Published online Apr 28, 2017. doi: 10.4329/wjr.v9.i4.199
Peer-review started: August 29, 2016
First decision: December 13, 2016
Revised: January 11, 2017
Accepted: February 28, 2017
Article in press: March 2, 2017
Published online: April 28, 2017
To evaluate the correlation between degree of kinetic growth (kGR) of the liver following portal vein embolization (PVE) liver and the enhancement of the during the hepatobiliary phase of contrast administration and to evaluate if the enhancement can be used to predict response to PVE prior to the procedure.
Seventeen patients were consented for the prospective study. All patients had an MR of the abdomen with Gd-EOB-DTPA. Fourteen patients underwent PVE. The correlation between the kGR of the liver and the degree of enhancement was evaluated with linear regression (strong assumptions) and Spearman’s correlation test (rank based, no assumptions). The correlation was examined for the whole liver, segments I, VIII, VII, VI, V, IV, right liver and left liver.
There was no correlation between the degree of enhancement during the hepatobiliary phase and kGR for any segment, lobe of the liver or whole liver (P = 0.19 to 0.91 by Spearman’s correlation test).
The relative enhancement of the liver during the hepatobiliary phase with Gd-EOB-DTPA cannot be used to predict the liver response to PVE.
Core tip: Our hypothesis was that the degree of enhancement of the liver during the hepatobiliary phase will correlate with the degree of liver response to portal vein embolization. This will be able to be used as a screen method for patients scheduled for portal vein embolization (PVE). The use of Gd-EOB-DTPA in the assessment of liver function has been correlated with clinical assessment of liver function classification. We evaluated the correlation between degree of kinetic growth (kGR) of the liver following PVE liver and the enhancement of the during the hepatobiliary phase of contrast administration. There was no correlation between the degree of enhancement during the hepatobiliary phase and kGR.