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For: Choi JM, Oh SJ, Lee SY, Im JH, Oh JM, Ryu CS, Kwak HC, Lee JY, Kang KW, Kim SK. HepG2 cells as an in vitro model for evaluation of cytochrome P450 induction by xenobiotics. Arch Pharm Res 2015;38:691-704. [PMID: 25336106 DOI: 10.1007/s12272-014-0502-6] [Cited by in Crossref: 46] [Cited by in F6Publishing: 42] [Article Influence: 5.8] [Reference Citation Analysis]
Number Citing Articles
1 Martínez-Peinado N, Cortes-Serra N, Tallini LR, Pinazo MJ, Gascon J, Bastida J, Alonso-Padilla J. Amaryllidaceae plants: a potential natural resource for the treatment of Chagas disease. Parasit Vectors 2021;14:337. [PMID: 34174959 DOI: 10.1186/s13071-021-04837-9] [Reference Citation Analysis]
2 Arzumanian VA, Kiseleva OI, Poverennaya EV. The Curious Case of the HepG2 Cell Line: 40 Years of Expertise. Int J Mol Sci 2021;22:13135. [PMID: 34884942 DOI: 10.3390/ijms222313135] [Reference Citation Analysis]
3 Kouka P, Chatzieffraimidi GA, Raftis G, Stagos D, Angelis A, Stathopoulos P, Xynos N, Skaltsounis AL, Tsatsakis AM, Kouretas D. Antioxidant effects of an olive oil total polyphenolic fraction from a Greek Olea europaea variety in different cell cultures. Phytomedicine 2018;47:135-42. [PMID: 30166098 DOI: 10.1016/j.phymed.2018.04.054] [Cited by in Crossref: 14] [Cited by in F6Publishing: 10] [Article Influence: 3.5] [Reference Citation Analysis]
4 Zhan T, Pan L, Liu Z, Chen J, Ge Z, Lu L, Zhang X, Cui S, Zhang C, Liu W, Zhuang S. Metabolic Susceptibility of 2-Chlorothioxanthone and Its Toxic Effects on mRNA and Protein Expression and Activities of Human CYP1A2 and CYP3A4 Enzymes. Environ Sci Technol 2018. [DOI: 10.1021/acs.est.8b04643] [Cited by in Crossref: 3] [Cited by in F6Publishing: 3] [Article Influence: 0.8] [Reference Citation Analysis]
5 Taymour R, Kilian D, Ahlfeld T, Gelinsky M, Lode A. 3D bioprinting of hepatocytes: core-shell structured co-cultures with fibroblasts for enhanced functionality. Sci Rep 2021;11:5130. [PMID: 33664366 DOI: 10.1038/s41598-021-84384-6] [Cited by in Crossref: 6] [Cited by in F6Publishing: 4] [Article Influence: 6.0] [Reference Citation Analysis]
6 Martinez-Peinado N, Lorente-Macías Á, García-Salguero A, Cortes-Serra N, Fenollar-Collado Á, Ros-Lucas A, Gascon J, Pinazo MJ, Molina IJ, Unciti-Broceta A, Díaz-Mochón JJ, Pineda de Las Infantas Y Villatoro MJ, Izquierdo L, Alonso-Padilla J. Novel Purine Chemotypes with Activity against Plasmodium falciparum and Trypanosoma cruzi. Pharmaceuticals (Basel) 2021;14:638. [PMID: 34358064 DOI: 10.3390/ph14070638] [Reference Citation Analysis]
7 Martinez-Peinado N, Cortes-Serra N, Sherman J, Rodriguez A, Bustamante JM, Gascon J, Pinazo MJ, Alonso-Padilla J. Identification of Trypanosoma cruzi Growth Inhibitors with Activity In Vivo within a Collection of Licensed Drugs. Microorganisms 2021;9:406. [PMID: 33669310 DOI: 10.3390/microorganisms9020406] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 1.0] [Reference Citation Analysis]
8 Bulutoglu B, Rey-Bedón C, Mert S, Tian L, Jang YY, Yarmush ML, Usta OB. A comparison of hepato-cellular in vitro platforms to study CYP3A4 induction. PLoS One 2020;15:e0229106. [PMID: 32106230 DOI: 10.1371/journal.pone.0229106] [Cited by in Crossref: 4] [Cited by in F6Publishing: 6] [Article Influence: 2.0] [Reference Citation Analysis]
9 Jinakote M, Ontawong A, Soodvilai S, Pimta J, Pasachan T, Chatsudthipong V, Srimaroeng C. High affinity of 4-(4-(dimethylamino)styryl)-N-methylpyridinium transport for assessing organic cation drugs in hepatocellular carcinoma cells. Fundam Clin Pharmacol 2020;34:365-79. [PMID: 31883148 DOI: 10.1111/fcp.12531] [Reference Citation Analysis]
