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For: Yang L, Pei Z. Bacteria, inflammation, and colon cancer. World J Gastroenterol 2006; 12(42): 6741-6746 [PMID: 17106919 DOI: 10.3748/wjg.v12.i42.6741]
URL: https://www.wjgnet.com/1007-9327/full/v12/i42/6741.htm
Number Citing Articles
1
Rosana B. R. Ferreira, Navkiran Gill, Benjamin P. Willing, L. Caetano M. Antunes, Shannon L. Russell, Matthew A. Croxen, B. Brett Finlay, Stefan Bereswill. The Intestinal Microbiota Plays a Role in Salmonella-Induced Colitis Independent of Pathogen ColonizationPLoS ONE 2011; 6(5): e20338 doi: 10.1371/journal.pone.0020338
2
Jee-Yon Lee, Mi-Kyung Lee, Nam-Kyu Kim, Sang-Hui Chu, Duk-Chul Lee, Hye-Sun Lee, Ji-Won Lee, Justin Y. Jeon, John Green. Serum chemerin levels are independently associated with quality of life in colorectal cancer survivors: A pilot studyPLOS ONE 2017; 12(5): e0176929 doi: 10.1371/journal.pone.0176929
3
Xiaohong Liu, Xinyue Chang, Haizhen Wu, Jingfan Xiao, Yuan Gao, Yuanxing Zhang. Role of intestinal inflammation in predisposition of Edwardsiella tarda infection in zebrafish (Danio rerio)Fish & Shellfish Immunology 2014; 41(2): 271 doi: 10.1016/j.fsi.2014.09.009
4
Gilbert Cornut, Claude Fortin, Denis Soulières. Antineoplastic Properties of BacteriocinsAmerican Journal of Clinical Oncology 2008; 31(4): 399 doi: 10.1097/COC.0b013e31815e456d
5
Mark J. Sinnamon, Kathy J. Carter, Lauren P. Sims, Bonnie LaFleur, Barbara Fingleton, Lynn M. Matrisian. A protective role of mast cells in intestinal tumorigenesisCarcinogenesis 2008; 29(4): 880 doi: 10.1093/carcin/bgn040
6
Lobke Snoeks, Christopher R. Weber, Jerrold R. Turner, Mitra Bhattacharyya, Kaarin Wasland, Suzana D. Savkovic. Tumor Suppressor Foxo3a Is Involved in the Regulation of Lipopolysaccharide-Induced Interleukin-8 in Intestinal HT-29 CellsInfection and Immunity 2008; 76(10): 4677 doi: 10.1128/IAI.00227-08
7
Purnima Guda, Sridar V. Chittur, Chittibabu Guda. Comparative Analysis of Protein-Protein Interactions in Cancer-Associated GenesGenomics, Proteomics and Bioinformatics 2009; 7(1-2): 25 doi: 10.1016/S1672-0229(08)60030-3
8
Trupti Patel, Priyanjali Bhattacharya, Suvrajit Das. Gut microbiota: an Indicator to Gastrointestinal Tract DiseasesJournal of Gastrointestinal Cancer 2016; 47(3): 232 doi: 10.1007/s12029-016-9820-x
9
Antonio Galvao Neto, April Whitaker, Zhiheng Pei. Microbiome and potential targets for chemoprevention of esophageal adenocarcinomaSeminars in Oncology 2016; 43(1): 86 doi: 10.1053/j.seminoncol.2015.09.005
10
Martha L. Slattery, Roger K. Wolff, Karen Curtin, Frank Fitzpatrick, Jennifer Herrick, John D. Potter, Bette J. Caan, Wade S. Samowitz. Colon tumor mutations and epigenetic changes associated with genetic polymorphism: Insight into disease pathwaysMutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 2009; 660(1-2): 12 doi: 10.1016/j.mrfmmm.2008.10.001
11
Kjetil Søreide. Bacterial genotoxins, gene methylation, and RNA interference: Pointing to colorectal cancer as an infectious disease?Scandinavian Journal of Gastroenterology 2008; 43(12): 1529 doi: 10.1080/00365520802272134
12
