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For: Zallar LJ, Farokhnia M, Tunstall BJ, Vendruscolo LF, Leggio L. The Role of the Ghrelin System in Drug Addiction. Int Rev Neurobiol 2017;136:89-119. [PMID: 29056157 DOI: 10.1016/bs.irn.2017.08.002] [Cited by in Crossref: 41] [Cited by in F6Publishing: 39] [Article Influence: 8.2] [Reference Citation Analysis]
Number Citing Articles
1 Cobbina E, Lee MR, Leggio L, Akhlaghi F. A Population Pharmacokinetic Analysis of PF-5190457, a Novel Ghrelin Receptor Inverse Agonist in Healthy Volunteers and in Heavy Alcohol Drinkers. Clin Pharmacokinet 2021;60:471-84. [PMID: 33155163 DOI: 10.1007/s40262-020-00942-7] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 0.5] [Reference Citation Analysis]
2 Cornejo MP, Barrile F, Cassano D, Aguggia JP, García Romero G, Reynaldo M, Andreoli MF, De Francesco PN, Perello M. Growth hormone secretagogue receptor in dopamine neurons controls appetitive and consummatory behaviors towards high-fat diet in ad-libitum fed mice. Psychoneuroendocrinology 2020;119:104718. [PMID: 32535402 DOI: 10.1016/j.psyneuen.2020.104718] [Cited by in Crossref: 2] [Cited by in F6Publishing: 1] [Article Influence: 1.0] [Reference Citation Analysis]
3 Herrington JA, Guss Darwich J, Harshaw C, Brigande AM, Leif EB, Currie PJ. Elevated ghrelin alters the behavioral effects of perinatal acetaminophen exposure in rats. Developmental Psychobiology 2022;64. [DOI: 10.1002/dev.22252] [Reference Citation Analysis]
4 Cuzon Carlson VC, Ford MM, Carlson TL, Lomniczi A, Grant KA, Ferguson B, Cervera-Juanes RP. Modulation of Gpr39, a G-protein coupled receptor associated with alcohol use in non-human primates, curbs ethanol intake in mice. Neuropsychopharmacology. 2019;44:1103-1113. [PMID: 30610192 DOI: 10.1038/s41386-018-0308-1] [Cited by in Crossref: 9] [Cited by in F6Publishing: 8] [Article Influence: 3.0] [Reference Citation Analysis]
5 Lee MR, Farokhnia M, Cobbina E, Saravanakumar A, Li X, Battista JT, Farinelli LA, Akhlaghi F, Leggio L. Endocrine effects of the novel ghrelin receptor inverse agonist PF-5190457: Results from a placebo-controlled human laboratory alcohol co-administration study in heavy drinkers. Neuropharmacology 2020;170:107788. [PMID: 31557492 DOI: 10.1016/j.neuropharm.2019.107788] [Cited by in Crossref: 5] [Cited by in F6Publishing: 4] [Article Influence: 1.7] [Reference Citation Analysis]
6 Sztainert T, Hay R, Wohl MJA, Abizaid A. Hungry to gamble? Ghrelin as a predictor of persistent gambling in the face of loss. Biol Psychol 2018;139:115-23. [PMID: 30392826 DOI: 10.1016/j.biopsycho.2018.10.011] [Cited by in Crossref: 6] [Cited by in F6Publishing: 3] [Article Influence: 1.5] [Reference Citation Analysis]
7 You ZB, Galaj E, Alén F, Wang B, Bi GH, Moore AR, Buck T, Crissman M, Pari S, Xi ZX, Leggio L, Wise RA, Gardner EL. Involvement of the ghrelin system in the maintenance and reinstatement of cocaine-motivated behaviors: a role of adrenergic action at peripheral β1 receptors. Neuropsychopharmacology 2021. [PMID: 34923576 DOI: 10.1038/s41386-021-01249-2] [Cited by in Crossref: 2] [Cited by in F6Publishing: 2] [Article Influence: 2.0] [Reference Citation Analysis]
8 Weinland C, Mühle C, Kornhuber J, Lenz B. Body mass index and craving predict 24-month hospital readmissions of alcohol-dependent in-patients following withdrawal. Progress in Neuro-Psychopharmacology and Biological Psychiatry 2019;90:300-7. [DOI: 10.1016/j.pnpbp.2018.11.019] [Cited by in Crossref: 13] [Cited by in F6Publishing: 15] [Article Influence: 4.3] [Reference Citation Analysis]
