Liu S, Tao F. Role of α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor regulation in stress-induced pain chronification. World J Biol Chem 2017; 8(1): 1-3 [PMID: 28289513 DOI: 10.4331/wjbc.v8.i1.1]
Corresponding Author of This Article
Feng Tao, MD, PhD, Associate Professor, Department of Biomedical Sciences, Texas A&M University College of Dentistry, 3302 Gaston Avenue, Dallas, TX 75246, United States. tao@tamhsc.edu
Research Domain of This Article
Neurosciences
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Biol Chem. Feb 26, 2017; 8(1): 1-3 Published online Feb 26, 2017. doi: 10.4331/wjbc.v8.i1.1
Role of α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor regulation in stress-induced pain chronification
Sufang Liu, Feng Tao
Sufang Liu, Feng Tao, Department of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, TX 75246, United States
Sufang Liu, Department of Physiology, Zhengzhou University School of Medicine, Zhengzhou 450003, Henan Province, China
Feng Tao, Center for Craniofacial Research and Diagnosis, Texas A&M University College of Dentistry, Dallas, TX 75246, United States
Author contributions: Liu S and Tao F wrote the manuscript.
Supported byThe National Institute of Dental and Craniofacial Research Grants, Nos. R01 DE022880 and K02 DE023551.
Conflict-of-interest statement: The authors have no conflict of interests.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Feng Tao, MD, PhD, Associate Professor, Department of Biomedical Sciences, Texas A&M University College of Dentistry, 3302 Gaston Avenue, Dallas, TX 75246, United States. tao@tamhsc.edu
Telephone: +1-214-8288272 Fax: +1-214-8744538
Received: July 7, 2016 Peer-review started: July 14, 2016 First decision: September 12, 2016 Revised: October 29, 2016 Accepted: December 7, 2016 Article in press: December 9, 2016 Published online: February 26, 2017
Abstract
Persistent postsurgical pain is a serious issue in public health, which has received increased interest in recent years. Previous studies have reported that psychological factors promote the development of chronic postsurgical pain. However, it is unclear how chronification of postsurgical pain occurs. The α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor (AMPA) phosphorylation in the central nervous system plays a critical role in synaptic plasticity and contributes to central sensitization and chronic pain development. Here, we discuss the role of AMPA receptor regulation in stress-induced pain chronification after surgery.
Core tip: The α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor phosphorylation contributes to stress-induced pain chronification after surgery.
