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Cited by in CrossRef
For: Mathonnet M, Perraud A, Christou N, Akil H, Melin C, Battu S, Jauberteau MO, Denizot Y. Hallmarks in colorectal cancer: Angiogenesis and cancer stem-like cells. World J Gastroenterol 2014; 20(15): 4189-4196 [PMID: 24764657 DOI: 10.3748/wjg.v20.i15.4189]
URL: https://www.wjgnet.com/1007-9327/full/v20/i15/4189.htm
Number Citing Articles
1
Raheleh Amirkhah, Hojjat Naderi-Meshkin, Jaynish Shah, Philip Dunne, Ulf Schmitz. The Intricate Interplay between Epigenetic Events, Alternative Splicing and Noncoding RNA Deregulation in Colorectal CancerCells 2019; 8(8): 929 doi: 10.3390/cells8080929
2
Saba Sameri, Chiman Mohammadi, Mehrnaz Mehrabani, Rezvan Najafi. Targeting the hallmarks of cancer: the effects of silibinin on proliferation, cell death, angiogenesis, and migration in colorectal cancerBMC Complementary Medicine and Therapies 2021; 21(1) doi: 10.1186/s12906-021-03330-1
3
Rowida Mohamed, Catherine Kennedy, William G. Willmore. Responses of Porcupine and Wntless proteins to oxidative, hypoxic and endoplasmic reticulum stressesCellular Signalling 2021; 85: 110047 doi: 10.1016/j.cellsig.2021.110047
4
Arundhati Mehta, Vivek Kumar Soni, Yashwant Kumar Ratre, Rajat Pratap Singh, Dhananjay Shukla, Naveen Kumar Vishvakarma, Rakesh Kumar Rai, Navaneet Chaturvedi. Colon Cancer Diagnosis and Therapy2021; : 195 doi: 10.1007/978-3-030-63369-1_10
5
Shao-Jun Liu, Zhao-Qi Li, Xiao-Yan Wang, Fen Liu, Zhi-Ming Xiao, De-Cai Zhang. lncRNA UCA1 induced by SP1 and SP3 forms a positive feedback loop to facilitate malignant phenotypes of colorectal cancer via targeting miR-495Life Sciences 2021; 277: 119569 doi: 10.1016/j.lfs.2021.119569
6
Huaiming Wang, Rongkang Huang, Wentai Guo, Xiusen Qin, Zifeng Yang, Zixu Yuan, Yingqi Wei, Chunlin Mo, Zhantao Zeng, Jian Luo, Jian Cai, Hui Wang. RNA-binding protein CELF1 enhances cell migration, invasion, and chemoresistance by targeting ETS2 in colorectal cancerClinical Science 2020; 134(14): 1973 doi: 10.1042/CS20191174
7
Ziyue Li, Jierong Chen, Dandan Zhu, Xiaoxiao Wang, Jace Chen, Yu Zhang, Qizhou Lian, Bing Gu. Identification of prognostic stemness biomarkers in colon adenocarcinoma drug resistanceBMC Genomic Data 2022; 23(1) doi: 10.1186/s12863-022-01063-9
8
Anouck Huijbers, Gabi W. van Pelt, Rachel S. Kerr, Elaine C. Johnstone, Rob A.E.M. Tollenaar, David J. Kerr, Wilma E. Mesker. The value of additional bevacizumab in patients with high‐risk stroma‐high colon cancer. A study within the QUASAR2 trial, an open‐label randomized phase 3 trialJournal of Surgical Oncology 2018; 117(5): 1043 doi: 10.1002/jso.24998
9
Eugene Rosenberg. MicrobiomesThe Microbiomes of Humans, Animals, Plants, and the Environment 2021; 2: 57 doi: 10.1007/978-3-030-65317-0_3
10
Shivani Baisiwala, Shreya Budhiraja, Chirag Goel, Khizar R. Nandoliya, Miranda R. Saathoff, Atique U. Ahmed. Spelling Out CICs: A Multi-Organ Examination of the Contributions of Cancer Initiating Cells’ Role in Tumor ProgressionStem Cell Reviews and Reports 2022; 18(1): 228 doi: 10.1007/s12015-021-10195-x
11
