Mol Sci 2015;16:8415-29. [PMID: 25884331 DOI: 10.3390/ijms16048415] [Cited by in Crossref: 30] [Cited by in F6Publishing: 28] [Article Influence: 4.3] [Reference Citation Analysis]
26 Jiang WG, Sanders AJ, Katoh M, Ungefroren H, Gieseler F, Prince M, Thompson SK, Zollo M, Spano D, Dhawan P, Sliva D, Subbarayan PR, Sarkar M, Honoki K, Fujii H, Georgakilas AG, Amedei A, Niccolai E, Amin A, Ashraf SS, Ye L, Helferich WG, Yang X, Boosani CS, Guha G, Ciriolo MR, Aquilano K, Chen S, Azmi AS, Keith WN, Bilsland A, Bhakta D, Halicka D, Nowsheen S, Pantano F, Santini D. Tissue invasion and metastasis: Molecular, biological and clinical perspectives. Semin Cancer Biol. 2015;35 Suppl:S244-S275. [PMID: 25865774 DOI: 10.1016/j.semcancer.2015.03.008] [Cited by in Crossref: 243] [Cited by in F6Publishing: 248] [Article Influence: 34.7] [Reference Citation Analysis]
27 Kim E, Jang J, Lee Y, Sung E, Song I, Kim J, Kim S, Sohn H, Lee T. Dioscin induces caspase-independent apoptosis through activation of apoptosis-inducing factor in breast cancer cells. Apoptosis 2014;19:1165-75. [DOI: 10.1007/s10495-014-0994-z] [Cited by in Crossref: 32] [Cited by in F6Publishing: 32] [Article Influence: 4.0] [Reference Citation Analysis]
28 Kim TH, Woo JS, Kim YK, Kim KH. Silibinin Induces Cell Death through Reactive Oxygen Species–Dependent Downregulation of Notch-1/ERK/Akt Signaling in Human Breast Cancer Cells. J Pharmacol Exp Ther 2014;349:268-78. [DOI: 10.1124/jpet.113.207563] [Cited by in Crossref: 30] [Cited by in F6Publishing: 29] [Article Influence: 3.8] [Reference Citation Analysis]
29 Naso L, Valcarcel M, Villacé P, Roura-ferrer M, Salado C, Ferrer EG, Williams PAM. Specific antitumor activities of natural and oxovanadium(iv) complexed flavonoids in human breast cancer cells. New J Chem 2014;38:2414. [DOI: 10.1039/c3nj01649h] [Cited by in Crossref: 19] [Cited by in F6Publishing: 14] [Article Influence: 2.4] [Reference Citation Analysis]
30 Xu S, Guo P, Gao Y, Shi Q, He D, Gao Y, Zhang H. Acyldepsipeptides inhibit the growth of renal cancer cells through G1 phase cell cycle arrest. Biochemical and Biophysical Research Communications 2013;438:468-72. [DOI: 10.1016/j.bbrc.2013.07.119] [Cited by in Crossref: 12] [Cited by in F6Publishing: 11] [Article Influence: 1.3] [Reference Citation Analysis]
31 Vacas E, Arenas MI, Muñoz-Moreno L, Bajo AM, Sánchez-Chapado M, Prieto JC, Carmena MJ. Antitumoral effects of vasoactive intestinal peptide in human renal cell carcinoma xenografts in athymic nude mice. Cancer Lett 2013;336:196-203. [PMID: 23664888 DOI: 10.1016/j.canlet.2013.04.033] [Cited by in Crossref: 10] [Cited by in F6Publishing: 9] [Article Influence: 1.1] [Reference Citation Analysis]
32 Weng Y, Kong X, Yu Y, Wang Y, Hong J, Zhao S, Fang J. The role of ERK2 in colorectal carcinogenesis is partly regulated by TRAPPC4: TRAPPC4 PARTLY REGULATE ERK2 IN CRC. Mol Carcinog 2014;53:E72-84. [DOI: 10.1002/mc.22031] [Cited by in Crossref: 8] [Cited by in F6Publishing: 10] [Article Influence: 0.9] [Reference Citation Analysis]
33 Ting H, Deep G, Agarwal R. Molecular mechanisms of silibinin-mediated cancer chemoprevention with major emphasis on prostate cancer. AAPS J 2013;15:707-16. [PMID: 23588585 DOI: 10.1208/s12248-013-9486-2] [Cited by in Crossref: 51] [Cited by in F6Publishing: 43] [Article Influence: 5.7] [Reference Citation Analysis]
34 Yang X, Li X, An L, Bai B, Chen J. Silibinin induced the apoptosis of Hep-2 cells via oxidative stress and down-regulating survivin expression. Eur Arch Otorhinolaryngol 2013;270:2289-97. [PMID: 23580032 DOI: 10.1007/s00405-013-2444-x] [Cited by in Crossref: 6] [Cited by in F6Publishing: 6] [Article Influence: 0.7] [Reference Citation Analysis]
35 Anestopoulos I, Kavo A, Tentes I, Kortsaris A, Panayiotidis M, Lazou A, Pappa A. Silibinin protects H9c2 cardiac cells from oxidative stress and inhibits phenylephrine-induced hypertrophy: potential mechanisms. J Nutr Biochem 2013;24:586-94. [PMID: 22818713 DOI: 10.1016/j.jnutbio.2012.02.009] [Cited by in Crossref: 22] [Cited by in F6Publishing: 20] [Article Influence: 2.2] [Reference Citation Analysis]
