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For: Zhang HT, Luo H, Wu J, Lan LB, Fan DH, Zhu KD, Chen XY, Wen M, Liu HM. Galangin induces apoptosis of hepatocellular carcinoma cells via the mitochondrial pathway. World J Gastroenterol 2010; 16(27): 3377-3384 [PMID: 20632439 DOI: 10.3748/wjg.v16.i27.3377]
URL: https://www.wjgnet.com/1007-9327/full/v16/i27/3377.htm
Number Citing Articles
1
Yan-Qing Zhou, Hui Liu, Mu-Xue He, Ruibing Wang, Qing-Qian Zeng, Ying Wang, Wen-Cai Ye, Qing-Wen Zhang. Natural and Artificial Flavoring Agents and Food Dyes2018; : 351 doi: 10.1016/B978-0-12-811518-3.00011-9
2
Rabia Aqeel, Nidhi Srivastava, Poonam Kushwaha. Micelles in Cancer Therapy: An Update on Preclinical and Clinical StatusRecent Patents on Nanotechnology 2022; 16(4): 283 doi: 10.2174/1872210515666210720125717
3
Xv Li, Yajun Wang, Yuzhen Xiong, Jun Wu, Hang Ding, Xiaoyi Chen, Liubo Lan, Haitao Zhang. Galangin Induces Autophagy via Deacetylation of LC3 by SIRT1 in HepG2 CellsScientific Reports 2016; 6(1) doi: 10.1038/srep30496
4
Deuk Ae Kim, Young Keul Jeon, Myeong Jin Nam. Galangin induces apoptosis in gastric cancer cells via regulation of ubiquitin carboxy-terminal hydrolase isozyme L1 and glutathione S-transferase PFood and Chemical Toxicology 2012; 50(3-4): 684 doi: 10.1016/j.fct.2011.11.039
5
Hui Ma, Qing Fan, Jia Yu, Jile Xin, Ce Zhang. Novel Microemulsion of Tanshinone IIA, Isolated from Salvia miltiorrhiza Bunge, Exerts Anticancer Activity Through Inducing Apoptosis in Hepatoma CellsThe American Journal of Chinese Medicine 2013; 41(01): 197 doi: 10.1142/S0192415X13500146
6
Hassan Abbaszadeh, Bijan Keikhaei, Sayeh Mottaghi. A review of molecular mechanisms involved in anticancer and antiangiogenic effects of natural polyphenolic compoundsPhytotherapy Research 2019; 33(8): 2002 doi: 10.1002/ptr.6403
7
Manal A. Alfwuaires. Galangin mitigates oxidative stress, inflammation, and apoptosis in a rat model of methotrexate hepatotoxicityEnvironmental Science and Pollution Research 2022; 29(14): 20279 doi: 10.1007/s11356-021-16804-z
8
Min Ae Han, Dong Hee Lee, Seon Min Woo, Bo Ram Seo, Kyoung-jin Min, Shin Kim, Jong-Wook Park, Sang Hyun Kim, Yung Hyun Choi, Taeg Kyu Kwon. Galangin sensitizes TRAIL-induced apoptosis through down-regulation of anti-apoptotic proteins in renal carcinoma Caki cellsScientific Reports 2016; 6(1) doi: 10.1038/srep18642
9
Wenjing Zhang, Yan Lan, Qilai Huang, Zichun Hua. Galangin induces B16F10 melanoma cell apoptosis via mitochondrial pathway and sustained activation of p38 MAPKCytotechnology 2013; 65(3): 447 doi: 10.1007/s10616-012-9499-1
10
Mei Wang, Meng Liu, Lijing Tang, Lixian Shen, Junhui Xiao, Rong Li. RETRACTED ARTICLE: Liquiritin reduces ferroptosis in doxorubicin-induced cardiotoxicity through targeting SLC7A11/GPX4 pathwayNaunyn-Schmiedeberg's Archives of Pharmacology 2024; 397(1): 627 doi: 10.1007/s00210-023-02515-4
11
Fan Zhang, Yu Yan, Lin-Mei Zhang, Dong-Xu Li, Li Li, Wen-Wen Lian, Cong-Yuan Xia, Jun He, Jie-Kun Xu, Wei-Ku Zhang. Pharmacological activities and therapeutic potential of galangin, a promising natural flavone, in age-related diseasesPhytomedicine 2023; 120: 155061 doi: 10.1016/j.phymed.2023.155061
