Published online May 15, 2017. doi: 10.4291/wjgp.v8.i2.93
Peer-review started: November 5, 2016
First decision: December 29, 2016
Revised: January 27, 2017
Accepted: March 12, 2017
Article in press: March 13, 2017
Published online: May 15, 2017
Gastrointestinal involvement in plasma cell neoplasms, either as primary localizations (extramedullary plasmacytomas) or as secondary involvement in systemic multiple myeloma, is a well-known event. Accurate histological examination is crucial in defining the diagnosis. In this report, an uncommon case of duodenal localization of myeloma with plasmablastic features is described, with emphasis on the role of clinical data and findings from ancillary immunostaining techniques to avoid misdiagnosis.
Core tip: In cases of gastrointestinal involvement by high-grade plasma cell neoplasia, the presence of large atypical cells infiltrating the lamina propria of the mucosa may lead to an erroneous diagnosis of poorly differentiated carcinoma. Clinical data and findings from ancillary immunostaining techniques are crucial to avoid misdiagnosis.