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For: Hsu HC, Liu YS, Tseng KC, Hsu CL, Liang Y, Yang TS, Chen JS, Tang RP, Chen SJ, Chen HC. Overexpression of Lgr5 correlates with resistance to 5-FU-based chemotherapy in colorectal cancer. Int J Colorectal Dis. 2013;28:1535-1546. [PMID: 23784051 DOI: 10.1007/s00384-013-1721-x] [Cited by in Crossref: 52] [Cited by in F6Publishing: 51] [Article Influence: 5.8] [Reference Citation Analysis]
Number Citing Articles
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4 Hsu HC, Liu YS, Tseng KC, Tan BC, Chen SJ, Chen HC. LGR5 regulates survival through mitochondria-mediated apoptosis and by targeting the Wnt/β-catenin signaling pathway in colorectal cancer cells. Cell Signal 2014;26:2333-42. [PMID: 25025569 DOI: 10.1016/j.cellsig.2014.07.004] [Cited by in Crossref: 20] [Cited by in F6Publishing: 20] [Article Influence: 2.5] [Reference Citation Analysis]
5 Zhu Y, Yi Y, Bai B, Li L, You T, Sun W, Yu Y. The silencing of replication protein A1 induced cell apoptosis via regulating Caspase 3. Life Sciences 2018;201:141-9. [DOI: 10.1016/j.lfs.2018.03.054] [Cited by in Crossref: 5] [Cited by in F6Publishing: 5] [Article Influence: 1.3] [Reference Citation Analysis]
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7 Zhou Y, Xia L, Wang H, Oyang L, Su M, Liu Q, Lin J, Tan S, Tian Y, Liao Q, Cao D. Cancer stem cells in progression of colorectal cancer. Oncotarget. 2017;9:33403-33415. [PMID: 30279970 DOI: 10.18632/oncotarget.23607] [Cited by in Crossref: 73] [Cited by in F6Publishing: 78] [Article Influence: 14.6] [Reference Citation Analysis]
8 Kang XL, He LR, Chen YL, Wang SB. Role of doublecortin-like kinase 1 and leucine-rich repeat-containing G-protein-coupled receptor 5 in patients with stage II/III colorectal cancer: Cancer progression and prognosis. World J Gastroenterol 2020; 26(43): 6853-6866 [PMID: 33268966 DOI: 10.3748/wjg.v26.i43.6853] [Reference Citation Analysis]
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10 Shekarriz R, Montazer F, Alizadeh-Navaei R. Overexpression of cancer stem cell marker Lgr5 in colorectal cancer patients and association with clinicopathological findings. Caspian J Intern Med 2019;10:412-6. [PMID: 31814939 DOI: 10.22088/cjim.10.4.411] [Cited by in F6Publishing: 1] [Reference Citation Analysis]
11 Hsu HC, Liu YS, Tseng KC, Yang TS, Yeh CY, You JF, Hung HY, Chen SJ, Chen HC. CBB1003, a lysine-specific demethylase 1 inhibitor, suppresses colorectal cancer cells growth through down-regulation of leucine-rich repeat-containing G-protein-coupled receptor 5 expression. J Cancer Res Clin Oncol 2015;141:11-21. [PMID: 25060070 DOI: 10.1007/s00432-014-1782-4] [Cited by in Crossref: 15] [Cited by in F6Publishing: 13] [Article Influence: 1.9] [Reference Citation Analysis]
12 Lin YU, Wu T, Yao Q, Zi S, Cui L, Yang M, Li J. LGR5 promotes the proliferation of colorectal cancer cells via the Wnt/β-catenin signaling pathway. Oncol Lett 2015;9:2859-63. [PMID: 26137160 DOI: 10.3892/ol.2015.3144] [Cited by in Crossref: 14] [Cited by in F6Publishing: 14] [Article Influence: 2.0] [Reference Citation Analysis]
13 Nagata H, Ishihara S, Abe H, Ushiku T, Kishikawa J, Tanaka T, Hata K, Kawai K, Fukayama M, Nozawa H. LGR5 expression predicts peritoneal recurrence after curative resection of primary colon cancer. Br J Cancer 2019;120:996-1002. [PMID: 31000786 DOI: 10.1038/s41416-019-0442-5] [Cited by in Crossref: 4] [Cited by in F6Publishing: 4] [Article Influence: 1.3] [Reference Citation Analysis]
