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World J Diabetes. Mar 15, 2017; 8(3): 97-103
Published online Mar 15, 2017. doi: 10.4239/wjd.v8.i3.97
Involvement of Cbl-b-mediated macrophage inactivation in insulin resistance
Tomoki Abe, Katsuya Hirasaka, Takeshi Nikawa
Tomoki Abe, Takeshi Nikawa, Department of Nutritional Physiology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan
Katsuya Hirasaka, Graduate School of Fisheries Science and Environmental Studies, Nagasaki University, Nagasaki 852-8521, Japan
Author contributions: Abe T generated the figures and wrote the manuscript; Hirasaka K and Nikawa T specified the aims of the editorial and assisted in writing the manuscript.
Supported by The Japan Society for the Promotion of Science KAKENHI (to Tomoki Abe), No. JP15K16208.
Conflict-of-interest statement: No potential conflicts of interest relevant to this article were reported.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Takeshi Nikawa, MD, PhD, Professor, Department of Nutritional Physiology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan. nikawa@tokushima-u.ac.jp
Telephone: +81-88-6339248 Fax: +81-88-6337086
Received: March 25, 2016
Peer-review started: March 26, 2016
First decision: May 13, 2016
Revised: December 23, 2016
Accepted: January 11, 2017
Article in press: January 13, 2017
Published online: March 15, 2017
Core Tip

Core tip: Obesity leads to the development of chronic inflammation and insulin resistance (IR). Adipose tissue macrophages (ATMs) play a crucial role in the development of obesity-induced IR. Therefore, ATMs are attractive therapeutic targets for IR. Recently, we demonstrated that the ubiquitin ligase Casitas b-lineage lymphoma-b (Cbl-b) negatively regulates the migration and activation of ATMs. Here, we review key aspects of Cbl-b function in the regulation of ATMs.