S. Wada, Y. Matsushita, H. Tazawa, W. Aoi, Y. Naito, A. Higashi, H. Ohshima, T. Yoshikawa. Loss of p53 in stromal fibroblasts enhances tumor cell proliferation through nitric-oxide-mediated cyclooxygenase 2 activationFree Radical Research 2015; 49(3): 269 doi: 10.3109/10715762.2014.997230
13
Jee-Yon Lee, Sang-Hui Chu, Justin Y. Jeon, Mi-Kyung Lee, Ji-Hye Park, Duk-Chul Lee, Ji-Won Lee, Nam-Kyu Kim. Effects of 12 weeks of probiotic supplementation on quality of life in colorectal cancer survivors: A double-blind, randomized, placebo-controlled trialDigestive and Liver Disease 2014; 46(12): 1126 doi: 10.1016/j.dld.2014.09.004
14
R Okubo, C Chen, M Sekiguchi, K Hamazaki, Y J Matsuoka. Mechanisms underlying the effects of n-3 polyunsaturated fatty acids on fear memory processing and their hypothetical effects on fear of cancer recurrence in cancer survivorsProstaglandins, Leukotrienes and Essential Fatty Acids 2018; 131: 14 doi: 10.1016/j.plefa.2018.03.006
15
Rong Xu, QuanQiu Wang, Li Li. A genome-wide systems analysis reveals strong link between colorectal cancer and trimethylamine N-oxide (TMAO), a gut microbial metabolite of dietary meat and fatBMC Genomics 2015; 16(S7) doi: 10.1186/1471-2164-16-S7-S4
16
Veronika Cígerová, Marian Adamkov, Slávka Drahošová, Marián Grendár. Immunohistochemical expression and significance of SATB2 protein in colorectal cancerAnnals of Diagnostic Pathology 2021; 52: 151731 doi: 10.1016/j.anndiagpath.2021.151731
17
Ming-Ming Zhang, Jing-Qiu Cheng, Lin Xia, Yan-Rong Lu, Xiao-Ting Wu. Monitoring intestinal microbiota profile: A promising method for the ultraearly detection of colorectal cancerMedical Hypotheses 2011; 76(5): 670 doi: 10.1016/j.mehy.2011.01.028
18
Traci L Testerman. Fulfilling the Promise of Microbiomics to Revolutionize MedicineJournal of Microbiology & Experimentation 2015; 2(3) doi: 10.15406/jmen.2015.02.00050
19
Qian Zhang, Xue Li, Jun Li, Yuxia Hu, Jing Liu, Fang Wang, Wei Zhang, Fuhou Chang. Mechanism of Anti-Inflammatory and Antibacterial Effects of QingXiaoWuWei Decoction Based on Network Pharmacology, Molecular Docking and In Vitro ExperimentsFrontiers in Pharmacology 2021; 12 doi: 10.3389/fphar.2021.678685
20
Jingbo Jiao, Ping Li, Ying Gu, Xinjun Du, Shuo Wang, Junping Wang. A fluorescence quenching-recovery sensor based on RCA for the specific analysis of Fusobacterium nucleatum. nucleatumAnalytical Biochemistry 2020; 604: 113808 doi: 10.1016/j.ab.2020.113808
21
Abdurakhmon T. Babakhanov, Aueskhan T. Dzhumabekov, Alexey V. Zhao, Yerlan K. Kuandykov, Shynar B. Tanabayeva, Ildar R. Fakhradiyev, Yana Nazarenko, Timur M. Saliev. Impact of Appendectomy on Gut MicrobiotaSurgical Infections 2021; 22(7): 651 doi: 10.1089/sur.2020.422
22
Ahmed Hjazi, Faryal Nasir, Rabia Noor, Ali Alsalamy, Rahman S. Zabibah, Rosario Mireya Romero-Parra, Muhammad Ikram Ullah, Yasser Fakri Mustafa, Maytham T. Qasim, Shaik Vaseem Akram. The pathological role of C-X-C chemokine receptor type 4 (CXCR4) in colorectal cancer (CRC) progression; special focus on molecular mechanisms and possible therapeuticsPathology - Research and Practice 2023; 248: 154616 doi: 10.1016/j.prp.2023.154616
23
Kurt Hong, Eric Yan, Steve Chen, Zhaoping Li, David Heber. Obesity and Cancer: Inflammation and Molecular PathogenesisObesity Management 2007; 3(3): 115 doi: 10.1089/obe.2007.0031