14 Nishioka M, Suehiro Y, Sakai K, Matsumoto T, Okayama N, Mizuno H, Ueno K, Suzuki N, Hashimoto S, Takami T, Hazama S, Nagano H, Sakaida I, Yamasaki T. TROY is a promising prognostic biomarker in patients with colorectal cancer. Oncol Lett 2018;15:5989-94. [PMID: 29556315 DOI: 10.3892/ol.2018.8079] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 0.3] [Reference Citation Analysis]
15 Smolle MA, Pichler M, Haybaeck J, Gerger A. Genetic markers of recurrence in colorectal cancer. Pharmacogenomics 2015;16:1313-26. [DOI: 10.2217/pgs.15.83] [Cited by in Crossref: 11] [Cited by in F6Publishing: 11] [Article Influence: 1.6] [Reference Citation Analysis]
16 Han Y, Xue X, Jiang M, Guo X, Li P, Liu F, Yuan B, Shen Y, Guo X, Zhi Q, Zhao H. LGR5, a relevant marker of cancer stem cells, indicates a poor prognosis in colorectal cancer patients: a meta-analysis. Clin Res Hepatol Gastroenterol 2015;39:267-73. [PMID: 25193236 DOI: 10.1016/j.clinre.2014.07.008] [Cited by in Crossref: 23] [Cited by in F6Publishing: 22] [Article Influence: 2.9] [Reference Citation Analysis]
17 Stanisavljević L, Myklebust MP, Leh S, Dahl O. LGR5 and CD133 as prognostic and predictive markers for fluoropyrimidine-based adjuvant chemotherapy in colorectal cancer. Acta Oncol 2016;55:1425-33. [PMID: 27435662 DOI: 10.1080/0284186X.2016.1201215] [Cited by in Crossref: 5] [Cited by in F6Publishing: 5] [Article Influence: 0.8] [Reference Citation Analysis]
18 Sato K, Uehara T, Iwaya M, Nakajima T, Miyagawa Y, Ota H, Tanaka E. Correlation of clinicopathological features and LGR5 expression in colon adenocarcinoma. Ann Diagn Pathol 2020;48:151587. [PMID: 32829068 DOI: 10.1016/j.anndiagpath.2020.151587] [Reference Citation Analysis]
19 Siemens H, Jackstadt R, Kaller M, Hermeking H. Repression of c-Kit by p53 is mediated by miR-34 and is associated with reduced chemoresistance, migration and stemness. Oncotarget 2013;4:1399-415. [PMID: 24009080 DOI: 10.18632/oncotarget.1202] [Cited by in Crossref: 105] [Cited by in F6Publishing: 107] [Article Influence: 13.1] [Reference Citation Analysis]
20 Szkandera J, Herzog S, Pichler M, Stiegelbauer V, Stotz M, Schaberl-Moser R, Samonigg H, Asslaber M, Lax S, Leitner G, Renner W, Lenz HJ, Berghold A, Gerger A. LGR5 rs17109924 is a predictive genetic biomarker for time to recurrence in patients with colon cancer treated with 5-fluorouracil-based adjuvant chemotherapy. Pharmacogenomics J 2015;15:391-6. [PMID: 25665511 DOI: 10.1038/tpj.2015.2] [Cited by in Crossref: 8] [Cited by in F6Publishing: 8] [Article Influence: 1.1] [Reference Citation Analysis]
21 Lai S, Cheng R, Gao D, Chen YG, Deng C. LGR5 constitutively activates NF-κB signaling to regulate the growth of intestinal crypts. FASEB J 2020;34:15605-20. [PMID: 33001511 DOI: 10.1096/fj.202001329R] [Cited by in Crossref: 1] [Article Influence: 0.5] [Reference Citation Analysis]
22 Mimeault M, Batra SK. Molecular biomarkers of cancer stem/progenitor cells associated with progression, metastases, and treatment resistance of aggressive cancers. Cancer Epidemiol Biomarkers Prev. 2014;23:234-254. [PMID: 24273063 DOI: 10.1158/1055-9965.epi-13-0785] [Cited by in Crossref: 47] [Cited by in F6Publishing: 32] [Article Influence: 5.2] [Reference Citation Analysis]
