Copyright
©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pharmacol Ther. Feb 6, 2016; 7(1): 156-161
Published online Feb 6, 2016. doi: 10.4292/wjgpt.v7.i1.156
Published online Feb 6, 2016. doi: 10.4292/wjgpt.v7.i1.156
Therapeutic effect of melatonin on pediatric functional dyspepsia: A pilot study
Katherine Zybach, Craig A Friesen, Division of Gastroenterology, Hepatology and Nutrition, Children’s Mercy Kansas City, Kansas City, MO 64108, United States
Jennifer V Schurman, Division of Developmental and Behavioral Sciences, Children’s Mercy Kansas City, Kansas City, MO 64108, United States
Author contributions: Zybach K was the primary contributor to study design, study management, data analysis, and manuscript writing and revision; Friesen CA contributed to study design, analysis, and manuscript writing and revision; Schurman JV contributed to analysis, manuscript writing, and critical review.
Institutional review board statement: The study was reviewed and approved by the Children’s Mercy Hospital Institutional Review Board.
Clinical trial registration statement: This study is registered at ClinicalTrials.gov (NCT00148603).
Informed consent statement: The legal guardians of all study participants provided informed written consent and all study participants provided assent prior to study enrollment.
Conflict-of-interest statement: The authors have no conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Craig A Friesen, MD, Division of Gastroenterology, Hepatology and Nutrition, Children’s Mercy Kansas City, 2401 Gillham Road, Kansas City, MO 64108, United States. cfriesen@cmh.edu
Telephone: +1-816-2343016 Fax: +1-816-8021465
Received: August 8, 2015
Peer-review started: August 11, 2015
First decision: September 11, 2015
Revised: October 6, 2015
Accepted: November 23, 2015
Article in press: November 25, 2015
Published online: February 6, 2016
Peer-review started: August 11, 2015
First decision: September 11, 2015
Revised: October 6, 2015
Accepted: November 23, 2015
Article in press: November 25, 2015
Published online: February 6, 2016
Core Tip
Core tip: Medical therapy is limited in children with functional dyspepsia. This creates a challenging clinical dilemma with regards to managing their symptoms. Melatonin has been shown to have a positive effect on pain in adults with functional dyspepsia or irritable bowel syndrome, independent of its effects on sleep. To date, there have been no studies to evaluate the effect of melatonin on abdominal pain in children. In the current study, melatonin did not result in improvement in abdominal pain or sleep parameters in children with functional dyspepsia.