24
Dorothy F. Newton, Sandra Macfarlane, George T. Macfarlane. Effects of Antibiotics on Bacterial Species Composition and Metabolic Activities in Chemostats Containing Defined Populations of Human Gut MicroorganismsAntimicrobial Agents and Chemotherapy 2013; 57(5): 2016 doi: 10.1128/AAC.00079-13
25
Aleksandar D. Kostic, Dirk Gevers, Chandra Sekhar Pedamallu, Monia Michaud, Fujiko Duke, Ashlee M. Earl, Akinyemi I. Ojesina, Joonil Jung, Adam J. Bass, Josep Tabernero, José Baselga, Chen Liu, Ramesh A. Shivdasani, Shuji Ogino, Bruce W. Birren, Curtis Huttenhower, Wendy S. Garrett, Matthew Meyerson. Genomic analysis identifies association of Fusobacterium with colorectal carcinomaGenome Research 2012; 22(2): 292 doi: 10.1101/gr.126573.111
26
Xiao‐Yan Zhou, Yong‐Sheng Li, Ping Wu, Hong‐Mei Wang, Zhen‐Yu Cai, Fang‐Yun Xu, Du‐Yun Ye. Lipoxin A4 inhibited hepatocyte growth factor‐induced invasion of human hepatoma cellsHepatology Research 2009; 39(9): 921 doi: 10.1111/j.1872-034X.2009.00520.x
27
Yoram Vodovotz. Chronic Inflammation2012; : 3 doi: 10.1201/b12696-3
28
Maya Paritsky, Nina Pastukh, Diana Brodsky, Natalya Isakovich, Avi Peretz. Association of <italic>Streptococcus bovis</italic> presence in colonic content with advanced colonic lesionWorld Journal of Gastroenterology 2015; 21(18): 5663-5667 doi: 10.3748/wjg.v21.i18.5663
29
Susan Bullman, Chandra S. Pedamallu, Ewa Sicinska, Thomas E. Clancy, Xiaoyang Zhang, Diana Cai, Donna Neuberg, Katherine Huang, Fatima Guevara, Timothy Nelson, Otari Chipashvili, Timothy Hagan, Mark Walker, Aruna Ramachandran, Begoña Diosdado, Garazi Serna, Nuria Mulet, Stefania Landolfi, Santiago Ramon y Cajal, Roberta Fasani, Andrew J. Aguirre, Kimmie Ng, Elena Élez, Shuji Ogino, Josep Tabernero, Charles S. Fuchs, William C. Hahn, Paolo Nuciforo, Matthew Meyerson. Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer Science 2017; 358(6369): 1443 doi: 10.1126/science.aal5240
30
Bret D. Wallace, Hongwei Wang, Kimberly T. Lane, John E. Scott, Jillian Orans, Ja Seol Koo, Madhukumar Venkatesh, Christian Jobin, Li-An Yeh, Sridhar Mani, Matthew R. Redinbo. Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial EnzymeScience 2010; 330(6005): 831 doi: 10.1126/science.1191175
31
Haiying Cheng, Ting Zhang, Weizhong Gu, Xiaoli Shu, Yanyi Zhang, Xuping Zhang, Xiuying Wu, Jie Chen, Mizu Jiang. The Presence of Helicobacter pylori in Colorectal Polyps Detected by Immunohistochemical Methods in ChildrenPediatric Infectious Disease Journal 2012; 31(4): 364 doi: 10.1097/INF.0b013e3182467538
32
Lu Wang, Qingzhu Zhang. Application of the ApcMin/+ mouse model for studying inflammation-associated intestinal tumorBiomedicine & Pharmacotherapy 2015; 71: 216 doi: 10.1016/j.biopha.2015.02.023
33
Juliana Noguti, Alfred A. Chan, Bradley Bandera, Colin J. Brislawn, Mladjan Protic, Myung S. Sim, Janet K. Jansson, Anton J. Bilchik, Delphine J. Lee. Both the intratumoral immune and microbial microenvironment are linked to recurrence in human colon cancer: results from a prospective, multicenter nodal ultrastaging trialOncotarget 2018; 9(34): 23564 doi: 10.18632/oncotarget.25276
34