23 Usui T, Sakurai M, Enjoji S, Kawasaki H, Umata K, Ohama T, Fujiwara N, Yabe R, Tsuji S, Yamawaki H, Hazama S, Takenouchi H, Nakajima M, Tsunedomi R, Suzuki N, Nagano H, Sato K. Establishment of a Novel Model for Anticancer Drug Resistance in Three-Dimensional Primary Culture of Tumor Microenvironment. Stem Cells Int 2016;2016:7053872. [PMID: 28119740 DOI: 10.1155/2016/7053872] [Cited by in Crossref: 20] [Cited by in F6Publishing: 21] [Article Influence: 3.3] [Reference Citation Analysis]
24 Gzil A, Zarębska I, Jaworski D, Antosik P, Durślewicz J, Maciejewska J, Domanowska E, Skoczylas-Makowska N, Ahmadi N, Grzanka D, Szylberg Ł. The prognostic value of leucine-rich repeat-containing G-protein (Lgr5) and its impact on clinicopathological features of colorectal cancer. J Cancer Res Clin Oncol 2020;146:2547-57. [PMID: 32671503 DOI: 10.1007/s00432-020-03314-7] [Cited by in Crossref: 2] [Cited by in F6Publishing: 2] [Article Influence: 1.0] [Reference Citation Analysis]
25 Qin Y, Chen X, Liu Z, Tian X, Huo Z. miR-106a Reduces 5-Fluorouracil (5-FU) Sensitivity of Colorectal Cancer by Targeting Dual-Specificity Phosphatases 2 (DUSP2). Med Sci Monit 2018;24:4944-51. [PMID: 30011263 DOI: 10.12659/MSM.910016] [Cited by in Crossref: 5] [Cited by in F6Publishing: 5] [Article Influence: 1.3] [Reference Citation Analysis]
26 Cramer JM, Thompson T, Geskin A, LaFramboise W, Lagasse E. Distinct human stem cell populations in small and large intestine. PLoS One. 2015;10:e0118792. [PMID: 25751518 DOI: 10.1371/journal.pone.0118792] [Cited by in Crossref: 21] [Cited by in F6Publishing: 21] [Article Influence: 3.0] [Reference Citation Analysis]
27 Zhang F, Sun H, Zhang S, Yang X, Zhang G, Su T. Overexpression of PER3 Inhibits Self-Renewal Capability and Chemoresistance of Colorectal Cancer Stem-Like Cells via Inhibition of Notch and β-Catenin Signaling. Oncol Res 2017;25:709-19. [PMID: 27983919 DOI: 10.3727/096504016X14772331883976] [Cited by in Crossref: 20] [Cited by in F6Publishing: 14] [Article Influence: 3.3] [Reference Citation Analysis]
28 Sato K, Uehara T, Iwaya M, Nakajima T, Miyagawa Y, Suga T, Ota H, Tanaka E. Correlation of clinicopathological features and LGR5 expression in colon adenocarcinoma. Ann Diagn Pathol 2019;40:161-5. [PMID: 31100646 DOI: 10.1016/j.anndiagpath.2019.05.002] [Cited by in Crossref: 4] [Cited by in F6Publishing: 4] [Article Influence: 1.3] [Reference Citation Analysis]
29 Heydari K, Saidijam M, Sharifi MR, dermani FK, Soleimani Asl S, Shabab N, Najafi R. The Effect of miR-200c Inhibition on Chemosensitivity (5- FluoroUracil) in Colorectal Cancer. Pathol Oncol Res 2018;24:145-51. [DOI: 10.1007/s12253-017-0222-6] [Cited by in Crossref: 21] [Cited by in F6Publishing: 20] [Article Influence: 4.2] [Reference Citation Analysis]
30 Mebarki M, Bennaceur A, Bonhomme-faivre L. Human-cell-derived organoids as a new ex vivo model for drug assays in oncology. Drug Discovery Today 2018;23:857-63. [DOI: 10.1016/j.drudis.2018.02.003] [Cited by in Crossref: 17] [Cited by in F6Publishing: 10] [Article Influence: 4.3] [Reference Citation Analysis]
31 Lee SH, Hong JH, Park HK, Park JS, Kim BK, Lee JY, Jeong JY, Yoon GS, Inoue M, Choi GS, Lee IK. Colorectal cancer-derived tumor spheroids retain the characteristics of original tumors. Cancer Lett. 2015;367:34-42. [PMID: 26185002 DOI: 10.1016/j.canlet.2015.06.024] [Cited by in Crossref: 30] [Cited by in F6Publishing: 28] [Article Influence: 4.3] [Reference Citation Analysis]