9 Iyer MR, Wood CM, Kunos G. Recent progress in the discovery of ghrelin O-acyltransferase (GOAT) inhibitors. RSC Med Chem 2020;11:1136-44. [PMID: 33479618 DOI: 10.1039/d0md00210k] [Cited by in Crossref: 2] [Cited by in F6Publishing: 2] [Article Influence: 1.0] [Reference Citation Analysis]
10 Farokhnia M, Portelli J, Lee MR, McDiarmid GR, Munjal V, Abshire KM, Battista JT, Browning BD, Deschaine SL, Akhlaghi F, Leggio L. Effects of exogenous ghrelin administration and ghrelin receptor blockade, in combination with alcohol, on peripheral inflammatory markers in heavy-drinking individuals: Results from two human laboratory studies. Brain Res 2020;1740:146851. [PMID: 32339499 DOI: 10.1016/j.brainres.2020.146851] [Cited by in Crossref: 4] [Cited by in F6Publishing: 4] [Article Influence: 2.0] [Reference Citation Analysis]
11 Deschaine SL, Farokhnia M, Gregory-Flores A, Zallar LJ, You ZB, Sun H, Harvey DM, Marchette RCN, Tunstall BJ, Mani BK, Moose JE, Lee MR, Gardner E, Akhlaghi F, Roberto M, Hougland JL, Zigman JM, Koob GF, Vendruscolo LF, Leggio L. A closer look at alcohol-induced changes in the ghrelin system: novel insights from preclinical and clinical data. Addict Biol 2022;27:e13033. [PMID: 33908131 DOI: 10.1111/adb.13033] [Cited by in Crossref: 7] [Cited by in F6Publishing: 6] [Article Influence: 7.0] [Reference Citation Analysis]
12 Farokhnia M, Browning BD, Leggio L. Prospects for pharmacotherapies to treat alcohol use disorder: an update on recent human studies. Curr Opin Psychiatry 2019;32:255-65. [PMID: 31107292 DOI: 10.1097/YCO.0000000000000519] [Cited by in Crossref: 13] [Cited by in F6Publishing: 5] [Article Influence: 6.5] [Reference Citation Analysis]
13 Potretzke S, Lemieux A, Nakajima M, al'Absi M. Circulating ghrelin changes as a biomarker of the stress response and craving in abstinent smokers. Pharmacol Biochem Behav 2022;:173423. [PMID: 35750154 DOI: 10.1016/j.pbb.2022.173423] [Reference Citation Analysis]
14 Carr KD. Modulatory Effects of Food Restriction on Brain and Behavioral Effects of Abused Drugs. CPD 2020;26:2363-71. [DOI: 10.2174/1381612826666200204141057] [Cited by in Crossref: 3] [Cited by in F6Publishing: 3] [Article Influence: 1.5] [Reference Citation Analysis]
15 Vestlund J, Winsa-jörnulf J, Hovey D, Lundström S, Lichtenstein P, Anckarsäter H, Studer E, Suchankova P, Westberg L, Jerlhag E. Ghrelin and aggressive behaviours—Evidence from preclinical and human genetic studies. Psychoneuroendocrinology 2019;104:80-8. [DOI: 10.1016/j.psyneuen.2019.02.020] [Cited by in Crossref: 6] [Cited by in F6Publishing: 6] [Article Influence: 2.0] [Reference Citation Analysis]
16 Leggio L, Falk DE, Ryan ML, Fertig J, Litten RZ. Medication Development for Alcohol Use Disorder: A Focus on Clinical Studies. Handb Exp Pharmacol 2020;258:443-62. [PMID: 31628604 DOI: 10.1007/164_2019_295] [Cited by in Crossref: 9] [Cited by in F6Publishing: 6] [Article Influence: 4.5] [Reference Citation Analysis]
17 Zallar LJ, Tunstall BJ, Richie CT, Zhang YJ, You ZB, Gardner EL, Heilig M, Pickel J, Koob GF, Vendruscolo LF, Harvey BK, Leggio L. Development and initial characterization of a novel ghrelin receptor CRISPR/Cas9 knockout wistar rat model. Int J Obes (Lond) 2019;43:344-54. [PMID: 29453460 DOI: 10.1038/s41366-018-0013-5] [Cited by in Crossref: 19] [Cited by in F6Publishing: 14] [Article Influence: 4.8] [Reference Citation Analysis]
18 Deschaine SL, Leggio L. From "Hunger Hormone" to "It's Complicated": Ghrelin Beyond Feeding Control. Physiology (Bethesda) 2022;37:5-15. [PMID: 34964687 DOI: 10.1152/physiol.00024.2021] [Cited by in Crossref: 1] [Cited by in F6Publishing: 2] [Article Influence: 1.0] [Reference Citation Analysis]
