Meta-Analysis
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Apr 24, 2017; 7(2): 152-160
Published online Apr 24, 2017. doi: 10.5500/wjt.v7.i2.152
Living related and living unrelated kidney transplantations: A systematic review and meta-analysis
Nasser Simforoosh, Hamidreza Shemshaki, Mohammad Nadjafi-Semnani, Mehdi Sotoudeh
Nasser Simforoosh, Hamidreza Shemshaki, Mohammad Nadjafi-Semnani, Mehdi Sotoudeh, Department of Urology, Shahid Labbafi Nejad Hospital, Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran 198396-3113, Iran
Author contributions: Simforoosh N, Shemshaki H, Nadjafi-Semnani M and Sotoudeh M acquisition of data, analysis and interpretation of data, drafting the article and final approval; Sotoudeh M interpretation of data, revising the article and final approval.
Conflict-of-interest statement: The authors deny any conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Nasser Simforoosh, Professor, Department of Urology, Shahid Labbafi Nejad Hospital, Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, 9th Boostan Avenue, Pasdaran Avenue, Tehran 198396-3113, Iran. simforoosh@iurtc.org.ir
Telephone: +98-21-22588018 Fax: +98-21-22588016
Received: November 21, 2016
Peer-review started: November 23, 2016
First decision: January 16, 2017
Revised: February 20, 2017
Accepted: April 6, 2017
Article in press: April 10, 2017
Published online: April 24, 2017
Abstract
AIM

To compare the outcomes between related and unrelated kidney transplantations.

METHODS

Literature searches were performed following the Cochrane guidelines. We conducted a systematic review and a meta-analysis, which included 12 trials that investigated outcomes including the long-term (ten years), mid-term (one to five years), and short-term (one year) graft survival rate as well as the acute rejection rate. Meta-analyses were performed using fixed and random-effects models, which included tests for publication bias and heterogeneity.

RESULTS

No difference in graft survival rate was detected in patients who underwent living related kidney transplantations compared to unrelated (P = 0.44) transplantations after ten years. There were no significant differences between the graft survival rate in living related and unrelated kidney transplantations after a short- and mid-term follow-up (P = 0.35, P = 0.46). There were no significant differences between the acute rejection rate in living related and unrelated kidney transplantations (P = 0.06).

CONCLUSION

The long, mid and short term follow-up of living related and unrelated kidney transplantation showed no significant difference in graft survival rate. Also, acute rejection rate was not significantly different between groups.

Keywords: Transplantation, Living related, Living unrelated, Graft survival rate

Core tip: The long, mid and short term follow-up of living related and unrelated kidney transplantation showed no significant difference in graft survival rate. Also, acute rejection rate was not significantly different between groups.