Ryan Wai-Yan Sin, Dominic Chi-Chung Foo, Deepak Narayanan Iyer, May Sau-Yee Fan, Xue Li, Oswens Siu-Hung Lo, Wai-Lun Law, Lui Ng, Ludovic Zimmerlin. A Pilot Study Investigating the Expression Levels of Pluripotency-Associated Genes in Rectal Swab Samples for Colorectal Polyp and Cancer Diagnosis and PrognosisStem Cells International 2021; 2021: 1 doi: 10.1155/2021/4139528
12
Md Nur Alam, Muhammad Almoyad, Fazlul Huq. Polyphenols in Colorectal Cancer: Current State of Knowledge including Clinical Trials and Molecular Mechanism of ActionBioMed Research International 2018; 2018: 1 doi: 10.1155/2018/4154185
13
Constantin Stefani, Daniela Miricescu, Iulia-Ioana Stanescu-Spinu, Remus Iulian Nica, Maria Greabu, Alexandra Ripszky Totan, Mariana Jinga. Growth Factors, PI3K/AKT/mTOR and MAPK Signaling Pathways in Colorectal Cancer Pathogenesis: Where Are We Now?International Journal of Molecular Sciences 2021; 22(19): 10260 doi: 10.3390/ijms221910260
14
Veronika Skarkova, Vera Kralova, Barbora Vitovcova, Emil Rudolf. Selected Aspects of Chemoresistance Mechanisms in Colorectal Carcinoma—A Focus on Epithelial-to-Mesenchymal Transition, Autophagy, and ApoptosisCells 2019; 8(3): 234 doi: 10.3390/cells8030234
15
Ahmad R. Safa. Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies2020; : 57 doi: 10.1016/B978-0-12-819937-4.00003-0
16
Soumyadev Sarkar. Proteogenomic Approaches to Understand Gene Mutations and Protein Structural Alterations in Colon CancerPhysiologia 2023; 3(1): 11 doi: 10.3390/physiologia3010002
17
Minda Zhang, Zeyu Shi, Shuaishuai Zhang, Xudan Li, Sally Kit Yan To, Yijia Peng, Jie Liu, Siming Chen, Hongyu Hu, Alice Sze Tsai Wong, Jin-Zhang Zeng. The Ginsenoside Compound K Suppresses Stem-Cell-like Properties and Colorectal Cancer Metastasis by Targeting Hypoxia-Driven Nur77-Akt Feed-Forward SignalingCancers 2022; 15(1): 24 doi: 10.3390/cancers15010024
18
B Flood, K Oficjalska, D Laukens, J Fay, A O'Grady, F Caiazza, Z Heetun, K H G Mills, K Sheahan, E J Ryan, G A Doherty, E Kay, E M Creagh. Altered expression of caspases-4 and -5 during inflammatory bowel disease and colorectal cancer: Diagnostic and therapeutic potentialClinical and Experimental Immunology 2015; 181(1): 39 doi: 10.1111/cei.12617
19
Aldona Kasprzak. Angiogenesis-Related Functions of Wnt Signaling in Colorectal CarcinogenesisCancers 2020; 12(12): 3601 doi: 10.3390/cancers12123601
20
Daniele V. F. Tauriello, Alexandre Calon, Enza Lonardo, Eduard Batlle. Determinants of metastatic competency in colorectal cancerMolecular Oncology 2017; 11(1): 97 doi: 10.1002/1878-0261.12018
21
D. Brocco, P. Lanuti, P. Simeone, G. Bologna, D. Pieragostino, M. C. Cufaro, V. Graziano, M. Peri, P. Di Marino, M. De Tursi, A. Grassadonia, I. G. Rapposelli, L. Pierdomenico, E. Ercolino, F. Ciccocioppo, P. Del Boccio, M. Marchisio, C. Natoli, S. Miscia, N. Tinari. Circulating Cancer Stem Cell-Derived Extracellular Vesicles as a Novel Biomarker for Clinical Outcome EvaluationJournal of Oncology 2019; 2019: 1 doi: 10.1155/2019/5879616
22
Yang Yang, Jing-Jing Yang, Hui Tao, Wei-Sen Jin. New perspectives on β-catenin control of cell fate and proliferation in colon cancerFood and Chemical Toxicology 2014; 74: 14 doi: 10.1016/j.fct.2014.08.013
