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For: Guo Y, Chu X, Parrott NJ, Brouwer KLR, Hsu V, Nagar S, Matsson P, Sharma P, Snoeys J, Sugiyama Y, Tatosian D, Unadkat JD, Huang SM, Galetin A; International Transporter Consortium. Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro, Imaging and Physiologically Based Pharmacokinetic Modeling Approaches. Clin Pharmacol Ther 2018;104:865-89. [PMID: 30059145 DOI: 10.1002/cpt.1183] [Cited by in Crossref: 62] [Cited by in F6Publishing: 64] [Article Influence: 15.5] [Reference Citation Analysis]
Number Citing Articles
1 Pastor CM, Vilgrain V. Monocrotaline Toxicity Alters the Function of Hepatocyte Membrane Transporters in Rats. IJMS 2022;23:7928. [DOI: 10.3390/ijms23147928] [Reference Citation Analysis]
2 Yang X, Reynolds K, Madabushi R, Huang SM. Current Perspective on Residual Knowledge Gaps in the Assessment of Transporter-Mediated Drug Interactions. Clin Pharmacol Ther 2022. [PMID: 35722741 DOI: 10.1002/cpt.2671] [Reference Citation Analysis]
3 Saleh MAA, Bloemberg JS, Elassaiss-Schaap J, de Lange ECM. Drug Distribution in Brain and Cerebrospinal Fluids in Relation to IC50 Values in Aging and Alzheimer's Disease, Using the Physiologically Based LeiCNS-PK3.0 Model. Pharm Res 2022. [PMID: 35606598 DOI: 10.1007/s11095-022-03281-3] [Reference Citation Analysis]
4 Chu X, Prasad B, Neuhoff S, Yoshida K, Leeder JS, Mukherjee D, Taskar K, Varma MVS, Zhang X, Yang X, Galetin A. Clinical Implications of Altered Drug Transporter Abundance/Function and PBPK Modeling in Specific Populations: An ITC Perspective. Clin Pharmacol Ther 2022. [PMID: 35561140 DOI: 10.1002/cpt.2643] [Cited by in Crossref: 4] [Cited by in F6Publishing: 1] [Article Influence: 4.0] [Reference Citation Analysis]
5 Giacomini KM, Yee SW, Koleske ML, Zou L, Matsson P, Chen EC, Kroetz DL, Miller MA, Gozalpour E, Chu X. New and Emerging Research on Solute Carrier and ATP Binding Cassette Transporters in Drug Discovery and Development: Outlook from the International Transporter Consortium. Clin Pharmacol Ther 2022. [PMID: 35488474 DOI: 10.1002/cpt.2627] [Cited by in Crossref: 3] [Cited by in F6Publishing: 2] [Article Influence: 3.0] [Reference Citation Analysis]
6 Scotcher D, Galetin A. PBPK Simulation-Based Evaluation of Ganciclovir Crystalluria Risk Factors: Effect of Renal Impairment, Old Age, and Low Fluid Intake. AAPS J 2021;24:13. [PMID: 34907479 DOI: 10.1208/s12248-021-00654-1] [Reference Citation Analysis]
7 Wang L, Zhu Z, Tran D, Seo SK, Pan X. Advancing Estimation of Hepatobiliary Clearances in Physiologically Based Pharmacokinetic Models of Rosuvastatin Using Human Hepatic Concentrations. Pharm Res 2021. [PMID: 34862570 DOI: 10.1007/s11095-021-03138-1] [Reference Citation Analysis]
8 Pastor CM, Brouwer KLR. New Pharmacokinetic Parameters of Imaging Substrates Quantified from Rat Liver Compartments. Drug Metab Dispos 2022;50:58-64. [PMID: 34670777 DOI: 10.1124/dmd.121.000546] [Reference Citation Analysis]
9 Pastor CM, Joly F, Vilgrain V, Millet P. Concentrations and pharmacokinetic parameters of MRI and SPECT hepatobiliary agents in rat liver compartments. Eur Radiol Exp 2021;5:42. [PMID: 34545428 DOI: 10.1186/s41747-021-00236-y] [Reference Citation Analysis]
10 Al-Majdoub ZM, Scotcher D, Achour B, Barber J, Galetin A, Rostami-Hodjegan A. Quantitative Proteomic Map of Enzymes and Transporters in the Human Kidney: Stepping Closer to Mechanistic Kidney Models to Define Local Kinetics. Clin Pharmacol Ther 2021. [PMID: 34390491 DOI: 10.1002/cpt.2396] [Cited by in F6Publishing: 1] [Reference Citation Analysis]
