Case Control Study Open Access
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Mar 16, 2015; 3(3): 310-317
Published online Mar 16, 2015. doi: 10.12998/wjcc.v3.i3.310
Endoscopic ear surgery: A case series and first United Kingdom experience
Hala Kanona, Jagdeep Singh Virk, Anthony Owa, ENT Department, Queen’s Hospital, RM7 0AG Romford, United Kingdom
Author contributions: All authors contributed to this work.
Ethics approval: Ethical approval was not deemed necessary by the Queen’s Hospital board as this surgery is already in use by the senior surgeon.
Informed consent: All patients gave informed consent prior to study inclusion.
Conflict-of-interest: No conflicting interests for all authors.
Data sharing: Technical appendix, statistical code, and dataset available from corresponding author at above email address. Participants consented to study inclusion. Consent was not obtained for data sharing but the presented data are all anonymised and risk of identification is very low.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Ms Hala Kanona, MRCS, MRCS (ENT), ENT Department, Queen’s Hospital, Rom Valley Way, RM7 0AG Romford, United Kingdom. hkanona@yahoo.co.uk
Telephone: +44-07-792001863
Received: October 23, 2014
Peer-review started: October 24, 2014
First decision: December 12, 2014
Revised: January 1, 2015
Accepted: January 15, 2015
Article in press: January 19, 2015
Published online: March 16, 2015

Abstract

AIM: To present the United Kingdom’s first case series of 70 otological cases of endoscopic and non-endoscopic ear surgeries.

METHODS: Prospective case series incorporating a range of endoscopic procedures performed using a 4 mm, 18 cm rigid endoscope, performed by a single surgeon at a single centre. Primary outcome measures included mean average pre and post-operative air-bone gap hearing thresholds and duration of surgery.

RESULTS: Thirty-eight patients underwent endoscopic assisted ear surgery and 32 underwent non-endoscopic assisted ear surgery. In both surgical groups, there was a significant difference between pre and post-operative mean air-bone gaps (P = 0.02). Mean operating time was comparable between both groups. Eight patients developed post-operative complications.

CONCLUSION: Endoscopic ear surgery can be performed safely in a range of otological procedures. This has the potential to become a well-established surgical option for middle ear surgery in the near future. Advantages and limitations are discussed.

Key Words: Endoscopic, Mastoid, Surgery, Imaging, Otology, Cholesteatoma

Core tip: The role of endoscopic ear surgery is yet to be properly established but as more otologists adopt this technique, its role will become much more clearly defined and may lead to widespread use based upon positive outcomes for surgery. As with every new surgical technique, a learning curve must first be overcome before reliable conclusions can be drawn about its use. Our series has shown the benefits of using this technique in limited cholesteatoma disease and in providing a good view during revision mastoid surgery with simple pathology.



INTRODUCTION

The advantages of using endoscopes in surgery are well described and relate mainly to their portability and ability to provide clear, high quality images[1]. Endoscopes can also be used in theatre and the outpatient setting. In particular, the benefits for middle ear surgery include the ability to visualise poorly seen structures, such as the hypotympanum and sinus tympani, which are often an obstacle during the open-technique approach[2]. In addition, their use via the permeatal approach in bypassing a narrow isthmus can provide direct access and a wide view into the middle ear for surgery[3-5]. Benefits of using an endoscope can therefore decrease operating time due to the reduction in time need to gain access into the middle ear cleft[6] and the subsequent closure at the end of the procedure. The disadvantages of endoscopes used in ear surgery include operator dependence (especially in relation to the one-handed technique), restricted views from narrower endoscopes (e.g., 2.7 mm as compared to 4 mm), the ability to manage complications such as bleeding within a narrower operating field, loss of depth perception, limited magnification, and the need for further training in their use[4,5]. Furthermore, when used solely in a permeatal approach, the surgeon must use a one-handed technique for instrumentation and there may be difficulty passing other instruments alongside, even in wide ear canals. Certainly there is no scope for using the operating drill in its present form.