23
David Gozal, Sandra A. Ham, Babak Mokhlesi. Sleep Apnea and Cancer: Analysis of a Nationwide Population SampleSleep 2016; 39(8): 1493 doi: 10.5665/sleep.6004
24
Aurélie Lacroix, Elise Deluche, Ling Yan Zhang, Claire Dalmay, Carole Mélin, Jonathan Leroy, Meissa Babay, Christophe Morand Du Puch, Stéphanie Giraud, Barbara Bessette, Gaëlle Bégaud, Sofiane Saada, Christophe Lautrette, Arnaud Pothier, Serge Battu, Fabrice Lalloué. A New Label-Free Approach to Glioblastoma Cancer Stem Cell Sorting and DetectionAnalytical Chemistry 2019; 91(14): 8948 doi: 10.1021/acs.analchem.9b00913
25
Céline Hervieu, Niki Christou, Serge Battu, Muriel Mathonnet. The Role of Cancer Stem Cells in Colorectal Cancer: From the Basics to Novel Clinical TrialsCancers 2021; 13(5): 1092 doi: 10.3390/cancers13051092
26
Antonio Giordani, Giovanna Poce, Sara Consalvi, Samuele Maramai, Mario Saletti, Antonietta Rossi, Paola Patrignani, Mariangela Biava, Maurizio Anzini. Nitric Oxide in Health and Disease2023; : 57 doi: 10.1016/B978-0-443-13342-8.00009-0
27
Isabel Kurth, Norihiro Yamaguchi, Celia Andreu-Agullo, Helen S. Tian, Subhasree Sridhar, Shugaku Takeda, Foster C. Gonsalves, Jia Min Loo, Afsar Barlas, Katia Manova-Todorova, Robert Busby, Johanna C. Bendell, James Strauss, Marwan Fakih, Autumn J. McRee, Andrew E. Hendifar, Lee S. Rosen, Andrea Cercek, Robert Wasserman, Michael Szarek, Scott L. Spector, Syed Raza, Masoud F. Tavazoie, Sohail F. Tavazoie. Therapeutic targeting of SLC6A8 creatine transporter suppresses colon cancer progression and modulates human creatine levelsScience Advances 2021; 7(41) doi: 10.1126/sciadv.abi7511
28
Kazufumi Tanigawa, Masashi Maekawa, Takeshi Kiyoi, Jun Nakayama, Riko Kitazawa, Sohei Kitazawa, Kentaro Semba, Tomohiko Taguchi, Satoshi Akita, Motohira Yoshida, Kei Ishimaru, Yuji Watanabe, Shigeki Higashiyama. SNX9 determines the surface levels of integrin β1 in vascular endothelial cells: Implication in poor prognosis of human colorectal cancers overexpressing SNX9Journal of Cellular Physiology 2019; 234(10): 17280 doi: 10.1002/jcp.28346
29
Federica Ungaro, Silvia D’Alessio, Silvio Danese. The Role of Pro-Resolving Lipid Mediators in Colorectal Cancer-Associated Inflammation: Implications for Therapeutic StrategiesCancers 2020; 12(8): 2060 doi: 10.3390/cancers12082060
30
Margareta Žlajpah, Emanuela Boštjančič, Bojan Tepeš, Nina Zidar. Expression of Extracellular Matrix-Related Genes and Their Regulatory microRNAs in Problematic Colorectal PolypsCancers 2020; 12(12): 3715 doi: 10.3390/cancers12123715
31
Wu-Zhen Chen, Jing-Xin Jiang, Xiu-Yan Yu, Wen-Jie Xia, Peng-Xin Yu, Ke Wang, Zhi-Yong Zhao, Zhi-Gang Chen. Endothelial cells in colorectal cancerWorld Journal of Gastrointestinal Oncology 2019; 11(11): 946-956 doi: 10.4251/wjgo.v11.i11.946
32
Caren Jayasinghe, Nektaria Simiantonaki, Charles James Kirkpatrick. Cell type- and tumor zone-specific expression of pVEGFR-1 and its ligands influence colon cancer metastasisBMC Cancer 2015; 15(1) doi: 10.1186/s12885-015-1130-3
33
Mohamed Elbadawy, Tatsuya Usui, Hideyuki Yamawaki, Kazuaki Sasaki. Development of an Experimental Model for Analyzing Drug Resistance in Colorectal CancerCancers 2018; 10(6): 164 doi: 10.3390/cancers10060164