11 Cleary Y, Gertz M, Grimsey P, Günther A, Heinig K, Ogungbenro K, Aarons L, Galetin A, Kletzl H. Model-Based Drug-Drug Interaction Extrapolation Strategy From Adults to Children: Risdiplam in Pediatric Patients With Spinal Muscular Atrophy. Clin Pharmacol Ther 2021. [PMID: 34347881 DOI: 10.1002/cpt.2384] [Cited by in F6Publishing: 3] [Reference Citation Analysis]
12 Scotcher D, Melillo N, Tadimalla S, Darwich AS, Ziemian S, Ogungbenro K, Schütz G, Sourbron S, Galetin A. Physiologically Based Pharmacokinetic Modeling of Transporter-Mediated Hepatic Disposition of Imaging Biomarker Gadoxetate in Rats. Mol Pharm 2021;18:2997-3009. [PMID: 34283621 DOI: 10.1021/acs.molpharmaceut.1c00206] [Reference Citation Analysis]
13 Lang J, Vincent L, Chenel M, Ogungbenro K, Galetin A. Reduced physiologically-based pharmacokinetic model of dabigatran etexilate-dabigatran and its application for prediction of intestinal P-gp-mediated drug-drug interactions. Eur J Pharm Sci 2021;165:105932. [PMID: 34260894 DOI: 10.1016/j.ejps.2021.105932] [Reference Citation Analysis]
14 Martinec O, Biel C, de Graaf IAM, Huliciak M, de Jong KP, Staud F, Cecka F, Olinga P, Vokral I, Cerveny L. Rifampicin Induces Gene, Protein, and Activity of P-Glycoprotein (ABCB1) in Human Precision-Cut Intestinal Slices. Front Pharmacol 2021;12:684156. [PMID: 34177592 DOI: 10.3389/fphar.2021.684156] [Cited by in F6Publishing: 4] [Reference Citation Analysis]
15 Parvez MM, Basit A, Jariwala PB, Gáborik Z, Kis E, Heyward S, Redinbo MR, Prasad B. Quantitative Investigation of Irinotecan Metabolism, Transport, and Gut Microbiome Activation. Drug Metab Dispos 2021;49:683-93. [PMID: 34074730 DOI: 10.1124/dmd.121.000476] [Reference Citation Analysis]
16 Zhou K, Mi K, Ma W, Xu X, Huo M, Algharib SA, Pan Y, Xie S, Huang L. Application of physiologically based pharmacokinetic models to promote the development of veterinary drugs with high efficacy and safety. J Vet Pharmacol Ther 2021;44:663-78. [PMID: 34009661 DOI: 10.1111/jvp.12976] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 1.0] [Reference Citation Analysis]
17 Ravenstijn P, Chetty M, Manchandani P. Design and conduct considerations for studies in patients with impaired renal function. Clin Transl Sci 2021. [PMID: 33982447 DOI: 10.1111/cts.13061] [Reference Citation Analysis]
18 Gallo JM. Hybrid physiologically-based pharmacokinetic model for remdesivir: Application to SARS-CoV-2. Clin Transl Sci 2021;14:1082-91. [PMID: 33404204 DOI: 10.1111/cts.12975] [Reference Citation Analysis]
19 Ahmad A, Ogungbenro K, Kunze A, Jacobs F, Snoeys J, Rostami-Hodjegan A, Galetin A. Population pharmacokinetic modeling and simulation to support qualification of pyridoxic acid as endogenous biomarker of OAT1/3 renal transporters. CPT Pharmacometrics Syst Pharmacol 2021;10:467-77. [PMID: 33704919 DOI: 10.1002/psp4.12610] [Cited by in Crossref: 3] [Cited by in F6Publishing: 5] [Article Influence: 3.0] [Reference Citation Analysis]
20 Wu F, Cristofoletti R, Zhao L, Rostami‐hodjegan A. Scientific considerations to move towards biowaiver for biopharmaceutical classification system class III drugs: How modeling and simulation can help. Biopharm Drug Dispos 2021;42:118-27. [DOI: 10.1002/bdd.2274] [Cited by in Crossref: 3] [Cited by in F6Publishing: 4] [Article Influence: 3.0] [Reference Citation Analysis]