12
Xue Guan, Zhonghua Li, Shu Zhu, Meijia Cheng, Yetao Ju, Lu Ren, Guanlin Yang, Dongyu Min. Galangin attenuated cerebral ischemia-reperfusion injury by inhibition of ferroptosis through activating the SLC7A11/GPX4 axis in gerbilsLife Sciences 2021; 264: 118660 doi: 10.1016/j.lfs.2020.118660
13
Yasuko Kitagishi, Mayumi Kobayashi, Satoru Matsuda. Protection against Cancer with Medicinal Herbs via Activation of Tumor SuppressorJournal of Oncology 2012; 2012: 1 doi: 10.1155/2012/236530
14
Daibo Wang, Junren Chen, Lin Pu, Lei Yu, Fang Xiong, Luyao Sun, Qian Yu, Xiaoyu Cao, Yan Chen, Fu Peng, Cheng Peng. Galangin: A food‐derived flavonoid with therapeutic potential against a wide spectrum of diseasesPhytotherapy Research 2023; 37(12): 5700 doi: 10.1002/ptr.8013
15
Hai-Tao Zhang, Jun Wu, Min Wen, Li-Juan Su, Hui Luo. Galangin induces apoptosis in hepatocellular carcinoma cells through the caspase 8/t-Bid mitochondrial pathwayJournal of Asian Natural Products Research 2012; 14(7): 626 doi: 10.1080/10286020.2012.682152
16
Nouf Juaid, Amr Amin, Ali Abdalla, Kevin Reese, Zaenah Alamri, Mohamed Moulay, Suzan Abdu, Nabil Miled. Anti-Hepatocellular Carcinoma Biomolecules: Molecular Targets InsightsInternational Journal of Molecular Sciences 2021; 22(19): 10774 doi: 10.3390/ijms221910774
17
Wenjing Zhang, Qilai Huang, Zichun Hua. Galangin and TRAIL cooperate to suppress A549 lung cancer proliferation via apoptosis and p38 MAPK activationActa Pharmaceutica Sinica B 2012; 2(6): 569 doi: 10.1016/j.apsb.2012.10.009
18
Yingfeng Tu, Shu Zhu, Jing Wang, Ezra Burstein, Da Jia. Natural compounds in the chemoprevention of alcoholic liver diseasePhytotherapy Research 2019; 33(9): 2192 doi: 10.1002/ptr.6410
19
Kit-Kay Mak, Joe-Jen Tan, Puvaneswari Marappan, Madhu Katyayani Balijepalli, Hira Choudhury, Srinivasan Ramamurthy, Mallikarjuna Rao Pichika. Galangin’s potential as a functional food ingredientJournal of Functional Foods 2018; 46: 490 doi: 10.1016/j.jff.2018.04.054
20
Christophe Wiart. Lead Compounds from Medicinal Plants for the Treatment of Cancer2013; : 267 doi: 10.1016/B978-0-12-398371-8.00003-9
21
Jung Yoen Park, See-Hyoung Park, Sae Woong Oh, Kitae Kwon, Eunbi Yu, Seoyoung Choi, Seoyoun Yang, Su Bin Han, Kwangsun Jung, Minkyung Song, Jae Youl Cho, Jongsung Lee. Yellow Chaste Weed and Its Components, Apigenin and Galangin, Affect Proliferation and Oxidative Stress in Blue Light-Irradiated HaCaT CellsNutrients 2022; 14(6): 1217 doi: 10.3390/nu14061217
22
Mahak Fatima, Ritu Karwasra, Waleed H. Almalki, Amirhossein Sahebkar, Prashant Kesharwani. Galactose engineered nanocarriers: Hopes and hypes in cancer therapyEuropean Polymer Journal 2023; 183: 111759 doi: 10.1016/j.eurpolymj.2022.111759
23
Vadanasundari Vedarethinam, Karthik Dhanaraj, Soundharrajan Ilavenil, Mariadhas Arasu, Ki Choi, Naif Al-Dhabi, Srigopalram Srisesharam, Kyung Lee, Da Kim, Tamilvenvendan Dhanapal, Ravikumar Sivanesan, Han Choi, Young Kim. Antitumor Effect of the Mannich Base(1,3-bis-((3-Hydroxynaphthalen-2-yl)phenylmethyl)urea) on Hepatocellular CarcinomaMolecules 2016; 21(5): 632 doi: 10.3390/molecules21050632