34
Henning Karlsson, Wojciech Senkowski, Mårten Fryknäs, Sharmineh Mansoori, Stig Linder, Joachim Gullbo, Rolf Larsson, Peter Nygren. A novel tumor spheroid model identifies selective enhancement of radiation by an inhibitor of oxidative phosphorylationOncotarget 2019; 10(51): 5372 doi: 10.18632/oncotarget.27166
35
Guo-Wan Zheng, Ming-Min Tang, Chen-Yan Shu, Wen-Xiu Xin, Yan-Hua Zhang, Bin-Bin Chi, Mu-Ran Shi, Xing Guo, Zhi-Zhen Zhang, Xiao-Yuan Lian. A small natural molecule CADPE kills residual colorectal cancer cells by inhibiting key transcription factors and translation initiation factorsCell Death & Disease 2020; 11(11) doi: 10.1038/s41419-020-03191-5
36
Sergey Koshkin, Anna Danilova, Grigory Raskin, Nikolai Petrov, Olga Bajenova, Stephen J. O’Brien, Alexey Tomilin, Elena Tolkunova. Primary cultures of human colon cancer as a model to study cancer stem cellsTumor Biology 2016; 37(9): 12833 doi: 10.1007/s13277-016-5214-8
37
Teresa Macarulla, Clara Montagut, Francisco Javier Sánchez-Martin, Mónica Granja, Helena Verdaguer, Javier Sastre, Josep Tabernero. The role of PIGF blockade in the treatment of colorectal cancer: overcoming the pitfallsExpert Opinion on Biological Therapy 2020; 20(1): 15 doi: 10.1080/14712598.2020.1677603
38
YIFENG ZOU, ZEXIAN CHEN, XIAOWEN HE, XIAOSHENG HE, XIANRUI WU, YUFENG CHEN, XIAOJIAN WU, JIANPING WANG, PING LAN. High expression levels of unc-51-like kinase 1 as a predictor of poor prognosis in colorectal cancerOncology Letters 2015; 10(3): 1583 doi: 10.3892/ol.2015.3417
39
Henu Kumar Verma, Yashwant Kumar Ratre, Pellegrino Mazzone. Colon Cancer Diagnosis and Therapy Vol. 32022; : 123 doi: 10.1007/978-3-030-72702-4_7
40
Han‐Qi Wang, Qi‐Wen Man, Fang‐Yi Huo, Xin Gao, Hao Lin, Su‐Ran Li, Jing Wang, Fu‐Chuan Su, Lulu Cai,, Yi Shi, Bing Liu,, Lin‐Lin Bu. STAT3 pathway in cancers: Past, present, and futureMedComm 2022; 3(2) doi: 10.1002/mco2.124
41
Carole Mélin, Aurélie Perraud, Niki Christou, Romain Bibes, Philippe Cardot, Marie-Odile Jauberteau, Serge Battu, Muriel Mathonnet. New ex-ovo colorectal-cancer models from different SdFFF-sorted tumor-initiating cellsAnalytical and Bioanalytical Chemistry 2015; 407(28): 8433 doi: 10.1007/s00216-015-9029-z
42
Qinjun Chu, Dan Shen, Long He, Hongwei Wang, Chunlan Liu, Wei Zhang. Prognostic significance of SOCS3 and its biological function in colorectal cancerGene 2017; 627: 114 doi: 10.1016/j.gene.2017.06.013
43
Xuejian Liu, Leilei Zhu, Xin Lu, Hairong Bian, Xia Wu, Wenchuan Yang, Qingliang Qin. IL-33/ST2 pathway contributes to metastasis of human colorectal cancerBiochemical and Biophysical Research Communications 2014; 453(3): 486 doi: 10.1016/j.bbrc.2014.09.106
44
Elsa N. Garza Treviño, Paulina Delgado González, Carlos I. Valencia Salgado, Alejandra Martinez Garza. Effects of pericytes and colon cancer stem cells in the tumor microenvironmentCancer Cell International 2019; 19(1) doi: 10.1186/s12935-019-0888-9
45