10 Yang S, Wesseling S, Rietjens IMCM. Estragole DNA adduct accumulation in human liver HepaRG cells upon repeated in vitro exposure. Toxicol Lett 2021;337:1-6. [PMID: 33189830 DOI: 10.1016/j.toxlet.2020.11.009] [Reference Citation Analysis]
11 Ellero AA, van den Bout I, Vlok M, Cromarty AD, Hurrell T. Continual proteomic divergence of HepG2 cells as a consequence of long-term spheroid culture. Sci Rep 2021;11:10917. [PMID: 34035320 DOI: 10.1038/s41598-021-89907-9] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 1.0] [Reference Citation Analysis]
12 Fregonezi NF, Aparecida de Souza F, Aleixo NA, Stefany da Silva Gomes P, Silvestre RB, De Grandis RA, Bento da Silva P, Pavan FR, Chorilli M, Resende FA. Cyto-genotoxic evaluation of novel anti-tubercular copper (II) complexes containing isoniazid-based ligands. Regulatory Toxicology and Pharmacology 2020;113:104653. [DOI: 10.1016/j.yrtph.2020.104653] [Cited by in Crossref: 2] [Cited by in F6Publishing: 2] [Article Influence: 1.0] [Reference Citation Analysis]
13 Kumari J, Teotia AK, Karande AA, Kumar A. A minimally-invasive cryogel based approach for the development of human ectopic liver in a mouse model. J Biomed Mater Res B Appl Biomater 2020;108:1022-32. [PMID: 31397074 DOI: 10.1002/jbm.b.34454] [Cited by in Crossref: 2] [Cited by in F6Publishing: 1] [Article Influence: 0.7] [Reference Citation Analysis]
14 Gori M, Giannitelli SM, Torre M, Mozetic P, Abbruzzese F, Trombetta M, Traversa E, Moroni L, Rainer A. Biofabrication of Hepatic Constructs by 3D Bioprinting of a Cell‐Laden Thermogel: An Effective Tool to Assess Drug‐Induced Hepatotoxic Response. Adv Healthcare Mater 2020;9:2001163. [DOI: 10.1002/adhm.202001163] [Cited by in Crossref: 8] [Cited by in F6Publishing: 7] [Article Influence: 4.0] [Reference Citation Analysis]
15 Kameyama N, Kobayashi K, Shimizu S, Yamasaki Y, Endo M, Hashimoto M, Furihata T, Chiba K. Involvement of ESE-3, epithelial-specific ETS factor family member 3, in transactivation of the ABCB1 gene via pregnane X receptor in intestine-derived LS180 cells but not in liver-derived HepG2 cells. Drug Metab Pharmacokinet 2016;31:340-8. [PMID: 27567379 DOI: 10.1016/j.dmpk.2016.05.004] [Cited by in Crossref: 2] [Cited by in F6Publishing: 2] [Article Influence: 0.3] [Reference Citation Analysis]
16 Fernandes C, Videira AJC, Veloso CD, Benfeito S, Soares P, Martins JD, Gonçalves B, Duarte JFS, Santos AMS, Oliveira PJ, Borges F, Teixeira J, Silva FSG. Cytotoxicity and Mitochondrial Effects of Phenolic and Quinone-Based Mitochondria-Targeted and Untargeted Antioxidants on Human Neuronal and Hepatic Cell Lines: A Comparative Analysis. Biomolecules 2021;11:1605. [PMID: 34827603 DOI: 10.3390/biom11111605] [Reference Citation Analysis]
17 Berger B, Donzelli M, Maseneni S, Boess F, Roth A, Krähenbühl S, Haschke M. Comparison of Liver Cell Models Using the Basel Phenotyping Cocktail. Front Pharmacol 2016;7:443. [PMID: 27917125 DOI: 10.3389/fphar.2016.00443] [Cited by in Crossref: 36] [Cited by in F6Publishing: 38] [Article Influence: 6.0] [Reference Citation Analysis]
18 Fischer FC, Abele C, Henneberger L, Klüver N, König M, Mühlenbrink M, Schlichting R, Escher BI. Cellular Metabolism in High-Throughput In Vitro Reporter Gene Assays and Implications for the Quantitative In VitroIn Vivo Extrapolation. Chem Res Toxicol 2020;33:1770-9. [DOI: 10.1021/acs.chemrestox.0c00037] [Cited by in Crossref: 6] [Cited by in F6Publishing: 6] [Article Influence: 3.0] [Reference Citation Analysis]
