Published online Feb 24, 2017. doi: 10.5500/wjt.v7.i1.64
Peer-review started: November 2, 2016
First decision: November 14, 2016
Revised: November 18, 2016
Accepted: December 7, 2016
Article in press: December 9, 2016
Published online: February 24, 2017
To report the first international living related two way kidney paired donation (KPD) transplantation from India which occurred on 17th February 2015 after legal permission from authorization committee.
Donor recipient pairs were from Portugal and India who were highly sensitized and ABO incompatible with their spouse respectively. The two donor recipient pairs had negative lymphocyte cross-matching, flow cross-match and donor specific antibody in two way kidney exchange with the intended KPD donor. Local KPD options were fully explored for Indian patient prior to embarking on international KPD.
Both pairs underwent simultaneous uneventful kidney transplant surgeries and creatinine was 1 mg/dL on tacrolimus based immunosuppression at 11 mo follow up. The uniqueness of these transplantations was that they are first international KPD transplantations in our center.
International KPD will increases quality and quantity of living donor kidney transplantation. This could be an important step to solving the kidney shortage with additional benefit of reduced costs, improved quality and increased access for difficult to match incompatible pairs like O blood group patient with non-O donor and sensitized patient. To the best of our knowledge this is first international KPD transplantation from India.
Core tip: Kidney paired donation (KPD) has rapidly increased the access to living donor kidney transplantation (LDKT) in the last decade. The participation in the international kidney exchange registries will expand the donor pool for kidney transplantation. We report first Indian international living related KPD transplantation which occurred on 17th February 2015 after legal permission from authorization committee between a pair from Portugal and India who were highly sensitized and ABO incompatible with their spouse respectively. International KPD will increases quality and quantity of LDKT. This could be an important step to solving the kidney shortage with additional benefit of reduced costs, improved quality and increased access for difficult to match incompatible pairs like O blood group patient with non-O donor and sensitized patient.