36 Zhang Y, Li Q, Ge Y, Chen Y, Chen J, Dong Y, Shi W. Silibinin Triggers Apoptosis and Cell-Cycle Arrest of SGC7901 Cells: SILIBININ CELL-CYCLE ARREST SGC7901. Phytother Res 2013;27:397-403. [DOI: 10.1002/ptr.4733] [Cited by in Crossref: 17] [Cited by in F6Publishing: 21] [Article Influence: 1.7] [Reference Citation Analysis]
37 Shafi G, Hasan TN, Syed NA, Al-hazzani AA, Alshatwi AA, Jyothi A, Munshi A. Artemisia absinthium (AA): a novel potential complementary and alternative medicine for breast cancer. Mol Biol Rep 2012;39:7373-9. [DOI: 10.1007/s11033-012-1569-0] [Cited by in Crossref: 34] [Cited by in F6Publishing: 26] [Article Influence: 3.4] [Reference Citation Analysis]
38 Kim K, Lee HJ, Lim SP, Sikder MA, Lee SY, Lee CJ. Silibinin Regulates Gene Expression, Production and Secretion of Mucin from Cultured Airway Epithelial Cells: SILIBININ AND AIRWAY MUCIN. Phytother Res 2012;26:1301-7. [DOI: 10.1002/ptr.3727] [Cited by in Crossref: 20] [Cited by in F6Publishing: 17] [Article Influence: 2.0] [Reference Citation Analysis]
39 Zhang Y, Ge Y, Chen Y, Li Q, Chen J, Dong Y, Shi W. Cellular and molecular mechanisms of silibinin induces cell-cycle arrest and apoptosis on HeLa cells. Cell Biochem Funct 2012;30:243-8. [PMID: 22170400 DOI: 10.1002/cbf.1842] [Cited by in Crossref: 17] [Cited by in F6Publishing: 18] [Article Influence: 1.5] [Reference Citation Analysis]
40 Ge Y, Zhang Y, Chen Y, Li Q, Chen J, Dong Y, Shi W. Silibinin causes apoptosis and cell cycle arrest in some human pancreatic cancer cells. Int J Mol Sci 2011;12:4861-71. [PMID: 21954330 DOI: 10.3390/ijms12084861] [Cited by in Crossref: 22] [Cited by in F6Publishing: 23] [Article Influence: 2.0] [Reference Citation Analysis]
41 Zhao X, Ogunwobi OO, Liu C. Survivin inhibition is critical for Bcl-2 inhibitor-induced apoptosis in hepatocellular carcinoma cells. PLoS One 2011;6:e21980. [PMID: 21829603 DOI: 10.1371/journal.pone.0021980] [Cited by in Crossref: 30] [Cited by in F6Publishing: 29] [Article Influence: 2.7] [Reference Citation Analysis]
42 Noh EM, Yi MS, Youn HJ, Lee BK, Lee YR, Han JH, Yu HN, Kim JS, Jung SH. Silibinin enhances ultraviolet B-induced apoptosis in mcf-7 human breast cancer cells. J Breast Cancer 2011;14:8-13. [PMID: 21847388 DOI: 10.4048/jbc.2011.14.1.8] [Cited by in Crossref: 17] [Cited by in F6Publishing: 18] [Article Influence: 1.5] [Reference Citation Analysis]
43 Deep G, Agarwal R. Antimetastatic efficacy of silibinin: molecular mechanisms and therapeutic potential against cancer. Cancer Metastasis Rev 2010;29:447-63. [PMID: 20714788 DOI: 10.1007/s10555-010-9237-0] [Cited by in Crossref: 149] [Cited by in F6Publishing: 129] [Article Influence: 12.4] [Reference Citation Analysis]
44 Ai W, Zhang Y, Tang QZ, Yan L, Bian ZY, Liu C, Huang H, Bai X, Yin L, Li H. Silibinin attenuates cardiac hypertrophy and fibrosis through blocking EGFR-dependent signaling. J Cell Biochem 2010;110:1111-22. [PMID: 20564207 DOI: 10.1002/jcb.22623] [Cited by in Crossref: 35] [Cited by in F6Publishing: 33] [Article Influence: 2.9] [Reference Citation Analysis]
45 Zhang J, Harrison JS, Uskokovic M, Danilenko M, Studzinski GP. Silibinin can induce differentiation as well as enhance vitamin D3-induced differentiation of human AML cells ex vivo and regulates the levels of differentiation-related transcription factors. Hematol Oncol 2010;28:124-32. [PMID: 19866452 DOI: 10.1002/hon.929] [Cited by in Crossref: 5] [Cited by in F6Publishing: 16] [Article Influence: 0.4] [Reference Citation Analysis]
46 Li L, Zeng J, Gao Y, He D. Targeting silibinin in the antiproliferative pathway. Expert Opinion on Investigational Drugs 2010;19:243-55. [DOI: 10.1517/13543780903533631] [Cited by in Crossref: 43] [Cited by in F6Publishing: 36] [Article Influence: 3.6] [Reference Citation Analysis]
47 Zhou QM, Wang S, Zhang H, Lu YY, Wang XF, Motoo Y, Su SB. The combination of baicalin and baicalein enhances apoptosis via the ERK/p38 MAPK pathway in human breast cancer cells. Acta Pharmacol Sin 2009;30:1648-58. [PMID: 19960010 DOI: 10.1038/aps.2009.166] [Cited by in Crossref: 67] [Cited by in F6Publishing: 71] [Article Influence: 5.2] [Reference Citation Analysis]