19 Cargnin ST, Staudt AF, Medeiros P, de Medeiros Sol Sol D, de Azevedo Dos Santos AP, Zanchi FB, Gosmann G, Puyet A, Garcia Teles CB, Gnoatto SB. Semisynthesis, cytotoxicity, antimalarial evaluation and structure-activity relationship of two series of triterpene derivatives. Bioorg Med Chem Lett 2018;28:265-72. [PMID: 29326018 DOI: 10.1016/j.bmcl.2017.12.060] [Cited by in Crossref: 8] [Cited by in F6Publishing: 5] [Article Influence: 1.6] [Reference Citation Analysis]
20 Thuy Phuong NT, Kim JW, Kim JA, Jeon JS, Lee JY, Xu WJ, Yang JW, Kim SK, Kang KW. Role of the CYP3A4-mediated 11,12-epoxyeicosatrienoic acid pathway in the development of tamoxifen-resistant breast cancer. Oncotarget 2017;8:71054-69. [PMID: 29050342 DOI: 10.18632/oncotarget.20329] [Cited by in Crossref: 11] [Cited by in F6Publishing: 11] [Article Influence: 2.2] [Reference Citation Analysis]
21 Kim K, Ryu K, Cho H, Shim MS, Cho YY, Lee JY, Lee HS, Kang HC. Effects of Decomplexation Rates on Ternary Gene Complex Transfection with α-Poly(l-Lysine) or ε-Poly(l-Lysine) as a Decomplexation Controller in An Easy-To-Transfect Cell or A Hard-To-Transfect Cell. Pharmaceutics 2020;12:E490. [PMID: 32481637 DOI: 10.3390/pharmaceutics12060490] [Reference Citation Analysis]
22 Leão TK, Ribeiro DL, Machado ART, Costa TR, Sampaio SV, Antunes LMG. Synephrine and caffeine combination promotes cytotoxicity, DNA damage and transcriptional modulation of apoptosis-related genes in human HepG2 cells. Mutat Res Genet Toxicol Environ Mutagen 2021;868-869:503375. [PMID: 34454690 DOI: 10.1016/j.mrgentox.2021.503375] [Reference Citation Analysis]
23 Ramos E, Palomino-Antolín A, Bartolini M, Iriepa I, Moraleda I, Diez-Iriepa D, Samadi A, Cortina CV, Chioua M, Egea J, Romero A, Marco-Contelles J. QuinoxalineTacrine QT78, a Cholinesterase Inhibitor as a Potential Ligand for Alzheimer's Disease Therapy. Molecules 2019;24:E1503. [PMID: 30999586 DOI: 10.3390/molecules24081503] [Cited by in Crossref: 8] [Cited by in F6Publishing: 7] [Article Influence: 2.7] [Reference Citation Analysis]
24 Che S, Yuan J, Chen S, Li S, Zhang L, Ruan Z, Yao Y. Hesperidin prevents the combined toxicity of decabromodiphenyl ether and sodium nitrite in vitro. Food Chem Toxicol 2021;156:112410. [PMID: 34260953 DOI: 10.1016/j.fct.2021.112410] [Reference Citation Analysis]
25 Steinbrecht S, Kammerer S, Küpper J. HepG2 cells with recombinant cytochrome P450 enzyme overexpression: Their use and limitation as in vitro liver model. JCB 2019;5:55-64. [DOI: 10.3233/jcb-189013] [Cited by in Crossref: 5] [Article Influence: 1.7] [Reference Citation Analysis]
26 Zhang Y, Zhang W, Hou J, Wang X, Zheng H, Xiong W, Yuan J. Combined effect of tris(2-chloroethyl)phosphate and benzo (a) pyrene on the release of IL-6 and IL-8 from HepG2 cells via the EGFR-ERK1/2 signaling pathway. RSC Adv 2017;7:54281-90. [DOI: 10.1039/c7ra11273d] [Cited by in Crossref: 6] [Article Influence: 1.2] [Reference Citation Analysis]
27 Tsoutsoulopoulos A, Brockmöller S, Thiermann H, Steinritz D. Comparison of the toxicity of sulfur mustard and its oxidation products in vitro. Toxicol Lett 2020;321:69-72. [PMID: 31863871 DOI: 10.1016/j.toxlet.2019.12.015] [Cited by in Crossref: 3] [Cited by in F6Publishing: 3] [Article Influence: 1.0] [Reference Citation Analysis]