32 Paschall AV, Liu K. Epigenetic and Immune Regulation of Colorectal Cancer Stem Cells. Curr Colorectal Cancer Rep 2015;11:414-21. [PMID: 30655730 DOI: 10.1007/s11888-015-0301-6] [Cited by in Crossref: 3] [Cited by in F6Publishing: 2] [Article Influence: 0.4] [Reference Citation Analysis]
33 Jang BG, Kim HS, Chang WY, Bae JM, Kim WH, Kang GH. Expression Profile of LGR5 and Its Prognostic Significance in Colorectal Cancer Progression. Am J Pathol 2018;188:2236-50. [PMID: 30036518 DOI: 10.1016/j.ajpath.2018.06.012] [Cited by in Crossref: 18] [Cited by in F6Publishing: 18] [Article Influence: 4.5] [Reference Citation Analysis]
34 Jiang Y, Li W, He X, Zhang H, Jiang F, Chen Z. Lgr5 expression is a valuable prognostic factor for colorectal cancer: evidence from a meta-analysis. BMC Cancer 2015;15:948. [PMID: 26674601 DOI: 10.1186/s12885-015-1985-3] [Cited by in Crossref: 6] [Cited by in F6Publishing: 7] [Article Influence: 0.9] [Reference Citation Analysis]
35 Chen X, Wei B, Han X, Zheng Z, Huang J, Liu J, Huang Y, Wei H. LGR5 is required for the maintenance of spheroid-derived colon cancer stem cells. Int J Mol Med 2014;34:35-42. [PMID: 24789370 DOI: 10.3892/ijmm.2014.1752] [Cited by in Crossref: 23] [Cited by in F6Publishing: 23] [Article Influence: 2.9] [Reference Citation Analysis]
36 Tucker DW, Getchell CR, McCarthy ET, Ohman AW, Sasamoto N, Xu S, Ko JY, Gupta M, Shafrir A, Medina JE, Lee JJ, MacDonald LA, Malik A, Hasselblatt KT, Li W, Zhang H, Kaplan SJ, Murphy GF, Hirsch MS, Liu JF, Matulonis UA, Terry KL, Lian CG, Dinulescu DM. Epigenetic Reprogramming Strategies to Reverse Global Loss of 5-Hydroxymethylcytosine, a Prognostic Factor for Poor Survival in High-grade Serous Ovarian Cancer. Clin Cancer Res 2018;24:1389-401. [PMID: 29263182 DOI: 10.1158/1078-0432.CCR-17-1958] [Cited by in Crossref: 20] [Cited by in F6Publishing: 15] [Article Influence: 4.0] [Reference Citation Analysis]
37 Fiore D, Ramesh P, Proto MC, Piscopo C, Franceschelli S, Anzelmo S, Medema JP, Bifulco M, Gazzerro P. Rimonabant Kills Colon Cancer Stem Cells without Inducing Toxicity in Normal Colon Organoids. Front Pharmacol 2017;8:949. [PMID: 29354056 DOI: 10.3389/fphar.2017.00949] [Cited by in Crossref: 18] [Cited by in F6Publishing: 16] [Article Influence: 4.5] [Reference Citation Analysis]
38 Han SH, Kim JW, Kim M, Kim JH, Lee KW, Kim BH, Oh HK, Kim DW, Kang SB, Kim H, Shin E. Prognostic implication of ABC transporters and cancer stem cell markers in patients with stage III colon cancer receiving adjuvant FOLFOX-4 chemotherapy. Oncol Lett 2019;17:5572-80. [PMID: 31186779 DOI: 10.3892/ol.2019.10234] [Cited by in Crossref: 3] [Cited by in F6Publishing: 5] [Article Influence: 1.0] [Reference Citation Analysis]
39 Yang WJ, Wang HB, Wang WD, Bai PY, Lu HX, Sun CH, Liu ZS, Guan DK, Yang GW, Zhang GL. A network-based predictive gene expression signature for recurrence risks in stage II colorectal cancer. Cancer Med 2020;9:179-93. [PMID: 31724326 DOI: 10.1002/cam4.2642] [Cited by in Crossref: 8] [Cited by in F6Publishing: 7] [Article Influence: 2.7] [Reference Citation Analysis]
40 Paschall AV, Yang D, Lu C, Redd PS, Choi JH, Heaton CM, Lee JR, Nayak-Kapoor A, Liu K. CD133+CD24lo defines a 5-Fluorouracil-resistant colon cancer stem cell-like phenotype. Oncotarget 2016;7:78698-712. [PMID: 27659530 DOI: 10.18632/oncotarget.12168] [Cited by in Crossref: 19] [Cited by in F6Publishing: 17] [Article Influence: 4.8] [Reference Citation Analysis]