19 Carr KD. Homeostatic regulation of reward via synaptic insertion of calcium-permeable AMPA receptors in nucleus accumbens. Physiol Behav 2020;219:112850. [PMID: 32092445 DOI: 10.1016/j.physbeh.2020.112850] [Cited by in Crossref: 7] [Cited by in F6Publishing: 6] [Article Influence: 3.5] [Reference Citation Analysis]
20 Wittekind DA, Kratzsch J, Mergl R, Enzenbach C, Witte AV, Villringer A, Kluge M. Alcohol consumption is positively associated with fasting serum ghrelin in non-dependent adults: Results from the population-based LIFE-Adult-Study. Psychoneuroendocrinology 2018;97:143-8. [PMID: 30029157 DOI: 10.1016/j.psyneuen.2018.07.021] [Cited by in Crossref: 9] [Cited by in F6Publishing: 8] [Article Influence: 2.3] [Reference Citation Analysis]
21 Angoa-Pérez M, Kuhn DM. Evidence for Modulation of Substance Use Disorders by the Gut Microbiome: Hidden in Plain Sight. Pharmacol Rev 2021;73:571-96. [PMID: 33597276 DOI: 10.1124/pharmrev.120.000144] [Cited by in Crossref: 3] [Cited by in F6Publishing: 3] [Article Influence: 3.0] [Reference Citation Analysis]
22 al'Absi M, DeAngelis B, Nakajima M, Hatsukami D, Allen S. Early life adversity and appetite hormones: The effects of smoking status, nicotine withdrawal, and relapse on ghrelin and peptide YY during smoking cessation. Addict Behav 2021;118:106866. [PMID: 33640833 DOI: 10.1016/j.addbeh.2021.106866] [Cited by in Crossref: 1] [Article Influence: 1.0] [Reference Citation Analysis]
23 Charalambous C, Havlickova T, Lapka M, Puskina N, Šlamberová R, Kuchar M, Sustkova-Fiserova M. Cannabinoid-Induced Conditioned Place Preference, Intravenous Self-Administration, and Behavioral Stimulation Influenced by Ghrelin Receptor Antagonism in Rats. Int J Mol Sci 2021;22:2397. [PMID: 33673659 DOI: 10.3390/ijms22052397] [Reference Citation Analysis]
24 Sustkova-Fiserova M, Charalambous C, Khryakova A, Certilina A, Lapka M, Šlamberová R. The Role of Ghrelin/GHS-R1A Signaling in Nonalcohol Drug Addictions. Int J Mol Sci 2022;23:761. [PMID: 35054944 DOI: 10.3390/ijms23020761] [Cited by in Crossref: 2] [Cited by in F6Publishing: 2] [Article Influence: 2.0] [Reference Citation Analysis]
25 Davis TR, Pierce MR, Novak SX, Hougland JL. Ghrelin octanoylation by ghrelin O-acyltransferase: protein acylation impacting metabolic and neuroendocrine signalling. Open Biol 2021;11:210080. [PMID: 34315274 DOI: 10.1098/rsob.210080] [Cited by in F6Publishing: 1] [Reference Citation Analysis]
26 Dev R, Haider A. Alcohol, Tobacco, and Substance Use and Association with Opioid Use Disorder in Patients with Non-malignant and Cancer Pain: a Review. Curr Anesthesiol Rep 2020;10:388-95. [DOI: 10.1007/s40140-020-00415-4] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 0.5] [Reference Citation Analysis]
27 Bouhlal S, Farokhnia M, Lee MR, Akhlaghi F, Leggio L. Identifying and Characterizing Subpopulations of Heavy Alcohol Drinkers Via a Sucrose Preference Test: A Sweet Road to a Better Phenotypic Characterization? Alcohol Alcohol 2018;53:560-9. [PMID: 30016385 DOI: 10.1093/alcalc/agy048] [Cited by in Crossref: 5] [Cited by in F6Publishing: 5] [Article Influence: 1.3] [Reference Citation Analysis]
28 Farokhnia M, Lee MR, Farinelli LA, Ramchandani VA, Akhlaghi F, Leggio L. Pharmacological manipulation of the ghrelin system and alcohol hangover symptoms in heavy drinking individuals: Is there a link? Pharmacol Biochem Behav 2018;172:39-49. [PMID: 30030128 DOI: 10.1016/j.pbb.2018.07.004] [Cited by in Crossref: 8] [Cited by in F6Publishing: 8] [Article Influence: 2.0] [Reference Citation Analysis]
