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For: Dong WW, Mou Q, Chen J, Cui JT, Li WM, Xiao WH. Differential expression of Rab27A/B correlates with clinical outcome in hepatocellular carcinoma. World J Gastroenterol 2012; 18(15): 1806-1813 [PMID: 22553406 DOI: 10.3748/wjg.v18.i15.1806]
URL: https://www.wjgnet.com/1007-9327/full/v18/i15/1806.htm
Number Citing Articles
1
Kejia Wang, Zhujun Mao, Li Liu, Ronghua Zhang, Qing Liang, Yaokang Xiong, Wenjun Yuan, Li Wei. Rab17 inhibits the tumourigenic properties of hepatocellular carcinomas via the Erk pathwayTumor Biology 2015; 36(8): 5815 doi: 10.1007/s13277-015-3251-3
2
Yu Dai, Bo Ai, Ying Liu, Laura E. Pascal, Zhou Wang, Rajiv Dhir, Xuegang Sun, Yu Jiang. Abnormal expression of Rab27B in prostatic epithelial cells of benign prostatic hyperplasia alters intercellular communicationThe International Journal of Biochemistry & Cell Biology 2021; 131: 105898 doi: 10.1016/j.biocel.2020.105898
3
Fabian R. Villagomez, Oscar Medina-Contreras, Jorge Francisco Cerna-Cortes, Genaro Patino-Lopez. The role of the oncogenic Rab35 in cancer invasion, metastasis, and immune evasion, especially in leukemiaSmall GTPases 2020; 11(5): 334 doi: 10.1080/21541248.2018.1463895
4
Joshua D. Ochocki, Mark D. Distefano. Prenyltransferase inhibitors: treating human ailments from cancer to parasitic infectionsMed. Chem. Commun. 2013; 4(3): 476 doi: 10.1039/C2MD20299A
5
Jun Bao, Yijiang Ni, Hui Qin, Li Xu, Zhijun Ge, Feng Zhan, Huijun Zhu, Jiabi Zhao, Xiaoli Zhou, Xiaojun Tang, Liming Tang. Rab27b Is a Potential Predictor for Metastasis and Prognosis in Colorectal CancerGastroenterology Research and Practice 2014; 2014: 1 doi: 10.1155/2014/913106
6
Qingyan Li, Huixia Zhao, Weiwei Dong, Na Guan, Yanyan Hu, Zhiyan Zeng, He Zhang, Fengyun Zhang, Qiuwen Li, Jingwen Yang, Wenhua Xiao. RAB27A promotes the proliferation and invasion of colorectal cancer cellsScientific Reports 2022; 12(1) doi: 10.1038/s41598-022-23696-7
7
Jia-Xing Zhang, Xiao-Xia Huang, Man-Bo Cai, Zhu-Ting Tong, Jie-Wei Chen, Dong Qian, Yi-Ji Liao, Hai-Xia Deng, Ding-Zhun Liao, Ma-Yan Huang, Yi-Xin Zeng, Dan Xie, Shi-Juan Mai. Overexpression of the secretory small GTPase Rab27B in human breast cancer correlates closely with lymph node metastasis and predicts poor prognosisJournal of Translational Medicine 2012; 10(1) doi: 10.1186/1479-5876-10-242
8
Yuling Li, Shudong Chen, Zhengfei Shan, Liyan Bi, Shengqiang Yu, Yongwei Li, Sen Xu. miR-182-5p improves the viability, mitosis, migration, and invasion ability of human gastric cancer cells by down-regulating RAB27ABioscience Reports 2017; 37(3) doi: 10.1042/BSR20170136
9
Khetam Sounbuli, Nadezhda Mironova, Ludmila Alekseeva. Diverse Neutrophil Functions in Cancer and Promising Neutrophil-Based Cancer TherapiesInternational Journal of Molecular Sciences 2022; 23(24): 15827 doi: 10.3390/ijms232415827
10
Hongjun Wang, Yan Zhao, Chuanbao Zhang, Mingyang Li, Chuanlu Jiang, Yongli Li, Sonia Rocha. Rab27a Was Identified as a Prognostic Biomaker by mRNA Profiling, Correlated with Malignant Progression and Subtype Preference in GliomasPLoS ONE 2014; 9(2): e89782 doi: 10.1371/journal.pone.0089782
