Connolly KA, Eddleman KA. Amniocentesis: A contemporary review. World J Obstet Gynecol 2016; 5(1): 58-65 [DOI: 10.5317/wjog.v5.i1.58]
Corresponding Author of This Article
Katherine Ann Connolly, MD, Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, Mount Sinai Hospital, 5 East 98th Street, Room 256, New York, NY 10029, United States. katherine.connolly@mssm.edu
Research Domain of This Article
Obstetrics & Gynecology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Obstet Gynecol. Feb 10, 2016; 5(1): 58-65 Published online Feb 10, 2016. doi: 10.5317/wjog.v5.i1.58
Amniocentesis: A contemporary review
Katherine Ann Connolly, Keith Arnold Eddleman
Katherine Ann Connolly, Keith Arnold Eddleman, Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, Mount Sinai Hospital, New York, NY 10029, United States
Author contributions: All authors equally contributed to this paper with conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version.
Conflict-of-interest statement: No potential conflicts of interest. No financial support.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Katherine Ann Connolly, MD, Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, Mount Sinai Hospital, 5 East 98th Street, Room 256, New York, NY 10029, United States. katherine.connolly@mssm.edu
Telephone: +1-212-2415681 Fax: +1-212-3487438
Received: August 1, 2015 Peer-review started: August 6, 2015 First decision: September 16, 2015 Revised: October 27, 2015 Accepted: December 13, 2015 Article in press: December 15, 2015 Published online: February 10, 2016
Core Tip
Core tip: Invasive testing remains the only way to provide comprehensive testing for chromosomal abnormalities. Despite availability of cell free fetal DNA testing, amniocentesis should still be offered to all women who desire complete genetic testing. Amniocentesis is also useful if intraamniotic infection is suspected, but the clinical picture is unclear. Additionally, when late preterm delivery is indicated, amniocentesis need not be used. There are, however, some instances when delivery timing is unclear and amniocentesis for fetal lung maturity may provide information to guide delivery timing. Amniocentesis is a relatively safe procedure. We counsel patients that technique has changed since the original studies in the 1970s and feel comfortable quoting a loss rate of 1/500-1/1000 based on contemporary data.