21 Lee J, Yang Y, Zhang X, Fan J, Grimstein M, Zhu H, Wang Y. Usage of In Vitro Metabolism Data for Drug-Drug Interaction in Physiologically Based Pharmacokinetic Analysis Submissions to the US Food and Drug Administration. J Clin Pharmacol 2021;61:782-8. [PMID: 33460193 DOI: 10.1002/jcph.1819] [Cited by in Crossref: 1] [Cited by in F6Publishing: 6] [Article Influence: 1.0] [Reference Citation Analysis]
22 Izat N, Sahin S. Hepatic transporter-mediated pharmacokinetic drug-drug interactions: Recent studies and regulatory recommendations. Biopharm Drug Dispos 2021;42:45-77. [PMID: 33507532 DOI: 10.1002/bdd.2262] [Reference Citation Analysis]
23 Peng Y, Cheng Z, Xie F. Evaluation of Pharmacokinetic Drug-Drug Interactions: A Review of the Mechanisms, In Vitro and In Silico Approaches. Metabolites 2021;11:75. [PMID: 33513941 DOI: 10.3390/metabo11020075] [Cited by in Crossref: 1] [Cited by in F6Publishing: 10] [Article Influence: 1.0] [Reference Citation Analysis]
24 Takita H, Barnett S, Zhang Y, Ménochet K, Shen H, Ogungbenro K, Galetin A. PBPK Model of Coproporphyrin I: Evaluation of the Impact of SLCO1B1 Genotype, Ethnicity, and Sex on its Inter-Individual Variability. CPT Pharmacometrics Syst Pharmacol 2021;10:137-47. [PMID: 33289952 DOI: 10.1002/psp4.12582] [Cited by in Crossref: 3] [Cited by in F6Publishing: 10] [Article Influence: 3.0] [Reference Citation Analysis]
25 Naji-Talakar S, Sharma S, Martin LA, Barnhart D, Prasad B. Potential implications of DMET ontogeny on the disposition of commonly prescribed drugs in neonatal and pediatric intensive care units. Expert Opin Drug Metab Toxicol 2021;17:273-89. [PMID: 33256492 DOI: 10.1080/17425255.2021.1858051] [Reference Citation Analysis]
26 Schmitt MV, Reichel A, Liu X, Fricker G, Lienau P. Extension of the Mechanistic Tissue Distribution Model of Rodgers and Rowland by Systematic Incorporation of Lysosomal Trapping: Impact on Unbound Partition Coefficient and Volume of Distribution Predictions in the Rat. Drug Metab Dispos 2021;49:53-61. [PMID: 33148688 DOI: 10.1124/dmd.120.000161] [Reference Citation Analysis]
27 Meyer MJ, Tuerkova A, Römer S, Wenzel C, Seitz T, Gaedcke J, Oswald S, Brockmöller J, Zdrazil B, Tzvetkov MV. Differences in Metformin and Thiamine Uptake between Human and Mouse Organic Cation Transporter 1: Structural Determinants and Potential Consequences for Intrahepatic Concentrations. Drug Metab Dispos 2020;48:1380-92. [PMID: 33037045 DOI: 10.1124/dmd.120.000170] [Cited by in Crossref: 7] [Cited by in F6Publishing: 6] [Article Influence: 3.5] [Reference Citation Analysis]
28 Lang J, Vincent L, Chenel M, Ogungbenro K, Galetin A. Simultaneous Ivabradine Parent-Metabolite PBPK/PD Modelling Using a Bayesian Estimation Method. AAPS J 2020;22. [DOI: 10.1208/s12248-020-00502-8] [Cited by in Crossref: 3] [Cited by in F6Publishing: 3] [Article Influence: 1.5] [Reference Citation Analysis]
29 Hafey MJ, Houle R, Tanis KQ, Knemeyer I, Shang J, Chen Q, Baudy A, Monroe J, Sistare FD, Evers R. A Two-Tiered In Vitro Approach to De-Risk Drug Candidates for Potential Bile Salt Export Pump Inhibition Liabilities in Drug Discovery. Drug Metab Dispos 2020;48:1147-60. [PMID: 32943412 DOI: 10.1124/dmd.120.000086] [Reference Citation Analysis]