Endoscopic ear surgery can be applied to a variety of operations including; grommet insertion, myringoplasty[2], attic retractions[6], cholesteatoma surgery[7-15], stapedectomy[1,15], benign neoplasms of the middle ear[16] and neuro-otological procedures[4,17,18]. Based on the literature their use has been most commonly described for middle ear disease (cholesteatoma). It has been suggested that preservation of middle ear mucosa by limited surgery using the endoscope can improve the re-aeration of the mastoid cavity leading to better outcomes in surgery[2]. There are also roles in “second look” middle ear surgery using 30 degree endoscopes to check for disease clearance[14,19].

Many of the surgeries described above are derived from international case series from France, Germany, Italy, India, UAE, China, Egypt, Iran and the United States[1,5,12-14,17-24]. We present the first United Kingdom case series that uses a permeatal exclusively endoscopic approach[20].

MATERIALS AND METHODS

We describe a case series of 70 patients who underwent either endoscope-assisted or non-endoscope-assisted ear surgery by a single senior surgeon in a district general hospital. Data collection was carried out prospectively for endoscopic cases and retrospectively for non-endoscopic cases where all cases were performed within a 2 year period (2012-2014). A 4 mm diameter, 18 cm long rigid endoscope was used in all cases. Primary outcomes include mean average pre and post-operative air-bone gap hearing thresholds or duration of surgery, depending on the type of surgery. Pre and post-operative audiometric data using both air and bone conduction (at 500 Hz, 1 KHz, 2 KHz and 4 KHz frequencies) was recorded. Complications were noted. Statistical analysis was performed using GraphPad Prism (GraphPad Software Inc, La Jolla, CA, United States).

Statistical analysis

The statistical methods of this study were reviewed by Virk J, Cambridge University graduate. The dataset was principally descriptive with simple paired t-testing only.

RESULTS

Seventy patients underwent surgery between the ages of 7-85. Of these, 38 underwent endoscope-assisted ear surgery (Group A) and 32 underwent non-endoscope-assisted ear surgery (Group B). All cases were performed under general anaesthesia. Imaging was reviewed prior to surgery. An endoscope was used exclusively for all patients who underwent endoscope-assisted ear surgery, except in parts of an operation which required the use of a microscope (e.g., mastoid portion of modified radical mastoidectomy or canal wall up mastoidectomy). Procedures in Group B patients were preferentially performed with the microscope such as revision stapedectomies under local anaesthetic or those with extensive disease and the endoscope was not used during the procedure. No cases were converted from endoscopic to open operations. Both groups were matched as closely as possible for type of surgery and demographics.

In Group A, 20 patients had had previous surgery to the operated ear (i.e., ipsilateral ear) compared to 7 patients in Group B. A summary of different operations within Group A and B are shown in Table 1. Tables 2-6 summarise data for each operative group.