11
Yaqi Dai, Kunlun Huang, Boyang Zhang, Liye Zhu, Wentao Xu. Aflatoxin B1-induced epigenetic alterations: An overviewFood and Chemical Toxicology 2017; 109: 683 doi: 10.1016/j.fct.2017.06.034
12
Mauro Di Vito Nolfi, Davide Vecchiotti, Irene Flati, Daniela Verzella, Monica Di Padova, Edoardo Alesse, Daria Capece, Francesca Zazzeroni. EV-Mediated Chemoresistance in the Tumor Microenvironment: Is NF-κB a Player?Frontiers in Oncology 2022; 12 doi: 10.3389/fonc.2022.933922
13
Youguang Pu, Fangfang Zhao, Wenjing Cai, Xianghui Meng, Yinpeng Li, Shanbao Cai. MiR-193a-3p and miR-193a-5p suppress the metastasis of human osteosarcoma cells by down-regulating Rab27B and SRR, respectivelyClinical & Experimental Metastasis 2016; 33(4): 359 doi: 10.1007/s10585-016-9783-0
14
Seema Sinha, Daisuke Hoshino, Nan Hyung Hong, Kellye C. Kirkbride, Nathan E. Grega-Larson, Motoharu Seiki, Matthew J. Tyska, Alissa M. Weaver. Cortactin promotes exosome secretion by controlling branched actin dynamicsJournal of Cell Biology 2016; 214(2): 197 doi: 10.1083/jcb.201601025
15
Xue Yang, Xieqiong Ye, Le Sun, Fangyuan Gao, Yuxin Li, Xiaomin Ji, Xuejiang Wang, Ying Feng, Xianbo Wang. Downregulation of serum RAB27B confers improved prognosis and is associated with hepatocellular carcinoma progression through PI3K-AKT-P21 signalingOncotarget 2017; 8(37): 61118 doi: 10.18632/oncotarget.18010
16
Dajiang Guo, Goldie Y.L. Lui, Siew Li Lai, James S. Wilmott, Shweta Tikoo, Louise A. Jackett, Camelia Quek, Darren L. Brown, Danae M. Sharp, Rain Y.Q. Kwan, Diego Chacon, Jason H. Wong, Dominik Beck, Michelle van Geldermalsen, Jeff Holst, John F. Thompson, Graham J. Mann, Richard A. Scolyer, Jennifer L. Stow, Wolfgang Weninger, Nikolas K. Haass, Kimberley A. Beaumont. RAB27A promotes melanoma cell invasion and metastasis via regulation of pro‐invasive exosomesInternational Journal of Cancer 2019; 144(12): 3070 doi: 10.1002/ijc.32064
17
Mostafa Jamshidiha, Inmaculada Pérez-Dorado, James W. Murray, Edward W. Tate, Ernesto Cota, Randy J. Read. Coping with strong translational noncrystallographic symmetry and extreme anisotropy in molecular replacement with Phaser: human Rab27aActa Crystallographica Section D Structural Biology 2019; 75(3): 342 doi: 10.1107/S2059798318017825
18
Rui Li, Chengyong Dong, Keqiu Jiang, Rui Sun, Yang Zhou, Zeli Yin, Jiaxin Lv, Junlin Zhang, Qi Wang, Liming Wang. Rab27B enhances drug resistance in hepatocellular carcinoma by promoting exosome-mediated drug effluxCarcinogenesis 2020; 41(11): 1583 doi: 10.1093/carcin/bgaa029
19
Mahalakshmi Ramadass, Sergio D Catz. Molecular mechanisms regulating secretory organelles and endosomes in neutrophils and their implications for inflammationImmunological Reviews 2016; 273(1): 249 doi: 10.1111/imr.12452
20
Tian-Wei Chen, Fen-Fen Yin, Yan-Mei Yuan, Dong-Xian Guan, Erbin Zhang, Feng-Kun Zhang, Hao Jiang, Ning Ma, Jing-Jing Wang, Qian-Zhi Ni, Lin Qiu, Jing Feng, Xue-Li Zhang, Ying Bao, Kang Wang, Shu-Qun Cheng, Xiao-Fan Wang, Xiang Wang, Jing-Jing Li, Dong Xie. CHML promotes liver cancer metastasis by facilitating Rab14 recycleNature Communications 2019; 10(1) doi: 10.1038/s41467-019-10364-0