30 Cheung KWK, van Groen BD, Burckart GJ, Zhang L, de Wildt SN, Huang SM. Incorporating Ontogeny in Physiologically Based Pharmacokinetic Modeling to Improve Pediatric Drug Development: What We Know About Developmental Changes in Membrane Transporters. J Clin Pharmacol 2019;59 Suppl 1:S56-69. [PMID: 31502692 DOI: 10.1002/jcph.1489] [Cited by in Crossref: 5] [Cited by in F6Publishing: 8] [Article Influence: 2.5] [Reference Citation Analysis]
31 Nicolaï J, Chapy H, Gillent E, Saunders K, Ungell AL, Nicolas JM, Chanteux H. Impact of In Vitro Passive Permeability in a P-gp-transfected LLC-PK1 Model on the Prediction of the Rat and Human Unbound Brain-to-Plasma Concentration Ratio. Pharm Res 2020;37:175. [PMID: 32856111 DOI: 10.1007/s11095-020-02867-z] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 0.5] [Reference Citation Analysis]
32 Yamada M, Ishizuka T, Inoue SI, Rozehnal V, Fischer T, Sugiyama D. Drug-Drug Interaction Risk Assessment of Esaxerenone as a Perpetrator by In Vitro Studies and Static and Physiologically Based Pharmacokinetic Models. Drug Metab Dispos 2020;48:769-77. [PMID: 32616542 DOI: 10.1124/dmd.120.090928] [Cited by in Crossref: 3] [Cited by in F6Publishing: 1] [Article Influence: 1.5] [Reference Citation Analysis]
33 Isoherranen N, Madabushi R, Huang SM. Emerging Role of Organ-on-a-Chip Technologies in Quantitative Clinical Pharmacology Evaluation. Clin Transl Sci 2019;12:113-21. [PMID: 30740886 DOI: 10.1111/cts.12627] [Cited by in Crossref: 23] [Cited by in F6Publishing: 21] [Article Influence: 11.5] [Reference Citation Analysis]
34 Francis L, Harrell A, Hallifax D, Galetin A. Utilising Magnetically Isolated Lysosomes for Direct Quantification of Intralysosomal Drug Concentrations by LC-MS/MS Analysis: An Investigatory Study With Imipramine. J Pharm Sci 2020;109:2891-901. [PMID: 32504630 DOI: 10.1016/j.xphs.2020.05.026] [Cited by in Crossref: 1] [Cited by in F6Publishing: 2] [Article Influence: 0.5] [Reference Citation Analysis]
35 Dai Y, Yang Y, Liu B, Qiao L. Water-in-oil microcompartments for the study of biomimetic drug metabolism. J Colloid Interface Sci 2020;569:378-85. [PMID: 32126350 DOI: 10.1016/j.jcis.2020.02.096] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 0.5] [Reference Citation Analysis]
36 Scotcher D, Arya V, Yang X, Zhao P, Zhang L, Huang SM, Rostami-Hodjegan A, Galetin A. A Novel Physiologically Based Model of Creatinine Renal Disposition to Integrate Current Knowledge of Systems Parameters and Clinical Observations. CPT Pharmacometrics Syst Pharmacol 2020;9:310-21. [PMID: 32441889 DOI: 10.1002/psp4.12509] [Cited by in Crossref: 4] [Cited by in F6Publishing: 7] [Article Influence: 2.0] [Reference Citation Analysis]
37 Scotcher D, Arya V, Yang X, Zhao P, Zhang L, Huang SM, Rostami-Hodjegan A, Galetin A. Mechanistic Models as Framework for Understanding Biomarker Disposition: Prediction of Creatinine-Drug Interactions. CPT Pharmacometrics Syst Pharmacol 2020;9:282-93. [PMID: 32410382 DOI: 10.1002/psp4.12508] [Cited by in Crossref: 6] [Cited by in F6Publishing: 11] [Article Influence: 3.0] [Reference Citation Analysis]
38 Choi YH. Interpretation of Drug Interaction Using Systemic and Local Tissue Exposure Changes. Pharmaceutics 2020;12:E417. [PMID: 32370191 DOI: 10.3390/pharmaceutics12050417] [Cited by in Crossref: 7] [Cited by in F6Publishing: 7] [Article Influence: 3.5] [Reference Citation Analysis]