24
Mariam Abotaleb, Samson Samuel, Elizabeth Varghese, Sharon Varghese, Peter Kubatka, Alena Liskova, Dietrich Büsselberg. Flavonoids in Cancer and ApoptosisCancers 2018; 11(1): 28 doi: 10.3390/cancers11010028
25
Roohi Mohi-ud-din, Reyaz Hassan Mir, Saba Sabreen, Rafia Jan, Faheem Hyder Pottoo, Inder Pal Singh. Recent Insights into Therapeutic Potential of Plant-Derived Flavonoids against CancerAnti-Cancer Agents in Medicinal Chemistry 2022; 22(20): 3343 doi: 10.2174/1871520622666220421094055
26
Dengyang Fang, Zuming Xiong, Jinming Xu, Jun Yin, Runlan Luo. Chemopreventive mechanisms of galangin against hepatocellular carcinoma: A reviewBiomedicine & Pharmacotherapy 2019; 109: 2054 doi: 10.1016/j.biopha.2018.09.154
27
Hardeep Singh Tuli, Katrin Sak, Shubham Adhikary, Ginpreet Kaur, Diwakar Aggarwal, Jagjit Kaur, Manoj Kumar, Nidarshana Chaturvedi Parashar, Gaurav Parashar, Uttam Sharma, Aklank Jain. Galangin: A metabolite that suppresses anti-neoplastic activities through modulation of oncogenic targetsExperimental Biology and Medicine 2022; 247(4): 345 doi: 10.1177/15353702211062510
28
Xinxu Zhang, Yuanyuan Deng, Juan Xiang, Huixia Liu, Jiani Zhang, Jie Liao, Ke Chen, Bo Liu, Jun Liu, Ying Pu. <p>Galangin Improved Non-Alcoholic Fatty Liver Disease in Mice by Promoting Autophagy</p>Drug Design, Development and Therapy 2020; : 3393 doi: 10.2147/DDDT.S258187
29
Monika Jokubaite, Mindaugas Marksa, Kristina Ramanauskiene. Application of Poloxamer for In Situ Eye Drop Modeling by Enrichment with Propolis and Balsam Poplar Buds Phenolic CompoundsGels 2024; 10(3): 161 doi: 10.3390/gels10030161
30
Shailendra Kapoor. Galangin and its emerging anti-neoplastic effectsCytotechnology 2013; 65(4): 467 doi: 10.1007/s10616-012-9507-5
31
Jung-Jin Lee, Ji-Hye Lee, Nam-Hui Yim, Joo-Hui Han, Jin Yeul Ma. Application of galangin, an active component of Alpinia officinarum Hance (Zingiberaceae), for use in drug-eluting stentsScientific Reports 2017; 7(1) doi: 10.1038/s41598-017-08410-2
32
Çağatay OLTULU, Melek AKINCI, Elvan BAKAR. Antitumor Activity of Etoposide, Puerarin, Galangin and Their Combinations in Neuroblastoma CellsInternational Journal of Life Sciences and Biotechnology 2022; 5(3): 407 doi: 10.38001/ijlsb.1089164
33
Wenjing Zhang, Bo Tang, Qilai Huang, Zichun Hua. Galangin inhibits tumor growth and metastasis of B16F10 melanomaJournal of Cellular Biochemistry 2013; 114(1): 152 doi: 10.1002/jcb.24312
34
Tae Kwun Ha, Mi Eun Kim, Ju Hwa Yoon, Sung Jin Bae, Jihye Yeom, Jun Sik Lee. Galangin induces human colon cancer cell death via the mitochondrial dysfunction and caspase-dependent pathwayExperimental Biology and Medicine 2013; 238(9): 1047 doi: 10.1177/1535370213497882
35
Xiaohui Liang, Ping Wang, Chun Yang, Fei Huang, Hui Wu, Hailian Shi, Xiaojun Wu. Galangin Inhibits Gastric Cancer Growth Through Enhancing STAT3 Mediated ROS ProductionFrontiers in Pharmacology 2021; 12 doi: 10.3389/fphar.2021.646628
