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For: Onishi H, Katano M. Hedgehog signaling pathway as a new therapeutic target in pancreatic cancer. World J Gastroenterol 2014; 20(9): 2335-2342 [PMID: 24605030 DOI: 10.3748/wjg.v20.i9.2335]
URL: https://www.wjgnet.com/1007-9327/full/v20/i9/2335.htm
Number Citing Articles
1
Mian Wei, Rong Ma, Shaoliang Huang, Yan Liao, Youxiang Ding, Zhaohe Li, Qinglong Guo, Renxiang Tan, Lulu Zhang, Li Zhao. Oroxylin A increases the sensitivity of temozolomide on glioma cells by hypoxia‐inducible factor 1α/hedgehog pathway under hypoxiaJournal of Cellular Physiology 2019; 234(10): 17392 doi: 10.1002/jcp.28361
2
Jian Guo, Huating Zeng, Yan Chen. Emerging Nano Drug Delivery Systems Targeting Cancer-Associated Fibroblasts for Improved Antitumor Effect and Tumor Drug PenetrationMolecular Pharmaceutics 2020; 17(4): 1028 doi: 10.1021/acs.molpharmaceut.0c00014
3
Anmada Nayak, Shakti Ranjan Satapathy, Dipon Das, Sumit Siddharth, Neha Tripathi, Prasad V. Bharatam, ChanakyaNath Kundu. Nanoquinacrine induced apoptosis in cervical cancer stem cells through the inhibition of hedgehog-GLI1 cascade: Role of GLI-1Scientific Reports 2016; 6(1) doi: 10.1038/srep20600
4
D Amar, S Izraeli, R Shamir. Utilizing somatic mutation data from numerous studies for cancer research: proof of concept and applicationsOncogene 2017; 36(24): 3375 doi: 10.1038/onc.2016.489
5
Destina Ekingen Genc, Ozlem Ozbek, Burcu Oral, Ramazan Yıldırım, Nazar Ileri Ercan. Phytochemicals in Pancreatic Cancer Treatment: A Machine Learning StudyACS Omega 2024; 9(1): 413 doi: 10.1021/acsomega.3c05861
6
Motahareh Mortazavi, Fatemeh Moosavi, Miriam Martini, Elisa Giovannetti, Omidreza Firuzi. Prospects of targeting PI3K/AKT/mTOR pathway in pancreatic cancerCritical Reviews in Oncology/Hematology 2022; 176: 103749 doi: 10.1016/j.critrevonc.2022.103749
7
Jun Zhao, Huamin Wang, Cheng-Hui Hsiao, Diana S.-L. Chow, Eugene J. Koay, Yaan Kang, Xiaoxia Wen, Qian Huang, Ying Ma, James A. Bankson, Stephen E. Ullrich, Willem Overwijk, Anirban Maitra, David Piwnica-Worms, Jason B. Fleming, Chun Li. Simultaneous inhibition of hedgehog signaling and tumor proliferation remodels stroma and enhances pancreatic cancer therapyBiomaterials 2018; 159: 215 doi: 10.1016/j.biomaterials.2018.01.014
8
Negin Rahnama, Mohammadsaleh Jahangir, Samira Alesaeid, Mohammad Saeed kahrizi, Ali Adili, Rebar N. Mohammed, Ramin Aslaminabad, Morteza Akbari, Ali Mert Özgönül. Association between microRNAs and chemoresistance in pancreatic cancer: Current knowledge, new insights, and forthcoming perspectivesPathology - Research and Practice 2022; 236: 153982 doi: 10.1016/j.prp.2022.153982
9
Bolun Jiang, Li Zhou, Jun Lu, Yizhi Wang, Chengxi Liu, Lei You, Junchao Guo. Stroma-Targeting Therapy in Pancreatic Cancer: One Coin With Two Sides?Frontiers in Oncology 2020; 10 doi: 10.3389/fonc.2020.576399
10