29 Neasta J, Darcq E, Jeanblanc J, Carnicella S, Ben Hamida S. GPCR and Alcohol-Related Behaviors in Genetically Modified Mice. Neurotherapeutics 2020;17:17-42. [PMID: 31919661 DOI: 10.1007/s13311-019-00828-y] [Cited by in Crossref: 3] [Cited by in F6Publishing: 2] [Article Influence: 3.0] [Reference Citation Analysis]
30 Farokhnia M, Faulkner ML, Piacentino D, Lee MR, Leggio L. Ghrelin: From a gut hormone to a potential therapeutic target for alcohol use disorder. Physiology & Behavior 2019;204:49-57. [DOI: 10.1016/j.physbeh.2019.02.008] [Cited by in Crossref: 35] [Cited by in F6Publishing: 30] [Article Influence: 11.7] [Reference Citation Analysis]
31 Stone LA, Harmatz ES, Goosens KA. Ghrelin as a Stress Hormone: Implications for Psychiatric Illness. Biol Psychiatry 2020;88:531-40. [PMID: 32912426 DOI: 10.1016/j.biopsych.2020.05.013] [Cited by in Crossref: 19] [Cited by in F6Publishing: 15] [Article Influence: 9.5] [Reference Citation Analysis]
32 Zallar LJ, Beurmann S, Tunstall BJ, Fraser CM, Koob GF, Vendruscolo LF, Leggio L. Ghrelin receptor deletion reduces binge-like alcohol drinking in rats. J Neuroendocrinol 2019;31:e12663. [PMID: 30456835 DOI: 10.1111/jne.12663] [Cited by in Crossref: 13] [Cited by in F6Publishing: 15] [Article Influence: 4.3] [Reference Citation Analysis]
33 Geisel O, Hellweg R, Wernecke KD, Wiedemann K, Müller CA. Total and acylated ghrelin plasma levels as potential long-term response markers in alcohol-dependent patients receiving high-dose of the GABA-B receptor agonist baclofen. Psychiatry Res 2019;272:431-7. [PMID: 30611960 DOI: 10.1016/j.psychres.2018.12.095] [Cited by in Crossref: 3] [Cited by in F6Publishing: 4] [Article Influence: 0.8] [Reference Citation Analysis]
34 Kurt Tunagur EM, Yazici AB, Guzel D, Tunagur MT, Ermis C, Suda MA, Yazici E. Investigating associations between appetite-regulating hormones, aggression and craving in males with cannabis use disorder. Drug Alcohol Depend 2022;238:109577. [PMID: 35905593 DOI: 10.1016/j.drugalcdep.2022.109577] [Reference Citation Analysis]
35 Adusumalli S, Jamwal R, Leggio L, Akhlaghi F. Development and validation of an assay for a novel ghrelin receptor inverse agonist PF-5190457 and its major hydroxy metabolite (PF-6870961) by LC-MS/MS in human plasma. Journal of Chromatography B 2019;1130-1131:121820. [DOI: 10.1016/j.jchromb.2019.121820] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 0.3] [Reference Citation Analysis]
36 Farokhnia M, Abshire KM, Hammer A, Deschaine SL, Saravanakumar A, Cobbina E, You ZB, Haass-Koffler CL, Lee MR, Akhlaghi F, Leggio L. Neuroendocrine Response to Exogenous Ghrelin Administration, Combined With Alcohol, in Heavy-Drinking Individuals: Findings From a Randomized, Double-Blind, Placebo-Controlled Human Laboratory Study. Int J Neuropsychopharmacol 2021;24:464-76. [PMID: 33560411 DOI: 10.1093/ijnp/pyab004] [Cited by in Crossref: 3] [Cited by in F6Publishing: 3] [Article Influence: 3.0] [Reference Citation Analysis]
37 Sulima A, Akhlaghi F, Leggio L, Rice KC. Synthesis of PF-6870961, a major hydroxy metabolite of the novel ghrelin receptor inverse agonist PF-5190457. Bioorg Med Chem 2021;50:116465. [PMID: 34662828 DOI: 10.1016/j.bmc.2021.116465] [Reference Citation Analysis]
38 Farokhnia M, Sheskier MB, Lee MR, Le AN, Singley E, Bouhlal S, Ton T, Zhao Z, Leggio L. Neuroendocrine response to GABA-B receptor agonism in alcohol-dependent individuals: Results from a combined outpatient and human laboratory experiment. Neuropharmacology 2018;137:230-9. [PMID: 29665351 DOI: 10.1016/j.neuropharm.2018.04.011] [Cited by in Crossref: 6] [Cited by in F6Publishing: 6] [Article Influence: 1.5] [Reference Citation Analysis]
