Copyright
©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Inflammatory diseases modelling in zebrafish
Camila Idelí Morales Fénero, Niels Olsen Saraiva Câmara, Laboratory of Transplantation Immunobiology, Department of Immunology, Institute of Biomedical Sciences IV, University of São Paulo, Cidade Universitária, São Paulo 05508-900, Brazil
Alicia Angelina Colombo Flores, Laboratory of Neuronal Circuit and Craniofacial Development, Anatomy and Developmental Biology Program, ICBM, University of Chile, Santiago 8380453, Chile
Author contributions: Morales Fénero CI designed and wrote the manuscript; Colombo Flores AA and Câmara NOS revised and corrected the manuscript.
Supported by The National Counsel of Technological and Scientific Development, No. 134660/2013-7.
Conflict-of-interest statement: Morales Fénero CI and Câmara NOS report the affiliation to the Latin American Zebrafish Network (LAZEN) with non-financial interest in the subject matter or materials discussed in this manuscript; Colombo A has not declared conflict-of-interest in this work.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Niels Olsen Saraiva Câmara, MD, PhD, Titular Professor, Laboratory of Transplantation Immunobiology, Department of Immunology, Institute of Biomedical Sciences IV, University of São Paulo, Cidade Universitária, São Paulo 05508-900, Brazil. niels@icb.usp.br
Telephone: +55-11-30917388 Fax: +55-11-30917224
Received: July 29, 2015
Peer-review started: July 29, 2015
First decision: September 29, 2015
Revised: October 20, 2015
Accepted: December 18, 2015
Article in press: December 21, 2015
Published online: February 20, 2016
Peer-review started: July 29, 2015
First decision: September 29, 2015
Revised: October 20, 2015
Accepted: December 18, 2015
Article in press: December 21, 2015
Published online: February 20, 2016
Core Tip
Core tip: The western lifestyle with a high fat and carbohydrates diet, lack of physical activity and stress, is a trigger for different diseases with complex interactions between the host genetics, the metabolism, the immune system and the microbiota, as the inflammatory bowel disease (IBD), obesity and diabetes. The zebrafish has 70% homology with our genes, shares anatomic and physiological characteristics with mammals, and emerges as a new model for the study of metabolic and inflammatory diseases. In this review, we examine the existing genetic and induced zebrafish models of two important Western diseases with strong inflammatory component, IBD and obesity.