James A. McCubrey, Dariusz Rakus, Agnieszka Gizak, Linda S. Steelman, Steve L. Abrams, Kvin Lertpiriyapong, Timothy L. Fitzgerald, Li V. Yang, Giuseppe Montalto, Melchiorre Cervello, Massimo Libra, Ferdinando Nicoletti, Aurora Scalisi, Francesco Torino, Concettina Fenga, Luca M. Neri, Sandra Marmiroli, Lucio Cocco, Alberto M. Martelli. Effects of mutations in Wnt/β-catenin, hedgehog, Notch and PI3K pathways on GSK-3 activity—Diverse effects on cell growth, metabolism and cancerBiochimica et Biophysica Acta (BBA) - Molecular Cell Research 2016; 1863(12): 2942 doi: 10.1016/j.bbamcr.2016.09.004
11
Azam Rajabpour, Farzad Rajaei, Ladan Teimoori-Toolabi. Molecular alterations contributing to pancreatic cancer chemoresistancePancreatology 2017; 17(2): 310 doi: 10.1016/j.pan.2016.12.013
12
Chang Liu, Rensheng Wang. The Roles of Hedgehog Signaling Pathway in Radioresistance of Cervical CancerDose-Response 2019; 17(4): 155932581988529 doi: 10.1177/1559325819885293
13
Wei Li, Shuanlin Miao, Manyuan Miao, Renshuan Li, Xiaopeng Cao, Kun Zhang, Genzuan Huang, Bin Fu. Hedgehog Signaling Activation in Hepatic Stellate Cells Promotes Angiogenesis and Vascular Mimicry in Hepatocellular CarcinomaCancer Investigation 2016; 34(9): 424 doi: 10.1080/07357907.2016.1227442
14
Bo Ren, Ming Cui, Gang Yang, Huanyu Wang, Mengyu Feng, Lei You, Yupei Zhao. Tumor microenvironment participates in metastasis of pancreatic cancerMolecular Cancer 2018; 17(1) doi: 10.1186/s12943-018-0858-1
15
Huifa Ma, Yongsheng Tian, Xiangyang Yu. Targeting Smoothened Sensitizes Gastric Cancer to Chemotherapy in Experimental ModelsMedical Science Monitor 2017; 23: 1493 doi: 10.12659/MSM.903012
16
David Vetvicka, Ladislav Sivak, Chinmay M. Jogdeo, Raj Kumar, Rubayat Khan, Yu Hang, David Oupický. Gene silencing delivery systems for the treatment of pancreatic cancer: Where and what to target next?Journal of Controlled Release 2021; 331: 246 doi: 10.1016/j.jconrel.2021.01.020
17
Chandrayee Ghosh, Santanu Paul, Prasad Dandawate, Sumedha S. Gunewardena, Dharmalingam Subramaniam, Cameron West, Shrikant Anant, Animesh Dhar. Super-enhancers: novel target for pancreatic ductal adenocarcinomaOncotarget 2019; 10(16): 1554 doi: 10.18632/oncotarget.26704
18
Agnieszka A. Rucki, Qian Xiao, Stephen Muth, Jianlin Chen, Xu Che, Jennifer Kleponis, Rajni Sharma, Robert A. Anders, Elizabeth M. Jaffee, Lei Zheng. Dual Inhibition of Hedgehog and c-Met Pathways for Pancreatic Cancer TreatmentMolecular Cancer Therapeutics 2017; 16(11): 2399 doi: 10.1158/1535-7163.MCT-16-0452
19
Sepideh Ardalan Khales, Mohammad Mahdi Forghanifard, Mohammad Reza Abbaszadegan, Seyed Ebrahim Hosseini. EZH2 deregulates BMP, Hedgehog, and Hippo cell signaling pathways in esophageal squamous cell carcinomaAdvances in Medical Sciences 2023; 68(1): 21 doi: 10.1016/j.advms.2022.11.002
20
Jungwhoi Lee, Jeong Hun Yun, Jungsul Lee, Chulhee Choi, Jae Hoon Kim. Blockade of dual-specificity phosphatase 28 decreases chemo-resistance and migration in human pancreatic cancer cellsScientific Reports 2015; 5(1) doi: 10.1038/srep12296