21
Hui Zhao, Qingqing Wang, Xudong Wang, Huijun Zhu, Shu Zhang, Wei Wang, Zhiwei Wang, Jianfei Huang. Correlation Between RAB27B and p53 Expression and Overall Survival in Pancreatic CancerPancreas 2016; 45(2): 204 doi: 10.1097/MPA.0000000000000453
22
Hyun Min Koh, Bo Gun Jang, Dong Chul Kim. Prognostic significance of Rab27 expression in solid cancer: a systematic review and meta-analysisScientific Reports 2020; 10(1) doi: 10.1038/s41598-020-71104-9
23
Qingqing Wang, Qichao Ni, Xudong Wang, Huijun Zhu, Zhiwei Wang, Jianfei Huang. High expression of RAB27A and TP53 in pancreatic cancer predicts poor survivalMedical Oncology 2015; 32(1) doi: 10.1007/s12032-014-0372-2
24
Zhelong Liu, Jian Xiong, Song Gao, Michael X. Zhu, Kai Sun, Min Li, Guohua Zhang, Yi‐Ping Li. Ameliorating cancer cachexia by inhibiting cancer cell release of Hsp70 and Hsp90 with omeprazoleJournal of Cachexia, Sarcopenia and Muscle 2022; 13(1): 636 doi: 10.1002/jcsm.12851
25
Pengfei Jiang, Peiying Zhang, Rajesh Mukthavaram, Natsuko Nomura, Sandeep C. Pingle, Dayu Teng, Shu Chien, Fang Guo, Santosh Kesari. Anti-cancer effects of nitrogen-containing bisphosphonates on human cancer cellsOncotarget 2016; 7(36): 57932 doi: 10.18632/oncotarget.10773
26
Hyun Min Koh, Dae Hyun Song. Prognostic role of Rab27A and Rab27B expression in patients with non‐small cell lung carcinomaThoracic Cancer 2019; 10(2): 143 doi: 10.1111/1759-7714.12919
27
Chiara Recchi, Miguel C. Seabra. Novel functions for Rab GTPases in multiple aspects of tumour progressionBiochemical Society Transactions 2012; 40(6): 1398 doi: 10.1042/BST20120199
28
Li Fan, Yongmei Tang, Jingjing Li, Wenjie Huang. Increased expression of TBC1D10B as a potential prognostic and immunotherapy relevant biomarker in liver hepatocellular carcinomaScientific Reports 2023; 13(1) doi: 10.1038/s41598-022-20341-1
29
Jeong-In Park, Kyung-Hee Song, Seong-Mook Kang, Jeeyong Lee, Seong-Jun Cho, Hyun Kyung Choi, Jiyeon Ahn, Jong-Kuk Park, Jaesung Kim, Sang-Gu Hwang, Dae-Seog Lim, Joon Kim, Seung-Youn Jung, Jie-Young Song. BHMPS Inhibits Breast Cancer Migration and Invasion by Disrupting Rab27a-Mediated EGFR and Fibronectin SecretionCancers 2022; 14(2): 373 doi: 10.3390/cancers14020373
30
Hongyan Chen, Gong Chen, Gang Li, Shuo Zhang, Haitao Chen, Yuanyuan Chen, Dave Duggan, Zhibin Hu, Juxing Chen, Yingjie Zhao, Yao Zhao, Huiling Huang, S. Lilly Zheng, Jeffrey M. Trent, Long Yu, Deke Jiang, Zengnan Mo, Hongwei Wang, Yonggao Mou, Tao Jiang, Ying Mao, Jianfeng Xu, Daru Lu. Two novel genetic variants in the STK38L and RAB27A genes are associated with glioma susceptibilityInternational Journal of Cancer 2019; 145(9): 2372 doi: 10.1002/ijc.32179
31
Mahalakshmi Ramadass, Jennifer Linda Johnson, Sergio D Catz. Rab27a regulates GM-CSF-dependent priming of neutrophil exocytosisJournal of Leukocyte Biology 2017; 101(3): 693 doi: 10.1189/jlb.3AB0416-189RR
32
