Retrospective Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Radiol. Apr 28, 2017; 9(4): 206-211
Published online Apr 28, 2017. doi: 10.4329/wjr.v9.i4.206
C-reactive protein and radiographic findings of lower respiratory tract infection in infants
Maria Twomey, Hannah Fleming, Fiachra Moloney, Kevin P Murphy, Lee Crush, Siobhan B O’Neill, Oisin Flanagan, Karl James, Conor Bogue, Owen J O’Connor, Michael M Maher
Maria Twomey, Hannah Fleming, Fiachra Moloney, Kevin P Murphy, Lee Crush, Siobhan B O’Neill, Oisin Flanagan, Karl James, Conor Bogue, Owen J O’Connor, Michael M Maher, Department of Radiology, Cork University Hospital, Wilton, T12 DC4A Cork, Ireland
Author contributions: Twomey M drafted the manuscript; Fleming H collected the data and drafted the manuscript; Moloney F collected data and performed statistical analysis; Murphy KP collected the data; Crush L collected data and reported the chest radiographs; O’Neill SB collected the data and performed data analysis; Flanagan O was involved in data analysis, drafting the manuscript and editing; James K redrafted and revised the manuscript, created the audio file and added supplementary comments; Bogue C edited the manuscript; O’Connor OJ edited the manuscript; Maher MM designed the research study and oversaw all aspects of the study.
Institutional review board statement: The study was reviewed and approved by the Cork Clinical Research Ethics Committee, Lancaster Hall, Cork, Ireland.
Informed consent statement: Informed consent was not deemed necessary for this study. Clinical and radiological data was collected retrospectively in an anonymised fashion and no patient underwent additional procedures or investigations as a result of recruitment to the study. Ethical approval was granted without a requirement for informed consent.
Conflict-of-interest statement: All authors wish to declare no conflicts of interest.
Data sharing statement: The technical appendix, statistical code, and dataset are available form the corresponding author at drkarljames@outlook.com. Informed consent was not obtained but the presented data are anonymised and the risk of identification is low.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Karl James, FFR RCSI, Department of Radiology, Cork University Hospital, 1 Bishopstown Road, Wilton, T12 DC4A Cork, Ireland. drkarljames@outlook.com
Telephone: +353-021-4920288 Fax: +353-021-4922002
Received: June 14, 2016
Peer-review started: June 17, 2016
First decision: July 27, 2016
Revised: August 10, 2016
Accepted: October 17, 2016
Article in press: October 18, 2016
Published online: April 28, 2017
Core Tip

Core tip: Abnormal chest radiograph findings are significantly more common in patients with elevated C-reactive protein (CRP) levels. Young children are most likely to have abnormal chest radiograph findings if they have all three of the following; a CRP level of 50-99 mg/L, respiratory symptoms and if they are aged greater than 1 year.