21
LIANG CHANG, DAN ZHAO, HUI-BIN LIU, QIU-SHI WANG, PING ZHANG, CHEN-LONG LI, WEN-ZHONG DU, HONG-JUN WANG, XING LIU, ZHI-REN ZHANG, CHUAN-LU JIANG. Activation of sonic hedgehog signaling enhances cell migration and invasion by induction of matrix metalloproteinase-2 and -9 via the phosphoinositide-3 kinase/AKT signaling pathway in glioblastomaMolecular Medicine Reports 2015; 12(5): 6702 doi: 10.3892/mmr.2015.4229
22
Michela Cortesi, Michele Zanoni, Francesca Pirini, Maria Maddalena Tumedei, Sara Ravaioli, Ilario Giovanni Rapposelli, Giovanni Luca Frassineti, Sara Bravaccini. Pancreatic Cancer and Cellular Senescence: Tumor Microenvironment under the SpotlightInternational Journal of Molecular Sciences 2021; 23(1): 254 doi: 10.3390/ijms23010254
23
Sabrina Bimonte, Antonio Barbieri, Maddalena Leongito, Giuseppe Palma, Vitale del Vecchio, Michela Falco, Raffaele Palaia, Vittorio Albino, Mauro Piccirillo, Alfonso Amore, Antonella Petrillo, Vincenza Granata, Francesco Izzo. The Role of miRNAs in the Regulation of Pancreatic Cancer Stem CellsStem Cells International 2016; 2016: 1 doi: 10.1155/2016/8352684
24
Ahmed H.E. Hassan, Cai Yi Wang, Hyo Jong Lee, Su Jin Jung, Yeon Ju Kim, Soo Bin Cho, Chae Hyeon Lee, Gyeongpyo Ham, Taegeun Oh, Sang Kook Lee, Yong Sup Lee. Scaffold hopping of N-benzyl-3,4,5-trimethoxyaniline: 5,6,7-Trimethoxyflavan derivatives as novel potential anticancer agents modulating hippo signaling pathwayEuropean Journal of Medicinal Chemistry 2023; 256: 115421 doi: 10.1016/j.ejmech.2023.115421
25
Gautham Chengizkhan, Bharti Bisht, Sridhar Muthusami, Muralidharan Anbalagan, Ilangovan Ramachandran, R. Ileng Kumaran. Cancer Stem Cells: New Horizons in Cancer Therapies2020; : 15 doi: 10.1007/978-981-15-5120-8_2
26
Jungwhoi Lee, Jungsul Lee, Myungseung Kim, Jae Hoon Kim. Fermented Extraction ofCitrus unshiuPeel Inhibits Viability and Migration of Human Pancreatic CancersJournal of Medicinal Food 2018; 21(1): 5 doi: 10.1089/jmf.2017.3984
27
Hwa Jin Lee, Qian Wu, Hua Li, Gyu-Un Bae, An Keun Kim, Jae-Ha Ryu. A sesquiterpene lactone from Siegesbeckia glabrescens suppresses Hedgehog/Gli-mediated transcription in pancreatic cancer cellsOncology Letters 2016; 12(4): 2912 doi: 10.3892/ol.2016.4994
28
E. Giovannetti, C.L. van der Borden, A.E. Frampton, A. Ali, O. Firuzi, G.J. Peters. Never let it go: Stopping key mechanisms underlying metastasis to fight pancreatic cancerSeminars in Cancer Biology 2017; 44: 43 doi: 10.1016/j.semcancer.2017.04.006
29
Bhaskar Venkata Kameswara Subrahmanya Lakkakula, Batoul Farran, Saikrishna Lakkakula, Sujatha Peela, Nagendra Sastry Yarla, Pallaval Veera Bramhachari, Mohammad Amjad Kamal, Madhu Sudhana Saddala, Ganji Purnachandra Nagaraju. Small molecule tyrosine kinase inhibitors and pancreatic cancer—Trials and troublesSeminars in Cancer Biology 2019; 56: 149 doi: 10.1016/j.semcancer.2018.09.011
30