Abadia Gilda Buso, Haroldo Luis Oliva Gomes Rocha, Débora Miranda Diogo, Priscila Miranda Diogo, Augusto Diogo-Filho. Seroprevalence of Helicobacter pylori in patients with colon adenomas in a brazilian university hospitalArquivos de Gastroenterologia 2009; 46(2): 97 doi: 10.1590/S0004-28032009000200004
35
Sergei I. Grivennikov. Inflammation and colorectal cancer: colitis-associated neoplasiaSeminars in Immunopathology 2013; 35(2): 229 doi: 10.1007/s00281-012-0352-6
36
Claude Petit, Eric Oswald, Jean-Philippe Nougayrede. Rôle des génotoxines produites par des bactéries du microbiote dans le cancer colorectalRevue Francophone des Laboratoires 2013; 2013(456): 77 doi: 10.1016/S1773-035X(13)72226-3
37
Cynthia L. Sears, Drew M. Pardoll. Perspective: Alpha-Bugs, Their Microbial Partners, and the Link to Colon CancerThe Journal of Infectious Diseases 2011; 203(3): 306 doi: 10.1093/jinfdis/jiq061
38
Giorgio Trinchieri. Cancer and Inflammation: An Old Intuition with Rapidly Evolving New ConceptsAnnual Review of Immunology 2012; 30(1): 677 doi: 10.1146/annurev-immunol-020711-075008
39
Temitope O. Keku, Santosh Dulal, April Deveaux, Biljana Jovov, Xuesong Han. The gastrointestinal microbiota and colorectal cancerAmerican Journal of Physiology-Gastrointestinal and Liver Physiology 2015; 308(5): G351 doi: 10.1152/ajpgi.00360.2012
40
Hong-Wei Pan, Lu-Tao Du, Wei Li, Yong-Mei Yang, Yi Zhang, Chuan-Xin Wang. Biodiversity and richness shifts of mucosa-associated gut microbiota with progression of colorectal cancerResearch in Microbiology 2020; 171(3-4): 107 doi: 10.1016/j.resmic.2020.01.001
41
Shiyu Ma, Lan Shen, Meiwan Chen, Xiao Lin, Qiang Wang, Ruofei Du, Yi Feng. The study of metabonomics combined with diversity of intestinal flora in LDP intervention in kidney-yin deficiency hyperthyroid ratsRSC Advances 2015; 5(71): 57975 doi: 10.1039/C5RA10134D
42
Robert R. Maronpot, Jeffrey Davis, Glenda Moser, Dipak K. Giri, Shim-mo Hayashi. Evaluation of 90-day oral rat toxicity studies on the food additive, gum ghattiFood and Chemical Toxicology 2013; 51: 215 doi: 10.1016/j.fct.2012.09.037
43
Ryo Okubo, Takayuki Kinoshita, Noriko Katsumata, Yasuhito Uezono, Jinzhong Xiao, Yutaka J. Matsuoka. Impact of chemotherapy on the association between fear of cancer recurrence and the gut microbiota in breast cancer survivorsBrain, Behavior, and Immunity 2020; 85: 186 doi: 10.1016/j.bbi.2019.02.025
44
Andrew M. Thomas, Eliane C. Jesus, Ademar Lopes, Samuel Aguiar, Maria D. Begnami, Rafael M. Rocha, Paola Avelar Carpinetti, Anamaria A. Camargo, Christian Hoffmann, Helano C. Freitas, Israel T. Silva, Diana N. Nunes, João C. Setubal, Emmanuel Dias-Neto. Tissue-Associated Bacterial Alterations in Rectal Carcinoma Patients Revealed by 16S rRNA Community ProfilingFrontiers in Cellular and Infection Microbiology 2016; 6 doi: 10.3389/fcimb.2016.00179
45
Ena Wang, Silvia Selleri, Marianna Sabatino, Alessandro Monaco, Zoltan Pos, Andrea Worschech, David F Stroncek, Francesco M Marincola. Spontaneous and treatment-induced cancer rejection in humansExpert Opinion on Biological Therapy 2008; 8(3): 337 doi: 10.1517/14712598.8.3.337
46