39 Trünkle C, Lechner C, Korr D, Bouché L, Barak N, Fernández-montalván A, Süssmuth RD, Reichel A. Concentration Dependence of the Unbound Partition Coefficient Kp uu and Its Application to Correct for Exposure-Related Discrepancies between Biochemical and Cellular Potency of KAT6A Inhibitors. Drug Metab Dispos 2020;48:553-62. [DOI: 10.1124/dmd.120.090563] [Cited by in Crossref: 4] [Cited by in F6Publishing: 4] [Article Influence: 2.0] [Reference Citation Analysis]
40 Alluri RV, Li R, Varma MVS. Transporter–enzyme interplay and the hepatic drug clearance: what have we learned so far? Expert Opinion on Drug Metabolism & Toxicology 2020;16:387-401. [DOI: 10.1080/17425255.2020.1749595] [Cited by in Crossref: 7] [Cited by in F6Publishing: 6] [Article Influence: 3.5] [Reference Citation Analysis]
41 Patel D, Yang W, Lipert M, Wu T. Application and Impact of Human Dose Projection from Discovery to Early Drug Development. AAPS PharmSciTech 2020;21:44. [PMID: 31897807 DOI: 10.1208/s12249-019-1598-2] [Reference Citation Analysis]
42 Taskar KS, Pilla Reddy V, Burt H, Posada MM, Varma M, Zheng M, Ullah M, Emami Riedmaier A, Umehara KI, Snoeys J, Nakakariya M, Chu X, Beneton M, Chen Y, Huth F, Narayanan R, Mukherjee D, Dixit V, Sugiyama Y, Neuhoff S. Physiologically-Based Pharmacokinetic Models for Evaluating Membrane Transporter Mediated Drug-Drug Interactions: Current Capabilities, Case Studies, Future Opportunities, and Recommendations. Clin Pharmacol Ther 2020;107:1082-115. [PMID: 31628859 DOI: 10.1002/cpt.1693] [Cited by in Crossref: 27] [Cited by in F6Publishing: 43] [Article Influence: 9.0] [Reference Citation Analysis]
43 Drozdzik M, Szelag‐pieniek S, Post M, Zeair S, Wrzesinski M, Kurzawski M, Prieto J, Oswald S. Protein Abundance of Hepatic Drug Transporters in Patients With Different Forms of Liver Damage. Clin Pharmacol Ther 2020;107:1138-48. [DOI: 10.1002/cpt.1717] [Cited by in Crossref: 10] [Cited by in F6Publishing: 16] [Article Influence: 3.3] [Reference Citation Analysis]
44 Treyer A, Walday S, Boriss H, Matsson P, Artursson P. A Cell-Free Approach Based on Phospholipid Characterization for Determination of the Cell Specific Unbound Drug Fraction (fu,cell). Pharm Res 2019;36:178. [PMID: 31701258 DOI: 10.1007/s11095-019-2717-1] [Cited by in Crossref: 3] [Cited by in F6Publishing: 2] [Article Influence: 1.0] [Reference Citation Analysis]
45 Li Y, Meng Q, Yang M, Liu D, Hou X, Tang L, Wang X, Lyu Y, Chen X, Liu K, Yu AM, Zuo Z, Bi H. Current trends in drug metabolism and pharmacokinetics. Acta Pharm Sin B 2019;9:1113-44. [PMID: 31867160 DOI: 10.1016/j.apsb.2019.10.001] [Cited by in Crossref: 58] [Cited by in F6Publishing: 45] [Article Influence: 19.3] [Reference Citation Analysis]
46 van der Made TK, Fedecostante M, Scotcher D, Rostami-Hodjegan A, Sastre Toraño J, Middel I, Koster AS, Gerritsen KG, Jankowski V, Jankowski J, Hoenderop JGJ, Masereeuw R, Galetin A. Quantitative Translation of Microfluidic Transporter in Vitro Data to in Vivo Reveals Impaired Albumin-Facilitated Indoxyl Sulfate Secretion in Chronic Kidney Disease. Mol Pharm 2019;16:4551-62. [PMID: 31525064 DOI: 10.1021/acs.molpharmaceut.9b00681] [Cited by in Crossref: 14] [Cited by in F6Publishing: 12] [Article Influence: 4.7] [Reference Citation Analysis]
47 Giacomini KM, Galetin A, Huang SM. The International Transporter Consortium: Summarizing Advances in the Role of Transporters in Drug Development. Clin Pharmacol Ther 2018;104:766-71. [PMID: 30137696 DOI: 10.1002/cpt.1224] [Cited by in Crossref: 28] [Cited by in F6Publishing: 28] [Article Influence: 9.3] [Reference Citation Analysis]