39 You ZB, Gardner EL, Galaj E, Moore AR, Buck T, Jordan CJ, Humburg BA, Bi GH, Xi ZX, Leggio L. Involvement of the ghrelin system in the maintenance of oxycodone self-administration: converging evidence from endocrine, pharmacologic and transgenic approaches. Mol Psychiatry 2022. [PMID: 35064236 DOI: 10.1038/s41380-022-01438-5] [Cited by in Crossref: 3] [Cited by in F6Publishing: 2] [Article Influence: 3.0] [Reference Citation Analysis]
40 Nagi K, Habib AM. Biased signaling: A viable strategy to drug ghrelin receptors for the treatment of obesity. Cell Signal 2021;83:109976. [PMID: 33713808 DOI: 10.1016/j.cellsig.2021.109976] [Cited by in Crossref: 3] [Cited by in F6Publishing: 2] [Article Influence: 3.0] [Reference Citation Analysis]
41 Farokhnia M, Murphy G, Weinstein SJ, Shah NN, Parisi D, Albanes D, Leggio L. A population-based investigation of the association between alcohol intake and serum total ghrelin concentrations among cigarette-smoking, non-alcohol-dependent male individuals. Drug Alcohol Depend 2021;226:108835. [PMID: 34214881 DOI: 10.1016/j.drugalcdep.2021.108835] [Reference Citation Analysis]
42 Haass-Koffler CL, Long VM, Farokhnia M, Magill M, Kenna GA, Swift RM, Leggio L. Intravenous administration of ghrelin increases serum cortisol and aldosterone concentrations in heavy-drinking alcohol-dependent individuals: Results from a double-blind, placebo-controlled human laboratory study. Neuropharmacology 2019;158:107711. [PMID: 31310775 DOI: 10.1016/j.neuropharm.2019.107711] [Cited by in Crossref: 5] [Cited by in F6Publishing: 4] [Article Influence: 1.7] [Reference Citation Analysis]
43 Ponzoni L, Moretti M, Braida D, Zoli M, Clementi F, Viani P, Sala M, Gotti C. Increased sensitivity to Δ9-THC-induced rewarding effects after seven-week exposure to electronic and tobacco cigarettes in mice. Eur Neuropsychopharmacol 2019;29:566-76. [PMID: 30773388 DOI: 10.1016/j.euroneuro.2019.02.001] [Cited by in Crossref: 7] [Cited by in F6Publishing: 7] [Article Influence: 2.3] [Reference Citation Analysis]
44 Kärkkäinen O, Farokhnia M, Klåvus A, Auriola S, Lehtonen M, Deschaine SL, Piacentino D, Abshire KM, Jackson SN, Leggio L. Effect of intravenous ghrelin administration, combined with alcohol, on circulating metabolome in heavy drinking individuals with alcohol use disorder. Alcohol Clin Exp Res 2021. [PMID: 34590334 DOI: 10.1111/acer.14719] [Reference Citation Analysis]
45 Wittekind DA, Kratzsch J, Mergl R, Enzenbach C, Witte V, Villringer A, Kluge M. Higher fasting ghrelin serum levels in active smokers than in former and never-smokers. World J Biol Psychiatry 2020;21:748-56. [PMID: 31552785 DOI: 10.1080/15622975.2019.1671610] [Cited by in Crossref: 6] [Cited by in F6Publishing: 6] [Article Influence: 2.0] [Reference Citation Analysis]
46 Adusumalli S, Jamwal R, Obach RS, Ryder TF, Leggio L, Akhlaghi F. Role of Molybdenum-Containing Enzymes in the Biotransformation of the Novel Ghrelin Receptor Inverse Agonist PF-5190457: A Reverse Translational Bed-to-Bench Approach. Drug Metab Dispos 2019;47:874-82. [PMID: 31182423 DOI: 10.1124/dmd.119.087015] [Cited by in Crossref: 3] [Cited by in F6Publishing: 3] [Article Influence: 1.0] [Reference Citation Analysis]
47 Lenz B, Köllner MG, Mühle C, Weinland C, Kornhuber J. Basic Human Body Dimensions Relate to Alcohol Dependence and Predict Hospital Readmission. J Clin Med 2019;8:E2076. [PMID: 31783685 DOI: 10.3390/jcm8122076] [Cited by in Crossref: 5] [Cited by in F6Publishing: 5] [Article Influence: 1.7] [Reference Citation Analysis]