Wei Wang, Qichao Ni, Hua Wang, Shu Zhang, Huijun Zhu. Prognostic Value of Rab27B Nuclear Expression in Gastrointestinal Stromal TumorsDisease Markers 2014; 2014: 1 doi: 10.1155/2014/942181
33
Ping Ren, Xiao-Qing Yang, Xiao-Lu Zhai, Yu-Quan Zhang, Jian-Fei Huang. Overexpression of Rab27B is correlated with distant metastasis and poor prognosis in ovarian cancerOncology Letters 2016; 12(2): 1539 doi: 10.3892/ol.2016.4801
34
Seyed Hamid Jalalian, Mohammad Ramezani, Seyed Ali Jalalian, Khalil Abnous, Seyed Mohammad Taghdisi. Exosomes, new biomarkers in early cancer detectionAnalytical Biochemistry 2019; 571: 1 doi: 10.1016/j.ab.2019.02.013
35
Shipra Malik, W. Mark Saltzman, Raman Bahal. Extracellular vesicles mediated exocytosis of antisense peptide nucleic acidsMolecular Therapy - Nucleic Acids 2021; 25: 302 doi: 10.1016/j.omtn.2021.07.018
36
Mitsunori Fukuda. Rab27 Effectors, Pleiotropic Regulators in Secretory PathwaysTraffic 2013; 14(9): 949 doi: 10.1111/tra.12083
37
Sama Izadpanah, Parastoo Shabani, Ali Aghebati-Maleki, Elham Baghbani, Amir Baghbanzadeh, Ali Fotouhi, Babak Bakhshinejad, Leili Aghebati-Maleki, Behzad Baradaran. Insights into the roles of miRNAs; miR-193 as one of small molecular silencer in osteosarcoma therapyBiomedicine & Pharmacotherapy 2019; 111: 873 doi: 10.1016/j.biopha.2018.12.106
38
Shitong Lin, Canhui Cao, Yifan Meng, Ping Wu, Peipei Gao, Wenhua Zhi, Ting Peng, Peng Wu, Lingli Gui. Comprehensive analysis of the value of RAB family genes in prognosis of breast invasive carcinomaBioscience Reports 2020; 40(5) doi: 10.1042/BSR20201103
39
Johann Mar Gudbergsson, Kasper Bendix Johnsen, Martin Najbjerg Skov, Meg Duroux. Systematic review of factors influencing extracellular vesicle yield from cell culturesCytotechnology 2016; 68(4): 579 doi: 10.1007/s10616-015-9913-6
40
Marzia Pennati, Alessia Lopergolo, Valentina Profumo, Michelandrea De Cesare, Stefania Sbarra, Riccardo Valdagni, Nadia Zaffaroni, Paolo Gandellini, Marco Folini. miR-205 impairs the autophagic flux and enhances cisplatin cytotoxicity in castration-resistant prostate cancer cellsBiochemical Pharmacology 2014; 87(4): 579 doi: 10.1016/j.bcp.2013.12.009
41
Xiaoyu Qin, Jiongyi Wang, Xinxin Wang, Feng Liu, Bin Jiang, Yanjie Zhang. Targeting Rabs as a novel therapeutic strategy for cancer therapyDrug Discovery Today 2017; 22(8): 1139 doi: 10.1016/j.drudis.2017.03.012
42
Chuanbing Shi, Xiaojun Yang, Yijiang Ni, Ning Hou, Li Xu, Feng Zhan, Huijun Zhu, Lin Xiong, Pingsheng Chen. High Rab27A expression indicates favorable prognosis in CRCDiagnostic Pathology 2015; 10(1) doi: 10.1186/s13000-015-0303-3
43
Jingxuan Yang, Zicheng Zhang, Yuqing Zhang, Xiaoling Ni, Guohua Zhang, Xiaobo Cui, Mingyang Liu, Can Xu, Qiang Zhang, Huiyun Zhu, Jie Yan, Vivian F. Zhu, Yusheng Luo, John P. Hagan, Zhaoshen Li, Jing Fang, Aminah Jatoi, Martin E. Fernandez-Zapico, Lei Zheng, Barish H. Edil, Michael S. Bronze, Courtney W. Houchen, Yi-Ping Li, Min Li. ZIP4 Promotes Muscle Wasting and Cachexia in Mice With Orthotopic Pancreatic Tumors by Stimulating RAB27B-Regulated Release of Extracellular Vesicles From Cancer CellsGastroenterology 2019; 156(3): 722 doi: 10.1053/j.gastro.2018.10.026