48 Billington S, Shoner S, Lee S, Clark-Snustad K, Pennington M, Lewis D, Muzi M, Rene S, Lee J, Nguyen TB, Kumar V, Ishida K, Chen L, Chu X, Lai Y, Salphati L, Hop CECA, Xiao G, Liao M, Unadkat JD. Positron Emission Tomography Imaging of [11 C]Rosuvastatin Hepatic Concentrations and Hepatobiliary Transport in Humans in the Absence and Presence of Cyclosporin A. Clin Pharmacol Ther 2019;106:1056-66. [PMID: 31102467 DOI: 10.1002/cpt.1506] [Cited by in Crossref: 23] [Cited by in F6Publishing: 28] [Article Influence: 7.7] [Reference Citation Analysis]
49 Zhang D, Hop CECA, Patilea-Vrana G, Gampa G, Seneviratne HK, Unadkat JD, Kenny JR, Nagapudi K, Di L, Zhou L, Zak M, Wright MR, Bumpus NN, Zang R, Liu X, Lai Y, Khojasteh SC. Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule-Related Therapeutic Modalities. Drug Metab Dispos 2019;47:1122-35. [PMID: 31266753 DOI: 10.1124/dmd.119.086744] [Cited by in Crossref: 22] [Cited by in F6Publishing: 18] [Article Influence: 7.3] [Reference Citation Analysis]
50 Treyer A, Ullah M, Parrott N, Molitor B, Fowler S, Artursson P. Impact of Intracellular Concentrations on Metabolic Drug-Drug Interaction Studies. AAPS J 2019;21:77. [PMID: 31214810 DOI: 10.1208/s12248-019-0344-8] [Cited by in Crossref: 8] [Cited by in F6Publishing: 7] [Article Influence: 2.7] [Reference Citation Analysis]
51 Ribeiro AJS, Yang X, Patel V, Madabushi R, Strauss DG. Liver Microphysiological Systems for Predicting and Evaluating Drug Effects. Clin Pharmacol Ther 2019;106:139-47. [PMID: 30993668 DOI: 10.1002/cpt.1458] [Cited by in Crossref: 20] [Cited by in F6Publishing: 21] [Article Influence: 6.7] [Reference Citation Analysis]
52 Polak S, Tylutki Z, Holbrook M, Wiśniowska B. Better prediction of the local concentration-effect relationship: the role of physiologically based pharmacokinetics and quantitative systems pharmacology and toxicology in the evolution of model-informed drug discovery and development. Drug Discov Today 2019;24:1344-54. [PMID: 31132414 DOI: 10.1016/j.drudis.2019.05.016] [Cited by in Crossref: 8] [Cited by in F6Publishing: 7] [Article Influence: 2.7] [Reference Citation Analysis]
53 Harwood MD, Zhang M, Pathak SM, Neuhoff S. The Regional-Specific Relative and Absolute Expression of Gut Transporters in Adult Caucasians: A Meta-Analysis. Drug Metab Dispos 2019;47:854-64. [DOI: 10.1124/dmd.119.086959] [Cited by in Crossref: 13] [Cited by in F6Publishing: 10] [Article Influence: 4.3] [Reference Citation Analysis]
54 Mielke H, Partosch F, Gundert-remy U. Letter to the Editor: Comment on ‘Use of an in vitro–in silico testing strategy to predict inter-species and inter-ethnic human differences in liver toxicity of the pyrrolizidine alkaloids lasiocarpine and riddelliine’ by Ning et al., Arch Toxicol doi: https://doi.org/10.1007/s00204-019-02397-7. Arch Toxicol 2019;93:1465-6. [DOI: 10.1007/s00204-019-02421-w] [Cited by in Crossref: 2] [Cited by in F6Publishing: 2] [Article Influence: 0.7] [Reference Citation Analysis]
55 Tornio A, Filppula AM, Niemi M, Backman JT. Clinical Studies on Drug-Drug Interactions Involving Metabolism and Transport: Methodology, Pitfalls, and Interpretation. Clin Pharmacol Ther 2019;105:1345-61. [PMID: 30916389 DOI: 10.1002/cpt.1435] [Cited by in Crossref: 41] [Cited by in F6Publishing: 54] [Article Influence: 13.7] [Reference Citation Analysis]