Table 1 Summary of procedures.
Procedure (including revision surgery)Endoscopic assisted
Non-endoscopic assisted
Group AGroup B
Ventilation Tube insertion12
Myringoplasty, tympanoplasty, ossiculoplasty, Tympanotomy1010
CSOM and cholesteotoma surgery1510
Stapedectomy119
Petrosectomy11
Total3832
Table 2 Ventilation tube insertion.
No.AgeSideDuration (min)Previous ipsilateral surgeryPre-op mean air-bone gap1Post-op mean air-bone gap1ClosureFollow up (mo)Complications
Endoscopic assisted, Group A
115R25No22.50Within 10-30 dB4None
Non-endoscopic assisted, Group B
114R + L20No2510Within 10-30 dB9None
253R + L15No2020No change24Recurrent otitis media with effusion
Table 3 Myringoplasty, Tympanoplasty, Ossiculoplaty and Tympanotomy.
No.AgeDetailsSideDuration (min)Previous ipsilateral surgeryPre-op mean air-bone gap1Post-op mean air-bone gap1ClosureGraft materialFollow up (mo)Complications
Endoscopic assisted, Group A
163MyringoplastyR66YesDead earDead earNo changeConchal cartilage1Tragal abscess and otitis externa
237MyringoplastyL60No15.512.5No changeTemporalis fascia4None
355MyringoplastyL45Yes55No changeComposite tragal graft4None
416Revision myringoplastyR45Yes00No changeTragal cartilage5None
522TympanoplastyR88No00No changeComposite tragal graft12None
645TympanoplastyL101Yes2015Within 10-30 dBTragal cartilage4None
732TympanoplastyL98No7.56.25Within 10 dBTragal cartilage2None
846TympanoplastyL111Yes18.7523.3No changeTragal cartilage2None
935TympanoplastyR121No3011.25Within 10 dBNot stated3None
1034OssiculoplastyR123Yes42.512.5Within 10-30 dBNot stated10None
Non-endoscopic assisted, Group B
112MyringoplastyR55No12.511.25Within 10-30 dB55None
29MyringoplastyL130No27.5Not availableNot availableTemporalis fasciaLost to follow up
330Revision myringoplastyL97No16.2515Within 10-30 dBTemporalis fascia12None
466TympanoplastyL127YesNot availableNot availableNot availableNot stated5Will need ossiculoplasty
559TympanoplastyL114No1540> 30 dBNot stated4Scarring, false fundus recurrence
633TympanoplastyL174NoDeadDeadNo changeComposite tragal graft5None
710TympanoplastyL88No23.7521.25Within 10-30 dBTemporalis fascia3None
821TympanoplastyR92No16.256.25OverclosureTemporalis fascia10None
963TympanoplastyR100NoDeadDeadNo changeNot stated3None
1050Revision tympanoplastyR101Yes020> 30 dBTragal cartilage2None
Table 4 CSOM and cholesteatoma surgery.
No.AgeDetailsSideDuration (min)Previous ipsilateral surgeryPre-op mean air-bone gap1Post-op mean air-bone gap1ClosureGraft materialFollow up (mo)Complications
Endoscopic assisted, Group A
142MastoidectomyL211No7.57.5No changeTemporalis fascia6None
240Revision mastoidectomyR155Yes4040No changeNot stated3None
37Tympanoplasty and mastoid explorationL169Yes13.755OverclosureConchal cartilage3None
435TympanotomyL48No2525No changeNot stated2None
518CWU mastoidectomyL195No7.517.5Within 10 dBConchal cartilage7None
652CWU mastoidectomyL287Yes2018.75> 30 dBTragal cartilage6None
713Revision CWU mastoidectomyL188Yes1125> 30 dBTragal cartilage2None
847MR mastoidectomyR287No27.523.75Within 10-30 dBNot stated2None
940MR mastoidectomyL223YesData unavailable16.25Within 10-30 dBTragal cartilage2Post op. pain
1028Revision MR mastoidectomyL228Yes21.2521.25No changeNot stated4None
1141Revision MR mastoidectomyL140Yes31.2531.25No changeNot stated4None
1235Revision MR mastoidectomyR95Yes42.542.5No changeNot stated6None
1385Revision MR mastoidectomyL110Yes2020No changeNot stated11None
1468Revision MR mastoidectomyL155Yes4550No changeTemporalis fascia3None
1543Revision MR mastoidectomy78YesDead earDead earNo changeNot stated4Transient delayed facial palsy
Non-endoscopic assisted, Group B
18CWU mastoidectomyL220No17.512.5Within 10-30 dBTemporalis fascia12None
252CWU mastoidectomyL286No27.525> 30 dBNot stated7None
313Revision CWU mastoidectomyL189Yes7.530Within 10-30 dBTragal cartilage5None
470MR mastoidectomyL131No13.7520> 30 dBComposite tragal graft3None
542MR mastoidectomyR255No28.7535> 30 dBTemporalis fascia3None
634MR mastoidectomyR312No33.7537.5> 30 dBComposite tragal graft2None
773Revision MR mastoidectomyL150YesDead earDead earNo changeTragal cartilage9None
877Revision MR mastoidectomyL179Yes2.521.25Within 10-30 dBTragal Cartilage8None
956Revision MR mastoidectomyL251No2010Within 10-30 dBTemporalis ascia4None
1078Revision MR mastoidectomyR199NoDead earDead earNo changeNot stated6None
Table 5 Stapedectomy.
No.AgeDetailsSideDuration (min)Previous ipsilateral surgeryPre-op mean air-bone gap1Post-op mean air-bone gap1ClosureProsthesisFollow up (mo)Complications
Endoscopic Assisted, Group A
130StapedectomyL149No28.7510OverclosureSMart piston9None
257StapedectomyL119No11.2515Within 10-30 dBSMart piston3None
343StapedectomyR137No356.25Within 10-30 dBSMart piston6None
444StapedectomyR145No32.510Within 10-30 dBSMart piston4None
532StapedectomyR150No2526.25No changePlastipore PORP5None
639StapedectomyR115No4013.75Within 10 dBPORP3None
745StapedectomyR151No38.7540OverclosurePorphexpiston2Infection in mastoid cavity
833StapedectomyR125No13.756.25OverclosureSMart piston5None
937Revision stapedctomyL139Yes2517.5Within 10 dBSMart piston8None
1032Revision stapedectomyL142Yes6060No changeSMart piston2Labyrinthitis
1147Revision revision stapedectomyR129Yes16.2520Within 10-30 dBSMart piston7None
Non-endoscopic Assisted, Group B
148StapedectomyR254No457.5< 10 dBfluoroplastic piston11None
244StapedectomyR230No21.25Not availablen/aFluoroplastic pistonLost to follow up
345StapedectomyL118No26.258.75< 10 dBSmart piston5None
441StapedectomyR265No37.513.75Within 10-30 dBSmart piston3None
541StapedectomyL253No33.7516.25Within 10-30 dBSmart piston13None
642StapedectomyL98No32.520OverclosureFluoroplastic piston22None
740StapedectomyL169No405< 10 dBFluoroplastic piston14None
856Revision stapedectomyL111Yes2010< 10 dBFluoroplastic piston5None
938Revision stapedectomyR79Yes26.2521.25> 30 dBFluoroplastic piston8Planned for revision revision surgery
Table 6 Petrosectomy.
No.AgeSideDuration (min)Previous ipsilateral surgeryPre-op mean air-bone gap1Post-op mean air-bone gap1ClosureGraft materialFollow up (mo)Complications
Endoscopic assisted, Group A
163R387NoDead earDead earNo changeFat, Fascia lata3Intraoperative CSF leak; TM perforation
Non-endoscopic assisted, Group B
179R253NoDead ear90No changeNot stated6referral for cochlear implant

