Clinical Trials Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Orthop. Jan 18, 2017; 8(1): 49-56
Published online Jan 18, 2017. doi: 10.5312/wjo.v8.i1.49
Microvascular response to transfusion in elective spine surgery
J Matthias Walz, Ottokar Stundner, Federico P Girardi, Bruce A Barton, Aimee R Koll-Desrosiers, Stephen O Heard, Stavros G Memtsoudis
J Matthias Walz, Stephen O Heard, Department of Anesthesiology and Perioperative Medicine, UMass Memorial Healthcare, Worcester, MA 01655, United States
Ottokar Stundner, Department of Anesthesiology, Hospital for Special Surgery, Weill Cornell Medical Center, New York, NY 10021, United States
Ottokar Stundner, Department of Anesthesiology, Perioperative Medicine and Intensive Care Medicine, Paracelsus Medical University, 5020 Salzburg, Austria
Federico P Girardi, Department of Orthopedic Surgery, Hospital for Special Surgery, Weill Cornell Medical Center, New York, NY 10021, United States
Bruce A Barton, Aimee R Kroll-Desrosiers, Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA 01655, United States
Stavros G Memtsoudis, Department of Anesthesiology, Hospital for Special Surgery, Weill Cornell Medical Center, New York, NY 10021, United States
Author contributions: Walz JM, Heard SO and Memtsoudis SG designed the research; Girardi FP, Stundner O and Memtsoudis SG conducted the research; Barton BA and Kroll-Desrosiers AR developed the statistical model and performed all statistical analysis; all authors analyzed and interpreted the data; Walz JM wrote the first draft of the manuscript; all authors revised the manuscript, approved the final manuscript, and are accountable for all aspects of the work; Walz JM is the guarantor of the manuscript and takes full responsibility for the integrity of the work as a whole, from inception to published article.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board at the Hospital for Special Surgery, NY.
Informed consent statement: All study participants provided informed written consent prior to study enrollment.
Conflict-of-interest statement: None of the authors has any conflicts of interest relevant to this study.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: J Matthias Walz, MD, Department of Anesthesiology and Perioperative Medicine, UMass Memorial Healthcare, 55 Lake Avenue North, Worcester, MA 01655, United States. matthias.walz@umassmemorial.org
Telephone: +1-508-8563266
Received: June 12, 2016
Peer-review started: June 17, 2016
First decision: July 18, 2016
Revised: August 21, 2016
Accepted: October 25, 2016
Article in press: October 27, 2016
Published online: January 18, 2017
Core Tip

Core tip: Tissue oxygenation determined by Near Infrared Spectroscopy has been used to assess the adequacy of end-organ perfusion in models of trauma and sepsis and has been shown to correlate with stroke volume in models of hemorrhagic shock. We sought to investigate muscle tissue oxygenation (SmO2) during transfusion in patients undergoing complex spine surgery, and to study the association of SmO2 with invasive hemodynamic parameters in the clinical setting. In our study, we were unable to demonstrate a statistically significant correlation between SmO2 and either invasive hemodynamic, or laboratory parameters in patients undergoing elective complex spine surgery.