Michael Doulberis, Georgios Kotronis, Robert Thomann, Stergios A. Polyzos, Marina Boziki, Dimitra Gialamprinou, Georgia Deretzi, Panagiotis Katsinelos, Jannis Kountouras. Review: Impact of Helicobacter pylori on Alzheimer's disease: What do we know so far?Helicobacter 2018; 23(1) doi: 10.1111/hel.12454
47
Rubén Varela-Calviño, Oscar J. Cordero. Cancer Immunology2015; : 217 doi: 10.1007/978-3-662-46410-6_11
48
Liying Yang, Xiaohua Lu, Carlos W. Nossa, Fritz Francois, Richard M. Peek, Zhiheng Pei. Inflammation and Intestinal Metaplasia of the Distal Esophagus Are Associated With Alterations in the MicrobiomeGastroenterology 2009; 137(2): 588 doi: 10.1053/j.gastro.2009.04.046
49
Daylia Thet, Nutthada Areepium, Tippawan Siritientong. Effects of Probiotics on Chemotherapy-induced DiarrheaNutrition and Cancer 2023; 75(10): 1811 doi: 10.1080/01635581.2023.2267779
50
Stefan Fichtner-Feigl, Rebecca Kesselring, Warren Strober. Chronic inflammation and the development of malignancy in the GI tractTrends in Immunology 2015; 36(8): 451 doi: 10.1016/j.it.2015.06.007
51
D. Brandão, L. Ribeiro. Dietary fatty acids modulation of human colon cancer cells: mechanisms and future perspectivesInternational Journal of Food Sciences and Nutrition 2018; 69(4): 437 doi: 10.1080/09637486.2017.1382456
52
Ellen Teresa Boehm, Cosima Thon, Juozas Kupcinskas, Ruta Steponaitiene, Jurgita Skieceviciene, Ali Canbay, Peter Malfertheiner, Alexander Link. Fusobacterium nucleatum is associated with worse prognosis in Lauren’s diffuse type gastric cancer patientsScientific Reports 2020; 10(1) doi: 10.1038/s41598-020-73448-8
53
José M. García-Heredia, Amancio Carnero. Dr. Jekyll and Mr. Hyde: MAP17’s up-regulation, a crosspoint in cancer and inflammatory diseasesMolecular Cancer 2018; 17(1) doi: 10.1186/s12943-018-0828-7
54
Ahmet Uyar, Abdulahad Doğan, Turan Yaman, Ömer Faruk Keleş, Zabit Yener, İsmail Çelik, Elif Ebru Alkan. The Protective Role ofUrtica dioicaSeed Extract Against Azoxymethane-Induced Colon Carcinogenesis in RatsNutrition and Cancer 2022; 74(1): 306 doi: 10.1080/01635581.2021.1881568
55
William F. Wright. Clostridium septicum myonecrosis presenting as an acute painful footThe American Journal of Emergency Medicine 2012; 30(1): 253.e3 doi: 10.1016/j.ajem.2010.10.009
56
Jiyoung Ahn, Rashmi Sinha, Zhiheng Pei, Christine Dominianni, Jing Wu, Jianxin Shi, James J. Goedert, Richard B. Hayes, Liying Yang. Human Gut Microbiome and Risk for Colorectal CancerJNCI: Journal of the National Cancer Institute 2013; 105(24): 1907 doi: 10.1093/jnci/djt300
57
Jeremy Goc, Matthew R. Hepworth, Gregory F. Sonnenberg. Group 3 innate lymphoid cells: regulating host–commensal bacteria interactions in inflammation and cancerInternational Immunology 2016; 28(1): 43 doi: 10.1093/intimm/dxv056
58
Artem Artemev, Sheetal Naik, Anastasia Pougno, Prasanna Honnavar, Nandan M Shanbhag. The Association of Microbiome Dysbiosis With Colorectal CancerCureus 2022;  doi: 10.7759/cureus.22156
59
Pasquale Sansone, Giulia Piazzi, Paola Paterini, Antonio Strillacci, Claudio Ceccarelli, Francesco Minni, Guido Biasco, Pasquale Chieco, Massimiliano Bonafè. Cyclooxygenase‐2/carbonic anhydrase‐IX up‐regulation promotes invasive potential and hypoxia survival in colorectal cancer cellsJournal of Cellular and Molecular Medicine 2009; 13(9b): 3876 doi: 10.1111/j.1582-4934.2008.00580.x