Overall, air-bone gap closure was achieved within 10 dB in 9 patients (5 Group A vs 4 Group B), within 10-30 dB in 18 patients (8 Group A vs 10 Group B), over 30 dB in 9 patients (2 Group A vs 7 Group B), over-closure in 5 patients (4 Group A vs 1 Group B) and no change in 25 patients (18 Group A vs 7 Group B). In both groups, there was a significant difference between pre and post-operative mean air-bone gaps (P < 0.05) (paired t test, P = 0.036 group A and P = 0.002 for group B) for patients who underwent stapedectomy, where air-bone gap was a primary outcome.

Mean operating times were as follows; ventilation tube insertion 25 min vs 17.5 min in (Group A, n = 1 vs Group B, n = 2), myringoplasty, tympanoplasty, tympanotomy and ossiculoplasty 85.8 min vs and 107.8 min (Group A, n = 10 vs Group B, n = 10), CSOM and cholesteotoma surgery 171 min vs 217.2 min (Group A, n = 15 vs Group B, n = 10), stapedectomy 136.5 min vs 175.2 min (Group A, n = 11 vs Group B, n = 9) and petrosectomy 387 min vs 253 min (Group A, n = 1 vs Group B, n = 1).

Graft material was used in a total of 30 patients (15 vs 15 patients from Group A and B respectively). Choice of graft material varied from tragal cartilage (7 vs 5), conchal cartilage (3 vs 0), composite tragal graft (2 vs 4), temporalis fascia (3 vs 6) and fascia lata and fat (1 vs 0) from patients in Group A and B respectively.

Eight patients developed post-operative complications that later resolved including otalgia, recurrent otitis media with effusion, transient delayed facial palsy, labyrinthitis, tragal abscess and tympanic membrane perforation and infection of the mastoid cavity (see Tables 2-6). Three patients were planned for further surgery at follow up. Mean post-operative follow up was 8.8 mo; 2 patients were lost to follow up.