44
Hong-jun Wang, Yang Gao, Ling Chen, Yong-li Li, Chuan-lu Jiang. RAB34 was a progression- and prognosis-associated biomarker in gliomasTumor Biology 2015; 36(3): 1573 doi: 10.1007/s13277-014-2732-0
45
Zhihao Xing, Chen Chu, Lei Chen, Xiangyin Kong. The use of Gene Ontology terms and KEGG pathways for analysis and prediction of oncogenesBiochimica et Biophysica Acta (BBA) - General Subjects 2016; 1860(11): 2725 doi: 10.1016/j.bbagen.2016.01.012
46
Kira Bettermann, Anita Kuldeep Mehta, Eva M. Hofer, Christina Wohlrab, Nicole Golob-Schwarzl, Vendula Svendova, Michael G. Schimek, Cornelia Stumptner, Andrea Thüringer, Michael R. Speicher, Carolin Lackner, Kurt Zatloukal, Helmut Denk, Johannes Haybaeck. Keratin 18-deficiency results in steatohepatitis and liver tumors in old mice: A model of steatohepatitis-associated liver carcinogenesisOncotarget 2016; 7(45): 73309 doi: 10.18632/oncotarget.12325
47
Zhihong Li, Rui Fang, Jia Fang, Shasha He, Tang Liu. Functional implications of Rab27 GTPases in CancerCell Communication and Signaling 2018; 16(1) doi: 10.1186/s12964-018-0255-9
48
Fengqiang Yu, Weihan Wu, Mingqiang Liang, Yu Huang, Chun Chen. <p>Prognostic Significance of Rab27A and Rab27B Expression in Esophageal Squamous Cell Cancer</p>Cancer Management and Research 2020; : 6353 doi: 10.2147/CMAR.S258940
49
Feixue Feng, Yinghao Jiang, Huanyu Lu, Xiaozhao Lu, Shan Wang, Lifeng Wang, Mengying Wei, Wei Lu, Zhichao Du, Zichen Ye, Guodong Yang, Fang Yuan, Yanxia Ma, Xiaoying Lei, Zifan Lu. Rab27A mediated by NF-κB promotes the stemness of colon cancer cells via up-regulation of cytokine secretionOncotarget 2016; 7(39): 63342 doi: 10.18632/oncotarget.11454
50
Jieying Li, Qin Jin, Fang Huang, Zhiyuan Tang, Jianfei Huang. Effects of Rab27A and Rab27B on Invasion, Proliferation, Apoptosis, and Chemoresistance in Human Pancreatic Cancer CellsPancreas 2017; 46(9): 1173 doi: 10.1097/MPA.0000000000000910
51
An Hendrix, Olivier De Wever. Rab27 GTPases Distribute Extracellular Nanomaps for Invasive Growth and Metastasis: Implications for Prognosis and TreatmentInternational Journal of Molecular Sciences 2013; 14(5): 9883 doi: 10.3390/ijms14059883
52
Chun-Cheng Yang, Guang-Xiao Meng, Zhao-Ru Dong, Tao Li. Role of Rab GTPases in Hepatocellular CarcinomaJournal of Hepatocellular Carcinoma 2021; : 1389 doi: 10.2147/JHC.S336251
53
Feixue Feng, Jianping Zhang, Xiaoxuan Fan, Fang Yuan, Yinghao Jiang, Ruihua Lv, Yanxia Ma. Downregulation of Rab27A contributes to metformin-induced suppression of breast cancer stem cellsOncology Letters 2017; 14(3): 2947 doi: 10.3892/ol.2017.6542
54
Linda Rieswijk, Sandra M.H. Claessen, Otto Bekers, Marcel van Herwijnen, Daniël H.J. Theunissen, Danyel G.J. Jennen, Theo M.C.M. de Kok, Jos C.S. Kleinjans, Simone G.J. van Breda. Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinomaToxicology 2016; : 31 doi: 10.1016/j.tox.2016.05.002
55
Marc Ruiz-Martinez, Alfons Navarro, Ramón M. Marrades, Nuria Viñolas, Sandra Santasusagna, Carmen Muñoz, Josep Ramírez, Laureano Molins, Mariano Monzo. YKT6 expression, exosome release, and survival in non-small cell lung cancerOncotarget 2016; 7(32): 51515 doi: 10.18632/oncotarget.9862