Susan A. Kennedy, Maria E. Morrissey, Margaret R. Dunne, Fiona O’Connell, Clare T. Butler, Mary-Clare Cathcart, Amy M. Buckley, Brian J. Mehigan, John O. Larkin, Paul McCormick, Breandán N. Kennedy, Jacintha O’Sullivan. Combining 1,4-dihydroxy quininib with Bevacizumab/FOLFOX alters angiogenic and inflammatory secretions in ex vivo colorectal tumorsBMC Cancer 2020; 20(1) doi: 10.1186/s12885-020-07430-y
46
Afsane Bahrami, Majid Khazaei, Seyed Mahdi Hassanian, Soodabeh ShahidSales, Mona Joudi‐Mashhad, Mina Maftouh, Mir Hadi Jazayeri, Mohammad Reza Parizade, Gordon A. Ferns, Amir Avan. Targeting the tumor microenvironment as a potential therapeutic approach in colorectal cancer: Rational and progressJournal of Cellular Physiology 2018; 233(4): 2928 doi: 10.1002/jcp.26041
47
Daniele V.F. Tauriello, Eduard Batlle. Targeting the Microenvironment in Advanced Colorectal CancerTrends in Cancer 2016; 2(9): 495 doi: 10.1016/j.trecan.2016.08.001
48
Farhadul Islam, Vinod Gopalan, Alfred King-yin Lam. Digestive System DiseasesStem Cell Biology and Regenerative Medicine 2019; : 93 doi: 10.1007/978-3-030-11965-2_6
49
Chen Li, Na Xu, Yu-Qiang Li, Yu Wang, Zhi-Tu Zhu. Inhibition of SW620 human colon cancer cells by upregulating miRNA-145World Journal of Gastroenterology 2016; 22(9): 2771-2778 doi: 10.3748/wjg.v22.i9.2771
50
Sung Hoon Choi, Sang Woo Lee, Minseon Ok, Kyung Sik Kim, Sungsik Kim, Sang Hoon Ahn. Gene Expression Profiling of Hepatocellular Carcinoma Derived Cancer Stem Like Cell under HypoxiaYonsei Medical Journal 2017; 58(5): 925 doi: 10.3349/ymj.2017.58.5.925
51
Meng-Yan Wang, Yu-Han Qiu, Mei-Lian Cai, Cong-Hui Zhang, Xiao-Wei Wang, Hong Liu, Yi- Chen, Wu-Li Zhao, Jing-Bo Liu, Rong-Guang Shao. Role and molecular mechanism of stem cells in colorectal cancer initiationJournal of Drug Targeting 2020; 28(1): 1 doi: 10.1080/1061186X.2019.1632317
52
Xiaoguang Lu, Mahnoush Tayebi, Ye Ai. A low‐cost and high‐throughput benchtop cell sorter for isolating white blood cells from whole bloodELECTROPHORESIS 2021; 42(21-22): 2281 doi: 10.1002/elps.202100024
53
Chun Loong Ho, Hui Qing Tan, Koon Jiew Chua, Aram Kang, Kiat Hon Lim, Khoon Lin Ling, Wen Shan Yew, Yung Seng Lee, Jean Paul Thiery, Matthew Wook Chang. Engineered commensal microbes for diet-mediated colorectal-cancer chemopreventionNature Biomedical Engineering 2018; 2(1): 27 doi: 10.1038/s41551-017-0181-y
54
Fereshteh Asgharzadeh, Reyhaneh Moradi-Marjaneh, Mahdi Moradi Marjaneh. The Role of Heat Shock Protein 40 in Carcinogenesis and Biology of Colorectal CancerCurrent Pharmaceutical Design 2022; 28(18): 1457 doi: 10.2174/1381612828666220513124603
55
Yu-Hsuan Chen, Chun-Wei Wang, Ming-Feng Wei, Yi-Shin Tzeng, Keng-Hsueh Lan, Ann-Lii Cheng, Sung-Hsin Kuo. Maintenance BEZ235 Treatment Prolongs the Therapeutic Effect of the Combination of BEZ235 and Radiotherapy for Colorectal CancerCancers 2019; 11(8): 1204 doi: 10.3390/cancers11081204
56
Klaus Pors, Jan S. Moreb. Aldehyde dehydrogenases in cancer: an opportunity for biomarker and drug development?Drug Discovery Today 2014; 19(12): 1953 doi: 10.1016/j.drudis.2014.09.009
57