DISCUSSION
Ventilation tube insertion

Only one patient in our case series had ventilation tube insertion lasting 25 min. Though numbers are extremely low, and therefore difficult to analyse, this operation took 7.5 min longer than the mean duration of non-endoscope-assisted surgery. In contrast, a recent study examining 260 endoscopic grommet insertions demonstrated operating times between 5 and 10 min in all cases[2]. Another study has shown that there is no significant difference in duration compared to using a microscope, though it does advocate the use of an endoscope when ventilation tube placement is technically difficult[21].

Myringoplasty, Tympanoplasty and Tympanotomy

This series demonstrates that the endoscope can effectively access the middle ear for these procedures. No further incisions were required and an exclusively permeatal approach was used in all endoscopic procedures. Surgical outcomes were good in all cases (Table 2) with shorter mean operating times as compared to Group B (non-endoscope = assisted surgery), 85.8 min vs 107.8 min for Group A vs B respectively. This is a fairly accurate representation of true operating time, since the same numbers of operations were performed in each group. There is also evidence that excellent hearing thresholds can be achieved endoscopically, as reported by Balasubramanian and Venkatesan, who achieved pure tone average hearing thresholds of 20 dB in 50 myringoplasties performed endoscopically, further confirming the efficacy of this technique in selected cases[2].

CSOM and cholesteatoma surgery

Mean operating time was shorter in Group A compared to Group B (171 min vs 217.2 min respectively). Since total number of operations here were not equal (n = 15 vs n = 10), it is unreliable to claim the difference between these figures is of clinical significance. Variation in anatomy and pre-operative disease state (e.g., actively discharging ear), will also have implications on duration of operation due to technical difficulty.

Cholesteatoma can vary in anatomical spread and severity of disease. In widespread, severe cases, canal wall up mastoidectomy or modified radical mastoidectomy can be performed. Our case series shows a variation in the number of these procedures between both groups. Performing mastoidectomy exclusively with an endoscope is impossible, and therefore drawing comparisons between these groups is difficult, as the endoscope will not have been used during a proportion of surgery in Group A. However, only the endoscope was used for the entire operation where there were cases of limited cholesteatoma, or recurrent disease in revision surgery. Recent literature supports this, demonstrating that an exclusively endoscopic approach can be very useful as a “second look” surgery in in order to identify residual cholesteotoma[11].

The most widely documented use of endoscopic ear surgery has been for cholesteatoma disease. Some studies have examined the use of the endoscope as an adjunct for surgery. Residual cholesteatoma rates in closed cavity surgery have been documented around 9%, which is comparable to use with a microscope alone[14]. One study examined its use peri-operatively after surgery using the microscope. Residual disease was identified in 65/80 cases, and was documented to commonly occur on the stapes footplate, the stapes crura, and the sinus tympani[13]. The use of the endoscope has also been shown to decrease the rate of “open tympanoplasty” during this surgery. Results for localised attic disease have achieved air bone gap closure within 20 dB in around 90% of patients between 3 and 6 years follow up. Figures of 80% disease-free follow up have also been documented on 27 cases with limited attic retractions[6]. Our series demonstrates relatively efficient use of the endoscope during revision surgery, which highlights the importance of a good visibility during technically challenging operations within the middle ear. However longer follow up is required to confirm its efficacy in these revision cases.

Stapedectomy

Our case series of 11 stapedectomies performed using a 4 mm endoscope at 0 and 30 degrees demonstrated the preservation of the chorda tympani all cases, as well as achieving significant improvement in pre and post-operative air-bone closure (P < 0.05) where thresholds were within < 30 dB for all cases. By comparison, the 9 operations performed without the endoscope, also show significant improvement in pre and post-operative air bone gap (P < 0.05), but with a longer mean duration of surgery (136.4 min vs 175.2 min for Group A and B respectively). First described by Poe in 2000, endoscopic stapedectomy has gone on to show promise in other countries across the world, achieving significant improvement in air bone gap by comparing pre and post-operative hearing thresholds[1,15]. Our series is in keeping with this.

Petrosectomy

There are some reports of successful use of the endoscope during cholesteatoma surgery within the petrous apex, as was used for one case in our series[22]. Due to the discovery of a CSF leak intra-opertively, the duration of surgery is much higher compared to the non-endoscopic assisted surgery. It is difficult to compare these two surgical approaches for this operation from this single case series.