60
Jean-Philippe Nougayrède, Éric Oswald. Microbiote et cancer colorectal : des bactéries génotoxiques dans le tractus intestinalBulletin de l'Académie Nationale de Médecine 2011; 195(6): 1295 doi: 10.1016/S0001-4079(19)31989-2
61
Sergei I. Grivennikov, Kepeng Wang, Daniel Mucida, C. Andrew Stewart, Bernd Schnabl, Dominik Jauch, Koji Taniguchi, Guann-Yi Yu, Christoph H. Österreicher, Kenneth E. Hung, Christian Datz, Ying Feng, Eric R. Fearon, Mohamed Oukka, Lino Tessarollo, Vincenzo Coppola, Felix Yarovinsky, Hilde Cheroutre, Lars Eckmann, Giorgio Trinchieri, Michael Karin. Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growthNature 2012; 491(7423): 254 doi: 10.1038/nature11465
62
Giuseppina Tommonaro, Ali M. El-Hagrassi, Walid Fayad, Carmine Iodice, Kamel H. Shaker, Faten K. Abd EL-Hady. Fatty Acid Profile and In Vitro Anticancer Activity of Two Marine Sponge- Associated BacteriaCurrent Bioactive Compounds 2020; 16(9): 1273 doi: 10.2174/1573407216666200214095114
63
Xiaomin Zhou, Songze Ding, Ruobing Hu. The Related Study on the Pathogenesis of Gastrointestinal Diseases in Gastrointestinal Flora and the Risk of Gastric Ulcer CarcinogenesisJournal of Biomaterials and Tissue Engineering 2021; 11(7): 1418 doi: 10.1166/jbt.2021.2755
64
Inna Sekirov, Nicola M. Tam, Maria Jogova, Marilyn L. Robertson, Yuling Li, Claudia Lupp, B. Brett Finlay. Antibiotic-Induced Perturbations of the Intestinal Microbiota Alter Host Susceptibility to Enteric InfectionInfection and Immunity 2008; 76(10): 4726 doi: 10.1128/IAI.00319-08
65
Veronika Tupá, Slávka Drahošová, Marián Grendár, Marian Adamkov. Expression and association of carbonic anhydrase IX and cyclooxygenase-2 in colorectal cancerPathology - Research and Practice 2019; 215(4): 705 doi: 10.1016/j.prp.2019.01.012
66
Alvaro Toribio, Teresa Marrodán, Isabel Fernández-Natal, Honorina Martínez-Blanco, Leandro Rodríguez-Aparicio, Miguel Á. Ferrero. Study of conjunctival flora in anophthalmic patients: influence on the comfort of the socketGraefe's Archive for Clinical and Experimental Ophthalmology 2017; 255(8): 1669 doi: 10.1007/s00417-017-3708-8
67
Kjetil Søreide. Handbook of Epigenetics2011; : 477 doi: 10.1016/B978-0-12-375709-8.00029-0
68
Xiuli Xiao, Wenbo Long, Tingyu Huang, Tian Xia, Rupei Ye, Yong Liu, Hanan Long. Differences Between the Intestinal Lumen Microbiota of Aberrant Crypt Foci (ACF)-Bearing and Non-bearing RatsDigestive Diseases and Sciences 2018; 63(11): 2923 doi: 10.1007/s10620-018-5180-7
69
Kyla Cochrane, Avery V. Robinson, Robert A. Holt, Emma Allen-Vercoe. A survey of Fusobacterium nucleatum genes modulated by host cell infection Microbial Genomics 2020; 6(2) doi: 10.1099/mgen.0.000300
70
Maya Saleh, Giorgio Trinchieri. Innate immune mechanisms of colitis and colitis-associated colorectal cancerNature Reviews Immunology 2011; 11(1): 9 doi: 10.1038/nri2891
71
Imane Allali, Noureddine Boukhatem, Leila Bouguenouch, Hanaa Hardi, H. Abir Boudouaya, M. Belen Cadenas, Karim Ouldim, Saaïd Amzazi, M. Andrea Azcarate-Peril, Hassan Ghazal. Gut microbiome of Moroccan colorectal cancer patientsMedical Microbiology and Immunology 2018; 207(3-4): 211 doi: 10.1007/s00430-018-0542-5