56
Thomas S. van Solinge, Erik R. Abels, Lieke L. van de Haar, Killian S. Hanlon, Sybren L. N. Maas, Rosalie Schnoor, Jeroen de Vrij, Xandra O. Breakefield, Marike L. D. Broekman. Versatile Role of Rab27a in Glioma: Effects on Release of Extracellular Vesicles, Cell Viability, and Tumor ProgressionFrontiers in Molecular Biosciences 2020; 7 doi: 10.3389/fmolb.2020.554649
57
Hongyuan Jin, Yuanxin Tang, Liang Yang, Xueqiang Peng, Bowen Li, Qin Fan, Shibo Wei, Shuo Yang, Xinyu Li, Bo Wu, Mingyao Huang, Shilei Tang, Jingang Liu, Hangyu Li. Rab GTPases: Central Coordinators of Membrane Trafficking in CancerFrontiers in Cell and Developmental Biology 2021; 9 doi: 10.3389/fcell.2021.648384
58
Agnieszka Dominiak, Beata Chełstowska, Wioletta Olejarz, Grażyna Nowicka. Communication in the Cancer Microenvironment as a Target for Therapeutic InterventionsCancers 2020; 12(5): 1232 doi: 10.3390/cancers12051232
59
Jianwu Wu, Yijie Lu, Ancheng Qin, Zhiming Qiao, Xinwei Jiang. Overexpression of RAB34 correlates with poor prognosis and tumor progression in hepatocellular carcinomaOncology Reports 2017; 38(5): 2967 doi: 10.3892/or.2017.5957
60
Jian Yang, Wei Liu, Xin’an Lu, Yan Fu, Lin Li, Yongzhang Luo. High expression of small GTPase Rab3D promotes cancer progression and metastasisOncotarget 2015; 6(13): 11125 doi: 10.18632/oncotarget.3575
61
Dabing Huang, Geng Bian, Yueyin Pan, Xinghua Han, Yubei Sun, Yong Wang, Guodong Shen, Min Cheng, Xiang Fang, Shilian Hu. MiR–20a-5p promotes radio-resistance by targeting Rab27B in nasopharyngeal cancer cellsCancer Cell International 2017; 17(1) doi: 10.1186/s12935-017-0389-7
62
Aude Brunel, Gaëlle Bégaud, Clément Auger, Stéphanie Durand, Serge Battu, Barbara Bessette, Mireille Verdier. Autophagy and Extracellular Vesicles, Connected to rabGTPase Family, Support Aggressiveness in Cancer Stem CellsCells 2021; 10(6): 1330 doi: 10.3390/cells10061330
63
Yuhua Shan. Aflatoxin B1 Occurrence, Detection and Toxicological Effects2020;  doi: 10.5772/intechopen.88775
64
J.M. Gudbergsson, M. Duroux. Mesenchymal Stromal Cells as Tumor Stromal Modulators2017; : 521 doi: 10.1016/B978-0-12-803102-5.00021-5
65
Wei Sun, Wei-Wei Dong, Lin-Lin Mao, Wen-Mei Li, Jian-Tao Cui, Rui Xing, You-Yong Lu. Overexpression of p42.3 promotes cell growth and tumorigenicity in hepatocellular carcinomaWorld Journal of Gastroenterology 2013; 19(19): 2913-2920 doi: 10.3748/wjg.v19.i19.2913
66
Masafumi Tsuruda, Hirofumi Yoshino, Shunsuke Okamura, Kazuki Kuroshima, Yoichi Osako, Takashi Sakaguchi, Satoshi Sugita, Shuichi Tatarano, Masayuki Nakagawa, Hideki Enokida, Rajvir Dahiya. Oncogenic effects of RAB27B through exosome independent function in renal cell carcinoma including sunitinib-resistantPLOS ONE 2020; 15(5): e0232545 doi: 10.1371/journal.pone.0232545
67
Özgür Doğuş Erol, Şimal Şenocak, Fatima Aerts-Kaya. The Role of Rab GTPases in the development of genetic and malignant diseasesMolecular and Cellular Biochemistry 2024; 479(2): 255 doi: 10.1007/s11010-023-04727-x