Clinical applicability

Endoscopic surgery has also been used in a variety of neuro-otological procedures, including acoustic neuroma surgery. Some centres have also begun using it as the first surgical option or as an adjunct to conventional posterior tympanotomy approach in cochlear implantation[23-25]. Its benefit as an adjunct to conventional surgical techniques where wider exposure is required due to a limited direct vision has been well recognised[4,17,18]. Cadaveric studies using the endoscope alone have also documented superior views of the internal acoustic meatus over conventional techniques, although clinical applicability for this may well take several years to develop[23,25].

The endoscopic technique in ear surgery undoubtedly gives better quality images and access to blind sacs around the middle ear space that would otherwise not have been visualised adequately using a microscope, irrespective of surgical approach. It is minimally invasive thus providing better cosmesis in patients who do not wish to have a scar. Its use in the outpatient setting has gained popularity by consultant otolaryngologists and junior trainees due to its accessibility, portability and superiority over hand drawn diagrams of the tympanic membrane, which often can be unreliable and inaccurate. In addition, our series demonstrates a role in revision mastoid surgery in particular, where, for example, the cavity can be revised by curettage of a high “facial ridge” entirely endoscopically and permeatally.

The most commonly used rigid endoscopes are 18 cm long and 4 mm (as used for all operations in this case series). Some surgeons find this endoscope difficult to manoeuvre due to its length and larger diameter, and advocate using a paediatric nasal endoscope which is 2.7 mm diameter and 11 cm long[1]. However these endoscopes generate poor views and 3 mm endoscopes are available and better suited for ear surgery. Ideally, an endoscope with a small diameter, and shorter length, possibly with a modification to allow the surgeon to keep two hands free but that retains light intensity within a wider field, would be ideal for operating on the middle ear.

In addition, it is worth nothing that there is a learning curve when using any new technique. This may be improved for otolaryngologists where we regularly use the endoscope during endoscopic sinus surgery for example.

Limitations

The numbers for each operation in our prospective case series is low, leaving the study underpowered. However, this case series serves as a pilot study to open the debate of endoscopic ear surgery in the United Kingdom. To enhance our results, more cases would need to be examined in a similar prospective fashion. Only then could reliable conclusions be drawn from comparing endoscopic and open techniques.

Another limitation is the small number in each group, addressed above in regard of the power of the study, alongside the groups being somewhat heterogeneous particularly in the largest group of mastoid and tympanoplasty surgery. However we need to group the surgeries into a grading from simple to complex and these groupings certainly serve to follow this. The groupings, like the above point, serve to illustrate the possibilities of the endoscope rather than to compare the surgeries themselves. Likewise, including in our series, grommet insertion and petrosectomy demonstrates the utility of the endoscope, despite the few numbers. This will be of value and interest to the readership to investigate further despite the small numbers.

The role of endoscopic ear surgery is yet to be properly established but as more otologists adopt this technique, its role will become much more clearly defined and may lead to widespread use based upon positive outcomes for surgery. As with every new surgical technique, a learning curve must first be overcome before reliable conclusions can be drawn about its use. Our series has shown the benefits of using this technique in limited cholesteatoma disease and in providing a good view during revision mastoid surgery with simple pathology.

COMMENTS
Background

Endoscope assisted ear surgery is increasingly common. However its role has not been properly elucidated. The authors investigate potential roles across a range of otological procedures.

Research frontiers

Minimal access surgery from robotic to endoscopic approaches are being increasingly analysed.

Innovations and breakthroughs

This study highlights the role of endoscope surgery in revision mastoid surgery alongside the more well-established role in stapedectomy. The endoscope allows excellent visualisation of the middle ear cleft and any cholesteatoma.

Applications

The endoscope can assist in mastoid surgery, particularly in revision cases. It also has a role in stapedectomy and other middle ear surgery.

Peer-review

Authors described their experience about endoscopic ear surgery. As mentioned by authors, this surgical procedure has already been described in case series numerically significant.

Footnotes

P- Reviewer: Beegun I, Berlucchi M, Fragkiadakis G S- Editor: Ji FF L- Editor: A E- Editor: Lu YJ

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