28 Kim M, Jee SC, Kim KS, Kim HS, Yu KN, Sung JS. Quercetin and Isorhamnetin Attenuate Benzo[a]pyrene-Induced Toxicity by Modulating Detoxification Enzymes through the AhR and NRF2 Signaling Pathways. Antioxidants (Basel) 2021;10:787. [PMID: 34065697 DOI: 10.3390/antiox10050787] [Reference Citation Analysis]
29 Wu YL, Xue YR, Guo ZT, Chen ZD, Ge XY, Zhong DF, Diao XX. Furmonertinib (Alflutinib, AST2818) is a potential positive control drug comparable to rifampin for evaluation of CYP3A4 induction in sandwich-cultured primary human hepatocytes. Acta Pharmacol Sin 2021. [PMID: 34035488 DOI: 10.1038/s41401-021-00692-7] [Reference Citation Analysis]
30 Li H, Wang YG, Ma ZC, Yun-Hang G, Ling S, Teng-Fei C, Guang-Ping Z, Gao Y. A high-throughput cell-based gaussia luciferase reporter assay for measurement of CYP1A1, CYP2B6, and CYP3A4 induction. Xenobiotica 2021;51:752-63. [PMID: 33896369 DOI: 10.1080/00498254.2021.1918800] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 1.0] [Reference Citation Analysis]
31 Zanetti TA, Biazi BI, Coatti GC, Baranoski A, Marques LA, Corveloni AC, Mantovani MS. Mitotic spindle defects and DNA damage induced by dimethoxycurcumin lead to an intrinsic apoptosis pathway in HepG2/C3A cells. Toxicology in Vitro 2019;61:104643. [DOI: 10.1016/j.tiv.2019.104643] [Cited by in Crossref: 6] [Cited by in F6Publishing: 6] [Article Influence: 2.0] [Reference Citation Analysis]
32 Liu F, Zhu S, Ni L, Huang L, Wang K, Zhou Y. Dexmedetomidine alleviates insulin resistance in hepatocytes by reducing endoplasmic reticulum stress. Endocrine 2020;67:87-94. [PMID: 31679138 DOI: 10.1007/s12020-019-02118-1] [Cited by in Crossref: 3] [Cited by in F6Publishing: 4] [Article Influence: 1.0] [Reference Citation Analysis]
33 Hou J, Yin W, Li P, Huang Y, Wan Y, Hu C, Xu T, Cheng J, Wang L, Yu Z, Yuan J. Effect of exposure to phthalates on association of polycyclic aromatic hydrocarbons with 8-hydroxy-2'-deoxyguanosine. Sci Total Environ 2019;691:378-92. [PMID: 31323583 DOI: 10.1016/j.scitotenv.2019.07.113] [Cited by in Crossref: 9] [Cited by in F6Publishing: 7] [Article Influence: 3.0] [Reference Citation Analysis]
34 Barreto MR, Aleixo NA, Silvestre RB, Fregonezi NF, Barud HDS, Dias DDS, Ribeiro CA, Resende FA. Genotoxicological safety assessment of puree-only edible films from onion bulb (Allium cepa L.) for use in food packaging-related applications. J Food Sci 2020;85:201-8. [PMID: 31876295 DOI: 10.1111/1750-3841.14977] [Cited by in Crossref: 4] [Cited by in F6Publishing: 4] [Article Influence: 1.3] [Reference Citation Analysis]
35 Martinez-Peinado N, Cortes-Serra N, Torras-Claveria L, Pinazo MJ, Gascon J, Bastida J, Alonso-Padilla J. Amaryllidaceae alkaloids with anti-Trypanosoma cruzi activity. Parasit Vectors 2020;13:299. [PMID: 32522289 DOI: 10.1186/s13071-020-04171-6] [Cited by in Crossref: 5] [Cited by in F6Publishing: 4] [Article Influence: 2.5] [Reference Citation Analysis]
36 Levorato S, Dominici L, Fatigoni C, Zadra C, Pagiotti R, Moretti M, Villarini M. In vitro toxicity evaluation of estragole-containing preparations derived from Foeniculum vulgare Mill. (fennel) on HepG2 cells. Food and Chemical Toxicology 2018;111:616-22. [DOI: 10.1016/j.fct.2017.12.014] [Cited by in Crossref: 9] [Cited by in F6Publishing: 7] [Article Influence: 2.3] [Reference Citation Analysis]
37 Nishimwe K, Agbemafle I, Reddy MB, Keener K, Maier DE. Cytotoxicity assessment of Aflatoxin B1 after high voltage atmospheric cold plasma treatment. Toxicon 2021;194:17-22. [PMID: 33610633 DOI: 10.1016/j.toxicon.2021.02.008] [Cited by in Crossref: 2] [Cited by in F6Publishing: 2] [Article Influence: 2.0] [Reference Citation Analysis]