36
Hai-Xu Wang, Chen Tang. Galangin suppresses human laryngeal carcinoma via modulation of caspase-3 and AKT signaling pathwaysOncology Reports 2017; 38(2): 703 doi: 10.3892/or.2017.5767
37
Xiu-hua Wang, Song-min Jiang, Qing-wen Sun. Effects of berberine on human rheumatoid arthritis fibroblast-like synoviocytesExperimental Biology and Medicine 2011; 236(7): 859 doi: 10.1258/ebm.2011.010366
38
Anju Dhiman, Arun Nanda, Sayeed Ahmad. A quest for staunch effects of flavonoids: Utopian protection against hepatic ailmentsArabian Journal of Chemistry 2016; 9: S1813 doi: 10.1016/j.arabjc.2012.05.001
39
JINGYI CAO, HAINAN WANG, FEIFEI CHEN, JIANZHENG FANG, AIMING XU, WEI XI, SHENGLI ZHANG, GANG WU, ZENGJUN WANG. Galangin inhibits cell invasion by suppressing the epithelial-mesenchymal transition and inducing apoptosis in renal cell carcinomaMolecular Medicine Reports 2016; 13(5): 4238 doi: 10.3892/mmr.2016.5042
40
Deqiang Lei, Fangcheng Zhang, Dongxiao Yao, Nanxiang Xiong, Xiaobing Jiang, Hongyang Zhao. Galangin increases ERK1/2 phosphorylation to decrease ADAM9 expression and prevents invasion in A172 glioma cellsMolecular Medicine Reports 2017;  doi: 10.3892/mmr.2017.7920
41
Shuo Yu, Lian-sheng Gong, Nian-feng Li, Yi-feng Pan, Lun Zhang. Galangin (GG) combined with cisplatin (DDP) to suppress human lung cancer by inhibition of STAT3-regulated NF-κB and Bcl-2/Bax signaling pathwaysBiomedicine & Pharmacotherapy 2018; 97: 213 doi: 10.1016/j.biopha.2017.10.059
42
Liping Zhu, Qingqiong Luo, Jianjun Bi, Jieying Ding, Shengfang Ge, Fuxiang Chen. Galangin inhibits growth of human head and neck squamous carcinoma cells in vitro and in vivoChemico-Biological Interactions 2014; 224: 149 doi: 10.1016/j.cbi.2014.10.027
43
P. Skopiński, B. J. Bałan, J. Kocik, R. Zdanowski, S. Lewicki, M. Niemcewicz, K. Gawrychowski, E. Skopińska-Różewska, W. Stankiewicz. Inhibitory Effect of Herbal Remedy PERVIVO and Anti-Inflammatory Drug Sulindac on L-1 Sarcoma Tumor Growth and Tumor Angiogenesis in Balb/c MiceMediators of Inflammation 2013; 2013: 1 doi: 10.1155/2013/289789
44
Sharvil Patil, Vinayak Ujalambkar, Atul Rathore, Supada Rojatkar, Varsha Pokharkar. Galangin loaded galactosylated pluronic F68 polymeric micelles for liver targetingBiomedicine & Pharmacotherapy 2019; 112: 108691 doi: 10.1016/j.biopha.2019.108691
45
Indrani Manna, Debalina Das, Sejuty Mondal, Maumita Bandyopadhyay. Pharmacotherapeutic Botanicals for Cancer Chemoprevention2020; : 221 doi: 10.1007/978-981-15-5999-0_10
46
Lijuan Su, Xiaoyi Chen, Jun Wu, Biyun Lin, Haitao Zhang, Liubo Lan, Hui Luo. Galangin inhibits proliferation of hepatocellular carcinoma cells by inducing endoplasmic reticulum stressFood and Chemical Toxicology 2013; 62: 810 doi: 10.1016/j.fct.2013.10.019
47
Vinit Sharma, Ankita Arora, Sakshi Bansal, Ankita Semwal, Mayank Sharma, Anjali Aggarwal. Role of bio‐flavonols and their derivatives in improving mitochondrial dysfunctions associated with pancreatic tumorigenesisCell Biochemistry and Function 2024; 42(1) doi: 10.1002/cbf.3920