Rebeca C.M. Dantas, Vanessa S.N. Guimarães, Renata O. de Souza, Ludmila F. Valverde, Manuela T.A. Vidal, Raphael L.R. Nogueira, Leonardo O.S. da Rocha, Giovana T. Araújo, Jean N. dos Santos, Clarissa A.G. Rocha. Immunodetection of Epithelial-Mesenchymal Transition and Tumor Proliferation Markers in GLi-1-positive Oral Squamous Cell CarcinomaApplied Immunohistochemistry & Molecular Morphology 2021; 29(5): 335 doi: 10.1097/PAI.0000000000000866
31
Selvi Kunnimalaiyaan, Jose Trevino, Susan Tsai, T. Clark Gamblin, Muthusamy Kunnimalaiyaan. Xanthohumol-Mediated Suppression of Notch1 Signaling Is Associated with Antitumor Activity in Human Pancreatic Cancer CellsMolecular Cancer Therapeutics 2015; 14(6): 1395 doi: 10.1158/1535-7163.MCT-14-0915
32
Madiha Niyaz, Mosin S. Khan, Rauf A. Wani, Omar J. Shah, Syed Mudassar. Sonic Hedgehog Protein is Frequently Up-Regulated in Pancreatic Cancer Compared to Colorectal CancerPathology & Oncology Research 2020; 26(1): 551 doi: 10.1007/s12253-018-00564-2
33
Hwa Jin Lee, Ji Hye Jeong, Jae-Ha Ryu. Anti-pancreatic cancer activity of Z-ajoene from garlic: An inhibitor of the Hedgehog/Gli/FoxM1 axisJournal of Functional Foods 2019; 56: 102 doi: 10.1016/j.jff.2019.03.010
34
Jungwhoi Lee, Jungsul Lee, Myungseung Kim, Jae Hoon Kim. Dietary approach to attenuate human pancreatic cancer growth and migration with innoxiousnessJournal of Functional Foods 2017; 30: 303 doi: 10.1016/j.jff.2016.12.032
35
Delphine Quatannens, Yannick Verhoeven, Peter Van Dam, Filip Lardon, Hans Prenen, Geert Roeyen, Marc Peeters, Evelien L.J. Smits, Jonas Van Audenaerde. Targeting hedgehog signaling in pancreatic ductal adenocarcinomaPharmacology & Therapeutics 2022; 236: 108107 doi: 10.1016/j.pharmthera.2022.108107
36
Jun Zhao, Zhilan Xiao, Tingting Li, Huiqin Chen, Ying Yuan, Y. Alan Wang, Cheng-Hui Hsiao, Diana S-L. Chow, Willem W. Overwijk, Chun Li. Stromal Modulation Reverses Primary Resistance to Immune Checkpoint Blockade in Pancreatic CancerACS Nano 2018; 12(10): 9881 doi: 10.1021/acsnano.8b02481
37
Donger Zhou, Lei Zheng. Recent advances in cancer-associated fibroblast: Biomarkers, signaling pathways, and therapeutic opportunitiesChinese Medical Journal 2024; 137(6): 638 doi: 10.1097/CM9.0000000000003031
38
Sheng Chen, Min Zhang, Lili Xing, Yue Wang, Yongtao Xiao, Yeming Wu, Sharmila Shankar. HIF-1α Contributes to Proliferation and Invasiveness of Neuroblastoma Cells via SHH SignalingPLOS ONE 2015; 10(3): e0121115 doi: 10.1371/journal.pone.0121115
39
Xin Liu, Jason R. Pitarresi, Maria C. Cuitiño, Raleigh D. Kladney, Sarah A. Woelke, Gina M. Sizemore, Sunayana G. Nayak, Onur Egriboz, Patrick G. Schweickert, Lianbo Yu, Stefan Trela, Daniel J. Schilling, Shannon K. Halloran, Maokun Li, Shourik Dutta, Soledad A. Fernandez, Thomas J. Rosol, Gregory B. Lesinski, Reena Shakya, Thomas Ludwig, Stephen F. Konieczny, Gustavo Leone, Jinghai Wu, Michael C. Ostrowski. Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar–ductal metaplasiaGenes & Development 2016; 30(17): 1943 doi: 10.1101/gad.283499.116