Irving Alejandro Carrillo-Dávila, Asbiel Felipe Garibaldi-Ríos, Luis E. Figuera, Belinda Claudia Gómez-Meda, Guillermo M. Zúñiga-González, Ana María Puebla-Pérez, Patricia Montserrat García-Verdín, Paola Beatriz Castro-García, Itzae Adonai Gutiérrez-Hurtado, Blanca Miriam Torres-Mendoza, Martha Patricia Gallegos-Arreola. Association of the rs1966265 and rs351855 FGFR4 Variants with Colorectal Cancer in a Mexican Population and Their Analysis In SilicoBiomedicines 2024; 12(3): 602 doi: 10.3390/biomedicines12030602
58
Javier A Menendez. Metabolic control of cancer cell stemness: Lessons from iPS cellsCell Cycle 2015; 14(24): 3801 doi: 10.1080/15384101.2015.1022697
59
Imke Atreya, Markus Kindermann, Stefan Wirtz. Innate lymphoid cells in intestinal cancer developmentSeminars in Immunology 2019; 41: 101267 doi: 10.1016/j.smim.2019.02.001
60
Ichrak Riahi-Chebbi, Meriam Haoues, Makram Essafi, Ons Zakraoui, Sami Fattouch, Habib Karoui, Khadija Essafi-Benkhadir. Quince peel polyphenolic extract blocks human colon adenocarcinoma LS174 cell growth and potentiates 5-fluorouracil efficacyCancer Cell International 2015; 16(1) doi: 10.1186/s12935-016-0276-7
61
Tatsuya Usui, Masashi Sakurai, Shuhei Enjoji, Hideyoshi Kawasaki, Koji Umata, Takashi Ohama, Nobuyuki Fujiwara, Ryotaro Yabe, Shunya Tsuji, Hideyuki Yamawaki, Shoichi Hazama, Hiroko Takenouchi, Masao Nakajima, Ryouichi Tsunedomi, Nobuaki Suzuki, Hiroaki Nagano, Koichi Sato. Establishment of a Novel Model for Anticancer Drug Resistance in Three-Dimensional Primary Culture of Tumor MicroenvironmentStem Cells International 2016; 2016: 1 doi: 10.1155/2016/7053872
62
Elena Monti, Emanuela Marras, Pamela Prini, Marzia Bruna Gariboldi. Luteolin impairs hypoxia adaptation and progression in human breast and colon cancer cellsEuropean Journal of Pharmacology 2020; 881: 173210 doi: 10.1016/j.ejphar.2020.173210
63
Victor Ianole, Mihai Danciu, Constantin Volovat, Cipriana Stefanescu, Paul-Corneliu Herghelegiu, Florin Leon, Adrian Iftene, Ciprian-Gabriel Cusmuliuc, Bogdan Toma, Vasile Drug, Delia Gabriela Ciobanu Apostol. Is High Expression of Claudin-7 in Advanced Colorectal Carcinoma Associated with a Poor Survival Rate? A Comparative Statistical and Artificial Intelligence StudyCancers 2022; 14(12): 2915 doi: 10.3390/cancers14122915
64
Dordi Lea, Sven Håland, Hanne R. Hagland, Kjetil Søreide. Accuracy of TNM staging in colorectal cancer: a review of current culprits, the modern role of morphology and stepping-stones for improvements in the molecular eraScandinavian Journal of Gastroenterology 2014; 49(10): 1153 doi: 10.3109/00365521.2014.950692
65
Elisabet Cuyàs, Bruna Corominas-Faja, Javier A. Menendez. The nutritional phenome of EMT-induced cancer stem-like cellsOncotarget 2014; 5(12): 3970 doi: 10.18632/oncotarget.2147
66
Judith Pape, Tarig Magdeldin, Morium Ali, Claire Walsh, Mark Lythgoe, Mark Emberton, Umber Cheema. Cancer invasion regulates vascular complexity in a three-dimensional biomimetic modelEuropean Journal of Cancer 2019; 119: 179 doi: 10.1016/j.ejca.2019.07.005
67
Luca Massimino, Sara Lovisa, Luigi Antonio Lamparelli, Silvio Danese, Federica Ungaro. Gut eukaryotic virome in colorectal carcinogenesis: Is that a trigger?Computational and Structural Biotechnology Journal 2021; 19: 16 doi: 10.1016/j.csbj.2020.11.055