48
Xiaowei Zhong, Siyi Huang, Dianfeng Liu, Ziping Jiang, Qinglong Jin, Chengshun Li, Liu Da, Qunyan Yao, Dongxu Wang. Galangin promotes cell apoptosis through suppression of H19 expression in hepatocellular carcinoma cellsCancer Medicine 2020; 9(15): 5546 doi: 10.1002/cam4.3195
49
Sha Li, Hor Yue Tan, Ning Wang, Fan Cheung, Ming Hong, Yibin Feng. The Potential and Action Mechanism of Polyphenols in the Treatment of Liver DiseasesOxidative Medicine and Cellular Longevity 2018; 2018: 1 doi: 10.1155/2018/8394818
50
Xiaoming Long, Lin Chen, Jin Yang, Taotao Dong, Qisen Cheng, Weiwei Wang, Yujian Zou, Yao Su, Wenbin Dai, Bo Chen, Xin Zhou. Network-based Pharmacology and In vitro Validation Reveal that Galangin Induces Apoptosis in Bladder Cancer Cells by Promoting the P53 Signaling PathwayAnti-Cancer Agents in Medicinal Chemistry 2023; 23(7): 847 doi: 10.2174/1871520623666221026121600
51
Sanmuga Priya Ekambaram, Senthamil Selvan Perumal, Sivasakthi Paramasivam. Handbook of Dietary Flavonoids2023; : 1 doi: 10.1007/978-3-030-94753-8_10-1
52
Chen-Yi Liao, Ching-Chang Lee, Chi-chang Tsai, Chao-Wen Hsueh, Chih-Chiang Wang, I-Hung Chen, Ming-Kai Tsai, Mei-Yu Liu, An-Tie Hsieh, Kuan-Jen Su, Hau-Ming Wu, Shih-Chung Huang, Yi-Chen Wang, Chien-Yao Wang, Shu-Fang Huang, Yen-Cheng Yeh, Ren-Jy Ben, Shang-Tao Chien, Chin-Wen Hsu, Wu-Hsien Kuo. Novel Investigations of Flavonoids as Chemopreventive Agents for Hepatocellular CarcinomaBioMed Research International 2015; 2015: 1 doi: 10.1155/2015/840542
53
Wei Song, Hai-Bo Yang, Pu Chen, Shu-Min Wang, Li-Pei Zhao, Wen-Hao Xu, Hai-Fang Fan, Xu Gu, Lan-Ying Chen. Apoptosis of Human Gastric Carcinoma SGC-7901 Induced by Deoxycholic Acid via the Mitochondrial-Dependent PathwayApplied Biochemistry and Biotechnology 2013; 171(4): 1061 doi: 10.1007/s12010-013-0417-6
54
Haizhi Huang, Allen Y. Chen, Xingqian Ye, Rongfa Guan, Gary O. Rankin, Yi Charlie Chen. Galangin, a Flavonoid from Lesser Galangal, Induced Apoptosis via p53-Dependent Pathway in Ovarian Cancer CellsMolecules 2020; 25(7): 1579 doi: 10.3390/molecules25071579
55
Poungrat Pakdeechote, Anuson Poasakate, Patoomporn Prasatthong, Prapassorn Potue, Juthamas Khamseekaew, Putcharawipa Maneesai. Mitigation effect of galangin against aortic dysfunction and hypertrophy in rats with metabolic syndromeHeliyon 2023; 9(5): e16500 doi: 10.1016/j.heliyon.2023.e16500
56
HUI MA, QING FAN, JIA YU, JILE XIN, CE ZHANG. Anticancer activities of tanshinone microemulsion against hepatocellular carcinoma in vitro and in vivoMolecular Medicine Reports 2013; 7(1): 59 doi: 10.3892/mmr.2012.1129
57
Dan Liu, Pengtao You, Yan Luo, Min Yang, Yanwen Liu. Galangin Induces Apoptosis in MCF-7 Human Breast Cancer Cells Through Mitochondrial Pathway and Phosphatidylinositol 3-Kinase/Akt InhibitionPharmacology 2018; 102(1-2): 58 doi: 10.1159/000489564
58
Yun Chan Jung, Mi Eun Kim, Ju Hwa Yoon, Pu Reum Park, Hwa-Young Youn, Hee-Woo Lee, Jun Sik Lee. Anti-inflammatory effects of galangin on lipopolysaccharide-activated macrophages via ERK and NF-κB pathway regulationImmunopharmacology and Immunotoxicology 2014; 36(6): 426 doi: 10.3109/08923973.2014.968257