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42 Wahab SR, Islam F, Gopalan V, Lam AK. The Identifications and Clinical Implications of Cancer Stem Cells in Colorectal Cancer. Clinical Colorectal Cancer 2017;16:93-102. [DOI: 10.1016/j.clcc.2017.01.011] [Cited by in Crossref: 44] [Cited by in F6Publishing: 43] [Article Influence: 8.8] [Reference Citation Analysis]
43 Rassouli FB, Matin MM, Saeinasab M. Cancer stem cells in human digestive tract malignancies. Tumor Biol 2016;37:7-21. [DOI: 10.1007/s13277-015-4155-y] [Cited by in Crossref: 33] [Cited by in F6Publishing: 39] [Article Influence: 4.7] [Reference Citation Analysis]
44 Cao B, Luo L, Feng L, Ma S, Chen T, Ren Y, Zha X, Cheng S, Zhang K, Chen C. A network-based predictive gene-expression signature for adjuvant chemotherapy benefit in stage II colorectal cancer. BMC Cancer 2017;17:844. [PMID: 29237416 DOI: 10.1186/s12885-017-3821-4] [Cited by in Crossref: 10] [Cited by in F6Publishing: 8] [Article Influence: 2.0] [Reference Citation Analysis]
45 Azbazdar Y, Karabicici M, Erdal E, Ozhan G. Regulation of Wnt Signaling Pathways at the Plasma Membrane and Their Misregulation in Cancer. Front Cell Dev Biol 2021;9:631623. [PMID: 33585487 DOI: 10.3389/fcell.2021.631623] [Cited by in Crossref: 6] [Cited by in F6Publishing: 4] [Article Influence: 6.0] [Reference Citation Analysis]
46 Morgan RG, Mortensson E, Williams AC. Targeting LGR5 in Colorectal Cancer: therapeutic gold or too plastic? Br J Cancer 2018;118:1410-8. [PMID: 29844449 DOI: 10.1038/s41416-018-0118-6] [Cited by in Crossref: 40] [Cited by in F6Publishing: 37] [Article Influence: 10.0] [Reference Citation Analysis]
47 Chen Q, Zhang X, Li WM, Ji YQ, Cao HZ, Zheng P. Prognostic value of LGR5 in colorectal cancer: a meta-analysis. PLoS One 2014;9:e107013. [PMID: 25192390 DOI: 10.1371/journal.pone.0107013] [Cited by in Crossref: 19] [Cited by in F6Publishing: 20] [Article Influence: 2.4] [Reference Citation Analysis]
48 Mohan A, Raj Rajan R, Mohan G, Kollenchery Puthenveettil P, Maliekal TT. Markers and Reporters to Reveal the Hierarchy in Heterogeneous Cancer Stem Cells. Front Cell Dev Biol 2021;9:668851. [PMID: 34150761 DOI: 10.3389/fcell.2021.668851] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 1.0] [Reference Citation Analysis]
49 Chen W, Fu Q, Fang F, Fang J, Zhang Q, Hong Y. Overexpression of leucine-rich repeat-containing G protein-coupled receptor 5 predicts poor prognosis in hepatocellular carcinoma. Saudi J Biol Sci 2018;25:904-8. [PMID: 30108439 DOI: 10.1016/j.sjbs.2017.12.014] [Cited by in Crossref: 5] [Cited by in F6Publishing: 6] [Article Influence: 1.0] [Reference Citation Analysis]
50 Tsoumas D, Nikou S, Giannopoulou E, Champeris Tsaniras S, Sirinian C, Maroulis I, Taraviras S, Zolota V, Kalofonos HP, Bravou V. ILK Expression in Colorectal Cancer Is Associated with EMT, Cancer Stem Cell Markers and Chemoresistance. Cancer Genomics Proteomics 2018;15:127-41. [PMID: 29496692 DOI: 10.21873/cgp.20071] [Cited by in Crossref: 12] [Cited by in F6Publishing: 26] [Article Influence: 3.0] [Reference Citation Analysis]
51 Jiang Y, Li W, He X, Zhang H, Jiang F, Chen Z. Lgr5 expression is a valuable prognostic factor for colorectal cancer: evidence from a meta-analysis. BMC Cancer 2016;16:12. [PMID: 26758198 DOI: 10.1186/s12885-015-1986-2] [Cited by in Crossref: 18] [Cited by in F6Publishing: 21] [Article Influence: 3.0] [Reference Citation Analysis]