40
Hideya Onishi, Katsuya Nakamura, Kosuke Yanai, Shuntaro Nagai, Kazunori Nakayama, Yasuhiro Oyama, Akiko Fujimura, Keigo Ozono, Akio Yamasaki. Cancer therapy that targets the Hedgehog signaling pathway considering the cancer microenvironment (Review)Oncology Reports 2022; 47(5) doi: 10.3892/or.2022.8304
41
Wanting Hou, Biao Yang, Hong Zhu. Nanoparticle-Based Therapeutic Strategies for Enhanced Pancreatic Ductal Adenocarcinoma ImmunotherapyPharmaceutics 2022; 14(10): 2033 doi: 10.3390/pharmaceutics14102033
42
Do Luong Huynh, Hyebin Koh, Nisansala Chandimali, Jiao Jiao Zhang, Nameun Kim, Tae Yoon Kang, Mrinmoy Ghosh, Meeta Gera, Yang-Ho Park, Taeho Kwon, Dong Kee Jeong. BRM270 Inhibits the Proliferation of CD44 Positive Pancreatic Ductal Adenocarcinoma Cells via Downregulation of Sonic Hedgehog SignalingEvidence-Based Complementary and Alternative Medicine 2019; 2019: 1 doi: 10.1155/2019/8620469
43
Kanar Hamaamin, Falah Hussein, Dena Mohammad. Immunohistochemical Expression of PTCH1 and Laminin in Oral Hyperplastic, Premalignant, Squamous Cell Carcinoma and Recurrence Lesions SamplesSulaimani Dental Journal 2019; 6(1): 12 doi: 10.17656/sdj.10084
44
Pavan P. Adiseshaiah, Rachael M. Crist, Sara S. Hook, Scott E. McNeil. Nanomedicine strategies to overcome the pathophysiological barriers of pancreatic cancerNature Reviews Clinical Oncology 2016; 13(12): 750 doi: 10.1038/nrclinonc.2016.119
45
Jungwhoi Lee, Da-Hye Kim, Jae Hoon Kim. Combined administration of naringenin and hesperetin with optimal ratio maximizes the anti-cancer effect in human pancreatic cancer via down regulation of FAK and p38 signaling pathwayPhytomedicine 2019; 58: 152762 doi: 10.1016/j.phymed.2018.11.022
46
Zhengwei Xu, Chen Huang, Dingjun Hao. MicroRNA-1271 inhibits proliferation and promotes apoptosis of multiple myeloma cells through inhibiting smoothened-mediated Hedgehog signaling pathwayOncology Reports 2017; 37(2): 1261 doi: 10.3892/or.2016.5304
47
Hui-Ching Wang, Wen-Chun Hung, Li-Tzong Chen, Mei-Ren Pan. From Friend to Enemy: Dissecting the Functional Alteration of Immunoregulatory Components during Pancreatic TumorigenesisInternational Journal of Molecular Sciences 2018; 19(11): 3584 doi: 10.3390/ijms19113584
48
Sharavan Ramachandran, Sanjay K. Srivastava. Repurposing Pimavanserin, an Anti-Parkinson Drug for Pancreatic Cancer TherapyMolecular Therapy - Oncolytics 2020; 19: 19 doi: 10.1016/j.omto.2020.08.019
49
Shwetapadma Dash, Sonali Sahoo, Sanjeeb Kumar Sahoo. Recent Advances in Nanocarriers for Pancreatic Cancer Therapy2024; : 37 doi: 10.1016/B978-0-443-19142-8.00017-6
50
Naz Chaudary, Melania Pintilie, David Hedley, Richard P Hill, Michael Milosevic, Helen Mackay. Hedgehog inhibition enhances efficacy of radiation and cisplatin in orthotopic cervical cancer xenograftsBritish Journal of Cancer 2017; 116(1): 50 doi: 10.1038/bjc.2016.383
51