38 Howell L, Jenkins RE, Lynch S, Duckworth C, Kevin Park B, Goldring C. Proteomic profiling of murine biliary-derived hepatic organoids and their capacity for drug disposition, bioactivation and detoxification. Arch Toxicol 2021;95:2413-30. [PMID: 34050779 DOI: 10.1007/s00204-021-03075-3] [Reference Citation Analysis]
39 Strojny B, Sawosz E, Grodzik M, Jaworski S, Szczepaniak J, Sosnowska M, Wierzbicki M, Kutwin M, Orlińska S, Chwalibog A. Nanostructures of diamond, graphene oxide and graphite inhibit CYP1A2, CYP2D6 and CYP3A4 enzymes and downregulate their genes in liver cells. Int J Nanomedicine 2018;13:8561-75. [PMID: 30587978 DOI: 10.2147/IJN.S188997] [Cited by in Crossref: 6] [Cited by in F6Publishing: 3] [Article Influence: 1.5] [Reference Citation Analysis]
40 Morgado PI, Jose S, Wanke R, M. Antunes AM, Cardoso AS, Jordao L. Integration of cellular and molecular endpoints to assess the toxicity of polycyclic aromatic hydrocarbons in HepG2 cell line: Toxicity of PAHs in HepG2 cell line. Environ Toxicol Chem 2017;36:3404-14. [DOI: 10.1002/etc.3927] [Cited by in Crossref: 6] [Cited by in F6Publishing: 5] [Article Influence: 1.2] [Reference Citation Analysis]
41 Ren Z, Chen S, Ning B, Guo L. Use of Liver-Derived Cell Lines for the Study of Drug-Induced Liver Injury. In: Chen M, Will Y, editors. Drug-Induced Liver Toxicity. New York: Springer; 2018. pp. 151-77. [DOI: 10.1007/978-1-4939-7677-5_8] [Cited by in Crossref: 3] [Cited by in F6Publishing: 2] [Article Influence: 0.8] [Reference Citation Analysis]
42 Hou J, Yin W, Li P, Hu C, Zhang Y, Wang X, Wang G, Gao E, Zhang J, Wang L, Li T, Wang L, Yu Z, Yuan J. Seasonal modification of the associations of exposure to polycyclic aromatic hydrocarbons or phthalates of cellular aging. Ecotoxicol Environ Saf 2019;182:109384. [PMID: 31272023 DOI: 10.1016/j.ecoenv.2019.109384] [Cited by in Crossref: 5] [Cited by in F6Publishing: 5] [Article Influence: 1.7] [Reference Citation Analysis]
43 Moreira NCDS, Lima JEBF, Chierrito TPC, Carvalho I, Sakamoto-Hojo ET. Novel Hybrid Acetylcholinesterase Inhibitors Induce Differentiation and Neuritogenesis in Neuronal Cells in vitro Through Activation of the AKT Pathway. J Alzheimers Dis 2020;78:353-70. [PMID: 32986667 DOI: 10.3233/JAD-200425] [Reference Citation Analysis]
44 Wright WC, Chenge J, Wang J, Girvan HM, Yang L, Chai SC, Huber AD, Wu J, Oladimeji PO, Munro AW, Chen T. Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5. J Med Chem 2020;63:1415-33. [PMID: 31965799 DOI: 10.1021/acs.jmedchem.9b02067] [Cited by in Crossref: 13] [Cited by in F6Publishing: 11] [Article Influence: 6.5] [Reference Citation Analysis]
45 Vogel KR, Ainslie GR, Roullet JB, McConnell A, Gibson KM. In vitro toxicological evaluation of NCS-382, a high-affinity antagonist of γ-hydroxybutyrate (GHB) binding. Toxicol In Vitro 2017;40:196-202. [PMID: 28119166 DOI: 10.1016/j.tiv.2017.01.013] [Cited by in Crossref: 5] [Cited by in F6Publishing: 4] [Article Influence: 1.0] [Reference Citation Analysis]
46 Sukkummee W, Jittisak P, Wonganan P, Wittayalertpanya S, Chariyavilaskul P, Leelahavanichkul A. The prominent impairment of liver/intestinal cytochrome P450 and intestinal drug transporters in sepsis-induced acute kidney injury over acute and chronic renal ischemia, a mouse model comparison. Ren Fail 2019;41:314-25. [PMID: 30991873 DOI: 10.1080/0886022X.2019.1602054] [Cited by in Crossref: 8] [Cited by in F6Publishing: 3] [Article Influence: 2.7] [Reference Citation Analysis]