59
Haizhi Huang, Allen Y. Chen, Yon Rojanasakul, Xingqian Ye, Gary O. Rankin, Yi Charlie Chen. Dietary compounds galangin and myricetin suppress ovarian cancer cell angiogenesisJournal of Functional Foods 2015; 15: 464 doi: 10.1016/j.jff.2015.03.051
60
Xiaoling Hao, Hong Wang, Fang Cui, Zihan Yang, Liu Ye, Run Huang, Jiangping Meng. Reduction of SLC7A11 and GPX4 Contributing to Ferroptosis in Sperm from Asthenozoospermia IndividualsReproductive Sciences 2023; 30(1): 247 doi: 10.1007/s43032-022-01004-y
61
Bo Hei, Ru-en Liu, Meihua Li. Ursolic acid inhibits glioblastoma through suppressing TGFβ-mediated epithelial-mesenchymal transition (EMT) and angiogenesisHeliyon 2024; 10(6): e27722 doi: 10.1016/j.heliyon.2024.e27722
62
Meizhu He, Kamarya Yasin, Shaoqi Yu, Jinyao Li, Lijie Xia. Total Flavonoids in Artemisia absinthium L. and Evaluation of Its Anticancer ActivityInternational Journal of Molecular Sciences 2023; 24(22): 16348 doi: 10.3390/ijms242216348
63
Kewei Ren, Wenzhe Zhang, Gang Wu, Jianzhuang Ren, Huibin Lu, Zongming Li, Xinwei Han. Synergistic anti-cancer effects of galangin and berberine through apoptosis induction and proliferation inhibition in oesophageal carcinoma cellsBiomedicine & Pharmacotherapy 2016; 84: 1748 doi: 10.1016/j.biopha.2016.10.111
64
Aurélie de Rus Jacquet, Mitali Arun Tambe, Sin Ying Ma, George P. McCabe, Jay Hansford C. Vest, Jean-Christophe Rochet. Pikuni-Blackfeet traditional medicine: Neuroprotective activities of medicinal plants used to treat Parkinson’s disease-related symptomsJournal of Ethnopharmacology 2017; 206: 393 doi: 10.1016/j.jep.2017.01.001
65
Guangxin Chen, Juxiong Liu, Liqiang Jiang, Xin Ran, Dewei He, Yuhang Li, Bingxu Huang, Wei Wang, Shoupeng Fu. Galangin Reduces the Loss of Dopaminergic Neurons in an LPS-Evoked Model of Parkinson’s Disease in RatsInternational Journal of Molecular Sciences 2017; 19(1): 12 doi: 10.3390/ijms19010012
66
P.N. Ravindran, G.S. Pillai, I. Balachandran, M. Divakaran. Handbook of Herbs and Spices2012; : 303 doi: 10.1533/9780857095688.303
67
Nenad L. Vukovic, Ana D. Obradovic, Milena D. Vukic, Danijela Jovanovic, Predrag M. Djurdjevic. Cytotoxic, proapoptotic and antioxidative potential of flavonoids isolated from propolis against colon (HCT-116) and breast (MDA-MB-231) cancer cell linesFood Research International 2018; 106: 71 doi: 10.1016/j.foodres.2017.12.056
68
Tomasz Skalny, Anna Kleczka, Robert Kubina, Aleksandra Owczarzy, Magdalena Wyszyńska, Agata Kabała-Dzik. Assessment of antiproliferative, cytotoxic and proapoptotic properties of selected flavonoids in relation to liver cancers – in vitro studiesAnnales Academiae Medicae Silesiensis 2020; 74: 181 doi: 10.18794/aams/116016
69
L Wang, J Xue, F Wei, G Zheng, M Cheng, S Liu. Chemopreventive effect of galangin against benzo(a)pyrene-induced stomach tumorigenesis through modulating aryl hydrocarbon receptor in Swiss albino miceHuman & Experimental Toxicology 2021; 40(9): 1434 doi: 10.1177/0960327121997979