Libin Song, Xiangyuan Chen, Song Gao, Chenyue Zhang, Chao Qu, Peng Wang, Luming Liu. Ski modulate the characteristics of pancreatic cancer stem cells via regulating sonic hedgehog signaling pathwayTumor Biology 2016; 37(12): 16115 doi: 10.1007/s13277-016-5461-8
52
Hideya Onishi, Akio Yamasaki, Makoto Kawamoto, Akira Imaizumi, Mitsuo Katano. Hypoxia but not normoxia promotes Smoothened transcription through upregulation of RBPJ and Mastermind-like 3 in pancreatic cancerCancer Letters 2016; 371(2): 143 doi: 10.1016/j.canlet.2015.11.012
53
Chen Liang, Si Shi, Qingcai Meng, Dingkong Liang, Jie Hua, Yi Qin, Bo Zhang, Jin Xu, Quanxing Ni, Xianjun Yu. MiR‐29a, targeting caveolin 2 expression, is responsible for limitation of pancreatic cancer metastasis in patients with normal level of serum CA125International Journal of Cancer 2018; 143(11): 2919 doi: 10.1002/ijc.31654
54
Catherine Cochrane, Anette Szczepny, D. Watkins, Jason Cain. Hedgehog Signaling in the Maintenance of Cancer Stem CellsCancers 2015; 7(3): 1554 doi: 10.3390/cancers7030851
55
Shunrong Ji, Yi Qin, Chen Liang, Run Huang, Si Shi, Jiang Liu, Kaizhou Jin, Dingkong Liang, Wenyan Xu, Bo Zhang, Liang Liu, Chen Liu, Jin Xu, Quanxing Ni, Paul J. Chiao, Min Li, Xianjun Yu. FBW7 (F-box and WD Repeat Domain-Containing 7) Negatively Regulates Glucose Metabolism by Targeting the c-Myc/TXNIP (Thioredoxin-Binding Protein) Axis in Pancreatic CancerClinical Cancer Research 2016; 22(15): 3950 doi: 10.1158/1078-0432.CCR-15-2380
56
Jichun Gu, Hexige Saiyin, Deliang Fu, Ji Li. Stroma — A Double-Edged Sword in Pancreatic CancerPancreas 2018; 47(4): 382 doi: 10.1097/MPA.0000000000001023
57
Ann Mary Joseph, Ahmad Al Aiyan, Basel Al-Ramadi, Shiv K. Singh, Uday Kishore. Innate and adaptive immune-directed tumour microenvironment in pancreatic ductal adenocarcinomaFrontiers in Immunology 2024; 15 doi: 10.3389/fimmu.2024.1323198
58
Diego J. Jiménez, Aadil Javed, Teresa Rubio-Tomás, Ndioba Seye-Loum, Carles Barceló. Clinical and Preclinical Targeting of Oncogenic Pathways in PDAC: Targeted Therapeutic Approaches for the Deadliest CancerInternational Journal of Molecular Sciences 2024; 25(5): 2860 doi: 10.3390/ijms25052860
59
Han-xiang Zhan, Jian-wei Xu, Dong Wu, Tai-ping Zhang, San-yuan Hu. Pancreatic cancer stem cells: New insight into a stubborn diseaseCancer Letters 2015; 357(2): 429 doi: 10.1016/j.canlet.2014.12.004
60
Nicolas Carels, Lizânia Borges Spinassé, Tatiana Martins Tilli, Jack Adam Tuszynski. Toward precision medicine of breast cancerTheoretical Biology and Medical Modelling 2016; 13(1) doi: 10.1186/s12976-016-0035-4
61
Jerry Vriend, Saeid Ghavami, Hassan Marzban. The role of the ubiquitin proteasome system in cerebellar development and medulloblastomaMolecular Brain 2015; 8(1) doi: 10.1186/s13041-015-0155-5
62
Janaiah Kota, Julie Hancock, Jason Kwon, Murray Korc. Pancreatic cancer: Stroma and its current and emerging targeted therapiesCancer Letters 2017; 391: 38 doi: 10.1016/j.canlet.2016.12.035