56 Smith DA, Rowland M. Intracellular and Intraorgan Concentrations of Small Molecule Drugs: Theory, Uncertainties in Infectious Diseases and Oncology, and Promise. Drug Metab Dispos 2019;47:665-72. [PMID: 30910784 DOI: 10.1124/dmd.118.085951] [Cited by in Crossref: 13] [Cited by in F6Publishing: 10] [Article Influence: 4.3] [Reference Citation Analysis]
57 Rodrigues D, Rowland A. From Endogenous Compounds as Biomarkers to Plasma-Derived Nanovesicles as Liquid Biopsy; Has the Golden Age of Translational Pharmacokinetics-Absorption, Distribution, Metabolism, Excretion-Drug-Drug Interaction Science Finally Arrived? Clin Pharmacol Ther. 2019;105:1407-1420. [PMID: 30554411 DOI: 10.1002/cpt.1328] [Cited by in Crossref: 34] [Cited by in F6Publishing: 40] [Article Influence: 11.3] [Reference Citation Analysis]
58 Bonnaventure P, Cusin F, Pastor CM. Hepatocyte Concentrations of Imaging Compounds Associated with Transporter Inhibition: Evidence in Perfused Rat Livers. Drug Metab Dispos 2019;47:412-8. [PMID: 30674615 DOI: 10.1124/dmd.118.084624] [Cited by in Crossref: 6] [Cited by in F6Publishing: 5] [Article Influence: 2.0] [Reference Citation Analysis]
59 Matsunaga N, Ufuk A, Morse BL, Bedwell DW, Bao J, Mohutsky MA, Hillgren KM, Hall SD, Houston JB, Galetin A. Hepatic Organic Anion Transporting Polypeptide-Mediated Clearance in the Beagle Dog: Assessing In Vitro-In Vivo Relationships and Applying Cross-Species Empirical Scaling Factors to Improve Prediction of Human Clearance. Drug Metab Dispos 2019;47:215-26. [PMID: 30593544 DOI: 10.1124/dmd.118.084194] [Cited by in Crossref: 8] [Cited by in F6Publishing: 7] [Article Influence: 2.0] [Reference Citation Analysis]
60 Matsuzaki T, Scotcher D, Darwich AS, Galetin A, Rostami-hodjegan A. Towards Further Verification of Physiologically-Based Kidney Models: Predictability of the Effects of Urine-Flow and Urine-pH on Renal Clearance. J Pharmacol Exp Ther 2019;368:157-68. [DOI: 10.1124/jpet.118.251413] [Cited by in Crossref: 10] [Cited by in F6Publishing: 9] [Article Influence: 2.5] [Reference Citation Analysis]
61 Schmitt MV, Lienau P, Fricker G, Reichel A. Quantitation of Lysosomal Trapping of Basic Lipophilic Compounds Using In Vitro Assays and In Silico Predictions Based on the Determination of the Full pH Profile of the Endo-/Lysosomal System in Rat Hepatocytes. Drug Metab Dispos 2019;47:49-57. [PMID: 30409837 DOI: 10.1124/dmd.118.084541] [Cited by in Crossref: 12] [Cited by in F6Publishing: 12] [Article Influence: 3.0] [Reference Citation Analysis]
62 Grimstein M, Yang Y, Zhang X, Grillo J, Huang SM, Zineh I, Wang Y. Physiologically Based Pharmacokinetic Modeling in Regulatory Science: An Update From the U.S. Food and Drug Administration's Office of Clinical Pharmacology. J Pharm Sci 2019;108:21-5. [PMID: 30385284 DOI: 10.1016/j.xphs.2018.10.033] [Cited by in Crossref: 102] [Cited by in F6Publishing: 84] [Article Influence: 25.5] [Reference Citation Analysis]
63 Chu X, Liao M, Shen H, Yoshida K, Zur AA, Arya V, Galetin A, Giacomini KM, Hanna I, Kusuhara H, Lai Y, Rodrigues D, Sugiyama Y, Zamek-gliszczynski MJ, Zhang L; on behalf of the International Transporter Consortium. Clinical Probes and Endogenous Biomarkers as Substrates for Transporter Drug-Drug Interaction Evaluation: Perspectives From the International Transporter Consortium. Clin Pharmacol Ther 2018;104:836-64. [DOI: 10.1002/cpt.1216] [Cited by in Crossref: 57] [Cited by in F6Publishing: 80] [Article Influence: 14.3] [Reference Citation Analysis]
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